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keyword_report.txt
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KeyWord Report generated on: Sat Oct 12 16:59:24 2019
Total number of key words was: 332
Keyword Category Description Synonyms Frequency Proteins
Polymorphism Coding sequence diversity Protein for which there is at least one variant within the same species, that is not directly responsible for a disease. We make use of this keyword only in the context of multicellular organisms. 227 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HBB_HUMAN; HPT_HUMAN; A2MG_HUMAN; CO3_HUMAN; FETUB_HUMAN; HEMO_HUMAN; VTDB_HUMAN; APOC2_HUMAN; IC1_HUMAN; CO4B_HUMAN; CERU_HUMAN; A1AT_HUMAN; PLMN_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; ANT3_HUMAN; CFAH_HUMAN; ITIH4_HUMAN; APOC3_HUMAN; A1AG2_HUMAN; APOA4_HUMAN; A2MG_HUMAN; CFAB_HUMAN; VTNC_HUMAN; AFAM_HUMAN; FETUA_HUMAN; GPX3_HUMAN; APOB_HUMAN; APOH_HUMAN; IGLL1_HUMAN; TRFE_HUMAN; C1QA_HUMAN; THRB_HUMAN; CO5_HUMAN; CLUS_HUMAN; A2AP_HUMAN; KNG1_HUMAN; ACTB_HUMAN; ANGT_HUMAN; CO9_HUMAN; CO8B_HUMAN; THBG_HUMAN; FINC_HUMAN; GELS_HUMAN; CD5L_HUMAN; TETN_HUMAN; ITIH1_HUMAN; MYG_HUMAN; PROS_HUMAN; CO2_HUMAN; APOE_HUMAN; FIBA_HUMAN; HEP2_HUMAN; CO8A_HUMAN; BLVRB_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CBPB2_HUMAN; CO6_HUMAN; ECM1_HUMAN; PRDX1_HUMAN; SODE_HUMAN; A2GL_HUMAN; PHLD_HUMAN; FIBB_HUMAN; FA9_HUMAN; C1QB_HUMAN; ITIH2_HUMAN; C4BPB_HUMAN; LUM_HUMAN; CO8G_HUMAN; CD14_HUMAN; PROP_HUMAN; S10A9_HUMAN; SAA1_HUMAN; ADIPO_HUMAN; ZPI_HUMAN; APOD_HUMAN; FBLN1_HUMAN; ITIH3_HUMAN; FIBG_HUMAN; LYSC_HUMAN; PEDF_HUMAN; CO3_HUMAN; LCAT_HUMAN; TPM4_HUMAN; G3P_HUMAN; SEPP1_HUMAN; PRDX2_HUMAN; IPSP_HUMAN; CBG_HUMAN; PROC_HUMAN; IBP3_HUMAN; ALS_HUMAN; F13A_HUMAN; KPYM_HUMAN; PIGR_HUMAN; PSPB_HUMAN; F13B_HUMAN; TRFL_HUMAN; VINC_HUMAN; CFAD_HUMAN; CAH1_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; HGFA_HUMAN; TPIS_HUMAN; S10A6_HUMAN; FA10_HUMAN; H13_HUMAN; CCL14_HUMAN; TAGL2_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; PCYOX_HUMAN; ENOA_HUMAN; GGH_HUMAN; GSTP1_HUMAN; TFR1_HUMAN; HABP2_HUMAN; CATS_HUMAN; FOLR1_HUMAN; SAA1_HUMAN; CYTC_HUMAN; TKT_HUMAN; CALM3_HUMAN; IBP2_HUMAN; APOF_HUMAN; FA11_HUMAN; BGH3_HUMAN; LDHB_HUMAN; RNAS2_HUMAN; CD86_HUMAN; BTD_HUMAN; LBP_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PAEP_HUMAN; PRG4_HUMAN; C4BPA_HUMAN; PAEP_HUMAN; PGK1_HUMAN; CNTN1_HUMAN; LDHA_HUMAN; LAMP2_HUMAN; GPX1_HUMAN; GOLM1_HUMAN; RHOC_HUMAN; B4GA1_HUMAN; CAP1_HUMAN; PSA2_HUMAN; IBP6_HUMAN; TSP4_HUMAN; TSP1_HUMAN; PLTP_HUMAN; CADH5_HUMAN; TPM4_HUMAN; SKA1_HUMAN; LFA3_HUMAN; CREG2_HUMAN; ELNE_HUMAN; DHB3_HUMAN; BIP_HUMAN; VASN_HUMAN; VWF_HUMAN; TLN1_HUMAN; DMBT1_HUMAN; MASP2_HUMAN; ALDOA_HUMAN; RD23A_HUMAN; COMP_HUMAN; VASP_HUMAN; LAMP1_HUMAN; SPB10_HUMAN; FA7_HUMAN; EDNRB_HUMAN; CMGA_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; PEPD_HUMAN; P20D1_HUMAN; CATC_HUMAN; VNN1_HUMAN; CPN2_HUMAN; G6PI_HUMAN; DAF_HUMAN; BIN2_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; PGRP2_HUMAN; HPHL1_HUMAN; FA5_HUMAN; EGFR_HUMAN; PP2D1_HUMAN; A16L2_HUMAN; HSP7C_HUMAN; GRN_HUMAN; ENTP7_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; CA2D1_HUMAN; SEPR_HUMAN; CALD1_HUMAN; FLNA_HUMAN; IQGA2_HUMAN; ACTN1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; PRTG_HUMAN; EPHA3_HUMAN; MA2B1_HUMAN; CR2_HUMAN; CC180_HUMAN; CAR11_HUMAN; BCORL_HUMAN; LAMB1_HUMAN; AKP13_HUMAN; DYH9_HUMAN
3D-structure Technical term Protein, or part of a protein, whose three-dimensional structure has been resolved experimentally (for example by X-ray crystallography or NMR spectroscopy) and whose coordinates are available in the PDB database. Can also be used for theoretical models. 206 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HBB_HUMAN; HPT_HUMAN; A2MG_HUMAN; CO3_HUMAN; VTDB_HUMAN; APOC2_HUMAN; IC1_HUMAN; CO4B_HUMAN; CERU_HUMAN; A1AT_HUMAN; PLMN_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; ANT3_HUMAN; CFAH_HUMAN; APOC3_HUMAN; A1AG2_HUMAN; APOA4_HUMAN; A2MG_HUMAN; CFAB_HUMAN; RET4_HUMAN; VTNC_HUMAN; AFAM_HUMAN; GPX3_HUMAN; APOH_HUMAN; IGLL1_HUMAN; TRFE_HUMAN; C1QA_HUMAN; THRB_HUMAN; CO5_HUMAN; AMBP_HUMAN; KNG1_HUMAN; ACTB_HUMAN; ANGT_HUMAN; CO9_HUMAN; CO8B_HUMAN; THBG_HUMAN; FINC_HUMAN; GELS_HUMAN; TETN_HUMAN; ITIH1_HUMAN; MYG_HUMAN; PROS_HUMAN; CO2_HUMAN; APOE_HUMAN; FIBA_HUMAN; HEP2_HUMAN; CO8A_HUMAN; PROF1_HUMAN; CAMP_HUMAN; LG3BP_HUMAN; BLVRB_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CBPB2_HUMAN; CO6_HUMAN; PRDX1_HUMAN; SODE_HUMAN; CAMP_HUMAN; S10AC_HUMAN; FIBB_HUMAN; FA9_HUMAN; C1QB_HUMAN; RAP1B_HUMAN; CO8G_HUMAN; CD14_HUMAN; PPIA_HUMAN; COF1_HUMAN; PROP_HUMAN; S10A9_HUMAN; APOM_HUMAN; SAA1_HUMAN; TYB4_HUMAN; ADIPO_HUMAN; SODC_HUMAN; ZPI_HUMAN; APOD_HUMAN; FIBG_HUMAN; LYSC_HUMAN; PEDF_HUMAN; CO3_HUMAN; H2B2E_HUMAN; LCAT_HUMAN; G3P_HUMAN; PRDX2_HUMAN; IPSP_HUMAN; CBG_HUMAN; PROC_HUMAN; F13A_HUMAN; KPYM_HUMAN; PIGR_HUMAN; PSPB_HUMAN; TRFL_HUMAN; VINC_HUMAN; CFAD_HUMAN; CAH1_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; HGFA_HUMAN; TPIS_HUMAN; S10A6_HUMAN; FA10_HUMAN; CCL14_HUMAN; TAGL2_HUMAN; GDIR2_HUMAN; MASP1_HUMAN; ENOA_HUMAN; GGH_HUMAN; GSTP1_HUMAN; PLF4_HUMAN; THIO_HUMAN; TFR1_HUMAN; CATS_HUMAN; MTPN_HUMAN; CBPN_HUMAN; FOLR1_HUMAN; B2MG_HUMAN; 1433Z_HUMAN; CXCL7_HUMAN; SAA1_HUMAN; SYUA_HUMAN; H33_HUMAN; SLPI_HUMAN; CYTC_HUMAN; TKT_HUMAN; CALM3_HUMAN; IBP2_HUMAN; IF5A1_HUMAN; FA11_HUMAN; BGH3_HUMAN; LDHB_HUMAN; RNAS2_HUMAN; CD86_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PAEP_HUMAN; C4BPA_HUMAN; PAEP_HUMAN; PGK1_HUMAN; CNTN1_HUMAN; LDHA_HUMAN; LAMP2_HUMAN; GPX1_HUMAN; RHOC_HUMAN; HYAL1_HUMAN; CAP1_HUMAN; PSA2_HUMAN; IBP6_HUMAN; TSP1_HUMAN; BPIA1_HUMAN; PGAM1_HUMAN; NECT2_HUMAN; SAP_HUMAN; SKA1_HUMAN; LFA3_HUMAN; ELNE_HUMAN; BIP_HUMAN; VWF_HUMAN; TLN1_HUMAN; MASP2_HUMAN; ALDOA_HUMAN; RD23A_HUMAN; COMP_HUMAN; VASP_HUMAN; TBA1B_HUMAN; FA7_HUMAN; EDNRB_HUMAN; CMGA_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; PEPD_HUMAN; CATC_HUMAN; VNN1_HUMAN; G6PI_HUMAN; 4F2_HUMAN; DAF_HUMAN; BIN2_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; FA5_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; MOES_HUMAN; GRN_HUMAN; POSTN_HUMAN; TENA_HUMAN; SEPR_HUMAN; URP2_HUMAN; FLNA_HUMAN; IQGA2_HUMAN; ACTN1_HUMAN; NDST1_HUMAN; NRP1_HUMAN; EPHA3_HUMAN; CR2_HUMAN; CAR11_HUMAN; BCORL_HUMAN; LAMB1_HUMAN; AKP13_HUMAN
Signal Domain Protein which has a signal sequence, a peptide usually present at the N-terminus of proteins and which is destined to be either secreted or part of membrane components. The signal sequence (usually 20-30 amino acids long) interacts with the signal recognition particle and directs the ribosome to the endoplasmic reticulum where co-translational insertion takes place. Signal peptides are highly hydrophobic but have some positively charged amino acids. Normally, the signal sequence is removed from the growing peptide chain by specific peptidases (signal peptidases) located on the cisternal face of the endoplasmic reticulum. Signal peptide; Signal sequence 189 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HPT_HUMAN; A2MG_HUMAN; APOA2_HUMAN; CO3_HUMAN; FETUB_HUMAN; HEMO_HUMAN; VTDB_HUMAN; APOC2_HUMAN; IC1_HUMAN; CO4B_HUMAN; CERU_HUMAN; A1AT_HUMAN; PLMN_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; ANT3_HUMAN; CFAH_HUMAN; ITIH4_HUMAN; APOC3_HUMAN; A1AG2_HUMAN; APOA4_HUMAN; A2MG_HUMAN; CFAB_HUMAN; RET4_HUMAN; VTNC_HUMAN; AFAM_HUMAN; FETUA_HUMAN; GPX3_HUMAN; APOB_HUMAN; APOH_HUMAN; IGLL1_HUMAN; TRFE_HUMAN; C1QA_HUMAN; THRB_HUMAN; IGJ_HUMAN; CO5_HUMAN; CLUS_HUMAN; AMBP_HUMAN; A2AP_HUMAN; KNG1_HUMAN; ANGT_HUMAN; CO9_HUMAN; CO8B_HUMAN; THBG_HUMAN; FINC_HUMAN; GELS_HUMAN; CD5L_HUMAN; TETN_HUMAN; ITIH1_HUMAN; PROS_HUMAN; CO2_HUMAN; APOE_HUMAN; FIBA_HUMAN; HEP2_HUMAN; CO8A_HUMAN; CAMP_HUMAN; LG3BP_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CBPB2_HUMAN; CO6_HUMAN; ECM1_HUMAN; SODE_HUMAN; CAMP_HUMAN; A2GL_HUMAN; PHLD_HUMAN; FIBB_HUMAN; FA9_HUMAN; C1QB_HUMAN; ITIH2_HUMAN; C4BPB_HUMAN; LUM_HUMAN; CO8G_HUMAN; CD14_HUMAN; PROP_HUMAN; APOM_HUMAN; SAA1_HUMAN; ADIPO_HUMAN; ZPI_HUMAN; APOD_HUMAN; FBLN1_HUMAN; ITIH3_HUMAN; FIBG_HUMAN; LYSC_HUMAN; PEDF_HUMAN; CO3_HUMAN; LCAT_HUMAN; SEPP1_HUMAN; IPSP_HUMAN; CBG_HUMAN; PROC_HUMAN; IBP3_HUMAN; ALS_HUMAN; PIGR_HUMAN; PSPB_HUMAN; F13B_HUMAN; TRFL_HUMAN; CFAD_HUMAN; HGFA_HUMAN; FA10_HUMAN; CCL14_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; PCYOX_HUMAN; GGH_HUMAN; PLF4_HUMAN; HABP2_HUMAN; CATS_HUMAN; CBPN_HUMAN; FOLR1_HUMAN; B2MG_HUMAN; CXCL7_HUMAN; SAA1_HUMAN; SLPI_HUMAN; CYTC_HUMAN; IBP2_HUMAN; APOF_HUMAN; MIME_HUMAN; FA11_HUMAN; BGH3_HUMAN; RNAS2_HUMAN; CD86_HUMAN; BTD_HUMAN; LBP_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PAEP_HUMAN; PRG4_HUMAN; C4BPA_HUMAN; PAEP_HUMAN; CNTN1_HUMAN; LAMP2_HUMAN; HYAL1_HUMAN; IBP6_HUMAN; TSP4_HUMAN; TSP1_HUMAN; PLTP_HUMAN; CADH5_HUMAN; BPIA1_HUMAN; NECT2_HUMAN; SAP_HUMAN; LFA3_HUMAN; CREG2_HUMAN; ELNE_HUMAN; BIP_HUMAN; VASN_HUMAN; VWF_HUMAN; DMBT1_HUMAN; MASP2_HUMAN; LYPD3_HUMAN; COMP_HUMAN; PEPA5_HUMAN; LAMP1_HUMAN; FA7_HUMAN; NPTX2_HUMAN; EDNRB_HUMAN; CMGA_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; P20D1_HUMAN; CATC_HUMAN; VNN1_HUMAN; CPN2_HUMAN; DAF_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; PGRP2_HUMAN; HPHL1_HUMAN; FA5_HUMAN; EGFR_HUMAN; GRN_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; CA2D1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; PRTG_HUMAN; EPHA3_HUMAN; MA2B1_HUMAN; CR2_HUMAN; LAMB1_HUMAN; HMCN2_HUMAN
Glycoprotein PTM Protein containing one or more covalently linked carbohydrates of various types, i.e. from monosaccharides to branched polysaccharides, including glycosylphosphatidylinositol (GPI), glycosaminoglycans (GAG). Glycosylated 182 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HBB_HUMAN; HPT_HUMAN; A2MG_HUMAN; APOA2_HUMAN; CO3_HUMAN; FETUB_HUMAN; HEMO_HUMAN; VTDB_HUMAN; APOC2_HUMAN; IC1_HUMAN; CO4B_HUMAN; CERU_HUMAN; A1AT_HUMAN; PLMN_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; ANT3_HUMAN; CFAH_HUMAN; ITIH4_HUMAN; APOC3_HUMAN; A1AG2_HUMAN; A2MG_HUMAN; CFAB_HUMAN; VTNC_HUMAN; AFAM_HUMAN; FETUA_HUMAN; APOB_HUMAN; APOH_HUMAN; TRFE_HUMAN; C1QA_HUMAN; THRB_HUMAN; IGJ_HUMAN; CO5_HUMAN; CLUS_HUMAN; AMBP_HUMAN; A2AP_HUMAN; KNG1_HUMAN; ANGT_HUMAN; CO9_HUMAN; CO8B_HUMAN; THBG_HUMAN; FINC_HUMAN; CD5L_HUMAN; TETN_HUMAN; ITIH1_HUMAN; PROS_HUMAN; CO2_HUMAN; APOE_HUMAN; FIBA_HUMAN; HEP2_HUMAN; CO8A_HUMAN; LG3BP_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CBPB2_HUMAN; CO6_HUMAN; ECM1_HUMAN; SODE_HUMAN; A2GL_HUMAN; PHLD_HUMAN; FIBB_HUMAN; FA9_HUMAN; C1QB_HUMAN; ITIH2_HUMAN; C4BPB_HUMAN; LUM_HUMAN; CD14_HUMAN; PPIA_HUMAN; PROP_HUMAN; APOM_HUMAN; ADIPO_HUMAN; ZPI_HUMAN; APOD_HUMAN; FBLN1_HUMAN; ITIH3_HUMAN; FIBG_HUMAN; PEDF_HUMAN; CO3_HUMAN; H2B2E_HUMAN; LCAT_HUMAN; SEPP1_HUMAN; IPSP_HUMAN; CBG_HUMAN; PROC_HUMAN; IBP3_HUMAN; ALS_HUMAN; F13A_HUMAN; PIGR_HUMAN; PSPB_HUMAN; F13B_HUMAN; TRFL_HUMAN; HGFA_HUMAN; FA10_HUMAN; CCL14_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; PCYOX_HUMAN; GGH_HUMAN; TFR1_HUMAN; HABP2_HUMAN; CATS_HUMAN; CBPN_HUMAN; FOLR1_HUMAN; B2MG_HUMAN; CYTC_HUMAN; IBP2_HUMAN; APOF_HUMAN; MIME_HUMAN; FA11_HUMAN; RNAS2_HUMAN; CD86_HUMAN; BTD_HUMAN; LBP_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PAEP_HUMAN; PRG4_HUMAN; C4BPA_HUMAN; PAEP_HUMAN; CNTN1_HUMAN; LAMP2_HUMAN; GOLM1_HUMAN; RHOC_HUMAN; B4GA1_HUMAN; HYAL1_HUMAN; IBP6_HUMAN; TSP4_HUMAN; TSP1_HUMAN; PLTP_HUMAN; CADH5_HUMAN; BPIA1_HUMAN; NECT2_HUMAN; SAP_HUMAN; LFA3_HUMAN; CREG2_HUMAN; ELNE_HUMAN; VASN_HUMAN; VWF_HUMAN; DMBT1_HUMAN; LYPD3_HUMAN; COMP_HUMAN; LAMP1_HUMAN; FA7_HUMAN; NPTX2_HUMAN; EDNRB_HUMAN; CMGA_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; P20D1_HUMAN; CATC_HUMAN; VNN1_HUMAN; CPN2_HUMAN; 4F2_HUMAN; DAF_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; PGRP2_HUMAN; HPHL1_HUMAN; FA5_HUMAN; EGFR_HUMAN; GRN_HUMAN; ENTP7_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; CA2D1_HUMAN; SEPR_HUMAN; NDST1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; PRTG_HUMAN; EPHA3_HUMAN; MA2B1_HUMAN; CR2_HUMAN; LAMB1_HUMAN; HMCN2_HUMAN
Secreted Cellular component Protein secreted into the cell surroundings. 171 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HPT_HUMAN; A2MG_HUMAN; APOA2_HUMAN; CO3_HUMAN; FETUB_HUMAN; HEMO_HUMAN; VTDB_HUMAN; APOC2_HUMAN; IC1_HUMAN; CO4B_HUMAN; CERU_HUMAN; A1AT_HUMAN; PLMN_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; ANT3_HUMAN; CFAH_HUMAN; ITIH4_HUMAN; APOC3_HUMAN; A1AG2_HUMAN; APOA4_HUMAN; A2MG_HUMAN; CFAB_HUMAN; RET4_HUMAN; VTNC_HUMAN; AFAM_HUMAN; FETUA_HUMAN; GPX3_HUMAN; APOB_HUMAN; APOH_HUMAN; IGLL1_HUMAN; TRFE_HUMAN; C1QA_HUMAN; THRB_HUMAN; IGJ_HUMAN; CO5_HUMAN; CLUS_HUMAN; AMBP_HUMAN; A2AP_HUMAN; KNG1_HUMAN; ANGT_HUMAN; CO9_HUMAN; CO8B_HUMAN; THBG_HUMAN; FINC_HUMAN; GELS_HUMAN; CD5L_HUMAN; TETN_HUMAN; ITIH1_HUMAN; PROS_HUMAN; CO2_HUMAN; APOE_HUMAN; FIBA_HUMAN; CO8A_HUMAN; CAMP_HUMAN; LG3BP_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1R_HUMAN; CBPB2_HUMAN; CO6_HUMAN; ECM1_HUMAN; SODE_HUMAN; CAMP_HUMAN; S10AC_HUMAN; A2GL_HUMAN; PHLD_HUMAN; FIBB_HUMAN; FA9_HUMAN; C1QB_HUMAN; ITIH2_HUMAN; C4BPB_HUMAN; LUM_HUMAN; CO8G_HUMAN; CD14_HUMAN; PPIA_HUMAN; PROP_HUMAN; S10A9_HUMAN; APOM_HUMAN; SAA1_HUMAN; ADIPO_HUMAN; ZPI_HUMAN; APOD_HUMAN; FBLN1_HUMAN; ITIH3_HUMAN; FIBG_HUMAN; LYSC_HUMAN; PEDF_HUMAN; CO3_HUMAN; LCAT_HUMAN; SEPP1_HUMAN; IPSP_HUMAN; CBG_HUMAN; PROC_HUMAN; IBP3_HUMAN; ALS_HUMAN; F13A_HUMAN; PIGR_HUMAN; PSPB_HUMAN; F13B_HUMAN; TRFL_HUMAN; CFAD_HUMAN; HGFA_HUMAN; FA10_HUMAN; CCL14_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; GGH_HUMAN; PLF4_HUMAN; THIO_HUMAN; TFR1_HUMAN; HABP2_HUMAN; CBPN_HUMAN; FOLR1_HUMAN; B2MG_HUMAN; CXCL7_HUMAN; SAA1_HUMAN; SYUA_HUMAN; SLPI_HUMAN; CYTC_HUMAN; IBP2_HUMAN; APOF_HUMAN; MIME_HUMAN; FA11_HUMAN; BGH3_HUMAN; BTD_HUMAN; LBP_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PAEP_HUMAN; PRG4_HUMAN; C4BPA_HUMAN; PAEP_HUMAN; HYAL1_HUMAN; IBP6_HUMAN; TSP4_HUMAN; TSP1_HUMAN; PLTP_HUMAN; BPIA1_HUMAN; SAP_HUMAN; CREG2_HUMAN; VASN_HUMAN; VWF_HUMAN; DMBT1_HUMAN; MASP2_HUMAN; COMP_HUMAN; PEPA5_HUMAN; FA7_HUMAN; NPTX2_HUMAN; CMGA_HUMAN; ATRN_HUMAN; P20D1_HUMAN; CPN2_HUMAN; G6PI_HUMAN; DAF_HUMAN; PGRP2_HUMAN; FA5_HUMAN; EGFR_HUMAN; GRN_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; SEPR_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; EPHA3_HUMAN; LAMB1_HUMAN; HMCN2_HUMAN
Disulfide bond PTM Protein which is modified by the formation of a bond between the thiol groups of two peptidyl-cysteine residues. The process of chemical oxidation that forms interchain disulfide bonds can produce stable, covalently linked protein dimers, multimers or complexes, whereas intrachain disulfide bonds can contribute to protein folding and stability. Depending on the protein environment, some disulfide bonds are more labile, forming transient redox-active disulfide bonds that are alternately reduced and oxidized in the course of an enzymatic reaction. 168 ALBU_HUMAN; TRFE_HUMAN; HPT_HUMAN; A2MG_HUMAN; APOA2_HUMAN; CO3_HUMAN; FETUB_HUMAN; HEMO_HUMAN; VTDB_HUMAN; IC1_HUMAN; CO4B_HUMAN; CERU_HUMAN; PLMN_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; ANT3_HUMAN; CFAH_HUMAN; ITIH4_HUMAN; A1AG2_HUMAN; A2MG_HUMAN; CFAB_HUMAN; RET4_HUMAN; VTNC_HUMAN; AFAM_HUMAN; FETUA_HUMAN; APOB_HUMAN; APOH_HUMAN; IGLL1_HUMAN; TRFE_HUMAN; C1QA_HUMAN; THRB_HUMAN; IGJ_HUMAN; CO5_HUMAN; CLUS_HUMAN; AMBP_HUMAN; A2AP_HUMAN; KNG1_HUMAN; ANGT_HUMAN; CO9_HUMAN; CO8B_HUMAN; FINC_HUMAN; GELS_HUMAN; CD5L_HUMAN; TETN_HUMAN; ITIH1_HUMAN; PROS_HUMAN; CO2_HUMAN; FIBA_HUMAN; CO8A_HUMAN; CAMP_HUMAN; LG3BP_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CBPB2_HUMAN; CO6_HUMAN; PRDX1_HUMAN; SODE_HUMAN; CAMP_HUMAN; A2GL_HUMAN; FIBB_HUMAN; FA9_HUMAN; C1QB_HUMAN; ITIH2_HUMAN; C4BPB_HUMAN; LUM_HUMAN; CO8G_HUMAN; CD14_HUMAN; PROP_HUMAN; APOM_HUMAN; ADIPO_HUMAN; SODC_HUMAN; APOD_HUMAN; FBLN1_HUMAN; FIBG_HUMAN; LYSC_HUMAN; CO3_HUMAN; LCAT_HUMAN; PRDX2_HUMAN; PROC_HUMAN; IBP3_HUMAN; PIGR_HUMAN; PSPB_HUMAN; F13B_HUMAN; TRFL_HUMAN; CFAD_HUMAN; HGFA_HUMAN; FA10_HUMAN; CCL14_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; PLF4_HUMAN; THIO_HUMAN; TFR1_HUMAN; HABP2_HUMAN; CATS_HUMAN; CBPN_HUMAN; FOLR1_HUMAN; B2MG_HUMAN; CXCL7_HUMAN; SLPI_HUMAN; CYTC_HUMAN; IBP2_HUMAN; MIME_HUMAN; FA11_HUMAN; BGH3_HUMAN; RNAS2_HUMAN; CD86_HUMAN; LBP_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PAEP_HUMAN; PRG4_HUMAN; C4BPA_HUMAN; PAEP_HUMAN; CNTN1_HUMAN; LAMP2_HUMAN; HYAL1_HUMAN; IBP6_HUMAN; TSP4_HUMAN; TSP1_HUMAN; PLTP_HUMAN; BPIA1_HUMAN; NECT2_HUMAN; SAP_HUMAN; LFA3_HUMAN; ELNE_HUMAN; VASN_HUMAN; VWF_HUMAN; DMBT1_HUMAN; MASP2_HUMAN; COMP_HUMAN; PEPA5_HUMAN; LAMP1_HUMAN; SPB10_HUMAN; FA7_HUMAN; NPTX2_HUMAN; EDNRB_HUMAN; CMGA_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; CATC_HUMAN; CPN2_HUMAN; 4F2_HUMAN; DAF_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; PGRP2_HUMAN; HPHL1_HUMAN; FA5_HUMAN; EGFR_HUMAN; GRN_HUMAN; ENTP7_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; CA2D1_HUMAN; SEPR_HUMAN; NDST1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; PRTG_HUMAN; MA2B1_HUMAN; CR2_HUMAN; LAMB1_HUMAN; HMCN2_HUMAN
Alternative splicing Coding sequence diversity Protein for which at least two isoforms exist due to distinct pre-mRNA splicing events. 127 ALBU_HUMAN; HPT_HUMAN; FETUB_HUMAN; VTDB_HUMAN; IC1_HUMAN; A1AT_HUMAN; CFAH_HUMAN; CFAH_HUMAN; ITIH4_HUMAN; CFAB_HUMAN; IGLL1_HUMAN; CLUS_HUMAN; A2AP_HUMAN; KNG1_HUMAN; FINC_HUMAN; GELS_HUMAN; ITIH1_HUMAN; CO2_HUMAN; FIBA_HUMAN; CBPB2_HUMAN; ECM1_HUMAN; PHLD_HUMAN; FA9_HUMAN; RAP1B_HUMAN; C4BPB_HUMAN; PPIA_HUMAN; APOM_HUMAN; FBLN1_HUMAN; ITIH3_HUMAN; FIBG_HUMAN; TPM4_HUMAN; G3P_HUMAN; PRDX2_HUMAN; PROC_HUMAN; IBP3_HUMAN; ALS_HUMAN; KPYM_HUMAN; VINC_HUMAN; PLSL_HUMAN; TPIS_HUMAN; CCL14_HUMAN; TAGL2_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; PCYOX_HUMAN; THIO_HUMAN; HABP2_HUMAN; CATS_HUMAN; 1433Z_HUMAN; SYUA_HUMAN; TKT_HUMAN; IF5A1_HUMAN; FA11_HUMAN; CD86_HUMAN; BTD_HUMAN; TAZ_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PAEP_HUMAN; PRG4_HUMAN; PAEP_HUMAN; PGK1_HUMAN; CNTN1_HUMAN; LDHA_HUMAN; LAMP2_HUMAN; GPX1_HUMAN; ARF3_HUMAN; HYAL1_HUMAN; CAP1_HUMAN; TSP1_HUMAN; PLTP_HUMAN; CADH5_HUMAN; PSMA8_HUMAN; BPIA1_HUMAN; NECT2_HUMAN; SAP_HUMAN; TPM4_HUMAN; SKA1_HUMAN; LFA3_HUMAN; DHB3_HUMAN; VWF_HUMAN; DMBT1_HUMAN; MASP2_HUMAN; ALDOA_HUMAN; RD23A_HUMAN; COMP_HUMAN; LAMP1_HUMAN; TBA1B_HUMAN; FA7_HUMAN; EDNRB_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; PMYT1_HUMAN; PEPD_HUMAN; P20D1_HUMAN; CATC_HUMAN; G6PI_HUMAN; 4F2_HUMAN; DAF_HUMAN; BIN2_HUMAN; PGRP2_HUMAN; EGFR_HUMAN; PP2D1_HUMAN; A16L2_HUMAN; HSP7C_HUMAN; GRN_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; CA2D1_HUMAN; SEPR_HUMAN; URP2_HUMAN; CALD1_HUMAN; FLNA_HUMAN; IQGA2_HUMAN; ACTN1_HUMAN; NDST1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; EPHA3_HUMAN; MA2B1_HUMAN; CR2_HUMAN; CC180_HUMAN; BCORL_HUMAN; AKP13_HUMAN; HMCN2_HUMAN; DYH9_HUMAN
Phosphoprotein PTM Protein which is posttranslationally modified by the attachment of either a single phosphate group, or of a complex molecule, such as 5'- phospho-DNA, through a phosphate group. Target amino acid is usually serine, threonine or tyrosine residues (mostly in eukaryotes), aspartic acid or histidine residues (mostly in prokaryotes). Phosphorylation 126 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HBB_HUMAN; APOA2_HUMAN; CO3_HUMAN; FETUB_HUMAN; CO4B_HUMAN; CERU_HUMAN; A1AT_HUMAN; PLMN_HUMAN; ANT3_HUMAN; APOA4_HUMAN; VTNC_HUMAN; FETUA_HUMAN; APOB_HUMAN; TRFE_HUMAN; CLUS_HUMAN; KNG1_HUMAN; CO9_HUMAN; CO8B_HUMAN; FINC_HUMAN; GELS_HUMAN; ITIH1_HUMAN; MYG_HUMAN; APOE_HUMAN; FIBA_HUMAN; HEP2_HUMAN; PROF1_HUMAN; BLVRB_HUMAN; C1R_HUMAN; PRDX1_HUMAN; FA9_HUMAN; RAP1B_HUMAN; ITIH2_HUMAN; LUM_HUMAN; PPIA_HUMAN; COF1_HUMAN; S10A9_HUMAN; TYB4_HUMAN; SODC_HUMAN; ZPI_HUMAN; FIBG_HUMAN; PEDF_HUMAN; CO3_HUMAN; H2B2E_HUMAN; TPM4_HUMAN; G3P_HUMAN; SEPP1_HUMAN; PRDX2_HUMAN; PROC_HUMAN; IBP3_HUMAN; KPYM_HUMAN; PIGR_HUMAN; VINC_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; TPIS_HUMAN; S10A6_HUMAN; H13_HUMAN; TAGL2_HUMAN; GDIR2_HUMAN; ENOA_HUMAN; GSTP1_HUMAN; PLF4_HUMAN; TFR1_HUMAN; MTPN_HUMAN; 1433Z_HUMAN; SYUA_HUMAN; H33_HUMAN; CYTC_HUMAN; TKT_HUMAN; CALM3_HUMAN; APOF_HUMAN; BGH3_HUMAN; LDHB_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; PGK1_HUMAN; LDHA_HUMAN; GPX1_HUMAN; GOLM1_HUMAN; CAP1_HUMAN; PSA2_HUMAN; CADH5_HUMAN; PGAM1_HUMAN; NECT2_HUMAN; TPM4_HUMAN; BIP_HUMAN; TLN1_HUMAN; ALDOA_HUMAN; RD23A_HUMAN; VASP_HUMAN; PEPA5_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN; EDNRB_HUMAN; CMGA_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; PEPD_HUMAN; G6PI_HUMAN; 4F2_HUMAN; BIN2_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; PGRP2_HUMAN; FA5_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; MOES_HUMAN; TENA_HUMAN; CA2D1_HUMAN; URP2_HUMAN; CALD1_HUMAN; FLNA_HUMAN; IQGA2_HUMAN; ACTN1_HUMAN; NRP1_HUMAN; EPHA3_HUMAN; CAR11_HUMAN; BCORL_HUMAN; LAMB1_HUMAN; AKP13_HUMAN
Repeat Domain Protein which contains a stretch of amino acids present in multiple copies. 118 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HPT_HUMAN; FETUB_HUMAN; HEMO_HUMAN; VTDB_HUMAN; IC1_HUMAN; CERU_HUMAN; PLMN_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; CFAH_HUMAN; APOA4_HUMAN; CFAB_HUMAN; VTNC_HUMAN; AFAM_HUMAN; FETUA_HUMAN; APOH_HUMAN; TRFE_HUMAN; C1QA_HUMAN; THRB_HUMAN; AMBP_HUMAN; KNG1_HUMAN; CO8B_HUMAN; FINC_HUMAN; GELS_HUMAN; CD5L_HUMAN; PROS_HUMAN; CO2_HUMAN; APOE_HUMAN; HEP2_HUMAN; CO8A_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CO6_HUMAN; ECM1_HUMAN; S10AC_HUMAN; A2GL_HUMAN; PHLD_HUMAN; FA9_HUMAN; C1QB_HUMAN; C4BPB_HUMAN; LUM_HUMAN; CD14_HUMAN; PROP_HUMAN; S10A9_HUMAN; ADIPO_HUMAN; FBLN1_HUMAN; PROC_HUMAN; ALS_HUMAN; PIGR_HUMAN; PSPB_HUMAN; F13B_HUMAN; TRFL_HUMAN; VINC_HUMAN; PLSL_HUMAN; HGFA_HUMAN; S10A6_HUMAN; FA10_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; HABP2_HUMAN; MTPN_HUMAN; SYUA_HUMAN; SLPI_HUMAN; CALM3_HUMAN; MIME_HUMAN; FA11_HUMAN; BGH3_HUMAN; IL1AP_HUMAN; PRG4_HUMAN; C4BPA_HUMAN; CNTN1_HUMAN; TSP4_HUMAN; TSP1_HUMAN; CADH5_HUMAN; NECT2_HUMAN; SAP_HUMAN; VASN_HUMAN; VWF_HUMAN; DMBT1_HUMAN; MASP2_HUMAN; LYPD3_HUMAN; RD23A_HUMAN; COMP_HUMAN; VASP_HUMAN; FA7_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; CPN2_HUMAN; DAF_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; HPHL1_HUMAN; FA5_HUMAN; EGFR_HUMAN; A16L2_HUMAN; GRN_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; CALD1_HUMAN; FLNA_HUMAN; IQGA2_HUMAN; ACTN1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; PRTG_HUMAN; EPHA3_HUMAN; CR2_HUMAN; BCORL_HUMAN; LAMB1_HUMAN; HMCN2_HUMAN; DYH9_HUMAN
Disease mutation Disease Protein for which at least one variant, responsible for a disease, is described in the feature table of its Swiss-Prot entry. 109 ALBU_HUMAN; TRFE_HUMAN; APOA1_HUMAN; HBB_HUMAN; HPT_HUMAN; CO3_HUMAN; APOC2_HUMAN; IC1_HUMAN; PLMN_HUMAN; CFAH_HUMAN; ANT3_HUMAN; CFAH_HUMAN; APOC3_HUMAN; CFAB_HUMAN; RET4_HUMAN; FETUA_HUMAN; APOB_HUMAN; IGLL1_HUMAN; TRFE_HUMAN; THRB_HUMAN; A2AP_HUMAN; ACTB_HUMAN; ANGT_HUMAN; CO9_HUMAN; FINC_HUMAN; GELS_HUMAN; PROS_HUMAN; CO2_HUMAN; APOE_HUMAN; FIBA_HUMAN; HEP2_HUMAN; PROF1_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; ECM1_HUMAN; FIBB_HUMAN; FA9_HUMAN; C1QB_HUMAN; PROP_HUMAN; ADIPO_HUMAN; SODC_HUMAN; FIBG_HUMAN; LYSC_HUMAN; CO3_HUMAN; LCAT_HUMAN; CBG_HUMAN; PROC_HUMAN; ALS_HUMAN; F13A_HUMAN; PSPB_HUMAN; F13B_HUMAN; VINC_HUMAN; CFAD_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; TPIS_HUMAN; FA10_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; TFR1_HUMAN; CBPN_HUMAN; B2MG_HUMAN; SYUA_HUMAN; H33_HUMAN; CYTC_HUMAN; TKT_HUMAN; CALM3_HUMAN; FA11_HUMAN; BGH3_HUMAN; LDHB_HUMAN; BTD_HUMAN; TAZ_HUMAN; FIBA_HUMAN; PGK1_HUMAN; LDHA_HUMAN; LAMP2_HUMAN; B4GA1_HUMAN; HYAL1_HUMAN; SAP_HUMAN; ELNE_HUMAN; DHB3_HUMAN; VWF_HUMAN; MASP2_HUMAN; ALDOA_HUMAN; COMP_HUMAN; FA7_HUMAN; TBB4B_HUMAN; EDNRB_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PEPD_HUMAN; CATC_HUMAN; G6PI_HUMAN; DAF_HUMAN; GP1BA_HUMAN; FA5_HUMAN; EGFR_HUMAN; MOES_HUMAN; TENA_HUMAN; URP2_HUMAN; FLNA_HUMAN; ACTN1_HUMAN; NDST1_HUMAN; MA2B1_HUMAN; CAR11_HUMAN; DYH9_HUMAN
Membrane Cellular component Protein which is membrane-bound or membrane-associated. A membrane is the layer which forms the boundary of cells and intracellular organelles. It is composed of two oriented lipid layers in which proteins are embedded and acts as a selective permeability barrier. 67 CLUS_HUMAN; CO9_HUMAN; CO8A_HUMAN; S10AC_HUMAN; RAP1B_HUMAN; CD14_HUMAN; COF1_HUMAN; S10A9_HUMAN; G3P_HUMAN; PIGR_HUMAN; VINC_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; S10A6_HUMAN; ENOA_HUMAN; TFR1_HUMAN; FOLR1_HUMAN; SYUA_HUMAN; IF5A1_HUMAN; CD86_HUMAN; LBP_HUMAN; TAZ_HUMAN; IL1AP_HUMAN; CNTN1_HUMAN; LAMP2_HUMAN; GOLM1_HUMAN; RHOC_HUMAN; B4GA1_HUMAN; CAP1_HUMAN; CADH5_HUMAN; NECT2_HUMAN; LFA3_HUMAN; ICMT_HUMAN; VASN_HUMAN; TLN1_HUMAN; LYPD3_HUMAN; VASP_HUMAN; LAMP1_HUMAN; EDNRB_HUMAN; CMGA_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; VNN1_HUMAN; 4F2_HUMAN; DAF_HUMAN; BIN2_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; PGRP2_HUMAN; HPHL1_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; MOES_HUMAN; ENTP7_HUMAN; CA2D1_HUMAN; SEPR_HUMAN; ACTN1_HUMAN; NDST1_HUMAN; NRP1_HUMAN; PRTG_HUMAN; EPHA3_HUMAN; CR2_HUMAN; CAR11_HUMAN; AKP13_HUMAN
Cytoplasm Cellular component Protein found in the cytoplasm, the content of a cell within the plasma membrane and, in eukaryotics cells, surrounding the nucleus. This three-dimensional, jelly-like lattice interconnects and supports the other solid structures. The cytosol (the soluble portion of the cytoplasm outside the organelles) is mostly composed of water and many low molecular weight compounds. In eukaryotes, the cytoplasm also contains a network of cytoplasmic filaments (cytoskeleton). 66 APOB_HUMAN; CLUS_HUMAN; ACTB_HUMAN; GELS_HUMAN; CD5L_HUMAN; PROF1_HUMAN; BLVRB_HUMAN; PRDX1_HUMAN; S10AC_HUMAN; RAP1B_HUMAN; PPIA_HUMAN; COF1_HUMAN; S10A9_HUMAN; TYB4_HUMAN; SODC_HUMAN; TPM4_HUMAN; G3P_HUMAN; PRDX2_HUMAN; F13A_HUMAN; KPYM_HUMAN; TRFL_HUMAN; VINC_HUMAN; CAH1_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; TPIS_HUMAN; S10A6_HUMAN; GDIR2_HUMAN; ENOA_HUMAN; GSTP1_HUMAN; THIO_HUMAN; MTPN_HUMAN; 1433Z_HUMAN; SYUA_HUMAN; CALM3_HUMAN; IF5A1_HUMAN; LDHB_HUMAN; TAZ_HUMAN; PGK1_HUMAN; LDHA_HUMAN; GPX1_HUMAN; ARF3_HUMAN; PSA2_HUMAN; PSMA8_HUMAN; TPM4_HUMAN; SKA1_HUMAN; BIP_HUMAN; TLN1_HUMAN; ALDOA_HUMAN; VASP_HUMAN; SPB10_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN; G6PI_HUMAN; BIN2_HUMAN; A16L2_HUMAN; HSP7C_HUMAN; MOES_HUMAN; SEPR_HUMAN; CALD1_HUMAN; FLNA_HUMAN; ACTN1_HUMAN; CAR11_HUMAN; AKP13_HUMAN; DYH9_HUMAN
Acetylation PTM Protein which is posttranslationally modified by the attachment of at least one acetyl group; generally at the N-terminus. Acetylated; N-acetylated 60 HBB_HUMAN; APOB_HUMAN; ACTB_HUMAN; GELS_HUMAN; PROF1_HUMAN; PRDX1_HUMAN; PPIA_HUMAN; COF1_HUMAN; TYB4_HUMAN; SODC_HUMAN; H2B2E_HUMAN; TPM4_HUMAN; G3P_HUMAN; PRDX2_HUMAN; F13A_HUMAN; KPYM_HUMAN; VINC_HUMAN; CAH1_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; TPIS_HUMAN; S10A6_HUMAN; H13_HUMAN; TAGL2_HUMAN; GDIR2_HUMAN; ENOA_HUMAN; GSTP1_HUMAN; THIO_HUMAN; MTPN_HUMAN; 1433Z_HUMAN; SYUA_HUMAN; H33_HUMAN; TKT_HUMAN; CALM3_HUMAN; IF5A1_HUMAN; LDHB_HUMAN; PGK1_HUMAN; LDHA_HUMAN; GPX1_HUMAN; GOLM1_HUMAN; CAP1_HUMAN; PSA2_HUMAN; PGAM1_HUMAN; TPM4_HUMAN; SKA1_HUMAN; BIP_HUMAN; TLN1_HUMAN; ALDOA_HUMAN; VASP_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN; PMYT1_HUMAN; PEPD_HUMAN; G6PI_HUMAN; 4F2_HUMAN; HSP7C_HUMAN; MOES_HUMAN; FLNA_HUMAN; ACTN1_HUMAN
Metal-binding Ligand Protein which binds metals. 52 ALBU_HUMAN; TRFE_HUMAN; HBB_HUMAN; HEMO_HUMAN; CERU_HUMAN; TRFE_HUMAN; GELS_HUMAN; MYG_HUMAN; CO2_HUMAN; FIBA_HUMAN; CFAI_HUMAN; C1S_HUMAN; CBPB2_HUMAN; SODE_HUMAN; S10AC_HUMAN; FA9_HUMAN; S10A9_HUMAN; SODC_HUMAN; FIBG_HUMAN; TPM4_HUMAN; F13A_HUMAN; KPYM_HUMAN; TRFL_HUMAN; CAH1_HUMAN; CAH2_HUMAN; PLSL_HUMAN; S10A6_HUMAN; MASP1_HUMAN; ENOA_HUMAN; CBPN_HUMAN; SYUA_HUMAN; TKT_HUMAN; CALM3_HUMAN; FIBA_HUMAN; B4GA1_HUMAN; CADH5_HUMAN; TPM4_HUMAN; MASP2_HUMAN; NPTX2_HUMAN; PMYT1_HUMAN; PEPD_HUMAN; P20D1_HUMAN; PGRP2_HUMAN; HPHL1_HUMAN; FA5_HUMAN; ENTP7_HUMAN; CA2D1_HUMAN; ACTN1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; MA2B1_HUMAN; AKP13_HUMAN
