diff --git a/packages/isaac-typescript-definitions/src/enums/BackdropType.ts b/packages/isaac-typescript-definitions/src/enums/BackdropType.ts
index 6f165a532..162b845bf 100644
--- a/packages/isaac-typescript-definitions/src/enums/BackdropType.ts
+++ b/packages/isaac-typescript-definitions/src/enums/BackdropType.ts
@@ -67,4 +67,6 @@ export enum BackdropType {
   MINES_SHAFT = 58,
   ASHPIT_SHAFT = 59,
   DARK_CLOSET = 60,
+  DEATHMATCH = 61,
+  LIL_PORTAL = 62,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts b/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts
index 6b8185ea9..372e8e465 100644
--- a/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts
+++ b/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts
@@ -52,14 +52,14 @@ export enum ButtonAction {
   /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
   MENU_BACK = 15,
 
-  /** This only fires on `InputHook.IS_ACTION_PRESSED` (0). */
-  RESTART = 16,
-
   /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
-  FULLSCREEN = 17,
+  FULLSCREEN = 16,
 
   /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
-  MUTE = 18,
+  MUTE = 17,
+
+  /** This only fires on `InputHook.IS_ACTION_PRESSED` (0). */
+  RESTART = 18,
 
   /** Does not seem to trigger any input hooks while on keyboard. */
   JOIN_MULTIPLAYER = 19,
@@ -76,15 +76,21 @@ export enum ButtonAction {
   /** Does not seem to trigger any input hooks while on keyboard. */
   MENU_DOWN = 23,
 
+  MENU_LB = 24,
+  MENU_RB = 25,
+
   /** Does not seem to trigger any input hooks while on keyboard. */
-  MENU_LT = 24,
+  MENU_LT = 26,
 
   /** Does not seem to trigger any input hooks while on keyboard. */
-  MENU_RT = 25,
+  MENU_RT = 27,
 
   /** Does not seem to trigger any input hooks while on keyboard. */
-  MENU_TAB = 26,
+  MENU_TAB = 28,
+
+  MENU_EX = 29,
+  EMOTES = 30,
 
   /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
-  CONSOLE = 28,
+  CONSOLE = 32,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/DrawStringAlignment.ts b/packages/isaac-typescript-definitions/src/enums/DrawStringAlignment.ts
new file mode 100644
index 000000000..64e4eaa0d
--- /dev/null
+++ b/packages/isaac-typescript-definitions/src/enums/DrawStringAlignment.ts
@@ -0,0 +1,12 @@
+/** Added in Repentance+. */
+export enum DrawStringAlignment {
+  TOP_LEFT = 0,
+  TOP_CENTER = 1,
+  TOP_RIGHT = 2,
+  MIDDLE_LEFT = 3,
+  MIDDLE_CENTER = 4,
+  MIDDLE_RIGHT = 5,
+  BOTTOM_LEFT = 6,
+  BOTTOM_CENTER = 7,
+  BOTTOM_RIGHT = 8,
+}
diff --git a/packages/isaac-typescript-definitions/src/enums/JacobEsauControls.ts b/packages/isaac-typescript-definitions/src/enums/JacobEsauControls.ts
new file mode 100644
index 000000000..a2f386b7a
--- /dev/null
+++ b/packages/isaac-typescript-definitions/src/enums/JacobEsauControls.ts
@@ -0,0 +1,4 @@
+export enum JacobEsauControls {
+  CLASSIC = 0,
+  BETTER = 1,
+}
diff --git a/packages/isaac-typescript-definitions/src/index.ts b/packages/isaac-typescript-definitions/src/index.ts
index 9b075971f..8134e48ff 100644
--- a/packages/isaac-typescript-definitions/src/index.ts
+++ b/packages/isaac-typescript-definitions/src/index.ts
@@ -27,6 +27,7 @@ export * from "./enums/Difficulty";
 export * from "./enums/Dimension";
 export * from "./enums/Direction";
 export * from "./enums/DoorSlot";
+export * from "./enums/DrawStringAlignment";
 export * from "./enums/EntityCollisionClass";
 export * from "./enums/EntityGridCollisionClass";
 export * from "./enums/EntityType";
@@ -59,6 +60,7 @@ export * from "./enums/ItemConfigPillEffectClass";
 export * from "./enums/ItemConfigPillEffectType";
 export * from "./enums/ItemPoolType";
 export * from "./enums/ItemType";
+export * from "./enums/JacobEsauControls";
 export * from "./enums/Keyboard";
 export * from "./enums/LanguageAbbreviation";
 export * from "./enums/LaserOffset";
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts
index aed35a9bf..70cdc4f61 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts
@@ -17,8 +17,14 @@ declare global {
      * @param duration The number of frames that the effect should apply for. The minimum is 2
      *                 frames.
      * @param damage The damage taken per tick. Each damage tick is 20 frames apart.
+     * @param ignoreBosses Optional. Defaults to false.
      */
-    AddBurn: (source: EntityRef, duration: int, damage: float) => void;
+    AddBurn: (
+      source: EntityRef,
+      duration: int,
+      damage: float,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a charmed effect to the entity.
@@ -27,8 +33,13 @@ declare global {
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. If set to -1, the
      *                 effect will be permanent and the entity will follow you to different rooms.
+     * @param ignoreBosses Optional. Defaults to false.
      */
-    AddCharmed: (source: EntityRef, duration: int) => void;
+    AddCharmed: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a confusion effect to the entity.
@@ -36,12 +47,12 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
-     * @param ignoreBosses
+     * @param ignoreBosses Optional. Defaults to false.
      */
     AddConfusion: (
       source: EntityRef,
       duration: int,
-      ignoreBosses: boolean,
+      ignoreBosses?: boolean,
     ) => void;
 
