From 61236b419ad59513f9eac50b5b5aac417cae91e0 Mon Sep 17 00:00:00 2001 From: veghp Date: Thu, 7 Nov 2024 19:46:59 +0000 Subject: [PATCH] Fix #78 --- README.rst | 10 +++++++++- 1 file changed, 9 insertions(+), 1 deletion(-) diff --git a/README.rst b/README.rst index dbdfce8..139e7f4 100644 --- a/README.rst +++ b/README.rst @@ -26,9 +26,17 @@ composed to, for instance, codon-optimize genes, meet the constraints of a commercial DNA provider, avoid homologies between sequences, tune GC content, or all of this at once! Users can also define their own specifications using Python, making the library suitable for a large range of automated sequence -design applications, and complex custom design projects. +design applications, and complex custom design projects. A specification can be +either a hard constraint, which must be satisfied in the final sequence, or an +optimization objective, whose score must be maximized. +For more information, please see the publication. +Citation +~~~~~~~~ + +DNA Chisel, a versatile sequence optimizer, *Valentin Zulkower, Susan Rosser.* `Bioinformatics `_ (2020) 36, 16, 4508–4509 + Usage -----