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feature request: ignore duplicate-marked reads #57

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anoronh4 opened this issue Nov 10, 2020 · 1 comment
Open

feature request: ignore duplicate-marked reads #57

anoronh4 opened this issue Nov 10, 2020 · 1 comment

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@anoronh4
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anoronh4 commented Nov 10, 2020

this issue is to request ignoring dup reads as an option. gatk best practice is to keep all duplicates in the bam, and i have read from a few issues here and here that a deduplicated (not just marked duplicate) bam is best for msisensor msi. therefore, we have to run an extra step and use almost twice as much storage to run msisensor from a deduplicated bam. ignoring dup reads from marked bam would avoid the trouble while hopefully not adding to the run time of msisensor

@Beifang
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Beifang commented Nov 11, 2020

Sure. We will provide this option soon.

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