Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Enabling PDHMM causes GVCF mode to fail. #9041

Open
gokalpcelik opened this issue Nov 13, 2024 · 0 comments
Open

Enabling PDHMM causes GVCF mode to fail. #9041

gokalpcelik opened this issue Nov 13, 2024 · 0 comments

Comments

@gokalpcelik
Copy link
Contributor

Hi team.

Enabling --use-pdhmm true for HaplotypeCaller results in the below error message thrown when -ERC GVCF is enabled.

java.lang.IllegalArgumentException: refHaplotype cannot be null
	at org.broadinstitute.hellbender.utils.Utils.nonNull(Utils.java:643)
	at org.broadinstitute.hellbender.tools.walkers.haplotypecaller.ReferenceConfidenceModel.calculateRefConfidence(ReferenceConfidenceModel.java:216)
	at org.broadinstitute.hellbender.tools.walkers.haplotypecaller.HaplotypeCallerEngine.callRegion(HaplotypeCallerEngine.java:1018)
	at org.broadinstitute.hellbender.tools.walkers.haplotypecaller.HaplotypeCaller.apply(HaplotypeCaller.java:284)
	at org.broadinstitute.hellbender.engine.AssemblyRegionWalker.processReadShard(AssemblyRegionWalker.java:200)
	at org.broadinstitute.hellbender.engine.AssemblyRegionWalker.traverse(AssemblyRegionWalker.java:173)
	at org.broadinstitute.hellbender.engine.GATKTool.doWork(GATKTool.java:1119)
	at org.broadinstitute.hellbender.cmdline.CommandLineProgram.runTool(CommandLineProgram.java:150)
	at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMainPostParseArgs(CommandLineProgram.java:203)
	at org.broadinstitute.hellbender.cmdline.CommandLineProgram.instanceMain(CommandLineProgram.java:222)
	at org.broadinstitute.hellbender.Main.runCommandLineProgram(Main.java:166)
	at org.broadinstitute.hellbender.Main.mainEntry(Main.java:209)
	at org.broadinstitute.hellbender.Main.main(Main.java:306)

This happens under 4.6.0.0 and 4.6.1.0. I have not tested older versions.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant