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Enabling --use-pdhmm true for HaplotypeCaller results in the below error message thrown when -ERC GVCF is enabled.
java.lang.IllegalArgumentException: refHaplotype cannot be null
at org.broadinstitute.hellbender.utils.Utils.nonNull(Utils.java:643)
at org.broadinstitute.hellbender.tools.walkers.haplotypecaller.ReferenceConfidenceModel.calculateRefConfidence(ReferenceConfidenceModel.java:216)
at org.broadinstitute.hellbender.tools.walkers.haplotypecaller.HaplotypeCallerEngine.callRegion(HaplotypeCallerEngine.java:1018)
at org.broadinstitute.hellbender.tools.walkers.haplotypecaller.HaplotypeCaller.apply(HaplotypeCaller.java:284)
at org.broadinstitute.hellbender.engine.AssemblyRegionWalker.processReadShard(AssemblyRegionWalker.java:200)
at org.broadinstitute.hellbender.engine.AssemblyRegionWalker.traverse(AssemblyRegionWalker.java:173)
at org.broadinstitute.hellbender.engine.GATKTool.doWork(GATKTool.java:1119)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.runTool(CommandLineProgram.java:150)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMainPostParseArgs(CommandLineProgram.java:203)
at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMain(CommandLineProgram.java:222)
at org.broadinstitute.hellbender.Main.runCommandLineProgram(Main.java:166)
at org.broadinstitute.hellbender.Main.mainEntry(Main.java:209)
at org.broadinstitute.hellbender.Main.main(Main.java:306)
This happens under 4.6.0.0 and 4.6.1.0. I have not tested older versions.
The text was updated successfully, but these errors were encountered:
Hi team.
Enabling
--use-pdhmm true
for HaplotypeCaller results in the below error message thrown when-ERC GVCF
is enabled.This happens under 4.6.0.0 and 4.6.1.0. I have not tested older versions.
The text was updated successfully, but these errors were encountered: