Run_DEcode_toy.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "yFSDunLWO2yU"
   },
   "source": [
    "### Download data and install required libraries "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 119
    },
    "colab_type": "code",
    "id": "yI-Cs9wPO2yV",
    "outputId": "2ba2ef83-0241-4e9b-bf37-cab5102a248a"
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Cloning into 'DEcode'...\n",
      "remote: Enumerating objects: 77, done.\u001b[K\n",
      "remote: Counting objects: 100% (77/77), done.\u001b[K\n",
      "remote: Compressing objects: 100% (66/66), done.\u001b[K\n",
      "remote: Total 83 (delta 15), reused 49 (delta 5), pack-reused 6\u001b[K\n",
      "Unpacking objects: 100% (83/83), done.\n"
     ]
    }
   ],
   "source": [
    "!git clone https://github.com/stasaki/DEcode.git"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 34
    },
    "colab_type": "code",
    "id": "xKrTCCbeO2yY",
    "outputId": "625a885d-9cda-493e-dd8f-b0c14c0fe36c"
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "/content/DEcode\n"
     ]
    }
   ],
   "source": [
    "%cd DEcode"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 1000
    },
    "colab_type": "code",
    "id": "lhp9QqtYO2yb",
    "outputId": "2234461d-523f-406d-b0d0-812df47d8e8d"
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Requirement already up-to-date: setuptools in /usr/local/lib/python2.7/dist-packages (41.2.0)\n",
      "Collecting shap==0.27.0\n",
      "\u001b[?25l  Downloading https://files.pythonhosted.org/packages/fe/93/9d41296314fe7ac42f1f117695d6d17b65b2c00790a88555522e52dbdfbc/shap-0.27.0.tar.gz (216kB)\n",
      "\u001b[K     |████████████████████████████████| 225kB 48.3MB/s \n",
      "\u001b[?25hRequirement already satisfied: numpy in /usr/local/lib/python2.7/dist-packages (from shap==0.27.0) (1.16.4)\n",
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      "Requirement already satisfied: pathlib2; python_version == \"2.7\" or python_version == \"3.3\" in /usr/local/lib/python2.7/dist-packages (from ipython->shap==0.27.0) (2.3.4)\n",
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      "Building wheels for collected packages: shap\n",
      "  Building wheel for shap (setup.py) ... \u001b[?25l\u001b[?25hdone\n",
      "  Created wheel for shap: filename=shap-0.27.0-cp27-cp27mu-linux_x86_64.whl size=316528 sha256=70f401d43e1f21bc064a1868424694c48aa3904f50ed167439485ab40d88ac5f\n",
      "  Stored in directory: /root/.cache/pip/wheels/64/d5/0a/e3b56a63e961ee9afe3c72f0b7cb9bae172c86bd63763c6655\n",
      "Successfully built shap\n",
      "Installing collected packages: shap\n",
      "Successfully installed shap-0.27.0\n",
      "Installing package into ‘/usr/local/lib/R/site-library’\n",
      "(as ‘lib’ is unspecified)\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/rjson_0.2.20.tar.gz'\n",
      "Content type 'application/x-gzip' length 99600 bytes (97 KB)\n",
      "==================================================\n",
      "downloaded 97 KB\n",
      "\n",
      "* installing *source* package ‘rjson’ ...\n",
      "** package ‘rjson’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** libs\n",
      "g++ -std=gnu++11 -I\"/usr/share/R/include\" -DNDEBUG     -fpic  -g -O2 -fdebug-prefix-map=/build/r-base-uuRxut/r-base-3.6.1=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -g  -c dump.cpp -o dump.o\n",
      "gcc -std=gnu99 -I\"/usr/share/R/include\" -DNDEBUG     -fpic  -g -O2 -fdebug-prefix-map=/build/r-base-uuRxut/r-base-3.6.1=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -g  -c parser.c -o parser.o\n",
      "gcc -std=gnu99 -I\"/usr/share/R/include\" -DNDEBUG     -fpic  -g -O2 -fdebug-prefix-map=/build/r-base-uuRxut/r-base-3.6.1=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -g  -c register.c -o register.o\n",
      "g++ -std=gnu++11 -shared -L/usr/lib/R/lib -Wl,-Bsymbolic-functions -Wl,-z,relro -o rjson.so dump.o parser.o register.o -L/usr/lib/R/lib -lR\n",
      "installing to /usr/local/lib/R/site-library/00LOCK-rjson/00new/rjson/libs\n",
      "** R\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "** building package indices\n",
      "** installing vignettes\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** checking absolute paths in shared objects and dynamic libraries\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (rjson)\n",
      "\n",
      "The downloaded source packages are in\n",
      "\t‘/tmp/RtmpRkOceU/downloaded_packages’\n",
      "Installing package into ‘/usr/local/lib/R/site-library’\n",
      "(as ‘lib’ is unspecified)\n",
      "also installing the dependencies ‘ggrepel’, ‘ggsci’, ‘cowplot’, ‘ggsignif’, ‘gridExtra’, ‘polynom’\n",
      "\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/ggrepel_0.8.1.tar.gz'\n",
      "Content type 'application/x-gzip' length 520312 bytes (508 KB)\n",
      "==================================================\n",
      "downloaded 508 KB\n",
      "\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/ggsci_2.9.tar.gz'\n",
      "Content type 'application/x-gzip' length 2873033 bytes (2.7 MB)\n",
      "==================================================\n",
      "downloaded 2.7 MB\n",
      "\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/cowplot_1.0.0.tar.gz'\n",
      "Content type 'application/x-gzip' length 1275585 bytes (1.2 MB)\n",
      "==================================================\n",
      "downloaded 1.2 MB\n",
      "\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/ggsignif_0.6.0.tar.gz'\n",
      "Content type 'application/x-gzip' length 110226 bytes (107 KB)\n",
      "==================================================\n",
      "downloaded 107 KB\n",
      "\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/gridExtra_2.3.tar.gz'\n",
      "Content type 'application/x-gzip' length 1062844 bytes (1.0 MB)\n",
      "==================================================\n",
      "downloaded 1.0 MB\n",
      "\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/polynom_1.4-0.tar.gz'\n",
      "Content type 'application/x-gzip' length 243462 bytes (237 KB)\n",
      "==================================================\n",
      "downloaded 237 KB\n",
      "\n",
      "trying URL 'https://cran.rstudio.com/src/contrib/ggpubr_0.2.2.tar.gz'\n",
      "Content type 'application/x-gzip' length 2662167 bytes (2.5 MB)\n",
      "==================================================\n",
      "downloaded 2.5 MB\n",
      "\n",
      "* installing *source* package ‘ggrepel’ ...\n",
      "** package ‘ggrepel’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** libs\n",
      "g++ -std=gnu++11 -I\"/usr/share/R/include\" -DNDEBUG  -I\"/usr/lib/R/site-library/Rcpp/include\"   -fpic  -g -O2 -fdebug-prefix-map=/build/r-base-uuRxut/r-base-3.6.1=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -g  -c RcppExports.cpp -o RcppExports.o\n",
      "g++ -std=gnu++11 -I\"/usr/share/R/include\" -DNDEBUG  -I\"/usr/lib/R/site-library/Rcpp/include\"   -fpic  -g -O2 -fdebug-prefix-map=/build/r-base-uuRxut/r-base-3.6.1=. -fstack-protector-strong -Wformat -Werror=format-security -Wdate-time -D_FORTIFY_SOURCE=2 -g  -c repel_boxes.cpp -o repel_boxes.o\n",
      "g++ -std=gnu++11 -shared -L/usr/lib/R/lib -Wl,-Bsymbolic-functions -Wl,-z,relro -o ggrepel.so RcppExports.o repel_boxes.o -L/usr/lib/R/lib -lR\n",
      "installing to /usr/local/lib/R/site-library/00LOCK-ggrepel/00new/ggrepel/libs\n",
      "** R\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "** building package indices\n",
      "** installing vignettes\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** checking absolute paths in shared objects and dynamic libraries\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (ggrepel)\n",
      "* installing *source* package ‘ggsci’ ...\n",
      "** package ‘ggsci’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** R\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "** building package indices\n",
      "** installing vignettes\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (ggsci)\n",
      "* installing *source* package ‘cowplot’ ...\n",
      "** package ‘cowplot’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** R\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "*** copying figures\n",
      "** building package indices\n",
      "** installing vignettes\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (cowplot)\n",
      "* installing *source* package ‘ggsignif’ ...\n",
      "** package ‘ggsignif’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** R\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "** building package indices\n",
      "** installing vignettes\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (ggsignif)\n",
      "* installing *source* package ‘gridExtra’ ...\n",
      "** package ‘gridExtra’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** R\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "** building package indices\n",
      "** installing vignettes\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (gridExtra)\n",
      "* installing *source* package ‘polynom’ ...\n",
      "** package ‘polynom’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** R\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "** building package indices\n",
      "** installing vignettes\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (polynom)\n",
      "* installing *source* package ‘ggpubr’ ...\n",
      "** package ‘ggpubr’ successfully unpacked and MD5 sums checked\n",
      "** using staged installation\n",
      "** R\n",
      "** data\n",
      "*** moving datasets to lazyload DB\n",
      "** inst\n",
      "** byte-compile and prepare package for lazy loading\n",
      "** help\n",
      "*** installing help indices\n",
      "** building package indices\n",
      "** testing if installed package can be loaded from temporary location\n",
      "** testing if installed package can be loaded from final location\n",
      "** testing if installed package keeps a record of temporary installation path\n",
      "* DONE (ggpubr)\n",
      "\n",
      "The downloaded source packages are in\n",
      "\t‘/tmp/RtmpRkOceU/downloaded_packages’\n"
     ]
    }
   ],
   "source": [
    "!pip install --upgrade setuptools\n",
    "!pip2 install shap==0.27.0\n",
    "!Rscript functions/install_package.R"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "isgVu2RZO2yd"
   },
   "source": [
    "### Set location of input data"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 0,
   "metadata": {
    "colab": {},
    "colab_type": "code",
    "id": "Qhg6zacLO2ye"
   },
   "outputs": [],
   "source": [
    "# Set input data\n",
    "\n",
    "# Gene expression matrix (This example uses log2-transformed TPM (Transcripts Per Kilobase Million), but other log2-transformed expression values would work too.) \n",
    "deg_data_file = \"./data/toy/Transcriptome/expdata.txt.gz\"\n",
    "\n",
    "# Location of RNA features\n",
    "mRNA_data_loc = \"./data/toy/RNA_features/\"\n",
    "mRNA_annotation_data = [\"POSTAR\",\"TargetScan\"]\n",
    "\n",
    "# Location of promoter features\n",
    "promoter_data_loc = \"./data/toy/Promoter_features/\"\n",
    "promoter_annotation_data = [\"GTRD\"]\n",
    "\n",
    "# Genes used for traning, validation, and testing (A list of gene ids used for training, validation, and testing. These ids should match with gene expression data, RNA features, and promoter fatures)\n",
    "train_genes = \"./data/toy/Gene_splits/train.txt.gz\"\n",
    "validate_genes = \"./data/toy/Gene_splits/validate.txt.gz\"\n",
    "test_genes = \"./data/toy/Gene_splits/test.txt.gz\"    \n",
    "\n",
    "# Location of hyper-parameter\n",
    "params_loc='./pretrained/Tissue_gene_params.json'\n",
    "\n",
    "# Output directory\n",
    "outloc='./train_out/full_model/'"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "VZhaAYr1O2yg"
   },
   "source": [
    "### Define main function"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 0,
   "metadata": {
    "colab": {},
    "colab_type": "code",
    "id": "uxAPYMSVO2yh"
   },
   "outputs": [],
   "source": [
    "import os\n",
    "import sys\n",
    "sys.path.append('./functions/')\n",
    "import data\n",
    "import model_utils\n",
    "import pandas as pd\n",
    "import numpy as np\n",
    "import json\n",
    "\n",
    "#os.environ[\"CUDA_VISIBLE_DEVICES\"]=\"0\"\n",
    "\n",
    "def main(params):\n",
    "    # Descriptions of outputs\n",
    "    #{time_stamp}_history.json: Model performance at each epoch. Loss and val_loss indicates mean-squred error for traing data and validation data,respectively. Pcor and pcor_loss indicates Pearson's correlation for traing data and validation data,respectively. \n",
    "    #{time_stamp}_model.h5: The best model among epochs.\n",
    "    #{time_stamp}_params.json: Hyper parameters. \n",
    "    #{time_stamp}_test_performance.txt: Model performance of the best model against testing data. The first and the second row indicates mean-squred error and Pearson's correlation, respectively.\n",
    "    \n",
    "    from datetime import datetime\n",
    "    from keras.callbacks import EarlyStopping, ModelCheckpoint\n",
    "    from keras.models import load_model\n",
    "    import numpy as np\n",
    "    import metrics\n",
    "    import layer_utils\n",
    "    import network\n",
    "    \n",
    "    print(params)\n",
    "    just_return_model=False\n",
    "    \n",
    "    # model parameters and learning parameters\n",
    "    max_epoch = 100\n",
    "    batch_size = 128\n",
    "    \n",
    "    # batch initialization\n",
    "    train_steps, train_batches = data.batch_iter(X_mRNA_train.values[:,1],\n",
    "                                                 X_promoter_train.values[:,1],\n",
    "                                                 Y_train.values[:,1:],\n",
    "                                                 batch_size,\n",
    "                                                 shuffle=True)\n",
    "    valid_steps, valid_batches = data.batch_iter(X_mRNA_validate.values[:,1],\n",
    "                                                 X_promoter_validate.values[:,1],\n",
    "                                                 Y_validate.values[:,1:],\n",
    "                                                 batch_size,\n",
    "                                                 shuffle=True)\n",
    "    test_steps, test_batches = data.batch_iter(X_mRNA_test.values[:,1],\n",
    "                                               X_promoter_test.values[:,1],\n",
    "                                               Y_test.values[:,1:],\n",
    "                                               batch_size,\n",
    "                                               shuffle=True)\n",
    "\n",
    "    # Paramters for network structure\n",
    "    params['n_feature_mRNA']=X_mRNA_train.values[:,1][0].shape[0]\n",
    "    params['n_feature_promoter']=X_promoter_train.values[:,1][0].shape[0]\n",
    "    params['n_out'] = Y_train.values[:,1:].shape[1]\n",
    "    \n",
    "    # Define network structure\n",
    "    model = network.define_network(params)\n",
    "    \n",
    "    # If you don't need to traning model and just want to have model structure\n",
    "    if just_return_model:\n",
    "        return model\n",
    "    \n",
    "    # Set callback functions to early stop training and save the best model so far\n",
    "    time_stamp=datetime.now().strftime(\"%Y-%m-%d_%H-%M-%S\")\n",
    "    \n",
    "    callbacks = [EarlyStopping(monitor='val_loss', patience=10),\n",
    "                    ModelCheckpoint(outloc+time_stamp+'_model.h5', monitor='val_loss', verbose=0,\n",
    "                    save_best_only=True,\n",
    "                    save_weights_only=False,\n",
    "                    mode='min', period=1)]\n",
