publication_list.bib

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@article{Delvendahl:2015aa,
	Abstract = {Fast synchronous neurotransmitter release at the presynaptic active zone is triggered by local Ca2+ signals, which are confined in their spatiotemporal extent by endogenous Ca2+ buffers. However, it remains elusive how rapid and reliable Ca2+ signaling can be sustained during repetitive release. Here, we established quantitative two-photon Ca2+ imaging in cerebellar mossy fiber boutons, which fire at exceptionally high rates. We show that endogenous fixed buffers have a surprisingly low Ca2+-binding ratio (∼15) and low affinity, whereas mobile buffers have high affinity. Experimentally constrained modeling revealed that the low endogenous buffering promotes fast clearance of Ca2+ from the active zone during repetitive firing. Measuring Ca2+ signals at different distances from active zones with ultra-high-resolution confirmed our model predictions. Our results lead to the concept that reduced Ca2+ buffering enables fast active zone Ca2+ signaling, suggesting that the strength of endogenous Ca2+ buffering limits the rate of synchronous synaptic transmission.},
	Author = {Delvendahl, Igor and Jablonski, Lukasz and Baade, Carolin and Matveev, Victor and Neher, Erwin and Hallermann, Stefan},
	Date-Added = {2016-02-04 10:04:09 +0000},
	Date-Modified = {2016-02-04 10:37:29 +0000},
	Doi = {10.1073/pnas.1508419112},
	Eprint = {http://www.pnas.org/content/112/23/E3075.full.pdf},
	Journal = {Proceedings of the National Academy of Sciences},
	Number = {23},
	Pages = {E3075-E3084},
	Title = {Reduced endogenous {Ca$^{2+}$} buffering speeds active zone {Ca$^{2+}$} signaling},
	Url = {http://www.pnas.org/content/112/23/E3075.abstract},
	Volume = {112},
	Year = {2015},
	Bdsk-Url-1 = {http://www.pnas.org/content/112/23/E3075.abstract},
	Bdsk-Url-2 = {http://dx.doi.org/10.1073/pnas.1508419112}}