diff --git a/sdk/ml/azure-ai-ml/setup.py b/sdk/ml/azure-ai-ml/setup.py
index f5ec547e827d..83c0d47fe922 100644
--- a/sdk/ml/azure-ai-ml/setup.py
+++ b/sdk/ml/azure-ai-ml/setup.py
@@ -69,7 +69,6 @@
     install_requires=[
         # NOTE: To avoid breaking changes in a major version bump, all dependencies should pin an upper bound if possible.
         "pyyaml>=5.1.0,<7.0.0",
-        "msrest>=0.6.18,<1.0.0",
         "azure-core>=1.23.0",
         "azure-mgmt-core>=1.3.0",
         "marshmallow>=3.5,<4.0.0",
@@ -88,8 +87,6 @@
         "azure-common>=1.1",
         "typing-extensions<5.0.0",
         "azure-monitor-opentelemetry",
-        # TODO: remove six after using new autorest
-        "six>=1.11.0",
     ],
     extras_require={
         # user can run `pip install azure-ai-ml[designer]` to install mldesigner along with this package