     /**
@@ -56,8 +67,9 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
+     * @param ignoreBosses Optional. Defaults to false.
      */
-    AddFear: (source: EntityRef, duration: int) => void;
+    AddFear: (source: EntityRef, duration: int, ignoreBosses?: boolean) => void;
 
     /**
      * Adds a freeze effect to the entity.
@@ -65,8 +77,13 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
+     * @param ignoreBosses Optional. Defaults to false.
      */
-    AddFreeze: (source: EntityRef, duration: int) => void;
+    AddFreeze: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /** Heals the entity. */
     AddHealth: (hitPoints: float) => void;
@@ -80,8 +97,13 @@ declare global {
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
      *                 (However, if a value higher than 150 is passed, the freeze will be reduced to
      *                 150 frames, but the gold color will persist for the full duration.)
+     * @param ignoreBosses Optional. Defaults to false.
      */
-    AddMidasFreeze: (source: EntityRef, duration: int) => void;
+    AddMidasFreeze: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a poison effect to the entity.
@@ -91,8 +113,14 @@ declare global {
      * @param duration The number of frames that the effect should apply for. The minimum is 2
      *                 frames. The maximum is 150.
      * @param damage The damage taken per tick. Each damage tick is 20 frames apart.
+     * @param ignoreBosses Optional. Defaults to false.
      */
-    AddPoison: (source: EntityRef, duration: int, damage: float) => void;
+    AddPoison: (
+      source: EntityRef,
+      duration: int,
+      damage: float,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a shrink effect to the entity.
@@ -100,8 +128,13 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for.
+     * @param ignoreBosses Optional. Defaults to false.
      */
-    AddShrink: (source: EntityRef, duration: int) => void;
+    AddShrink: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a slowing effect to the entity.
@@ -111,13 +144,15 @@ declare global {
      * @param duration The number of frames that the effect should apply for.
      * @param slowValue This is the multiplier applied to the entity's movement speed. For example,
      *                  a value of 0.5 would slow down the entity by 50%.
-     * @param slowColor
+     * @param slowColor The color modification to make to the enemy.
+     * @param ignoreBosses Optional. Defaults to false.
      */
     AddSlowing: (
       source: EntityRef,
       duration: int,
       slowValue: float,
       slowColor: Color,
+      ignoreBosses?: boolean,
     ) => void;
 
     AddVelocity: (velocity: Vector) => void;
@@ -209,6 +244,7 @@ declare global {
     IsVulnerableEnemy: () => boolean;
 
     Kill: () => void;
+    KillWithSource: (source: EntityRef) => void;
     MultiplyFriction: (value: float) => void;
     PostRender: () => void;
     Remove: () => void;
diff --git a/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts b/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts
index a39a29334..9b6befa97 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts
@@ -20,6 +20,7 @@ import type { CacheFlag } from "../../enums/flags/CacheFlag";
 import type { DamageFlag } from "../../enums/flags/DamageFlag";
 import type { TearFlag } from "../../enums/flags/TearFlag";
 import type { UseFlag } from "../../enums/flags/UseFlag";
+import type { ItemPoolType } from "../../enums/ItemPoolType";
 import type { LaserOffset } from "../../enums/LaserOffset";
 import type { NullItemID } from "../../enums/NullItemID";
 import type { PillEffect } from "../../enums/PillEffect";
@@ -86,6 +87,7 @@ declare global {
      *                   `ActiveSlot.SLOT_PRIMARY`.
      * @param varData Sets the variable data for this collectible (this is used to store extra data
      *                for some active items like the number of uses for Jar of Wisps). Default is 0.
+     * @param itemPoolType
      */
     AddCollectible: (
       collectibleType: CollectibleType,
@@ -93,6 +95,7 @@ declare global {
       firstTimePickingUp?: boolean,
       activeSlot?: ActiveSlot.PRIMARY | ActiveSlot.SECONDARY,
       varData?: int,
+      itemPoolType?: ItemPoolType,
     ) => void;
 
     AddControlsCooldown: (cooldown: int) => void;
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts
index 5c5067857..6a5272cc4 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts
@@ -20,14 +20,23 @@ declare interface Font extends IsaacAPIClass {
    * @param boxWidth Default is 0.
    * @param center Default is false.
    */
-  DrawString: (
+  DrawString: ((
     str: string,
     positionX: float,
     positionY: float,
     renderColor: KColor,
     boxWidth?: int,
     center?: boolean,
-  ) => void;
+  ) => void)
+    & ((
+      str: string,
+      positionX: float,
+      positionY: float,
+      sizeX: float,
+      sizeY: float,
+      renderColor: KColor,
+      fontRenderSettings: FontRenderSettings,
+    ) => void);
 
   /**
    * Converts UTF8 to UTF16, then draws the scaled string on the screen.
diff --git a/packages/isaac-typescript-definitions/src/types/classes/FontRenderSettings.d.ts b/packages/isaac-typescript-definitions/src/types/classes/FontRenderSettings.d.ts
new file mode 100644
index 000000000..9235a0757
--- /dev/null
+++ b/packages/isaac-typescript-definitions/src/types/classes/FontRenderSettings.d.ts
@@ -0,0 +1,26 @@
+import type { DrawStringAlignment } from "../../enums/DrawStringAlignment";
+
+declare global {
+  function FontRenderSettings(this: void): FontRenderSettings;
+
+  /** Added in Repentance+. */
+  interface FontRenderSettings extends IsaacAPIClass {
+    EnableAutoWrap: (enabled: boolean) => void;
+    EnableTruncation: (enabled: boolean) => void;
+    GetAlignment: () => DrawStringAlignment;
+    GetLineHeightModifier: () => float;
+    GetMaxCharacters: () => int;
+    GetMissingCharacterOverride: () => int;
+    IsAutoWrapEnabled: () => boolean;
+    IsTruncationEnabled: () => boolean;
+    SetAlignment: (drawStringAlignment: DrawStringAlignment) => void;
+    SetLineHeightModifier: (value: float) => void;
+    SetMaxCharacters: (maxChars: int) => void;
+
+    /**
+     * Sets the character that will be used when a missing character in the font needs to be
+     * rendered. This overrides previous `Font:SetMissingCharacter` settings.
+     */
+    SetMissingCharacterOverride: (character: int) => void;
+  }
+}
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts
index f18c0f786..54c40abc0 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts
@@ -132,17 +132,24 @@ declare global {
     /**
      * @param speed A value between 0 and 1. Using a value of 0 will soft-lock the game. Using a
      *              value of 1 will instantaneously fade in.
+     * @param showIcon Optional. Defaults to true.
+     * @param kColor Optional. Defaults to `K_COLORS.Black`.
      */
-    Fadein: (speed: float) => void;
+    Fadein: (speed: float, showIcon?: boolean, kColor?: KColor) => void;
 
     /**
-     * Using non-valid `FadeoutTarget` values will be interpreted the same as `FadeoutTarget.NONE`.
+     * Using a non-valid `FadeoutTarget` value will be interpreted the same as `FadeoutTarget.NONE`.
      *
      * @param speed A value between 0 and 1. Using a value of 0 will never trigger the fade out
      *              target. Using a value of 1 will instantaneously trigger the fade out target.
-     * @param fadeoutTarget
+     * @param fadeoutTarget The place to go after the fade out is completed.
+     * @param kColor Optional. Defaults to `K_COLORS.Black`.
      */
-    Fadeout: (speed: float, fadeoutTarget: FadeoutTarget) => void;
+    Fadeout: (
+      speed: float,
+      fadeoutTarget: FadeoutTarget,
+      kColor?: KColor,
+    ) => void;
 
     /**
      * @param position
diff --git a/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts b/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts
index bde5f2f4a..a91afb659 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts
@@ -4,6 +4,7 @@ import type { GridEntityType } from "../../enums/GridEntityType";
 declare global {
   interface GridEntity extends IsaacAPIClass {
     Destroy: (immediate: boolean) => boolean;
+    DestroyWithSource: (immediate: boolean, source: EntityRef) => boolean;
     GetGridIndex: () => int;
 
     /** The RNG returned is a reference (i.e. not a copy). */
@@ -17,6 +18,7 @@ declare global {
     GetType: () => GridEntityType;
     GetVariant: () => int;
     Hurt: (damage: int) => boolean;
+    HurtWithSource: (damage: int, source: EntityRef) => boolean;
     Init: (seed: Seed) => void;
     PostInit: () => void;
     Render: (offset: Vector) => void;
diff --git a/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts b/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts
index 87e397022..496ce9809 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts
@@ -45,9 +45,23 @@ declare global {
     /**
      * Shows the pickup text for the specified item as if it was picked up by the specified player.
      * The overloaded method supports showing custom pickup text.
+     *
+     * If the `stackUpText` parameter is missing or true, then it clears the message stack
+     * (Repentance functionality). If it is false, then the text will stack up (Repentance+
+     * functionality). These values are counterintuitive, so it seems likely that the developers
+     * made a mistake.
      */
-    ShowItemText: ((player: EntityPlayer, item: ItemConfigItem) => void)
-      & ((name: string, description?: string, paper?: boolean) => void);
+    ShowItemText: ((
+      player: EntityPlayer,
+      item: ItemConfigItem,
+      stackUpText: boolean,
+    ) => void)
+      & ((
+        mainString: string,
+        secondaryString?: string,
+        isCurseDisplay?: boolean,
+        stackUpText?: boolean,
+      ) => void);
 
     Update: () => void;
   }
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts
index 56a7e75c9..94a91b778 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts
@@ -2,6 +2,7 @@ import type { AnnouncerVoiceMode } from "../../enums/AnnouncerVoiceMode";
 import type { CameraStyle } from "../../enums/CameraStyle";
 import type { ConsoleFont } from "../../enums/ConsoleFont";
 import type { ExtraHudStyle } from "../../enums/ExtraHudStyle";
+import type { JacobEsauControls } from "../../enums/JacobEsauControls";
 import type { LanguageAbbreviation } from "../../enums/LanguageAbbreviation";
 
 declare global {
@@ -120,6 +121,13 @@ declare global {
      */
     let BulletVisibility: boolean;
 
+    /**
+     * Toggles the way to activate Esau's items.
+     *
+     * This can be changed from the in-game options menu.
+     */
+    let JacobEsauControls: JacobEsauControls;
+
     /**
      * Whether the announcer voice should play when using items, pills, cards, and runes.
      *
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts
index 97a5b8854..ce1ba5bfc 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts
@@ -36,7 +36,17 @@ declare global {
     ) => LuaMultiReturn<[clear: boolean, collidePos: Vector]>;
 
     DamageGrid: (index: int, damage: int) => boolean;
+    DamageGridWithSource: (
+      index: int,
+      damage: int,
+      source: EntityRef,
+    ) => boolean;
     DestroyGrid: (index: int, immediate: boolean) => boolean;
+    DestroyGridWithSource: (
+      index: int,
+      immediate: boolean,
+      source: EntityRef,
+    ) => boolean;
     EmitBloodFromWalls: (duration: int, count: int) => void;
 
     /**
@@ -204,7 +214,14 @@ declare global {
     IsPositionInRoom: (position: Vector, margin: float) => boolean;
     IsSacrificeDone: () => boolean;
     KeepDoorsClosed: () => void;
-    MamaMegaExplosion: (position: Vector) => void;
+
+    /**
+     * @param position Optional. The position where the explosion should originate. Default is
+     *                 `Vector.Zero`.
+     * @param player Optional. The player that the explosion should come from.
+     */
+    MamaMegaExplosion: (position?: Vector, player?: EntityPlayer) => void;
+
     PlayMusic: () => void;
     RemoveDoor: (doorSlot: DoorSlot) => void;
 
diff --git a/packages/isaac-typescript-definitions/src/types/index.d.ts b/packages/isaac-typescript-definitions/src/types/index.d.ts
index 6107fbd02..9abf7cb90 100644
--- a/packages/isaac-typescript-definitions/src/types/index.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/index.d.ts
@@ -45,6 +45,7 @@
 /// <reference path="./classes/EntityTear.d.ts" />
 /// <reference path="./classes/EntriesList.d.ts" />
 /// <reference path="./classes/Font.d.ts" />
+/// <reference path="./classes/FontRenderSettings.d.ts" />
 /// <reference path="./classes/Game.d.ts" />
 /// <reference path="./classes/GridEntity.d.ts" />
 /// <reference path="./classes/GridEntityDesc.d.ts" />
diff --git a/packages/isaacscript-spell/dictionaries/isaac/api.txt b/packages/isaacscript-spell/dictionaries/isaac/api.txt
index 8e4c3c0be..2319fb0df 100644
--- a/packages/isaacscript-spell/dictionaries/isaac/api.txt
+++ b/packages/isaacscript-spell/dictionaries/isaac/api.txt
@@ -49,6 +49,7 @@ cutscenes
 CYCLOPIA
 DAGAZ
 DATAMINER
+DEATHMATCH
 DECAP
 DERP
 DINGA