diff --git a/packages/calcite-components/src/components/popover/PopoverManager.ts b/packages/calcite-components/src/components/popover/PopoverManager.ts
index 00f3cda446e..b872f75af11 100644
--- a/packages/calcite-components/src/components/popover/PopoverManager.ts
+++ b/packages/calcite-components/src/components/popover/PopoverManager.ts
@@ -87,7 +87,7 @@ export default class PopoverManager {
   };
 
   private clickHandler = (event: PointerEvent): void => {
-    if (isKeyboardTriggeredClick(event)) {
+    if (isKeyboardTriggeredClick(event) || event.defaultPrevented) {
       return;
     }
 
diff --git a/packages/calcite-components/src/components/tooltip/TooltipManager.ts b/packages/calcite-components/src/components/tooltip/TooltipManager.ts
index 1c5539ac0be..2f5f68ee73d 100644
--- a/packages/calcite-components/src/components/tooltip/TooltipManager.ts
+++ b/packages/calcite-components/src/components/tooltip/TooltipManager.ts
@@ -97,6 +97,10 @@ export default class TooltipManager {
   };
 
   private pointerMoveHandler = (event: PointerEvent): void => {
+    if (event.defaultPrevented) {
+      return;
+    }
+
     const composedPath = event.composedPath();
     const { activeTooltip } = this;
 
@@ -129,6 +133,10 @@ export default class TooltipManager {
   }
 
   private clickHandler = (event: Event): void => {
+    if (event.defaultPrevented) {
+      return;
+    }
+
     this.clickedTooltip = null;
     const composedPath = event.composedPath();
     const tooltip = this.queryTooltip(composedPath);
@@ -160,6 +168,10 @@ export default class TooltipManager {
   };
 
   private focusInHandler = (event: FocusEvent): void => {
+    if (event.defaultPrevented) {
+      return;
+    }
+
     const composedPath = event.composedPath();
     const tooltip = this.queryTooltip(composedPath);