diff --git a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/results/StrengthenGraphs.java b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/results/StrengthenGraphs.java
index 8204306cb557..61c10002bfee 100644
--- a/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/results/StrengthenGraphs.java
+++ b/substratevm/src/com.oracle.graal.pointsto/src/com/oracle/graal/pointsto/results/StrengthenGraphs.java
@@ -589,8 +589,11 @@ private void handleInvoke(Invoke invoke, SimplifierTool tool) {
 
             Collection<AnalysisMethod> callees = invokeFlow.getOriginalCallees();
             if (callees.isEmpty()) {
-                unreachableInvoke(invoke, tool);
-                /* Invoke is unreachable, there is no point in improving any types further. */
+                if (isClosedTypeWorld) {
+                    /* Invoke is unreachable, there is no point in improving any types further. */
+                    unreachableInvoke(invoke, tool);
+                }
+                /* In open world we cannot make any assumptions about an invoke with 0 callees. */
                 return;
             }
             assert invokeFlow.isFlowEnabled() : "Disabled invoke should have no callees: " + invokeFlow + ", in method " + getQualifiedName(graph);