    "    \n",
    "    # Optimizing model\n",
    "    result = model.fit_generator(train_batches, train_steps, \n",
    "                                 epochs=max_epoch,\n",
    "                                 validation_data=valid_batches,\n",
    "                                 validation_steps=valid_steps,\n",
    "                                 callbacks=callbacks,\n",
    "                                 max_queue_size=10,\n",
    "                                 verbose=0)\n",
    "    \n",
    "    # Test performance\n",
    "    # Load best model\n",
    "    model = load_model(outloc+time_stamp+'_model.h5',\n",
    "                   custom_objects={'pcor': metrics.pcor,\n",
    "                                  'GlobalSumPooling1D': layer_utils.GlobalSumPooling1D})\n",
    "    test_performance= np.array(model.evaluate_generator(test_batches,test_steps))\n",
    "    np.savetxt(outloc+time_stamp+'_test_performance.txt',\n",
    "               test_performance,delimiter=\"\\t\")\n",
    "    \n",
    "    # Saving optimization history\n",
    "    with open(outloc+time_stamp+'_history.json', 'w') as f:\n",
    "        result.history['pcor']=[np.float64(x) for x in result.history['pcor']] # need for json dump\n",
    "        json.dump(result.history, f)\n",
    "    \n",
    "    # Saving model and learning paramters\n",
    "    with open(outloc+time_stamp+'_params.json', 'w') as f:\n",
    "        json.dump(params, f)\n",
    "    \n",
    "    # Return validation loss for model selection\n",
    "    validation_loss = np.amin(result.history['val_loss']) \n",
    "    \n",
    "    return {'loss': validation_loss, 'status': STATUS_OK, 'model': model}"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "cwsrlU4eO2yj"
   },
   "source": [
    "### Training model"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 649
    },
    "colab_type": "code",
    "id": "iZp5_2-sO2yk",
    "outputId": "b5eb5238-31d5-4093-c7ae-2c1542440b9f"
   },
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/usr/local/lib/python2.7/dist-packages/pandas/core/indexing.py:543: SettingWithCopyWarning: \n",
      "A value is trying to be set on a copy of a slice from a DataFrame.\n",
      "Try using .loc[row_indexer,col_indexer] = value instead\n",
      "\n",
      "See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy\n",
      "  self.obj[item] = s\n",
      "/usr/local/lib/python2.7/dist-packages/pandas/core/indexing.py:635: SettingWithCopyWarning: \n",
      "A value is trying to be set on a copy of a slice from a DataFrame.\n",
      "Try using .loc[row_indexer,col_indexer] = value instead\n",
      "\n",
      "See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy\n",
      "  self.obj[item_labels[indexer[info_axis]]] = value\n",
      "Using TensorFlow backend.\n",
      "WARNING: Logging before flag parsing goes to stderr.\n",
      "W0826 19:20:53.835948 140285664106368 deprecation_wrapper.py:119] From /usr/local/lib/python2.7/dist-packages/keras/backend/tensorflow_backend.py:74: The name tf.get_default_graph is deprecated. Please use tf.compat.v1.get_default_graph instead.\n",
      "\n",
      "W0826 19:20:53.864257 140285664106368 deprecation_wrapper.py:119] From /usr/local/lib/python2.7/dist-packages/keras/backend/tensorflow_backend.py:517: The name tf.placeholder is deprecated. Please use tf.compat.v1.placeholder instead.\n",
      "\n",
      "W0826 19:20:53.872558 140285664106368 deprecation_wrapper.py:119] From /usr/local/lib/python2.7/dist-packages/keras/backend/tensorflow_backend.py:4138: The name tf.random_uniform is deprecated. Please use tf.random.uniform instead.\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{u'n_feature_mRNA': 372, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 726, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "W0826 19:20:54.049827 140285664106368 deprecation_wrapper.py:119] From /usr/local/lib/python2.7/dist-packages/keras/backend/tensorflow_backend.py:133: The name tf.placeholder_with_default is deprecated. Please use tf.compat.v1.placeholder_with_default instead.\n",
