diff --git a/msgio_test.go b/msgio_test.go
index 4167e02..f26dd86 100644
--- a/msgio_test.go
+++ b/msgio_test.go
@@ -6,10 +6,15 @@ import (
 	"fmt"
 	"io"
 	"math/rand"
-	str "strings"
+	"strings"
 	"sync"
 	"testing"
 	"time"
+
+	"github.com/libp2p/go-msgio/pbio/pb"
+	"github.com/libp2p/go-msgio/protoio"
+	"github.com/multiformats/go-varint"
+	"google.golang.org/protobuf/proto"
 )
 
 func randBuf(r *rand.Rand, size int) []byte {
@@ -79,7 +84,7 @@ func TestMultiError(t *testing.T) {
 	}
 
 	twoErrors := multiErr([]error{errors.New("one"), errors.New("two")})
-	if eStr := twoErrors.Error(); !str.Contains(eStr, "one") && !str.Contains(eStr, "two") {
+	if eStr := twoErrors.Error(); !strings.Contains(eStr, "one") && !strings.Contains(eStr, "two") {
 		t.Fatal("Expected error messages not included")
 	}
 }
@@ -328,3 +333,45 @@ func SubtestReadShortBuffer(t *testing.T, writer WriteCloser, reader ReadCloser)
 		t.Fatal("Expected short buffer error")
 	}
 }
+
+func TestHandleProtoGeneratedByGoogleProtobufInProtoio(t *testing.T) {
+	record := &pb.TestRecord{
+		Uint32:  42,
+		Uint64:  84,
+		Bytes:   []byte("test bytes"),
+		String_: "test string",
+		Int32:   -42,
+		Int64:   -84,
+	}
+
+	recordBytes, err := proto.Marshal(record)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	for _, tc := range []string{"read", "write"} {
+		t.Run(tc, func(t *testing.T) {
+			var buf bytes.Buffer
+			readRecord := &pb.TestRecord{}
+			switch tc {
+			case "read":
+				buf.Write(varint.ToUvarint(uint64(len(recordBytes))))
+				buf.Write(recordBytes)
+
+				reader := protoio.NewDelimitedReader(&buf, 1024)
+				defer reader.Close()
+				err = reader.ReadMsg(readRecord)
+			case "write":
+				writer := protoio.NewDelimitedWriter(&buf)
+				err = writer.WriteMsg(record)
+			}
+			if err == nil {
+				t.Fatal("expected error")
+			}
+			expectedError := "google Protobuf message passed into a GoGo Protobuf"
+			if !strings.Contains(err.Error(), expectedError) {
+				t.Fatalf("expected error to contain '%s'", expectedError)
+			}
+		})
+	}
+}
diff --git a/protoio/isgoog.go b/protoio/isgoog.go
new file mode 100644
index 0000000..9247613
--- /dev/null
+++ b/protoio/isgoog.go
@@ -0,0 +1,15 @@
+package protoio
+
+import (
+	"github.com/gogo/protobuf/proto"
+	"google.golang.org/protobuf/reflect/protoreflect"
+)
+
+// isGoogleProtobufMsg checks if the given proto.Message was
+// generated by the official Google protobuf compiler
+func isGoogleProtobufMsg(msg proto.Message) bool {
+	_, ok := msg.(interface {
+		ProtoReflect() protoreflect.Message
+	})
+	return ok
+}
diff --git a/protoio/uvarint_reader.go b/protoio/uvarint_reader.go
index 6722cd3..f2d4731 100644
--- a/protoio/uvarint_reader.go
+++ b/protoio/uvarint_reader.go
@@ -34,6 +34,7 @@ package protoio
 
 import (
 	"bufio"
+	"errors"
 	"fmt"
 	"io"
 	"os"
@@ -82,7 +83,23 @@ func (ur *uvarintReader) ReadMsg(msg proto.Message) (err error) {
 	if _, err := io.ReadFull(ur.r, buf); err != nil {
 		return err
 	}
-	return proto.Unmarshal(buf, msg)
+
+	// Hoist up gogo's proto.Unmarshal logic so we can also check if this is a google protobuf message
+	msg.Reset()
+	if u, ok := msg.(interface {
+		XXX_Unmarshal([]byte) error
+	}); ok {
+		return u.XXX_Unmarshal(buf)
+	} else if u, ok := msg.(interface {
+		Unmarshal([]byte) error
+	}); ok {
+		return u.Unmarshal(buf)
+	} else if isGoogleProtobufMsg(msg) {
+		return errors.New("google Protobuf message passed into a GoGo Protobuf reader. Use github.com/libp2p/go-msgio/pbio instead of github.com/gogo/protobuf/proto")
+	}
+
+	// Fallback to GoGo's proto.Unmarshal around this buffer
+	return proto.NewBuffer(buf).Unmarshal(msg)
 }
 
 func (ur *uvarintReader) Close() error {
diff --git a/protoio/uvarint_writer.go b/protoio/uvarint_writer.go
index e311075..ece42db 100644
--- a/protoio/uvarint_writer.go
+++ b/protoio/uvarint_writer.go
@@ -33,6 +33,7 @@
 package protoio
 
 import (
+	"errors"
 	"fmt"
 	"io"
 	"os"
@@ -80,6 +81,10 @@ func (uw *uvarintWriter) WriteMsg(msg proto.Message) (err error) {
 		}
 	}
 
+	if isGoogleProtobufMsg(msg) {
+		return errors.New("google Protobuf message passed into a GoGo Protobuf writer. Use github.com/libp2p/go-msgio/pbio instead of github.com/gogo/protobuf/proto")
+	}
+
 	// fallback
 	data, err = proto.Marshal(msg)
 	if err != nil {