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eoyrl_2020.Rmd
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---
title: "End of year research list"
author:
- name: Daniel B. Ibsen
affiliation: Steno Diabetes Center Aarhus
affiliation_url: https://stenoaarhus.dk
date: "`r Sys.Date()`"
output:
distill::distill_article:
self_contained: false
---
## EPIDEMIOLOGY
**Association of Type 2 Diabetes With Cancer: A Meta-analysis With Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million People**
Submitted by Suping Ling, PhD (Postdoc at University of Leicester).
Our findings strongly suggest a causal association between T2D and liver, pancreatic, and endometrial cancer incidence, and pancreatic cancer mortality, while associations with other cancers were less robust to unmeasured confounding.
**Multimorbidity, mortality, and HbA1c in type 2 diabetes: A cohort study with UK and Taiwanese cohorts**
Submitted by Jason Chiang, PhD (Research Fellow at University of Sydney).
The first study to assess and compare the relationship between total, concordant, and discordant multimorbidity counts; HbA1c; and all-cause mortality in two cohorts of people with type 2 diabetes.
**Diabetes & Musculoskeletal Disorders - A Review**
Submitted by Shraboni Ghosal, RNutr (Nutrition Consultant, Researcher).
The effects of diabetes on musculoskeletal disorders and the possible mechanisms through which diabetes may contribute to them.
**Impact of COVID-19 on routine care for chronic diseases: A global survey of views from healthcare professionals**
Submitted by Yogini Chudasama, PhD (Epidemiologist at University of Leicester).
This survey gave a better insight on the type of chronic disease most impacted by COVID-19 and highlighted the importance of routine care for chronic diseases in spite of the pandemic.
**Multimorbidity, glycaemic variability and time in target range in people with type 2 diabetes: A baseline analysis of the GP-OSMOTIC trial**
Submitted by Jason Chiang, PhD (Research Fellow at University of Sydney).
First study to explore associations between multimorbidity and novel glycaemic measures (e.g. glycaemic variability & time-in-range) in people with T2D.
**Healthy lifestyle and life expectancy in people with multimorbidity in the UK Biobank: A longitudinal cohort study**
Submitted by Yogini Chudasama, PhD (Epidemiologist at Uni of Leicester).
We found that an overall healthy lifestyle largely counterbalances the negative association between multimorbidity and life expectancy.
**Does Diabetes increase Joint pain? - A Review**
Submitted by Shraboni Ghosal, RNutr (Nutrition Consultant, Researcher).
Diabetes can affect bones and muscles and damage nerves, which may increase joint pain.
EPIDEMIOLOGY: Nutritional
**Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations: The EPIC-InterAct Study**
Submitted by Daniel Ibsen, PhD (Postdoc at Karolinska Institutet).
This study highlights that substituting red and processed meat by either cheese, yogurt, nuts or cereals may contribute to the prevention of incident type 2 diabetes in European populations.
**Association of the Mediterranean Diet With Onset of Diabetes in the Women's Health Study**
Submitted by Shafqat Ahmad, PhD (Postdoc at Uppsala University).
Potential biological mechanisms through which higher consumption of Mediterranean Diet intake may reduce the future risk of type 2 diabetes.
**Adherence to the Danish food-based dietary guidelines and risk of type 2 diabetes: the Danish diet, cancer, and health cohort**
Submitted by Daniel Ibsen, PhD (Postdoc at Karolinska Institutet).
Our paper suggests that shifting from low to high adherence to the Danish dietary guidelines may prevent 3–6% cases of type 2 diabetes.
**Effect of familial diabetes status and age at diagnosis on type 2 diabetes risk: a nation-wide register-based study from Denmark**
Submitted by Omar Silverman, PhD (Postdoc at Steno Diabetes Center Aarhus).
This study shows how an individual’s risk of type 2 diabetes depends on the age at which a family member is diagnosed with diabetes.
**Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis**
Submitted by Elpida Vounzoulaki, MSc, RN (PhD Researcher in Diabetes Epidemiology at University of Leicester).