Immunity Biological process Protein involved in immunity, any immune system process that functions in the response of an organism to a potential internal or invasive threat. The vertebrate immune system is formed by the innate immune system (composed of phagocytes, complement, antimicrobial peptides, etc) and by the adaptive immune system which consists of T- and B- lymphocytes. Immune response 47 HPT_HUMAN; CO3_HUMAN; IC1_HUMAN; CO4B_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; CFAH_HUMAN; CFAB_HUMAN; C1QA_HUMAN; CO5_HUMAN; CLUS_HUMAN; CO9_HUMAN; CO8B_HUMAN; CD5L_HUMAN; CO2_HUMAN; FIBA_HUMAN; CO8A_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CO6_HUMAN; S10AC_HUMAN; FIBB_HUMAN; C1QB_HUMAN; C4BPB_HUMAN; CO8G_HUMAN; CD14_HUMAN; PROP_HUMAN; S10A9_HUMAN; CO3_HUMAN; TRFL_HUMAN; CFAD_HUMAN; MASP1_HUMAN; B2MG_HUMAN; SLPI_HUMAN; CD86_HUMAN; LBP_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; C4BPA_HUMAN; BPIA1_HUMAN; MASP2_HUMAN; CSF1R_HUMAN; DAF_HUMAN; PGRP2_HUMAN; CR2_HUMAN
Hydrolase Molecular function Enzyme which catalyzes hydrolysis reaction, i.e. the addition of the hydrogen and hydroxyl ions of water to a molecule with its consequent splitting into two or more simpler molecules. 43 PLMN_HUMAN; CFAB_HUMAN; THRB_HUMAN; CO2_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CBPB2_HUMAN; PHLD_HUMAN; FA9_HUMAN; LYSC_HUMAN; PROC_HUMAN; TRFL_HUMAN; CFAD_HUMAN; PARK7_HUMAN; HGFA_HUMAN; FA10_HUMAN; MASP1_HUMAN; GGH_HUMAN; HABP2_HUMAN; CATS_HUMAN; CBPN_HUMAN; FA11_HUMAN; RNAS2_HUMAN; BTD_HUMAN; HYAL1_HUMAN; PSA2_HUMAN; PSMA8_HUMAN; PGAM1_HUMAN; ELNE_HUMAN; BIP_HUMAN; MASP2_HUMAN; PEPA5_HUMAN; FA7_HUMAN; PEPD_HUMAN; P20D1_HUMAN; CATC_HUMAN; VNN1_HUMAN; PGRP2_HUMAN; ENTP7_HUMAN; SEPR_HUMAN; NDST1_HUMAN; MA2B1_HUMAN
Cell membrane Cellular component Protein found in or associated with the cytoplasmic membrane, a selectively permeable membrane which separates the cytoplasm from its surroundings. Known as the cell inner membrane in prokaryotes with 2 membranes. Cytoplasmic membrane; Plasmalemma; Plasma membrane 43 CO8A_HUMAN; S10AC_HUMAN; RAP1B_HUMAN; CD14_HUMAN; COF1_HUMAN; S10A9_HUMAN; PIGR_HUMAN; VINC_HUMAN; CAH2_HUMAN; PLSL_HUMAN; PARK7_HUMAN; S10A6_HUMAN; ENOA_HUMAN; TFR1_HUMAN; FOLR1_HUMAN; CD86_HUMAN; IL1AP_HUMAN; CNTN1_HUMAN; LAMP2_HUMAN; RHOC_HUMAN; CAP1_HUMAN; CADH5_HUMAN; NECT2_HUMAN; LFA3_HUMAN; TLN1_HUMAN; LYPD3_HUMAN; VASP_HUMAN; LAMP1_HUMAN; EDNRB_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; VNN1_HUMAN; 4F2_HUMAN; DAF_HUMAN; BIN2_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; MOES_HUMAN; SEPR_HUMAN; ACTN1_HUMAN; NRP1_HUMAN; EPHA3_HUMAN; CR2_HUMAN
Innate immunity Biological process Protein involved in innate immunity, an inborn defense mechanism used by organisms to defend themselves against invasion by pathogens (bacteria, fungi, viruses, etc.). Initially discovered in insects which are devoid of an adaptive immune system and rely only on innate immune reactions for their defense, this immediate response accomplishes many activities including recognition and effector functions. Recognition is mediated by broad specificity, pattern recognition, receptors which recognize many related molecular structures (e.g. polysaccharides, polynucleotides) present in microorganisms but not found in the host. The innate responses include the release of antimicrobial peptides, production of cytokines, acute- phase proteins, complement. Although many different innate immune mechanisms are deployed for host defence, a unifying theme of innate immunity is the use of germline-encoded pattern recognition receptors for pathogens or damaged self components, such as the Toll-like receptors, nucleotide-binding domain leucine-rich repeat (LRR)- containing receptors, retinoic acid-inducible gene I-like RNA helicases and C-type lectin receptors. 41 CO3_HUMAN; IC1_HUMAN; CO4B_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; CFAH_HUMAN; CFAB_HUMAN; C1QA_HUMAN; CO5_HUMAN; CLUS_HUMAN; CO9_HUMAN; CO8B_HUMAN; CO2_HUMAN; FIBA_HUMAN; CO8A_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CO6_HUMAN; S10AC_HUMAN; FIBB_HUMAN; C1QB_HUMAN; C4BPB_HUMAN; CO8G_HUMAN; CD14_HUMAN; PROP_HUMAN; S10A9_HUMAN; CO3_HUMAN; CFAD_HUMAN; MASP1_HUMAN; SLPI_HUMAN; LBP_HUMAN; IL1AP_HUMAN; FIBA_HUMAN; C4BPA_HUMAN; BPIA1_HUMAN; MASP2_HUMAN; CSF1R_HUMAN; DAF_HUMAN; CR2_HUMAN
Calcium Ligand Protein which binds at least one calcium atom, or protein whose function is calcium-dependent. Calcium is a metal, chemical symbol Ca. Calcium is essential for a variety of bodily functions, such as neurotransmission, muscle contraction and proper heart function. Ca; Calcium ion 39 ALBU_HUMAN; THRB_HUMAN; GELS_HUMAN; PROS_HUMAN; FIBA_HUMAN; CFAI_HUMAN; C1S_HUMAN; S10AC_HUMAN; FA9_HUMAN; S10A9_HUMAN; FBLN1_HUMAN; FIBG_HUMAN; TPM4_HUMAN; PROC_HUMAN; F13A_HUMAN; PLSL_HUMAN; S10A6_HUMAN; FA10_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; TKT_HUMAN; CALM3_HUMAN; FIBA_HUMAN; TSP4_HUMAN; TSP1_HUMAN; CADH5_HUMAN; TPM4_HUMAN; MASP2_HUMAN; COMP_HUMAN; FA7_HUMAN; NPTX2_HUMAN; CMGA_HUMAN; FA5_HUMAN; ENTP7_HUMAN; CA2D1_HUMAN; ACTN1_HUMAN; NRP1_HUMAN; FSTL5_HUMAN; HMCN2_HUMAN
Ubl conjugation PTM Protein which is posttranslationally modified by the attachment of at least one ubiquitin-like modifier protein, such as ubiquitin, SUMO, APG12, URM1 or RUB1. Ubiquitin, for example, is linked through a isopeptide bond between its C-terminus and the epsilon group of a lysine residue present on either another ubiquitin-like modifier protein or a target protein. Sumoylation; Ubiquitination; Ubiquitin conjugation; Ubiquitin-like modifier conjugation; Ubiquitinylation 37 CLUS_HUMAN; ACTB_HUMAN; PROF1_HUMAN; PRDX1_HUMAN; PPIA_HUMAN; COF1_HUMAN; TYB4_HUMAN; SODC_HUMAN; H2B2E_HUMAN; G3P_HUMAN; KPYM_HUMAN; TRFL_HUMAN; PARK7_HUMAN; TPIS_HUMAN; TAGL2_HUMAN; ENOA_HUMAN; THIO_HUMAN; SYUA_HUMAN; H33_HUMAN; TKT_HUMAN; CALM3_HUMAN; CD86_HUMAN; LDHA_HUMAN; CAP1_HUMAN; BIP_HUMAN; ALDOA_HUMAN; RD23A_HUMAN; TBA1B_HUMAN; CSF1R_HUMAN; G6PI_HUMAN; 4F2_HUMAN; ICAM1_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; CALD1_HUMAN; FLNA_HUMAN; BCORL_HUMAN
Isopeptide bond PTM Protein which is posttranslationally modified by the formation of an amide bond between an amino-group and a carboxyl-group at least one of which is not an alpha group. An isopeptide bond involves the side chain of one or two amino acid residues. Because there are few enzymes that hydrolyze isopeptide bonds, the formation of interchain isopeptide bonds can produce stably linked protein dimers, multimers or complexes, such as blood clots. 36 A2MG_HUMAN; A2MG_HUMAN; A2AP_HUMAN; ACTB_HUMAN; FINC_HUMAN; FIBA_HUMAN; PROF1_HUMAN; PRDX1_HUMAN; PPIA_HUMAN; COF1_HUMAN; TYB4_HUMAN; FIBG_HUMAN; H2B2E_HUMAN; G3P_HUMAN; KPYM_HUMAN; TRFL_HUMAN; PARK7_HUMAN; TPIS_HUMAN; TAGL2_HUMAN; ENOA_HUMAN; TKT_HUMAN; CALM3_HUMAN; FIBA_HUMAN; LDHA_HUMAN; CAP1_HUMAN; BIP_HUMAN; ALDOA_HUMAN; RD23A_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN; 4F2_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; CALD1_HUMAN; FLNA_HUMAN; BCORL_HUMAN
Transport Biological process Protein involved in the transport of a molecule (metabolite, protein, etc), a ion or an electron across cell membranes, inside the cell or in a tissue fluid. 34 TRFE_HUMAN; APOA1_HUMAN; HBB_HUMAN; APOA2_HUMAN; HEMO_HUMAN; VTDB_HUMAN; APOC2_HUMAN; CERU_HUMAN; APOC3_HUMAN; A1AG2_HUMAN; APOA4_HUMAN; RET4_HUMAN; AFAM_HUMAN; APOB_HUMAN; TRFE_HUMAN; MYG_HUMAN; APOE_HUMAN; APOM_HUMAN; APOD_HUMAN; IPSP_HUMAN; CBG_HUMAN; TRFL_HUMAN; THIO_HUMAN; FOLR1_HUMAN; APOF_HUMAN; IF5A1_HUMAN; LBP_HUMAN; ARF3_HUMAN; PLTP_HUMAN; DMBT1_HUMAN; 4F2_HUMAN; HPHL1_HUMAN; A16L2_HUMAN; CA2D1_HUMAN
Transmembrane Domain Protein with at least one transmembrane domain, a membrane-spanning helical or beta-stranded domain embedded in a membrane. 33 CO9_HUMAN; CO8A_HUMAN; PIGR_HUMAN; TFR1_HUMAN; CD86_HUMAN; TAZ_HUMAN; IL1AP_HUMAN; LAMP2_HUMAN; GOLM1_HUMAN; B4GA1_HUMAN; CADH5_HUMAN; NECT2_HUMAN; LFA3_HUMAN; ICMT_HUMAN; VASN_HUMAN; LAMP1_HUMAN; EDNRB_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; 4F2_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; HPHL1_HUMAN; EGFR_HUMAN; ENTP7_HUMAN; CA2D1_HUMAN; SEPR_HUMAN; NDST1_HUMAN; NRP1_HUMAN; PRTG_HUMAN; EPHA3_HUMAN; CR2_HUMAN
Transmembrane helix Domain Protein with at least one transmembrane helical domain, a membrane- spanning domain with an hydrogen-bonded helical configuration, including alpha-, 3-10-, and pi-helices. The transmembrane alpha-helix is very common, while the 3-10-helix is found at the ends of alpha- helices and the pi-helix, is more rare. Alpha-helical transmembrane; Pauling-Corey-Branson alpha helix 31 PIGR_HUMAN; TFR1_HUMAN; CD86_HUMAN; TAZ_HUMAN; IL1AP_HUMAN; LAMP2_HUMAN; GOLM1_HUMAN; B4GA1_HUMAN; CADH5_HUMAN; NECT2_HUMAN; LFA3_HUMAN; ICMT_HUMAN; VASN_HUMAN; LAMP1_HUMAN; EDNRB_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; 4F2_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; HPHL1_HUMAN; EGFR_HUMAN; ENTP7_HUMAN; CA2D1_HUMAN; SEPR_HUMAN; NDST1_HUMAN; NRP1_HUMAN; PRTG_HUMAN; EPHA3_HUMAN; CR2_HUMAN
Protease Molecular function Enzyme which hydrolyzes peptide bonds. Peptidase; Peptide hydrolase; Proteinase 30 PLMN_HUMAN; CFAB_HUMAN; THRB_HUMAN; CO2_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CBPB2_HUMAN; FA9_HUMAN; PROC_HUMAN; TRFL_HUMAN; CFAD_HUMAN; PARK7_HUMAN; HGFA_HUMAN; FA10_HUMAN; MASP1_HUMAN; HABP2_HUMAN; CATS_HUMAN; CBPN_HUMAN; FA11_HUMAN; PSA2_HUMAN; PSMA8_HUMAN; ELNE_HUMAN; MASP2_HUMAN; PEPA5_HUMAN; FA7_HUMAN; PEPD_HUMAN; P20D1_HUMAN; CATC_HUMAN; SEPR_HUMAN
Nucleus Cellular component Protein located in the nucleus of a cell. 26 CLUS_HUMAN; ACTB_HUMAN; COF1_HUMAN; SODC_HUMAN; H2B2E_HUMAN; G3P_HUMAN; KPYM_HUMAN; TRFL_HUMAN; PARK7_HUMAN; S10A6_HUMAN; H13_HUMAN; ENOA_HUMAN; GSTP1_HUMAN; THIO_HUMAN; MTPN_HUMAN; SYUA_HUMAN; H33_HUMAN; IF5A1_HUMAN; PSA2_HUMAN; PSMA8_HUMAN; RD23A_HUMAN; SPB10_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; BCORL_HUMAN; AKP13_HUMAN
EGF-like domain Domain Protein containing at least one EGF-like domain, a sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF). It has been shown to be present, in a more or less conserved form, in a large number of proteins. The EGF- like domain contains six cysteines which form disulfide bonds within the domain (C1-C3, C2-C4, C5-C6). 26 CO9_HUMAN; CO8B_HUMAN; PROS_HUMAN; CO8A_HUMAN; CO7_HUMAN; C1S_HUMAN; C1R_HUMAN; CO6_HUMAN; FA9_HUMAN; FBLN1_HUMAN; PROC_HUMAN; HGFA_HUMAN; FA10_HUMAN; FBLN3_HUMAN; MASP1_HUMAN; HABP2_HUMAN; HYAL1_HUMAN; TSP4_HUMAN; TSP1_HUMAN; VASN_HUMAN; MASP2_HUMAN; COMP_HUMAN; FA7_HUMAN; ATRN_HUMAN; TENA_HUMAN; HMCN2_HUMAN
Cleavage on pair of basic residues PTM Protein which is posttranslationally modified by the cleavage on at least one pair of basic residues, in order to release one or more mature active peptides (such as hormones). 25 ALBU_HUMAN; APOA2_HUMAN; CO3_HUMAN; CO4B_HUMAN; PLMN_HUMAN; CFAB_HUMAN; THRB_HUMAN; CO5_HUMAN; AMBP_HUMAN; PROS_HUMAN; CO8A_HUMAN; CAMP_HUMAN; CFAI_HUMAN; CAMP_HUMAN; FA9_HUMAN; CO3_HUMAN; PROC_HUMAN; FA10_HUMAN; HABP2_HUMAN; CXCL7_HUMAN; CADH5_HUMAN; VWF_HUMAN; FA7_HUMAN; CMGA_HUMAN; SEPR_HUMAN
Methylation PTM Protein which is posttranslationally modified by the attachment of at least one methyl group. Methylated 24 ALBU_HUMAN; TRFE_HUMAN; RET4_HUMAN; TRFE_HUMAN; ACTB_HUMAN; RAP1B_HUMAN; S10A9_HUMAN; SAA1_HUMAN; H2B2E_HUMAN; G3P_HUMAN; KPYM_HUMAN; TPIS_HUMAN; TAGL2_HUMAN; SAA1_HUMAN; H33_HUMAN; CALM3_HUMAN; RHOC_HUMAN; CAP1_HUMAN; BIP_HUMAN; TBA1B_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; AKP13_HUMAN; HMCN2_HUMAN
Complement pathway Biological process Pathway which activates the proteins of the complement system, a group of blood proteins of the globulin class involved in the lysis of foreign cells after they have been coated with antibody, and which also promote the removal of antibody-coated foreign particles by phagocytic cells. The pathway proceeds by a cascade reaction of successive binding and proteolytic cleavage of complement components. This pathway can be activated by either IgG or IgM binding to an antigen. Classical complement pathway; Complement activation classical pathway 24 CO3_HUMAN; IC1_HUMAN; CO4B_HUMAN; C4BPA_HUMAN; C1QA_HUMAN; CO5_HUMAN; CLUS_HUMAN; CO9_HUMAN; CO8B_HUMAN; CO2_HUMAN; CO8A_HUMAN; CO7_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; CO6_HUMAN; C1QB_HUMAN; C4BPB_HUMAN; CO8G_HUMAN; CO3_HUMAN; C4BPA_HUMAN; MASP2_HUMAN; DAF_HUMAN; CR2_HUMAN
Blood coagulation Biological process Protein involved in blood clotting, a complex enzymatic cascade, in which the activated form of one factor catalyzes the activation of the next factor. Both, the extrinsic clotting pathway, induced by a damaged surface, and the intrinsic pathway, induced by a trauma, converge in a final common pathway to form cross-linked fibrin clots. 24 IC1_HUMAN; A1AT_HUMAN; PLMN_HUMAN; ANT3_HUMAN; THRB_HUMAN; KNG1_HUMAN; PROS_HUMAN; FIBA_HUMAN; HEP2_HUMAN; CBPB2_HUMAN; FIBB_HUMAN; FA9_HUMAN; ZPI_HUMAN; FIBG_HUMAN; PROC_HUMAN; F13A_HUMAN; F13B_HUMAN; FA10_HUMAN; FA11_HUMAN; FIBA_HUMAN; VWF_HUMAN; FA7_HUMAN; GP1BA_HUMAN; FA5_HUMAN
Hemostasis Biological process Protein involved in the arrest of bleeding through blood clotting and contraction of blood vessels. 24 IC1_HUMAN; A1AT_HUMAN; PLMN_HUMAN; ANT3_HUMAN; THRB_HUMAN; KNG1_HUMAN; PROS_HUMAN; FIBA_HUMAN; HEP2_HUMAN; CBPB2_HUMAN; FIBB_HUMAN; FA9_HUMAN; ZPI_HUMAN; FIBG_HUMAN; PROC_HUMAN; F13A_HUMAN; F13B_HUMAN; FA10_HUMAN; FA11_HUMAN; FIBA_HUMAN; VWF_HUMAN; FA7_HUMAN; GP1BA_HUMAN; FA5_HUMAN
Cytoskeleton Cellular component Protein which is a component or which is associated with the cytoskeleton, a dynamic three-dimensional structure that fills the cytoplasm of eukaryotic cells. The cytoskeleton is both a muscle and a skeleton, and is responsible for cell movement, cytokinesis, and the organization of the organelles within the cell. The major components of cytoskeleton are the microfilaments (of actin), microtubules (of tubulin) and intermediate filament systems in cells. 23 ACTB_HUMAN; GELS_HUMAN; PROF1_HUMAN; S10AC_HUMAN; COF1_HUMAN; S10A9_HUMAN; TYB4_HUMAN; TPM4_HUMAN; G3P_HUMAN; VINC_HUMAN; PLSL_HUMAN; CALM3_HUMAN; TPM4_HUMAN; SKA1_HUMAN; TLN1_HUMAN; VASP_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN; MOES_HUMAN; CALD1_HUMAN; FLNA_HUMAN; ACTN1_HUMAN; DYH9_HUMAN
Host-virus interaction Biological process Viral or cellular protein involved in a host-virus interaction. Viruses interact with many cellular pathways to achieve their replication cycle. Entry into the host cell, transport to the viral replication sites or viral exit from the host cell are all steps that require specific interactions between the virus and its host. Additionally, the evasion from the host immune response requires a lot of viral proteins to associate with and inhibit cellular proteins with antiviral functions. 21 APOA2_HUMAN; HEMO_HUMAN; CFAH_HUMAN; CFAH_HUMAN; C1QA_HUMAN; AMBP_HUMAN; CFAI_HUMAN; PPIA_HUMAN; FBLN1_HUMAN; TFR1_HUMAN; CD86_HUMAN; NECT2_HUMAN; TLN1_HUMAN; DMBT1_HUMAN; RD23A_HUMAN; LAMP1_HUMAN; DAF_HUMAN; ICAM1_HUMAN; HSP7C_HUMAN; MOES_HUMAN; CR2_HUMAN
Cell adhesion Biological process Protein involved in the adherence of cells to other cells or to a matrix. Cell adhesion is mediated by cell surface proteins. 21 VTNC_HUMAN; FINC_HUMAN; LG3BP_HUMAN; ALS_HUMAN; VINC_HUMAN; BGH3_HUMAN; CNTN1_HUMAN; TSP4_HUMAN; TSP1_HUMAN; CADH5_HUMAN; NECT2_HUMAN; VWF_HUMAN; COMP_HUMAN; GP1BA_HUMAN; ICAM1_HUMAN; POSTN_HUMAN; TENA_HUMAN; SEPR_HUMAN; URP2_HUMAN; EPHA3_HUMAN; LAMB1_HUMAN
Serine protease Molecular function Proteolytic enzyme with a serine residue (Ser) in its active site. The reactivity of the serine residue is ensured by the vicinity of a histidine and an aspartate residue (catalytic triad), all three residues are required for the charge relay system to take place. Serine endopeptidase; Serine peptidase; Serine proteinase 20 PLMN_HUMAN; CFAB_HUMAN; THRB_HUMAN; CO2_HUMAN; CFAI_HUMAN; C1S_HUMAN; C1R_HUMAN; FA9_HUMAN; PROC_HUMAN; TRFL_HUMAN; CFAD_HUMAN; HGFA_HUMAN; FA10_HUMAN; MASP1_HUMAN; HABP2_HUMAN; FA11_HUMAN; ELNE_HUMAN; MASP2_HUMAN; FA7_HUMAN; SEPR_HUMAN
Protease inhibitor Molecular function Protein which inhibits or antagonizes the biosynthesis of proteases or their activity. 19 A2MG_HUMAN; FETUB_HUMAN; IC1_HUMAN; A1AT_HUMAN; ANT3_HUMAN; ITIH4_HUMAN; A2MG_HUMAN; AMBP_HUMAN; A2AP_HUMAN; KNG1_HUMAN; ITIH1_HUMAN; HEP2_HUMAN; ITIH2_HUMAN; ZPI_HUMAN; ITIH3_HUMAN; IPSP_HUMAN; SLPI_HUMAN; CYTC_HUMAN; SPB10_HUMAN
Extracellular matrix Cellular component Protein found in the extracellular matrix. The extracellular matrix consists of any material produced by cells and secreted into the surrounding medium, but this term generally applies to the non- cellular components of animal tissues. The extracellular matrix forms a supportive meshwork around cells and is largely composed of collagen, laminin, fibronectin and glycosaminoglycans. It can influence the properties of the cells that it supports. In certain tissues, specific modifications to the extracellular matrix occur. For instance, the matrix of bone is mineralized to resist compression. 19 A1AT_HUMAN; FINC_HUMAN; APOE_HUMAN; LG3BP_HUMAN; ECM1_HUMAN; LUM_HUMAN; FBLN1_HUMAN; FBLN3_HUMAN; MIME_HUMAN; BGH3_HUMAN; TSP4_HUMAN; TSP1_HUMAN; VWF_HUMAN; COMP_HUMAN; POSTN_HUMAN; TENA_HUMAN; CHADL_HUMAN; LAMB1_HUMAN; HMCN2_HUMAN
Zymogen PTM The enzymatically inactive precursor of mostly proteolytic enzymes. Proenzyme 19 PLMN_HUMAN; CFAB_HUMAN; THRB_HUMAN; PROS_HUMAN; CBPB2_HUMAN; FA9_HUMAN; PROC_HUMAN; F13A_HUMAN; CFAD_HUMAN; PARK7_HUMAN; HGFA_HUMAN; FA10_HUMAN; CATS_HUMAN; ELNE_HUMAN; PEPA5_HUMAN; FA7_HUMAN; CATC_HUMAN; FA5_HUMAN; MA2B1_HUMAN
Heparin-binding Molecular function Protein which binds heparin, a highly sulfated glycosaminoglycan which consists of repeating units of disaccharides composed of D- glucosamine, D-glucuronic acid or L-iduronic acid. This anticoagulant is found in the granules of mast cells. 19 ANT3_HUMAN; VTNC_HUMAN; APOB_HUMAN; APOH_HUMAN; FINC_HUMAN; APOE_HUMAN; HEP2_HUMAN; SODE_HUMAN; SAA1_HUMAN; ZPI_HUMAN; IPSP_HUMAN; TRFL_HUMAN; PLF4_HUMAN; SAA1_HUMAN; FA11_HUMAN; TSP1_HUMAN; COMP_HUMAN; POSTN_HUMAN; NRP1_HUMAN
Hydroxylation PTM Protein which is posttranslationally modified by the attachment of at least one hydroxyl (-OH) group. Hydroxylated 19 C1QA_HUMAN; KNG1_HUMAN; PROS_HUMAN; FIBA_HUMAN; C1S_HUMAN; C1R_HUMAN; FA9_HUMAN; C1QB_HUMAN; ADIPO_HUMAN; H2B2E_HUMAN; PROC_HUMAN; KPYM_HUMAN; FA10_HUMAN; H13_HUMAN; MASP1_HUMAN; H33_HUMAN; FIBA_HUMAN; MASP2_HUMAN; FA7_HUMAN
Sushi Domain Protein which contains at least one sushi domain, a motif of approximately 60 amino acids characterized by a framework of four conserved half-cystine residues (1-3 and 2-4 disulfide-bonded) and several other highly conserved residues including proline, tryptophan, tyrosine/phenylalanine and cysteine. This type of structure, also designated SCR (Short Consensus Repeat), is predominantly present in proteins associated with the complement system. 18 HPT_HUMAN; C4BPA_HUMAN; CFAH_HUMAN; CFAH_HUMAN; CFAB_HUMAN; APOH_HUMAN; CO2_HUMAN; CO7_HUMAN; C1S_HUMAN; C1R_HUMAN; CO6_HUMAN; C4BPB_HUMAN; F13B_HUMAN; MASP1_HUMAN; C4BPA_HUMAN; MASP2_HUMAN; DAF_HUMAN; CR2_HUMAN
Lipoprotein PTM Protein which is posttranslationally modified by the attachment of at least one lipid or fatty acid, e.g. farnesyl, palmitate and myristate. Lipidated 17 APOA1_HUMAN; APOB_HUMAN; RAP1B_HUMAN; CD14_HUMAN; SODC_HUMAN; VINC_HUMAN; PARK7_HUMAN; TFR1_HUMAN; FOLR1_HUMAN; CNTN1_HUMAN; RHOC_HUMAN; ARF3_HUMAN; LYPD3_HUMAN; EDNRB_HUMAN; VNN1_HUMAN; DAF_HUMAN; EGFR_HUMAN
Coiled coil Domain Protein which contains at least one coiled coil domain, a type of secondary structure composed of two or more alpha helices which entwine to form a cable structure. In proteins, the helical cables serve a mechanical role in forming stiff bundles of fibres. Heptad repeat pattern 17 FIBA_HUMAN; FIBB_HUMAN; FIBG_HUMAN; TPM4_HUMAN; FIBA_HUMAN; GOLM1_HUMAN; TPM4_HUMAN; SKA1_HUMAN; VASP_HUMAN; BIN2_HUMAN; A16L2_HUMAN; TENA_HUMAN; CC180_HUMAN; CAR11_HUMAN; LAMB1_HUMAN; AKP13_HUMAN; DYH9_HUMAN
Serine protease inhibitor Molecular function Protein which inhibits serine proteases, a group of proteolytic enzymes which are characterized by a catalytically active serine residue in their active site. Serine endopeptidase inhibitor; Serine peptidase inhibitor; Serine proteinase inhibitor 16 A2MG_HUMAN; IC1_HUMAN; A1AT_HUMAN; ANT3_HUMAN; ITIH4_HUMAN; A2MG_HUMAN; AMBP_HUMAN; A2AP_HUMAN; ITIH1_HUMAN; HEP2_HUMAN; ITIH2_HUMAN; ZPI_HUMAN; ITIH3_HUMAN; IPSP_HUMAN; SLPI_HUMAN; SPB10_HUMAN
Nucleotide-binding Ligand Protein which binds a nucleotide, a phosphate ester of a nucleoside consisting of a purine or pyrimidine base linked to ribose or deoxyribose phosphates. 16 ACTB_HUMAN; RAP1B_HUMAN; KPYM_HUMAN; PGK1_HUMAN; RHOC_HUMAN; ARF3_HUMAN; BIP_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; EPHA3_HUMAN; DYH9_HUMAN
Receptor Molecular function Protein which binds to, or responds to, a ligand with high specificity. 16 TFR1_HUMAN; FOLR1_HUMAN; CD86_HUMAN; IL1AP_HUMAN; NECT2_HUMAN; LAMP1_HUMAN; EDNRB_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; DAF_HUMAN; ICAM1_HUMAN; EGFR_HUMAN; NRP1_HUMAN; EPHA3_HUMAN; CR2_HUMAN
Transferase Molecular function Enzyme that transfers a chemical group, e.g. a methyl group or a glycosyl group from one compound (donor) to another compound (acceptor). 15 LCAT_HUMAN; G3P_HUMAN; F13A_HUMAN; KPYM_HUMAN; GSTP1_HUMAN; TKT_HUMAN; PGK1_HUMAN; B4GA1_HUMAN; ICMT_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; EGFR_HUMAN; NDST1_HUMAN; EPHA3_HUMAN
Inflammatory response Biological process Protein involved in the localized protective response to tissue damage, microbial infection, or the presence of foreign matter. It is characterized by swelling, redness, heat and pain and involves a complex series of events including vascular changes and accumulation of blood cells, such as neutrophil leucocytes and mononuclear phagocytes, at the site of injury. Response to inflammation 14 CO3_HUMAN; CO4B_HUMAN; CO5_HUMAN; KNG1_HUMAN; CD5L_HUMAN; S10AC_HUMAN; CD14_HUMAN; S10A9_HUMAN; CO3_HUMAN; PARK7_HUMAN; IL1AP_HUMAN; ATRN_HUMAN; CSF1R_HUMAN; NDST1_HUMAN
Actin-binding Molecular function Protein which binds to actin, and thereby can modulate the properties and/or functions of the actin filament. Actin filament binding 14 VTDB_HUMAN; GELS_HUMAN; PROF1_HUMAN; COF1_HUMAN; TYB4_HUMAN; TPM4_HUMAN; VINC_HUMAN; PLSL_HUMAN; CAP1_HUMAN; TPM4_HUMAN; VASP_HUMAN; CALD1_HUMAN; FLNA_HUMAN; ACTN1_HUMAN
Oxidoreductase Molecular function Enzyme that catalyzes the oxidation of one compound with the reduction of another. 14 CERU_HUMAN; GPX3_HUMAN; BLVRB_HUMAN; PRDX1_HUMAN; SODE_HUMAN; SODC_HUMAN; G3P_HUMAN; PRDX2_HUMAN; PCYOX_HUMAN; LDHB_HUMAN; LDHA_HUMAN; GPX1_HUMAN; DHB3_HUMAN; HPHL1_HUMAN
Immunoglobulin domain Domain A globular structural motif found in many proteins of the immune system, including immunoglobulins (Igs), T cell receptors (TCRs) and major histocompatibility complex (MHC) molecules. Ig domains are approximately 110 amino acid residues in length, include an internal disulfide bond, and contain two layers of beta-pleated sheets, each layer composed of three to five strands of antiparallel polypeptide chains. Ig domains are classified as V-like or C-like on the basis of closest homology to either Ig V or C domains. Immunoglobulin fold 14 IGLL1_HUMAN; PIGR_HUMAN; B2MG_HUMAN; CD86_HUMAN; IL1AP_HUMAN; CNTN1_HUMAN; NECT2_HUMAN; LFA3_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; ICAM1_HUMAN; FSTL5_HUMAN; PRTG_HUMAN; HMCN2_HUMAN
Zinc Ligand Protein which binds at least one zinc atom, or protein whose function is zinc-dependent. Zinc is a metallic trace element, chemical symbol Zn. 13 ALBU_HUMAN; CBPB2_HUMAN; SODE_HUMAN; S10AC_HUMAN; S10A9_HUMAN; SODC_HUMAN; CAH1_HUMAN; CAH2_HUMAN; CBPN_HUMAN; P20D1_HUMAN; PGRP2_HUMAN; MA2B1_HUMAN; AKP13_HUMAN
Antimicrobial Molecular function Protein which has deleterious effects on any type of microbe. Microbe is a general term for microscopic unicellular organisms, such as bacteria, archaea, fungi and protista. While the term microbe is often also used for viruses, we do not apply the keyword antimicrobial to antiviral proteins. 13 HPT_HUMAN; CAMP_HUMAN; CAMP_HUMAN; S10AC_HUMAN; S10A9_HUMAN; LYSC_HUMAN; H2B2E_HUMAN; TRFL_HUMAN; CXCL7_HUMAN; SLPI_HUMAN; LBP_HUMAN; BPIA1_HUMAN; CMGA_HUMAN
Complement alternate pathway Biological process Protein involved in the complement alternate pathway which activates the proteins of the complement system. This pathway can be activated by IgA immune complexes, but also by bacterial endotoxins, polysaccharides and cell walls, without participation of an antigen- antibody reaction. Alternate complement pathway; Complement activation alternative pathway; Properdin system 13 CO3_HUMAN; CFAH_HUMAN; CFAH_HUMAN; CFAB_HUMAN; CO5_HUMAN; CO9_HUMAN; CO8B_HUMAN; CO8A_HUMAN; CO7_HUMAN; CO8G_HUMAN; PROP_HUMAN; CO3_HUMAN; CFAD_HUMAN
Cell junction Cellular component Protein found in or associated with a cell junction, a cell-cell or cell-extracellular matrix contact within a tissue of a multicellular organism, especially abundant in epithelia. In vertebrates, there are three major types of cell junctions: anchoring junctions (e.g. adherens junctions), communicating junctions (e.g. gap junctions) and occluding junctions (e.g. tight junctions). 13 CO4B_HUMAN; RAP1B_HUMAN; VINC_HUMAN; PLSL_HUMAN; SYUA_HUMAN; CADH5_HUMAN; TLN1_HUMAN; VASP_HUMAN; 4F2_HUMAN; BIN2_HUMAN; SEPR_HUMAN; URP2_HUMAN; ACTN1_HUMAN
Lipid transport Biological process Protein involved in the transport of lipids, a diverse class of compounds which are insoluble in water but soluble in organic solvents. They include fats, oils, triacylglycerols, fatty acids, glycolipids, phospholipids and steroids. 12 APOA1_HUMAN; APOA2_HUMAN; APOC2_HUMAN; APOC3_HUMAN; APOA4_HUMAN; APOB_HUMAN; APOE_HUMAN; APOM_HUMAN; IPSP_HUMAN; APOF_HUMAN; LBP_HUMAN; PLTP_HUMAN
Pyrrolidone carboxylic acid PTM Protein which is posttranslationally modified by the cyclization of a N-terminal glutamine. Pyro-Glu; Pyroglutamic acid 12 APOA2_HUMAN; A1AG2_HUMAN; IGJ_HUMAN; KNG1_HUMAN; FINC_HUMAN; FIBB_HUMAN; C1QB_HUMAN; LUM_HUMAN; CO8G_HUMAN; APOD_HUMAN; PEDF_HUMAN; B2MG_HUMAN
Lysosome Cellular component Protein found in the lysosome, a membrane-limited organelle present in all eukaryotic cells, which contains a large number of hydrolytic enzymes that are used for the intracellular degradation of macromolecules. 12 PCYOX_HUMAN; GGH_HUMAN; CATS_HUMAN; RNAS2_HUMAN; LAMP2_HUMAN; HYAL1_HUMAN; SAP_HUMAN; LAMP1_HUMAN; CATC_HUMAN; 4F2_HUMAN; GRN_HUMAN; MA2B1_HUMAN
Amyloid Cellular component Proteins which may form wide, insoluble, unbranched filaments possessing a cross-beta sheet quaternary structure, where the beta sheets are oriented perpendicular to the fibre axis. Amyloid fibrils may be involved in abnormal protein depositions, or amyloidosis, such as Alzheimer's or Parkinson's diseases. Functional amyloids, found in a wide range of organism, from bacteria to mammals are involved in diverse functions such as biofilm formation, formation of aerial hyphae, long-term memory or regulation of melanin biosynthesis. Amyloid fibre-forming; Amyloid fibril-forming; Amyloid filament-forming; Amyloid-forming; Amyloid-like fibre-forming; Amyloid-like fibril-forming; Amyloid-like filament-forming; Functional amyloid 11 APOA1_HUMAN; GELS_HUMAN; FIBA_HUMAN; SAA1_HUMAN; LYSC_HUMAN; B2MG_HUMAN; SAA1_HUMAN; SYUA_HUMAN; CYTC_HUMAN; BGH3_HUMAN; FIBA_HUMAN
Amyloidosis Disease Protein which, if defective, causes amyloidosis, a vast group of diseases defined by the accumulation of amyloid in tissues. Amyloidoses are classified according to clinical signs, biochemical type of amyloid protein involved, and the extent of amyloid deposition (generalized or localized). Most amyloidoses are multisystemic diseases affecting several organs or systems. Mainly affected organs are the kidneys, heart, gastrointestinal tract, liver, skin, peripheral nerves and eyes, but any organ can be affected. The most frequent forms are primary amyloidosis, also known as light-chain immunoglobulin amyloidosis (AL), reactive or inflammatory amyloidosis, also known as acquired amyloidosis (AA), and transthyretin amyloidosis (ATTR). Localized amyloidosis affecting the brain is characteristic of Alzheimer's disease, trisomy 21, and prion diseases (transmissible spongiform encephalitis, Creutzfeldt-Jakob disease, Gerstmann- Straussler-Scheinker syndrome, fatal familial insomnia). In prion diseases the amyloid precursor is the prion protein. 11 APOA1_HUMAN; GELS_HUMAN; APOE_HUMAN; FIBA_HUMAN; SAA1_HUMAN; LYSC_HUMAN; B2MG_HUMAN; SAA1_HUMAN; CYTC_HUMAN; BGH3_HUMAN; FIBA_HUMAN
