diff --git a/settings/SingleSampleNoRealign.ini b/settings/SingleSampleNoRealign.ini
new file mode 100644
index 0000000..d606a68
--- /dev/null
+++ b/settings/SingleSampleNoRealign.ini
@@ -0,0 +1,17 @@
+INIFILE	settings/include/settings.ini
+
+MAPPING	yes
+INDEL_REALIGNMENT	no
+
+POSTSTATS	yes
+DAMAGE_ESTIMATE	yes
+
+GERMLINE_CALLING	yes
+
+STRELKA	no
+AMBER	no
+COBALT	no
+PURPLE	no
+GRIDSS	no
+
+HEALTHCHECK	yes
\ No newline at end of file