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Releases: chrchang/plink-ng

Alpha 6.4: Unbreak --import-dosage + --map

07 Dec 01:01
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This fixes an --import-dosage + --map command-line parsing bug introduced in August.

Alpha 5.21: Unbreak --import-dosage + --map

07 Dec 00:59
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This fixes an --import-dosage + --map command-line parsing bug introduced in a5.13.

Alpha 6.3: --sort-vars forced-QUAL/FILTER bugfix

04 Dec 01:22
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This release fixes a segfault that occurred when --sort-vars was specified, .pvar output was requested with a required QUAL/FILTER column, and that column was not present in the input.

Alpha 5.20: --sort-vars forced-QUAL/FILTER bugfix

04 Dec 01:22
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This release fixes a segfault that occurred when --sort-vars was specified, .pvar output was requested with a required QUAL/FILTER column, and that column was not present in the input.

Alpha 6.2: --set-{all,missing}-var-ids bugfix

24 Nov 22:19
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--set-all-var-ids and --set-missing-var-ids should now work properly when $a is used in the template string without $r.

Alpha 5.19: --set-{all,missing}-var-ids bugfix

24 Nov 22:18
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--set-all-var-ids and --set-missing-var-ids should now work properly when $a is used in the template string without $r.

Alpha 6.1: --make-pgen segfault fix

14 Nov 23:59
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This build fixes a --make-pgen segfault that occurred when filtering samples from multiallelic variants.

Alpha 6.0: --r[2]-[un]phased

11 Nov 21:06
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New features:

  • LD-matrix computation (--r[2]-unphased)
  • --glm qt-residualize mode
  • --hwe enhancements for biobank-scale data: support for p-values < 2.23e-308, and sample-size-based thresholds
  • --ref-allele/--alt1-allele/--ref-from-fa/--maj-ref support for multiallelic variants
  • --check-sex/--impute-sex

Other significant behavior changes relative to alpha 5:

  • --allow-extra-chr is never necessary any more
  • --set-all-var-ids and related flags are now applied to all --pmerge[-list] inputs
  • Polyploid genotypes in VCF/BCF files now default to triggering an error; this behavior is controlled by the --polyploid-mode flag
  • -log10(x) column names now consistently start with "NEG_LOG10_", instead of "LOG10_"
  • --adjust[-file] QQ column is no longer affected by the 'log10' modifier
  • Most computations now consider unknown-sex samples on chrY, unless they explicitly state otherwise

--pedmap + --1 sex bugfix

11 Nov 20:45
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When --pedmap and --1 are both in effect, the temporary autoconverted .psam now uses 1/2 encoding for sex and 0/1 encoding for a binary phenotype, rather than the other way around.

--geno hh-missing bugfix

20 Oct 23:33
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This build fixes a "--geno hh-missing" segfault, lowers the --glm single-prec-cc warning threshold to 100k samples, and makes --hwe tolerate an extra "0" argument for forward compatibility.