Table of mutations in antigenic site Ø of the F protein associated with increased nirsevimab resistance in previous publications:
| Type | Mutations | IC fold change | Reference |
|---|---|---|---|
| A | K68E | 10-100 | Wilkins et al., 2023 |
| A | N67I;N208Y | 100-1000 | Zhu et al., 2018 |
| B | I64T | >400 | Ahani et al., 2023 |
| B | K68Q | 10-100 | Wilkins et al., 2023 |
| B | K68N | 10-100 | Wilkins et al., 2023 |
| B | N201S | 100-1000 | Wilkins et al., 2023 |
| B | N201T | 100-1000 | Wilkins et al., 2023 |
| B | N208S | 10000-100000 | Zhu et al., 2018 |
| B | N208S | >100 | Griffin et al., 2020 |
| B | N208S | >300 | Ahani et al., 2023 |
| B | N208D | >100000 | Zhu et al., 2018 |
| B | N208S | >400 | Ahani et al., 2023 |
| B | I64T;K68E | >100 | Griffin et al., 2020 |
| B | I64T;K68E | >400 | Ahani et al., 2023 |
| B | K68N;N201S | 1000-10000 | Zhu et al., 2018 |
| B | K68N;N208S | >100000 | Zhu et al., 2018 |
Note: Mutations of RSVB I206M, Q209R and S211N are common in the RSVB circulating in the last season. They have not been added in the table as they do not cause a decrease in Nirsevimab affinity for the F protein