      "\n",
      "W0826 19:20:54.149852 140285664106368 deprecation_wrapper.py:119] From /usr/local/lib/python2.7/dist-packages/keras/optimizers.py:790: The name tf.train.Optimizer is deprecated. Please use tf.compat.v1.train.Optimizer instead.\n",
      "\n",
      "W0826 19:20:54.603009 140285664106368 deprecation_wrapper.py:119] From /usr/local/lib/python2.7/dist-packages/keras/backend/tensorflow_backend.py:986: The name tf.assign_add is deprecated. Please use tf.compat.v1.assign_add instead.\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n",
      "{u'n_feature_mRNA': 271, u'DNA_n_channel_1st': 120.0, u'Last_fullConLayer': 2.0, u'DNA_conv_strides': 1.0, u'ConvRelu': u'No', u'FullRelu': u'Yes', u'n_feature_mRNA_basic': 1, u'n_feature_promoter': 601, u'lr': 0.001, u'RNA_n_channel_1st': 160.0, u'Last_n_channel': 160.0, u'RNA_conv_strides': 2.0, u'DNA_n_ConvLayer': 4.0, u'RNA_n_ConvLayer': 1.0, u'n_out': 54, u'Add_basic_info': u'No'}\n"
     ]
    }
   ],
   "source": [
    "! mkdir -p \"$outloc\"\n",
    "shuffle=\"None\"\n",
    "# Prepare learning data\n",
    "Y_train, Y_validate, Y_test, X_mRNA_train, X_mRNA_validate, X_mRNA_test, X_promoter_train, X_promoter_validate, X_promoter_test = data.prep_ml_data_split(\n",
    "    deg_data_file=deg_data_file,\n",
    "    mRNA_data_loc=mRNA_data_loc,\n",
    "    mRNA_annotation_data=mRNA_annotation_data,\n",
    "    promoter_data_loc=promoter_data_loc,\n",
    "    promoter_annotation_data=promoter_annotation_data,\n",
    "    train_genes=train_genes,\n",
    "    validate_genes=validate_genes,\n",
    "    test_genes=test_genes,\n",
    "    outloc=outloc,\n",
    "    shuffle=shuffle)\n",
    "\n",
    "# Obtain hyper parameters\n",
    "with open(params_loc) as f:\n",
    "    params=json.load(f)  \n",
    "\n",
    "# Training model\n",
    "from hyperopt import STATUS_OK\n",
    "# train model 10 times\n",
    "for i in range(10):\n",
    "    main(params)\n",
    "# Descriptions of outputs\n",
    "#{time_stamp}_history.json: Model performance at each epoch. Loss and val_loss indicates mean-squred error for traing data and validation data,respectively. Pcor and pcor_loss indicates Pearson's correlation for traing data and validation data,respectively. \n",
    "#{time_stamp}_model.h5: The best model among epochs.\n",
    "#{time_stamp}_params.json: Hyper parameters. \n",
    "#{time_stamp}_test_performance.txt: Model performance of the best model against testing data. The first and the second row indicates mean-squred error and Pearson's correlation, respectively.\n",
    "\n",
    "# Summarizing the result\n",
    "! Rscript functions/find_best_model.R \"$outloc\" &> /dev/null \n",
    "# Descriptions of outputs\n",
    "#./summary/loss_parameters.rds: Hyper paramters and performance of the 10 training runs.\n",
    "#./summary/best_model.txt: The best model among the 10 training runs. "
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "G0PmyH-KO2yl"
   },
   "source": [
    "### Compute Spearman's correlation between actual and predicted expression for each sample"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 0,
   "metadata": {
    "colab": {},
    "colab_type": "code",
    "id": "8sLng2TZO2ym"
   },
   "outputs": [],
   "source": [
    "# Read the best model\n",
    "with open(outloc+\"/summary/best_model.txt\") as f:\n",
    "    best_model=f.readline().rstrip()\n",
    "\n",
    "# Prediction for test samples with the best model\n",
    "model_utils.test_prediction(outloc,\n",
    "                            best_model,\n",
    "                            X_mRNA_test,\n",
    "                            X_promoter_test,\n",
    "                            Y_test)\n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/test_data/prediction.txt.gz: Predicted gene expression data\n",