Lipid metabolism Biological process Protein involved in the biochemical reactions of lipids. Lipids are a diverse class of compounds which are insoluble in water but soluble in organic solvents. They include fats, oils, triacylglycerols, fatty acids, glycolipids, phospholipids and steroids. Lipid metabolic process 11 APOA1_HUMAN; CO3_HUMAN; APOC2_HUMAN; APOC3_HUMAN; APOB_HUMAN; APOE_HUMAN; CO3_HUMAN; LCAT_HUMAN; APOF_HUMAN; SAP_HUMAN; DHB3_HUMAN
Antibiotic Molecular function Protein with antibacterial activity. Antibacterial; Bactericide 11 HPT_HUMAN; CAMP_HUMAN; CAMP_HUMAN; S10AC_HUMAN; H2B2E_HUMAN; TRFL_HUMAN; CXCL7_HUMAN; SLPI_HUMAN; LBP_HUMAN; BPIA1_HUMAN; CMGA_HUMAN
Cell projection Cellular component Protein found in or associated with a cell protrusion such as pseudopodium, filopodium, lamellipodium, growth cone, flagellum, acrosome or axon, or bacterial comet tail. These membrane- cytoskeleton-coupled processes are involved in many biological functions, such as cell motility, cancer-cell invasion, endocytosis, phagocytosis, exocytosis, pathogen infection, neurite extension and cytokinesis. Cell protrusion 11 CO4B_HUMAN; COF1_HUMAN; PLSL_HUMAN; TLN1_HUMAN; VASP_HUMAN; BIN2_HUMAN; MOES_HUMAN; SEPR_HUMAN; URP2_HUMAN; ACTN1_HUMAN; DYH9_HUMAN
Sulfation PTM Protein which is posttranslationally modified by the attachment of at least one sulfate group to a tyrosine residue. Serine and threonine may also serve as sulfate group acceptors. Sulfatation 11 CO4B_HUMAN; VTNC_HUMAN; A2AP_HUMAN; FINC_HUMAN; HEP2_HUMAN; FA9_HUMAN; LUM_HUMAN; FIBG_HUMAN; CMGA_HUMAN; GP1BA_HUMAN; FA5_HUMAN
Endoplasmic reticulum Cellular component Protein whose subcellular location is the endoplasmic reticulum, a membrane system continuous with the outer nuclear membrane. It consists of flattened, single-membrane vesicles whose inner compartments, the cisternae, interconnect to form channels throughout the cytoplasm. The rough-surface portion is studded with ribosomes. 11 A1AT_HUMAN; CLUS_HUMAN; PROC_HUMAN; IF5A1_HUMAN; TSP4_HUMAN; TSP1_HUMAN; ICMT_HUMAN; DHB3_HUMAN; BIP_HUMAN; PMYT1_HUMAN; EGFR_HUMAN
ATP-binding Ligand Protein which binds adenosine 5'-triphosphate (ATP), a ribonucleotide adenosine (a purine base adenine linked to the sugar D-ribofuranose) that carries three phosphate groups esterified to the sugar moiety. It is the cell's source for energy and phosphate. Adenosine 5'-triphosphate binding; Adenosine triphosphate binding 11 ACTB_HUMAN; KPYM_HUMAN; PGK1_HUMAN; BIP_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; EGFR_HUMAN; HSP7C_HUMAN; EPHA3_HUMAN; DYH9_HUMAN
Copper Ligand Protein which binds at least one copper atom, or protein whose function is copper-dependent. Copper is a trace metallic element, chemical symbol Cu. Copper cation; Copper ion; Cu; Cu cation; Cu ion 9 ALBU_HUMAN; CERU_HUMAN; SODE_HUMAN; S10AC_HUMAN; SODC_HUMAN; PARK7_HUMAN; SYUA_HUMAN; HPHL1_HUMAN; FA5_HUMAN
HDL Cellular component Protein or apolipoprotein associated with High-Density Lipoproteins (HDL), a class of proteins involved in lipid (cholesterol, phospholipids and triacylglycerol) metabolism in the body fluids. HDL are formed in the liver and are involved in reverse cholesterol transport, the transport of cholesterol from peripherical tissues to the liver. Apolipoproteins are proteins which are specifically associated with lipoproteins, which is not the case for all the proteins associated with HDL or with the other lipoprotein classes. 9 APOA1_HUMAN; APOA2_HUMAN; APOC2_HUMAN; APOA4_HUMAN; APOE_HUMAN; APOM_HUMAN; SAA1_HUMAN; SAA1_HUMAN; APOF_HUMAN
Acute phase Biological process Protein involved in acute phase, a response of the vertebrate body to insults, infections, immunological reactions or inflammatory processes; characterised by redness (rubor), heat (calor), swelling (tumor), pain (dolor) and sometimes loss of function. Acute-phase reaction; Acute-phase response 9 HPT_HUMAN; A1AT_HUMAN; ITIH4_HUMAN; A1AG2_HUMAN; THRB_HUMAN; A2AP_HUMAN; FINC_HUMAN; SAA1_HUMAN; SAA1_HUMAN
Age-related macular degeneration Disease Protein which, if defective, causes age-related macular degeneration (ARMD), the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role. ARMD 9 CO3_HUMAN; CFAH_HUMAN; CFAH_HUMAN; CFAB_HUMAN; CO9_HUMAN; CO2_HUMAN; CFAI_HUMAN; CO3_HUMAN; CYTC_HUMAN
Gamma-carboxyglutamic acid PTM Protein which possesses at least one gamma-carboxyglutamic acid, a vitamin K dependent post-translational modification of a glutamate residue found in blood coagulation proteins and in the proteins of calcified tissues. Gamma-carboxyglutamyl residues are good chelators of calcium ions. There are two natural forms of vitamin K, which are phylloquinone (vitamin K1 or phytylmenaquinone) in green vegetables and menaquinone (vitamin K2 or menaquinone-n, depending of the number of isoprene units of the side-chain or MK-n) in intestinal bacteria, as well as one synthetic provitamin form, menadione (vitamin K3). In infants, the primary symptom of a deficiency of this fat-soluble vitamin is a hemorrhagic syndrome. 1-carboxyglutamic acid 9 THRB_HUMAN; PROS_HUMAN; FA9_HUMAN; ITIH2_HUMAN; PROC_HUMAN; FA10_HUMAN; BGH3_HUMAN; FA7_HUMAN; POSTN_HUMAN
Leucine-rich repeat Domain Protein containing at least one leucine-rich repeat (LRR). LRR 9 A2GL_HUMAN; LUM_HUMAN; CD14_HUMAN; ALS_HUMAN; MIME_HUMAN; VASN_HUMAN; CPN2_HUMAN; GP1BA_HUMAN; CHADL_HUMAN
Golgi apparatus Cellular component Protein found in the Golgi apparatus, an organelle present in eukaryotic cells that appears as a stack of 6-8 plate-like membranous compartments and associated vesicles and vacuoles, often located near the centrosome. It has four functionally distinct compartments: cis, medial and trans Golgi stacks, and the trans Golgi network (TGN). The first three are involved in posttranslational modifications of proteins (e.g., N- or O-glycosylation, sulfation, processing of acid hydrolases), while the TGN is involved in sorting the proteins to their final destination (e.g., to lysosomes, to secretory vesicles, or to plasma membrane). Golgi complex; Golgi stack 9 CD14_HUMAN; PROC_HUMAN; GOLM1_HUMAN; B4GA1_HUMAN; ARF3_HUMAN; PMYT1_HUMAN; EGFR_HUMAN; POSTN_HUMAN; NDST1_HUMAN
Oxidation PTM Protein which is posttranslationally modified by oxidation of a residue. 8 APOA1_HUMAN; APOA2_HUMAN; ACTB_HUMAN; FINC_HUMAN; APOE_HUMAN; G3P_HUMAN; PARK7_HUMAN; CMGA_HUMAN
Palmitate PTM Protein which is posttranslationally modified by the attachment of at least one palmitate group. The palmitate (16-carbon saturated fatty acid) group is usually attached to cysteine via a thioester bond. Lysine, serine and threonine may also serve as palmitate acceptors. Many palmitoylproteins are membrane associated either directly through the palmitate moiety or as transmembrane proteins anchored by the fatty acid. However, a few are actually secreted from cells. n-hexadecanoate; Palmitoylated 8 APOA1_HUMAN; APOB_HUMAN; SODC_HUMAN; VINC_HUMAN; PARK7_HUMAN; TFR1_HUMAN; EDNRB_HUMAN; EGFR_HUMAN
Thrombophilia Disease Protein which, if defective, causes thrombophilia, a disorder of hemostasis in which the individuals are prone to serious spontaneous thrombosis. Recurrent venous thrombosis 8 PLMN_HUMAN; ANT3_HUMAN; THRB_HUMAN; PROS_HUMAN; HEP2_HUMAN; FA9_HUMAN; PROC_HUMAN; FA5_HUMAN
Glycolysis Biological process Protein involved in the anaerobic enzymatic conversion of glucose to lactate or pyruvate, resulting in energy stored in the form of adenosine triphosphate (ATP), as occurs in skeletal muscle and in embryonic tissue. 8 G3P_HUMAN; KPYM_HUMAN; TPIS_HUMAN; ENOA_HUMAN; PGK1_HUMAN; PGAM1_HUMAN; ALDOA_HUMAN; G6PI_HUMAN
Host cell receptor for virus entry Molecular function Cell surface protein used by a virus as an attachment and entry receptor. In some cases, binding to a cellular receptor is not sufficient for infection: an additional cell surface molecule, or coreceptor, is required for entry. Some viruses are able to use different receptors depending on the target cell type. In prokaryotic viruses, cell receptor for virus entry can also be localized on host outer membrane, pilus or flagellum. Viral receptor activity 8 TFR1_HUMAN; CD86_HUMAN; NECT2_HUMAN; LAMP1_HUMAN; DAF_HUMAN; ICAM1_HUMAN; EGFR_HUMAN; CR2_HUMAN
Glycation PTM Protein containing one or more covalently linked glucose residues, resulting from a non-enzymatic spontaneous reaction. The carbohydrate is attached to an amino-acid nitrogen atom (e.g. from a lysine side chain, or the amino-terminal group). This modification is a side effect of diabetes and aging. Glycation is the first step toward the formation of advanced glycation endproducts (AGEs). Some AGEs are benign, but others are implicated in age-related chronic diseases such as: type II diabetes mellitus, cardiovascular diseases, Alzheimer's disease, etc. Glycated 7 ALBU_HUMAN; APOA1_HUMAN; HBB_HUMAN; CFAB_HUMAN; APOE_HUMAN; SODE_HUMAN; B2MG_HUMAN
Cytolysis Biological process Protein involved in the rupture of cell membranes and loss of cytoplasm, e.g. exotoxin, cytolysin. Cell lysis 7 CO5_HUMAN; CO9_HUMAN; CO8B_HUMAN; CO8A_HUMAN; CO7_HUMAN; CO6_HUMAN; CO8G_HUMAN
Membrane attack complex Cellular component Component of the membrane attack complex which groups the complement plasma glycoproteins C5b, C6, C7, C8 and polymeric C9 on biological membranes. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The formation of the membrane attack complex is the terminal step in the complement cascade. 7 CO5_HUMAN; CO9_HUMAN; CO8B_HUMAN; CO8A_HUMAN; CO7_HUMAN; CO6_HUMAN; CO8G_HUMAN
Apoptosis Biological process Protein involved in apoptotic programmed cell death. Apoptosis is characterized by cell morphological changes, including blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation and chromosomal DNA fragmentation, and eventually death. Unlike necrosis, apoptosis produces cell fragments, called apoptotic bodies, that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage. In general, apoptosis confers advantages during an organism's life cycle. Active cell death; Apoptotic programmed cell death; Type I programmed cell death 7 CLUS_HUMAN; CD5L_HUMAN; S10A9_HUMAN; G3P_HUMAN; IBP3_HUMAN; COMP_HUMAN; SEPR_HUMAN
Proteoglycan PTM Protein containing one or more covalently linked and usually sulfated glycosaminoglycans, (e.g., chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, keratan sulfate). Glycosaminoglycans are polysaccharides made of repeating disaccharides (usually 40-100 times), which consist of uronic acid (or galactose) and hexosamines. Aggrecan, for example, is the major component in articular cartilage. 7 AMBP_HUMAN; ITIH1_HUMAN; ITIH2_HUMAN; LUM_HUMAN; ITIH3_HUMAN; PRG4_HUMAN; NRP1_HUMAN
Neurodegeneration Disease Protein which, if defective, causes neurodegeneration. 7 APOE_HUMAN; PROF1_HUMAN; SODC_HUMAN; PARK7_HUMAN; FOLR1_HUMAN; SYUA_HUMAN; GRN_HUMAN
Kinase Molecular function Enzyme that catalyzes the transfer of phosphate (phosphoryl or pyrophosphoryl transfer) usually from ATP to a second substrate. Phosphotransferase 7 KPYM_HUMAN; PGK1_HUMAN; CSF1R_HUMAN; MERTK_HUMAN; PMYT1_HUMAN; EGFR_HUMAN; EPHA3_HUMAN
Lyase Molecular function Enzyme that catalyzes the cleavage of C-C, C-O, C-S, C-N or other bonds by other means than by hydrolysis or oxidation, with two substrates in one reaction direction, and one in the other. In the latter direction, a molecule (of carbon dioxide, water, etc) is eliminated, thus creating a new double bond or a new ring. 7 CAH1_HUMAN; CAH2_HUMAN; TPIS_HUMAN; ENOA_HUMAN; RNAS2_HUMAN; ALDOA_HUMAN; P20D1_HUMAN
Ion transport Biological process Protein involved in the transport of ions. Such proteins are usually transmembrane and mediate a movement of ions across cell membranes. Transport may be passive (facilitated diffusion; down the electrochemical gradient), or active (against the electrochemical gradient). Active transport requires energy which may come from light, oxidation reactions, ATP hydrolysis, or cotransport of other ions or molecules. 6 TRFE_HUMAN; CERU_HUMAN; TRFE_HUMAN; TRFL_HUMAN; HPHL1_HUMAN; CA2D1_HUMAN
Iron Ligand Protein which binds at least one iron atom, or protein whose function is iron-dependent. Iron is a metal, chemical symbol Fe. Fe; Fe cation; Fe ion; Iron cation; Iron ion 6 TRFE_HUMAN; HBB_HUMAN; HEMO_HUMAN; TRFE_HUMAN; MYG_HUMAN; TRFL_HUMAN
Antioxidant Molecular function Protein capable of counteracting the damaging effects of oxidation, e.g. by trapping free radicals generated during the metabolic burst and possibly inhibiting ageing. Scavengers of highly reactive and harmful oxygen species. 6 HPT_HUMAN; PRDX1_HUMAN; SODE_HUMAN; S10A9_HUMAN; SODC_HUMAN; PRDX2_HUMAN
Hemolytic uremic syndrome Disease Protein which, if defective, causes hemolytic uremic syndrome, a disorder characterized by non-immune hemolytic anemia, thrombocytopenia and renal failure. The vast majority of cases are sporadic, occur in young children and are associated with epidemics of diarrhea due to bacterial infections. This typical form of the disease has a good prognosis and death rate is very low. In contrast to typical hemolytic uremic syndrome, atypical forms present without a prodrome of enterocolitis and diarrhea and have a poor prognosis, with frequent development of end-stage renal disease or death. Hemolytic-uremic syndrome; HUS 6 CO3_HUMAN; CFAH_HUMAN; CFAH_HUMAN; CFAB_HUMAN; CFAI_HUMAN; CO3_HUMAN
Cytoplasmic vesicle Cellular component Protein found in or associated with cytoplasmic vesicles, which mediate vesicular transport among the organelles of secretory and endocytic systems. These transport vesicles are classified by the identity of the protein coat used in their formation and also by the cargo they contain, e.g. clathrin-, COPI-, and COPII-coated vesicles, synaptic vesicles, secretory vesicles, phagosomes, etc. 6 CLUS_HUMAN; FOLR1_HUMAN; LAMP2_HUMAN; ELNE_HUMAN; CMGA_HUMAN; ENTP7_HUMAN