Women with a history of GDM appear to have a nearly 10-fold higher risk of developing T2DM than those with a normoglycaemic pregnancy.
**Gestational diabetes: screening uptake, current challenges and the future**
Submitted by Elpida Vounzoulaki, MSc, RN (PhD Researcher in Diabetes Epidemiology at University of Leicester).
This review highlights that, regardless of all the evidence, the uptake of both short-and long-term post-partum T2DM screening in women with previous GDM is low in the UK.
**A cross-sectional study of the association between the 1-hour oral glucose tolerance test and the metabolic syndrome in a high-risk sample with impaired fasting glucose**
Submitted by Juan Carlos Lizarzaburu-Robles, MD (Endocrinologist and Researcher at Hospital Central de la Fuerza Aérea del Perú).
Among subjects with IFG, performing an OGTT was helpful to identify subjects with 1-hour glucose levels ≥155 mg/dL and NGT who were significantly more likely to have MS and a worse cardiometabolic risk profile.
Monogenic-Onset Diabetes in the Young (MODY)
**Atypical hyperglycemia presentation suggests considering a diagnostic of other types of diabetes: first reported GCK-MODY in Perú**
Submitted by Juan Carlos Lizarzaburu-Robles, MD (Endocrinologist and Researcher at Hospital Central de la Fuerza Aérea del Perú).
Atypical hyperglycemia presentation suggests considering a diagnostic of other types of diabetes
Type 1 Diabetes
**Insulin pricing and other major diabetes-related concerns in the USA: a study of 46 407 tweets between 2017 and 2019**
Submitted by Adrian Ahne, MSc (PhD student at Université Paris Saclay).
Using social media data, we have been able to describe key diabetes-related concerns and their associated emotions.
**Metabolomics-related nutrient patterns at seroconversion and risk of progression to type 1 diabetes**
Submitted by Randi Johnson, PhD (Postdoc at University of Colorado Anschutz).
From metabolomics signatures reflective of islet autoimmunity, we identified a pattern of nutrient intake associated with increased risk of progression to type 1 diabetes, confirming prior individual nutrient associations with disease progression and suggesting new hypotheses for nutrients in T1D risk.
## GENOMICS
**Longitudinal DNA methylation differences precede type 1 diabetes**
Submitted by Randi Johnson, PhD (Postdoc at University of Colorado Anschutz).
This paper describes (for the first time) longitudinal DNA methylation differences that appear prior to type 1 diabetes diagnosis, suggesting epigenetic changes may influence disease progression.
**A Multi-omic Integrative Scheme Characterizes Tissues of Action at Loci Associated with Type 2 Diabetes**
Submitted by Jason Torres, PhD (Senior Genetic Epidemiologist at the Nuffield Department of Population Health, University of Oxford).
This work proposes an integrative approach to combine genetic and epigenomic data together at T2D-associated loci to resolve tissues that drive disease risk.
## BASIC SCIENCE
**Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche**
Submitted by Mirza Muhammad Fahd Qadir, PhD (Postdoc at University of Miami).
This paper shows ductal cell heterogeneity, in cells isolated from islet depleted exocrine tissue.
**Efficacy and tolerability of sodium‐glucose co‐transporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists: A systematic review and network meta‐analysis**
Submitted by Humaira Hussein, MSc (PhD student at University of Leicester).
This paper highlights the benefits and risks of treatments within two classes of glucose-lowering medications, which can provide essential evidence in the guidance of treatment management in type 2 diabetes
**Long-term culture of human pancreatic slices as a model to study real-time islet regeneration**
Submitted by Mirza Muhammad Fahd Qadir, PhD (Postdoc at University of Miami).
This paper enables the community to maintain 135micron thick live human pancreas slices for 7-10d, in order to study pancreas biology and endocrine cell regeneration.
## HEALTH ECONOMICS
**Challenges and economic burden of diabetes in Africa**
Submitted by Camille Mba, MD (PhD student at University of Cambridge, MRC Epidemiology Unit).
Book chapter reviewing the economic burden of diabetes in Africa. Sub-Saharan Africa will experience the greatest increases globally in the next 20 years: 143%.