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What does a negative expression distance mean? #55

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ThomasLLi opened this issue Dec 17, 2024 · 0 comments
Open

What does a negative expression distance mean? #55

ThomasLLi opened this issue Dec 17, 2024 · 0 comments

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@ThomasLLi
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I am consistently getting a few clusters with a negative "normalized expression distance" value.

My understanding is that this is supposed to be a magnitude, so how can it be negative? Looking at the preprint, it appears to be a possibility if the MED of the control is larger than the distance between conditions, but I'm not sure how to interpret a negative magnitude in the context of gene expression.

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