Magnesium Ligand Protein which binds at least one magnesium atom, or protein whose function is magnesium-dependent. Magnesium is a metallic element, chemical symbol Mg. Magnesium cation; Magnesium ion; Mg; Mg cation; Mg ion 6 FA9_HUMAN; KPYM_HUMAN; ENOA_HUMAN; TKT_HUMAN; PMYT1_HUMAN; ENTP7_HUMAN
GPI-anchor PTM Protein bound to the lipid bilayer of a membrane through either a GPI- anchor (glycosylphosphatidylinositol anchor), a complex oligoglycan linked to a phosphatidylinositol group, or a GPI-like-anchor, a similar complex oligoglycan linked to a sphingolipidinositol group, resulting in the attachment of the C-terminus of the protein to the membrane. Glycosylphosphatidylinositol anchor; Glycosylsphingolipidinositol anchor 6 CD14_HUMAN; FOLR1_HUMAN; CNTN1_HUMAN; LYPD3_HUMAN; VNN1_HUMAN; DAF_HUMAN
Signal-anchor Domain Single-pass transmembrane protein (type II, III, and IV) possessing a membrane-spanning domain which targets the protein to the ER membrane. Typical features of signal-anchors are the presence of positively charged residues on the amino terminal side followed by an apolar segment of approx. 20 residues. The amino-acid composition is not very different from typical signal sequences. 6 TFR1_HUMAN; GOLM1_HUMAN; B4GA1_HUMAN; 4F2_HUMAN; SEPR_HUMAN; NDST1_HUMAN
Lipid-binding Ligand Protein which binds one or more lipids. 5 ALBU_HUMAN; APOE_HUMAN; APOD_HUMAN; CBG_HUMAN; BPIA1_HUMAN
Cholesterol metabolism Biological process Protein which participates in the biochemical reactions where cholesterol is involved, including transport. Cholesterol is the major sterol of higher animals and an important component of cell membranes, especially of the plasma membrane. Cholesterol metabolic process 5 APOA1_HUMAN; APOB_HUMAN; APOE_HUMAN; LCAT_HUMAN; APOF_HUMAN
Steroid metabolism Biological process Protein involved in the biochemical reactions of steroids. Steroids are a large group of complex tetracyclic lipids that consist of a 17- carbon-ring system. Examples are bile acids, sterols, various hormones and saponins. 5 APOA1_HUMAN; APOB_HUMAN; APOE_HUMAN; LCAT_HUMAN; APOF_HUMAN
Sterol metabolism Biological process Protein involved in the metabolism of sterols, any steroid alcohol. Sterols are components of cell membranes in plants, animals and fungi. 5 APOA1_HUMAN; APOB_HUMAN; APOE_HUMAN; LCAT_HUMAN; APOF_HUMAN
Hereditary hemolytic anemia Disease Protein which, if defective, causes hereditary hemolytic anemia, a hereditary disease characterized by the premature destruction of red blood cells. Hereditary haemolytic anemia 5 HBB_HUMAN; TPIS_HUMAN; PGK1_HUMAN; ALDOA_HUMAN; G6PI_HUMAN
S-nitrosylation PTM Protein which is posttranslationally modified by the attachment of a nitric oxide group on the sulfur atom of one or more cysteine residues. 5 HBB_HUMAN; S10A9_HUMAN; G3P_HUMAN; THIO_HUMAN; MOES_HUMAN
Thioester bond PTM Protein which is posttranslationally modified by the formation of a thioester crosslink between two amino acids in the polypeptidic chain(s), usually formed between a cysteine side chain and the carboxamide group of an asparagine or glutamine side chain. Thiolester bond 5 A2MG_HUMAN; CO3_HUMAN; CO4B_HUMAN; A2MG_HUMAN; CO3_HUMAN
Chylomicron Cellular component Protein component of the chylomicrons or involved in their catabolism. Chylomicrons are the largest lipoprotein complexes with the lowest protein-to-lipid ratio. They are present in the blood or lymph and transport exogenous (dietary) cholesterol, triacylglycerols and other lipids from the intestine to the liver or to the adipose tissue. 5 APOC2_HUMAN; APOC3_HUMAN; APOA4_HUMAN; APOB_HUMAN; APOE_HUMAN
Protein transport Biological process Protein involved in the intracellular transport of proteins from one location to another. All proteins (except the ones synthesized in mitochondria and plastids) are synthesized on ribosomes in the cytosol. Most proteins remain in the cytosol. Proteins with a signal sequence either become plasma membrane components or are exported from the cell of origin. 5 AFAM_HUMAN; IF5A1_HUMAN; ARF3_HUMAN; DMBT1_HUMAN; A16L2_HUMAN
Deafness Disease Protein which, if defective, causes a partial or total inability to hear. The two principal types of deafness are conductive deafness that results from changes in the middle ear, and nerve or sensorineural deafness that is caused by damages to the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 5 ACTB_HUMAN; TBB4B_HUMAN; EDNRB_HUMAN; TENA_HUMAN; FLNA_HUMAN
Chemotaxis Biological process Protein involved in the movement of a cell, or organism, along a concentration gradient of a chemotactic agent, such as a protein which causes, mediates or responds to chemotaxis. Chemotactic molecules such as sugars, peptides, cell metabolites, cell-wall or membrane lipids bind to cell surface receptors and trigger activation of intracellular signaling pathways, as well as remodeling of the cytoskeleton through the activation or inhibition of various actin-binding proteins. 5 HEP2_HUMAN; S10A9_HUMAN; PLF4_HUMAN; CXCL7_HUMAN; RNAS2_HUMAN
GTP-binding Ligand Protein which binds guanosine 5'-triphosphate (GTP), a ribonucleotide guanosine (a purine base guanine linked to the sugar D-ribofuranose) that carries three phosphate groups esterified to the sugar moiety. Guanosine 5'-triphosphate-binding; Guanosine triphosphate-binding 5 RAP1B_HUMAN; RHOC_HUMAN; ARF3_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN
DNA-binding Molecular function Protein which binds to DNA, typically to pack or modify the DNA, or to regulate gene expression. Among those proteins that recognize specific DNA sequences, there are a number of characteristic conserved motifs believed to be essential for specificity. Many DNA-binding domains are described in PROSITE. 5 H2B2E_HUMAN; TRFL_HUMAN; H13_HUMAN; ENOA_HUMAN; H33_HUMAN
Transcription Biological process Protein involved in the transfer of genetic information from DNA to messenger RNA (mRNA) by DNA-directed RNA polymerase. In the case of some RNA viruses, protein involved in the transfer of genetic information from RNA to messenger RNA (mRNA) by RNA-directed RNA polymerase. 5 TRFL_HUMAN; ENOA_HUMAN; THIO_HUMAN; HSP7C_HUMAN; BCORL_HUMAN
Transcription regulation Biological process Protein involved in the regulation of the transcription process. 5 TRFL_HUMAN; ENOA_HUMAN; THIO_HUMAN; HSP7C_HUMAN; BCORL_HUMAN
Cytokine Molecular function Small secreted proteins from higher eukaryotes which affect the growth, division and functions of other cells, e.g. interleukins, lymphokines, TNF and interferons. Generally, growth factors are not classified as cytokines, though TGF is an exception. Chemokines are a subset of cytokines. They differ from classical hormones in that they are produced by a number of tissues or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. 5 CCL14_HUMAN; PLF4_HUMAN; CXCL7_HUMAN; G6PI_HUMAN; GRN_HUMAN
Growth factor Molecular function Protein which, by binding to a cell-surface receptor, triggers an intracellular signal-transduction pathway leading to differentiation, proliferation, or other cellular response. 5 FBLN3_HUMAN; CXCL7_HUMAN; MIME_HUMAN; TSP4_HUMAN; G6PI_HUMAN
VLDL Cellular component Protein present in particles of Very Low-Density Lipoproteins or protein which interacts with them. VLDL are composed of 50% triacylglycerols, 12% cholesteryl esters, 7% free cholesterol, 18% phospholipids, and 10% proteins including apoB-100, apoC-I, apoC-II, apoC-III and apoE. Excess fatty acids or carbohydrate in the diet can be converted into triacylglycerols in the liver and packaged into VLDL. These lipoproteins are transported by the blood to muscle and adipose tissue, where activation of lipoprotein lipase by apoC-II causes the release of free fatty acids from the triacylglycerols of the VLDL. 4 APOC2_HUMAN; APOC3_HUMAN; APOB_HUMAN; APOE_HUMAN
Fibrinolysis Biological process Protein involved in fibrin degradation leading to the dissolving of blood clots. 4 IC1_HUMAN; PLMN_HUMAN; PROS_HUMAN; CBPB2_HUMAN
Kringle Domain Protein containing at least one kringle domain, a triple-looped, disulfide cross-linked domain of approximately 80 amino acids in length and involved in protein-protein interactions. 4 PLMN_HUMAN; THRB_HUMAN; HGFA_HUMAN; HABP2_HUMAN
Peroxidase Molecular function Enzyme that catalyzes the oxidation of a substrate by reducing peroxide to water. These enzymes are often located in peroxisomes. 4 GPX3_HUMAN; PRDX1_HUMAN; PRDX2_HUMAN; GPX1_HUMAN
Pharmaceutical Technical term Protein which is used or may be used as a pharmaceutical drug, e.g. to treat specific diseases. 4 THRB_HUMAN; FA9_HUMAN; ADIPO_HUMAN; FA7_HUMAN
Chaperone Molecular function Protein which is transiently involved in the noncovalent folding, assembly and/or disassembly of other polypeptides or RNA molecules, including any transport and oligomerisation processes they may undergo, and the refolding and reassembly of protein and RNA molecules denatured by stress. Though involved in these processes, chaperones are not an integral part of these functioning molecules. Also used for metallochaperones, which function to provide a metal directly to target proteins while protecting this metal from scavengers. 4 CLUS_HUMAN; PARK7_HUMAN; BIP_HUMAN; HSP7C_HUMAN
Mitochondrion Cellular component Protein encoded by or localized in the mitochondrion, a semiautonomous, self-reproducing organelle that occurs in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. The size and coding capacity of the mitochondrial DNA varies considerably in different organisms, and encodes rRNAs, tRNAs and essential mitochondrial proteins. 4 CLUS_HUMAN; SODC_HUMAN; PARK7_HUMAN; GSTP1_HUMAN
Angiogenesis Biological process Protein involved in angiogenesis, the sprouting or splitting of capillaries from pre-existing vasculature. Angiogenesis plays an important role for example during embryonic development, normal growth of tissues and maintenance of the normal vasculature, wound healing, tumor growth and metastasis. Vascularization 4 FINC_HUMAN; ECM1_HUMAN; SEPR_HUMAN; NRP1_HUMAN
Dwarfism Disease Protein which, if defective, causes dwarfism, a skeletal growth defect resulting in the condition of being undersized. 4 FINC_HUMAN; PEDF_HUMAN; TKT_HUMAN; COMP_HUMAN
Muscle protein Molecular function Characteristic protein of a muscle cell. The major ones are myosin and actin, which are responsible for the contraction and relaxation of muscles. 4 MYG_HUMAN; TPM4_HUMAN; TPM4_HUMAN; CALD1_HUMAN
Adaptive immunity Biological process Protein involved in adaptive immunity. Vertebrates can develop a broad and almost infinite repertoire of antigen-specific receptors, which allows vertebrates to recognize almost any potential pathogen or toxin and to mount antigen-specific responses to it. Two types of adaptive immunity systems have evolved in vertebrates in order to generate immune receptor diversity. The jawed vertebrates strategy uses the V(D)JC recombination to achieve combinatorial diversity of immunoglobulin-based B cell receptors and T cell receptors. The jawless vertebrate strategy uses the somatic rearrangements of variable leucine-rich cassettes in the variable lymphocyte receptors (VLRs). The hallmarks of an adaptive immune system is the production of antigen-specific recognition receptor by somatic gene rearrangement. The long life of some antigen-primed cytotoxic lymphocytes and plasma cells provide protective memory to prevent reinvasion. Acquired immunity 4 FIBA_HUMAN; FIBB_HUMAN; CD86_HUMAN; FIBA_HUMAN
ADP-ribosylation PTM Protein which is posttranslationally modified by the attachment of at least one ADP-ribosyl group. Adenosinediphospho-ribosylation; ADP-ribosylated 4 RAP1B_HUMAN; G3P_HUMAN; H33_HUMAN; RHOC_HUMAN
Isomerase Molecular function Enzyme that catalyzes the 1,1-, 1,2- or 1,3-hydrogen shift. The 1,1- hydrogen shift is an inversion at an asymmetric carbon center (racemases, epimerases). The 1,2-hydrogen shift involved a hydrogen transfer between two adjacent carbon atoms, one undergoing oxidation, the other reduction (aldose-ketose isomerases). The 1,3-hydrogen shifts are allylic or azaallylic (when nitrogen is one of the three atoms) isomerizations. 4 PPIA_HUMAN; TPIS_HUMAN; PGAM1_HUMAN; G6PI_HUMAN
Autophagy Biological process Protein participating in autophagy, a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. There are three primary forms of autophagy: chaperone-mediated autophagy, microautophagy and macroautophagy. During macroautophagy, the sequestering vesicles, termed autophagosomes, fuse with the lysosome or vacuole resulting in the delivery of an inner vesicle (autophagic body) into the lumen of the degradative compartment. 4 S10A9_HUMAN; PARK7_HUMAN; LAMP2_HUMAN; A16L2_HUMAN
Chromosome Cellular component Protein which is associated with chromosomal DNA, including histones, protamines and high mobility group proteins. Chromosomal protein 4 H2B2E_HUMAN; H13_HUMAN; H33_HUMAN; SKA1_HUMAN
Nitration PTM Protein which is posttranslationally modified by replacement of a hydrogen on an aromatic ring of one or more tyrosine or tryptophan residues by a nitro (NO2) group. Nitrated 4 TPIS_HUMAN; RNAS2_HUMAN; BIP_HUMAN; TBA1B_HUMAN
Endosome Cellular component Protein found in or associated with endosomes. Endosomes are highly dynamic membrane systems involved in transport within the cell, they receive endocytosed cell membrane molecules and sort them for either degradation or recycling back to the cell surface. They also receive newly synthesised proteins destined for vacuolar/lysosomal compartments. In certain cell types, endosomal multivesicular bodies may fuse with the cell surface in an exocytic manner. These released vesicles are called exosomes. 4 FOLR1_HUMAN; LAMP2_HUMAN; LAMP1_HUMAN; EGFR_HUMAN
Microtubule Cellular component Protein associated with or component of the microtubule. The microtubule is formed by the arrangement of 13 parallel protofilaments arising from end-to-end aggregation of the tubulin alpha/beta-dimers. Microtubules are associated with various other proteins (MAPs, dynein, kinesin) and are involved in structures responsible for cellular movement such as flagella or cilia. Microtubules of the ciliary axoneme are more permanent than cytoplasmic and spindle microtubules. Microtubule formation is inhibited by agents such as colchicine, vinblastine or vincristine. 4 SKA1_HUMAN; TBA1B_HUMAN; TBB4B_HUMAN; DYH9_HUMAN
Developmental protein Molecular function Protein involved in development, the process whereby a multicellular organism develops from its early immature forms, e.g., zygote, larva, embryo, into an adult. 4 DMBT1_HUMAN; EGFR_HUMAN; NRP1_HUMAN; PRTG_HUMAN
Proto-oncogene Disease Protein whose normal cellular gene can be converted into a cancer- promoting oncogene by activating mutations, chromosomal translocation or DNA amplification. Once activated a proto-oncogene can promote cell transformation in culture or tumorigenesis in animals. Examples include the regulatory GTPase HRAS, which is commonly activated by dominant gain of function point mutations, and the transcription factor MYC, which can be activated by both chromosomal amplification and chromosomal translocation. 4 CSF1R_HUMAN; MERTK_HUMAN; EGFR_HUMAN; AKP13_HUMAN
Tyrosine-protein kinase Molecular function Enzyme which catalyzes the transfer of the terminal phosphate of ATP to a specific tyrosine residue on its target protein. Many of these kinases play significant roles in development and cell division. Tyrosine-protein kinases can be divided into two subfamilies: receptor tyrosine kinases, which have an intracellular tyrosine kinase domain, a transmembrane domain and an extracellular ligand-binding domain; and non-receptor (cytoplasmic) tyrosine kinases, which are soluble, cytoplasmic kinases. 4 CSF1R_HUMAN; MERTK_HUMAN; EGFR_HUMAN; EPHA3_HUMAN
Iron transport Biological process Protein involved in the transport of iron. Fe transport; Iron cation transport; Iron ion transport 3 TRFE_HUMAN; TRFE_HUMAN; TRFL_HUMAN
Heme Ligand Protein containing at least one heme, an iron atom coordinated to a protoporphyrin IX. In myoglobin and hemoglobin, one of the coordination positions of iron is occupied by oxygen or other ligands, such as carbon monoxide. Hemes are also found in cytochromes of the electron-transport chain where they bind electrons, in reducing peroxides (catalases and peroxidases), and act as terminal components in multienzyme systems involved in hydroxylation. Cytochrome c is the only common heme protein in which the heme is covalently bound. Haeme 3 HBB_HUMAN; HEMO_HUMAN; MYG_HUMAN
Vasoactive Molecular function Protein which is vasoactive, i.e. has a constricting or dilating effect on the caliber of blood vessels. 3 HBB_HUMAN; KNG1_HUMAN; ANGT_HUMAN
Fertilization Biological process Protein involved in fertilization, the union of two haploid cells, the gametes, to form a diploid cell, the zygote. 3 FETUB_HUMAN; IPSP_HUMAN; PARK7_HUMAN
LDL Cellular component Protein constituent of the low-density lipoproteins or protein which binds LDLs. LDLs are plasma lipoproteins rich in cholesterol esters, synthesized from the very low-density lipoprotein (VLDL), and which transport cholesterol to peripheral tissue and regulate de novo cholesterol synthesis. 3 APOC2_HUMAN; APOB_HUMAN; APOF_HUMAN
Sensory transduction Biological process Protein involved in sensory transduction, the process by which a cell converts an extracellular signal, such as light, taste, sound, touch or smell, into electric signals. 3 RET4_HUMAN; BGH3_HUMAN; HMCN2_HUMAN
Mental retardation Disease Protein which, if defective, causes mental retardation, a disorder characterized by subnormal intellectual functioning and manifested during the developmental period. Mental retardation is associated with impaired adaptive behavior. Intellectual disability; Mental deficiency; Mental subnormality 3 FETUA_HUMAN; ACTB_HUMAN; NDST1_HUMAN
Selenocysteine Coding sequence diversity Protein which contains a selenocysteine, a naturally occurring amino acid in both eukaryotic and prokaryotic organisms. 3-selenyl-L-alanine 3 GPX3_HUMAN; SEPP1_HUMAN; GPX1_HUMAN
Collagen Domain Protein which contains one or more collagen-like domain. Collagen is a fibrous protein found in vertebrates, the major element of skin, bone, tendon, cartilage, blood vessels and teeth. It forms insoluble fibres of high tensile strength and which contains the unusual amino acids hyroxyproline and hydroxylysine. It is rich in glycine but lacks cysteine and tryptophan, and has an unusually regular amino-acid domain. 3 C1QA_HUMAN; C1QB_HUMAN; ADIPO_HUMAN
Alternative initiation Coding sequence diversity Protein for which at least two isoforms exist due to the usage of alternative initiation codons in the same mRNA (the resulting isoforms differ in their N-terminus if they are in frame). 3 GELS_HUMAN; ENOA_HUMAN; GOLM1_HUMAN
Cilium biogenesis/degradation Biological process Protein which is involved in the formation, organization, maintenance and degradation of the cilium, a cell surface projection found at the surface of a large proportion of eukaryotic. Their most prominent structural component is the axoneme which consists of nine doublet microtubules, with all motile cilia - except those at the embryonic node - containing an additional central pair of microtubules. 3 GELS_HUMAN; FLNA_HUMAN; DYH9_HUMAN
Corneal dystrophy Disease Protein which, if defective, causes corneal dystrophy. The term corneal dystrophy includes a heterogeneous group of bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most corneal dystrophies present with variable shaped corneal opacities in a clear or cloudy cornea and they affect visual acuity to different degrees. Corneal dystrophies may be present at birth but more frequently develop during adolescence and progress slowly throughout life. 3 GELS_HUMAN; LCAT_HUMAN; BGH3_HUMAN
Lectin Ligand Protein which specifically binds carbohydrates. Lectins are obtained particularly from seeds of leguminous plants but also from other plant and animal sources. They contain binding sites for specific mono-and oligosaccharides. They agglutinate cells by binding to specific sugar residues in membrane glycoproteins. 3 TETN_HUMAN; NPTX2_HUMAN; ATRN_HUMAN
Metalloprotease Molecular function Proteolytic enzyme which use a metal for its catalytic mechanism. Most metalloproteases are zinc-dependent, some use cobalt. Metallopeptidase 3 CBPB2_HUMAN; CBPN_HUMAN; PEPD_HUMAN
Redox-active center Domain Protein which possesses at least one active center which mediates its participation in redox reactions, usually via reversible oxidation of a cysteine residue leading to a cysteine-sulfenic acid that can either be stabilized, or react with an unmodified cysteine residue and form a stable but reversible disulfide bond. 3 PRDX1_HUMAN; PRDX2_HUMAN; THIO_HUMAN
Glycosidase Molecular function Hydrolases which attack glycosidic bonds in carbohydrates, glycoproteins and glycolipids. The glycosidases are not highly specific. Usually they distinguish only the type of bond, e.g. O- or N-glycosidic, and its configuration (alpha or beta). 3 LYSC_HUMAN; HYAL1_HUMAN; MA2B1_HUMAN
NAD Ligand Enzymes which use NAD(H) as an electron acceptor or as a cofactor. Nicotinamide adenine dinucleotide, an important redox coenzyme that participates in a variety of enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). NAD also functions as an ADP-ribose donor in ADP-ribosylation reactions. Nicotinamide adenine dinucleotide; Nicotinic adenine dinucleotide 3 G3P_HUMAN; LDHB_HUMAN; LDHA_HUMAN
Growth factor binding Molecular function Protein other than a receptor that binds to a cell's growth factor. 3 IBP3_HUMAN; IBP2_HUMAN; IBP6_HUMAN
Repressor Molecular function Protein which interferes with transcription, usually by binding to specific sites on DNA. Also used for proteins which repress translation. 3 ENOA_HUMAN; HSP7C_HUMAN; BCORL_HUMAN
Glycogen storage disease Disease Protein which, if defective, causes glycogen storage disease, a group of inherited metabolic disorders involving the enzymes responsible for the synthesis and degradation of glycogen. At least thirteen types of this disease have been described. 3 LDHA_HUMAN; LAMP2_HUMAN; ALDOA_HUMAN
Proteasome Cellular component Protein which is part of the proteasome, a large protein complex in the cytosol that is responsible for degrading proteins which have been marked for destruction by ubiquitination or by some other means. Macropain; Prosome 3 PSA2_HUMAN; PSMA8_HUMAN; RD23A_HUMAN
Atherosclerosis Disease Protein which, if defective, causes atherosclerosis, which is characterized by deposits of plaques (atheromas) in the blood vessels, thus narrowing the vessel lumen and restricting blood flow. Atheromas consist of lipids (cholesterol), carbohydrates, blood products, fibrous tissue and calcium deposits. Arteriosclerosis 2 APOA1_HUMAN; APOB_HUMAN
Oxygen transport Biological process Protein involved in the transport of oxygen (e.g. hemoglobin and myoglobin). 2 HBB_HUMAN; MYG_HUMAN
Pyruvate Ligand Protein which uses at least one pyruvate as cofactor (pyruvoyl) or substrate, or protein required for pyruvate synthesis or degradation. Pyruvate is an intermediate compound in the metabolism of carbohydrates, proteins and fats. 2 HBB_HUMAN; KPYM_HUMAN
Bait region Domain Protein having a peptide stretch which contains specific cleavage sites for different proteinases, and which enables inhibition of all four classes of proteinases. 2 A2MG_HUMAN; A2MG_HUMAN
Fatty acid metabolism Biological process Protein involved in the biochemical reactions with fatty acids. Fatty acids are long chain organic acids of the general formula CH3(CnHx)COOH. They are constituents of lipids and can be saturated or unsaturated. The esterified forms are important both as energy storage molecules and structural molecules. Fatty acid metabolic process 2 CO3_HUMAN; CO3_HUMAN
Hyperlipidemia Disease Protein which, if defective, causes hyperlipidemia, a condition characterized by the elevation of lipids in the bloodstream. There are different types of hyperlipidemias: type I (lipoprotein lipase deficiency), IIa (hypercholesterolemia; LDL receptor deficiency), IIb (combined hyperlipidemia), III (dysbetalipoproteinemia), IV (hypertriglyceridemia) and V (mixed hyperlipidemia). 2 APOC2_HUMAN; APOE_HUMAN
Lipid degradation Biological process Protein involved in the breakdown of lipids, a diverse class of compounds, insoluble in water but soluble in organic solvents, and which include fats, oils, triacylglycerols, fatty acids, glycolipids, phospholipids and steroids. Lipid breakdown; Lipid catabolic process; Lipid catabolism 2 APOC2_HUMAN; APOC3_HUMAN
Sialic acid Ligand Protein with at least one sialic acid. The term "sialic acid" refers to the group of sugars including neuraminic acid and its derivatives, not to a specific sugar. They are widely distributed in bacteria and animal tissue as components of polysaccharides, glycoproteins and glycolipids. They are typically the terminal residues on cell surface oligosaccharides. 2 APOC2_HUMAN; APOC3_HUMAN
Blood group antigen Molecular function Protein belonging to the set of cell surface antigens found chiefly, but not solely, on blood cells. More than fifteen different blood group systems are recognised in humans. In most cases the antigenic determinant resides in the carbohydrate chains of membrane glycoproteins or glycolipids. Agglutinogen 2 CO4B_HUMAN; DAF_HUMAN
Synapse Cellular component Protein found in the synapses. Synapses are the communicating cell- cell junctions that allow signals to pass from a nerve cell to a target cell. In a chemical synapse, the signal is carried by a neurotransmitter which diffuses across a narrow synaptic cleft and activates a receptor on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, neuronal axon, a specialized region of a muscle or a secretory cell. In an electrical synapse, a direct connection is made between the cytoplasms of two cells via gap junctions. 2 CO4B_HUMAN; SYUA_HUMAN
Systemic lupus erythematosus Disease Protein involved in the systemic lupus erythematosus (SLE), a chronic autoimmune disease where the immune system is over-active and produces too many abnormal antibodies that react with the patient's own tissues. The exact cause of lupus is not known, but heredity, environment and hormonal changes may be involved. The immune complex deposition in many tissues leads to the manifestations of the disease. Immune complexes can be deposited in glomeruli, skin, lungs, synovium, mesothelium, and other places. Many SLE patients develop renal complications. SLE 2 CO4B_HUMAN; CR2_HUMAN
Copper transport Biological process Protein involved in the transport of ions of the trace element copper. Copper cation transport; Copper ion transport; Cu transport 2 CERU_HUMAN; HPHL1_HUMAN
Tissue remodeling Biological process Protein involved in tissue remodeling. As an example the matrix- degrading plasminogen activators (PAs) and matrix metalloproteinases (MMPs) are general proteolytic enzyme systems which mediate tissue remodeling and tissue destruction in a variety of physiological and pathological conditions, including ovulation, angiogenesis, implantation, tumor invasion and inflammatory diseases such as rheumatoid arthritis (RA). 2 PLMN_HUMAN; TSP4_HUMAN
Retinol-binding Ligand Protein which binds retinol, one of the active form of Vitamin A, a fat-soluble vitamin derived from carotenes. It is a precursor of retinal, the light-absorbing group of visual pigments. Vitamin A is also required for growth. Vitamin A-binding 2 RET4_HUMAN; CO8G_HUMAN
Vision Biological process Protein involved in vision, the special sense by which objects in the external environment are perceived by the light they give off or reflect, which stimulates the photoreceptors in the retina. 2 RET4_HUMAN; BGH3_HUMAN
Mineral balance Biological process Protein that influences the equilibrium of minerals present in bone, e.g., fetuin. Regulation of bone mineralization 2 FETUA_HUMAN; ECM1_HUMAN
Thiol protease inhibitor Molecular function Protein which inhibits the activity of a thiol protease, a class of proteases that contains an active site cysteine residue (Cys), e.g. papain, cathepsins, etc. Thiol peptidase inhibitor; Thiol proteinase inhibitor 2 KNG1_HUMAN; CYTC_HUMAN
Transmembrane beta strand Domain Protein with at least one transmembrane beta stranded domain, a membrane-spanning stretch, typically 5-10 amino acids long, whose peptide backbones are almost fully extended with the sidechains of two neighboring residues projected in the opposite direction from the backbone. Two or more hydrogen bonded (parallel or anti-parallel) beta strands form a beta sheet. A beta barrel is formed by a closed beta sheet around a central pore. Beta barrels consist usually of an even number of beta strands (between 8 and 24), they are found only in bacterial outer membranes, mitochondria and plastids. 2 CO9_HUMAN; CO8A_HUMAN
Alzheimer disease Disease Protein which, if defective, causes Alzheimer disease, a neurodegenerative disorder characterized by progressive dementia and global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy, senile plaques, neurofibrillary tangles, and neuropil threads. Early- onset forms also occurr. Alzheimer's disease 2 APOE_HUMAN; SYUA_HUMAN
Amyotrophic lateral sclerosis Disease Protein which, if defective, causes amyotrophic lateral sclerosis (ALS), a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy. ALS 2 PROF1_HUMAN; SODC_HUMAN
NADP Ligand Enzymes which use NADP(H) as an electron acceptor or as a cofactor. Nicotinamide adenine dinucleotide phosphate, a redox coenzyme that participates in a variety of enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NADP+) and reduced (NADPH). Analogue of NAD, but NADPH is used extensively in biosynthetic, rather than catabolic pathways as well as in photosynthesis. Nicotinamide adenine dinucleotide phosphate; Nicotinic adenine dinucleotide phosphate 2 BLVRB_HUMAN; DHB3_HUMAN
Ehlers-Danlos syndrome Disease Protein which, if defective, causes Ehlers-Danlos syndrome (EDS), a genetically and phenotypically heterogeneous group of connective- tissue disorders. It affects primarily the skin, ligaments, joints, and blood vessels. Typical features include skin hyperextensibility, joint hypermobility, easy bruisability, friability of tissues with bleeding and poor wound healing. Inheritance can be autosomal dominant, autosomal recessive, or X-linked recessive. EDS 2 C1S_HUMAN; C1R_HUMAN
Carboxypeptidase Molecular function Protein that hydrolyzes a C-terminal peptide bond in polypeptide chains. 2 CBPB2_HUMAN; CBPN_HUMAN
Osteogenesis Biological process Protein involved in osteogenesis, the mechanism of bone formation wether intramembranous or endochondral. In intramembranous ossification, bone is formed by differentiation of mesenchymal cells into osteoblasts with absence of a cartilaginous model. The flat bones of the skull, the sternum, and the scapula are examples of bones that develop by intramembranous ossification. The term endochondral refers to the close association of the developing bone with the pre-existing hyaline cartilage model of that bone. The long bones of the limbs (including the phalanges) and the ribs develop by endochondral ossification. Bone formation; Ossification 2 ECM1_HUMAN; TRFL_HUMAN
Fungicide Molecular function Protein capable of killing or inhibiting growth of fungi. Anti-fungal 2 S10AC_HUMAN; CMGA_HUMAN
Prenylation PTM Protein which is posttranslationally modified by the attachment of at least one prenyl group (e.g. farnesyl, geranylgeranyl) usually on cysteine residues which are at or near the C-terminal extremity. 2 RAP1B_HUMAN; RHOC_HUMAN
Chromosomal rearrangement Coding sequence diversity Protein which can be altered by a structural chromosomal rearrangement. Structural rearrangements result from chromosome breakage, followed by reconstitution in an abnormal combination. Classes of chromosomal rearrangements include: deletions, duplications, insertions, inversions, translocations and transpositions. 2 FBLN1_HUMAN; PLSL_HUMAN
Nucleosome core Cellular component Protein characteristic of the nucleosome, a repeating structural unit in chromatin that packages DNA to give the chromatin a 'beads-on-a- string' appearance. Each repeat consists of approximately 146 base pairs of DNA wound around a disk-shaped protein core which is composed of two of each of the nucleosomal histones H2A, H2B, H3 and H4. 2 H2B2E_HUMAN; H33_HUMAN
Acyltransferase Molecular function Enzyme catalyzing the transfer of acyl- (RCO-) groups. 2 LCAT_HUMAN; F13A_HUMAN
Alternative promoter usage Coding sequence diversity Protein for which at least two isoforms exist due to the alternative usage of promoters. 2 TRFL_HUMAN; TPIS_HUMAN
Cardiomyopathy Disease Protein which, if defective, causes cardiomyopathy, a chronic disorder which affects the heart muscle causing a reduced pumping function. It is a major cause of morbidity and mortality. 2 VINC_HUMAN; TAZ_HUMAN
DNA damage Biological process Protein induced by DNA damage or protein involved in the response to DNA damage. Drug- or radiation-induced injuries in DNA introduce deviations from its normal double-helical conformation. These changes include structural distortions which interfere with replication and transcription, as well as point mutations which disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. Response to DNA damage results in either repair or tolerance. DNA damage response; Response to DNA damage stimulus 2 PARK7_HUMAN; RD23A_HUMAN
DNA repair Biological process Protein involved in the repair of DNA, the various biochemical processes by which damaged DNA can be restored. DNA repair embraces, for instance, not only the direct reversal of some types of damage (such as the enzymatic photoreactivation of thymine dimers), but also multiple distinct mechanisms for excising damaged base; termed nucleotide excision repair (NER), base excision repair (BER) and mismatch repair (MMR); or mechanisms for repairing double-strand breaks. 2 PARK7_HUMAN; RD23A_HUMAN
Parkinson disease Disease Protein which, if defective, causes classic Parkinson disease. Parkinson disease is a complex multifactorial neurodegenerative disorder, usually occurring in late life, although an early onset and a juvenile form are known. Typical features are masklike facies, tremor of resting muscles, a slowing of voluntary movements (bradykinesia), festinating gait and postural instability. The signs and symptoms of the disease are the consequence of a striatal deficiency of dopamine, resulting from neuronal death in the substantia nigra. Parkinson disease is characterized by the presence of Lewy bodies, intraneuronal inclusions found in many brain regions which are not entirely specific to, but are a highly sensitive marker for, Parkinson disease. Paralysis agitans; Parkinson's disease; PD 2 PARK7_HUMAN; SYUA_HUMAN
Parkinsonism Disease Protein which, if defective, causes parkinsonism. Parkinsonism refers to disorders, both genetic and non-genetic, characterized by four primary parkinsonian symptoms: tremor, rigidity, postural instability and bradykinesia, resulting from the loss or dysfunction of dopamine- producing neurons in the substantia nigra. Lewy bodies, intraneuronal accumulations of aggregated proteins, may or may not be present in the brain of the patients. 2 PARK7_HUMAN; SYUA_HUMAN
RNA-binding Molecular function Protein which binds to RNA. 2 PARK7_HUMAN; IF5A1_HUMAN
Stress response Biological process Protein involved in the response to stress, a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of some stressful conditions. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation, hypertonicity, amino acid deprivation). 2 PARK7_HUMAN; HSP7C_HUMAN
Tumor suppressor Disease Protein that suppresses tumorigenesis. Tumor suppressors generally function as negative regulators of cell cycle progression or cell proliferation. They may act to enforce cell cycle arrest in response to specific signals, such as DNA damage, thereby allowing DNA repair to occur prior to DNA replication. Tumor suppressors that act in this way include TP53 and its downstream effector CDKN1A/p21. They may also act to induce programmed cell death (apoptosis) in response to specific developmental signals or under circumstances where DNA repair cannot be completed. Tumor suppressors that act in this way include PTEN and BAX. Anti-oncogene; Antitumor 2 PARK7_HUMAN; DMBT1_HUMAN
Gluconeogenesis Biological process Protein involved in the biosynthesis of "new" glucose from such noncarbohydrate precursors as pyruvate, lactate, certain amino acids and intermediates of the tricarboxylic acid cycle. Glucose biosynthesis; Glucose biosynthetic process 2 TPIS_HUMAN; G6PI_HUMAN
Citrullination PTM Protein which is posttranslationally modified by the deimination of one or more arginine residues. 2-amino-5-(carbamoylamino)pentanoic acid; Citrulline; N5-carbamoylornithine 2 H13_HUMAN; H33_HUMAN
Autocatalytic cleavage PTM Protein catalyzing its own cleavage. Autocatalytic peptide cleavage 2 MASP1_HUMAN; MASP2_HUMAN
Thiol protease Molecular function Proteolytic enzyme with a cysteine residue (Cys) in its active site. There are many families of thiol proteases. The most well known one is the papain family (C1 in MEROPS classification) which is known to exist in most eukaryotes. Sulfhydryl protease; Thiol peptidase; Thiol proteinase 2 CATS_HUMAN; CATC_HUMAN
ANK repeat Domain Protein containing at least one ANK repeat, a conserved domain of approximately 33 amino acids, that was originally identified in ankyrin. It has been described as an L-shaped structure consisting of a beta-hairpin and two alpha-helices. Many ankyrin repeat regions are known to function as protein-protein interaction domains. ANK motif; Ankyrin repeat 2 MTPN_HUMAN; BCORL_HUMAN
Mitogen Molecular function Protein which can induce mitosis of certain eukaryotic cells, i.e. it stimulates cellular proliferation. 2 CXCL7_HUMAN; TSP4_HUMAN
Lissencephaly Disease Protein which, if defective, causes lissencephaly, a brain malformation characterized by the absence (agyria) or reduction (pachygyria) of brain surface convolutions (gyri), in association with abnormal organisation of the cortical layers. It results from neuronal migration defects during embryogenesis. Two large groups can be distinguished: classical lissencephaly (and its variants) and cobblestone lissencephaly. Lissencephaly means "smooth brain". 2 B4GA1_HUMAN; LAMB1_HUMAN
Manganese Ligand Protein which binds at least one manganese atom, or protein whose function is manganese-dependent. Manganese is a metallic element, chemical symbol Mn. Manganese cation; Manganese ion; Mn; Mn cation; Mn ion 2 B4GA1_HUMAN; PEPD_HUMAN
Threonine protease Molecular function Proteolytic enzyme with a threonine residue (Thr) in its active site. The prototype members of this class of enzymes are the proteasome catalytic subunits. 2 PSA2_HUMAN; PSMA8_HUMAN
Sarcoplasmic reticulum Cellular component Protein found in a special form of agranular reticulum located in the sarcoplasm of striated muscle. The agranular reticulum comprises and comprising a system of smooth-surfaced tubules which form a plexus around each myofibril. 2 TSP4_HUMAN; TSP1_HUMAN
Unfolded protein response Biological process Protein involved in the unfolded protein response. An accumulation of unfolded proteins in the ER lumen triggers a stress response, resulting in the transcriptional induction in the nucleus of a set of genes, whose products are involved in protein folding, assembly and modification as well as in phospholipid biosynthesis. The unfolded protein response (UPR) is the intracellular pathway that mediates signaling from the endoplasmic reticulum (ER) to the nucleus. UPR is also tightly linked to ER-associated protein degradation (ERAD). UPR is a ubiquitous mechanism observed in all eukaryotes from humans to yeast. ER stress pathway; ER stress response; UPR 2 TSP4_HUMAN; TSP1_HUMAN
Cell cycle Biological process Protein involved in the complex series of events by which the cell duplicates its contents and divides into two. The eukaryotic cell cycle can be divided in four phases termed G1 (first gap period), S (synthesis, phase during which the DNA is replicated), G2 (second gap period) and M (mitosis). The prokaryotic cell cycle typically involves a period of growth followed by DNA replication, partition of chromosomes, formation of septum and division into two similar or identical daughter cells. 2 SKA1_HUMAN; PMYT1_HUMAN
von Willebrand disease Disease Protein which, if defective, causes von Willebrand disease, a hemorrhagic disorder in which the von Willebrand factor is either quantitatively or qualitatively abnormal. Usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. 2 VWF_HUMAN; GP1BA_HUMAN
Differentiation Biological process Protein involved in differentiation, the developmental process of a multicellular organism by which cells become specialized for particular functions. Differentiation requires selective expression of the genome; the fully differentiated state may be preceded by a stage in which the cell is already programmed for differentiation but is not yet expressing the characteristic phenotype determination. Also used for fungal conidiation proteins, and for some bacteria that present specialization of function in cell types, such as Caulobacter crescentus. Cell differentiation 2 DMBT1_HUMAN; NRP1_HUMAN
Laminin EGF-like domain Domain Protein containing at least one laminin EGF-like domain. Laminins are the major noncollagenous components of basement membranes. Their subunits contain consecutive repeats of about 60 amino acids, which include 8 conserved cysteines that form disulfide bonds (C1-C3, C2-C4, C5-C6, C7-C8). The tertiary structure of this domain is remotely similar, in its N-terminal, to that of the EGF-like module. 2 ATRN_HUMAN; LAMB1_HUMAN
Calmodulin-binding Molecular function Protein which binds at least one calmodulin, an ubiquitous small calcium-binding protein. Its binding to proteins may cause a conformational change which either activates or inactivates their function. 2 CALD1_HUMAN; IQGA2_HUMAN