    "#.{outloc}/{best_model}/test_data/actual.txt.gz: Actual gene expression data\n",
    "#.{outloc}/{best_model}/test_data/geneid.txt.gz: Genes in testing data."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 1000
    },
    "colab_type": "code",
    "id": "iTsvC9dHO2yo",
    "outputId": "4e6b340a-ce26-42c1-8783-240dd2cc47c5",
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>sample</th>\n",
       "      <th>estimate</th>\n",
       "      <th>statistic</th>\n",
       "      <th>p.value</th>\n",
       "      <th>method</th>\n",
       "      <th>alternative</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>Adipose_Subcutaneous</td>\n",
       "      <td>0.207047</td>\n",
       "      <td>2.601248e+06</td>\n",
       "      <td>6.181839e-04</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>Adipose_Visceral_Omentum</td>\n",
       "      <td>0.051037</td>\n",
       "      <td>3.113030e+06</td>\n",
       "      <td>4.035610e-01</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>Adrenal_Gland</td>\n",
       "      <td>-0.007165</td>\n",
       "      <td>3.303958e+06</td>\n",
       "      <td>9.067157e-01</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>Artery_Aorta</td>\n",
       "      <td>0.204438</td>\n",
       "      <td>2.609805e+06</td>\n",
       "      <td>7.263359e-04</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>Artery_Coronary</td>\n",
       "      <td>0.082329</td>\n",
       "      <td>3.010378e+06</td>\n",
       "      <td>1.773940e-01</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>Artery_Tibial</td>\n",
       "      <td>0.304999</td>\n",
       "      <td>2.279920e+06</td>\n",
       "      <td>3.210050e-07</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>Bladder</td>\n",
       "      <td>0.258763</td>\n",
       "      <td>2.431595e+06</td>\n",
       "      <td>1.664295e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>Brain_Amygdala</td>\n",
       "      <td>0.411786</td>\n",
       "      <td>1.929609e+06</td>\n",
       "      <td>1.786476e-12</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>Brain_Anterior_cingulate_cortex_BA24</td>\n",
       "      <td>0.388998</td>\n",
       "      <td>2.004365e+06</td>\n",
       "      <td>3.472624e-11</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>Brain_Caudate_basal_ganglia</td>\n",
       "      <td>0.368323</td>\n",
       "      <td>2.072187e+06</td>\n",
       "      <td>4.237770e-10</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>Brain_Cerebellar_Hemisphere</td>\n",
       "      <td>0.268250</td>\n",
       "      <td>2.400473e+06</td>\n",
       "      <td>7.839063e-06</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>Brain_Cerebellum</td>\n",
       "      <td>0.299351</td>\n",
       "      <td>2.298447e+06</td>\n",
       "      <td>5.403323e-07</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>Brain_Cortex</td>\n",
       "      <td>0.366863</td>\n",
       "      <td>2.076977e+06</td>\n",
       "      <td>5.023422e-10</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>Brain_Frontal_Cortex_BA9</td>\n",
       "      <td>0.340656</td>\n",
       "      <td>2.162948e+06</td>\n",
       "      <td>9.229925e-09</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>Brain_Hippocampus</td>\n",
       "      <td>0.392647</td>\n",
       "      <td>1.992394e+06</td>\n",
       "      <td>2.192079e-11</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>Brain_Hypothalamus</td>\n",
       "      <td>0.389243</td>\n",
       "      <td>2.003560e+06</td>\n",
       "      <td>3.367485e-11</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>Brain_Nucleus_accumbens_basal_ganglia</td>\n",
       "      <td>0.348408</td>\n",
       "      <td>2.137517e+06</td>\n",
       "      <td>4.010593e-09</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>Brain_Putamen_basal_ganglia</td>\n",
       "      <td>0.488127</td>\n",
       "      <td>1.679176e+06</td>\n",
       "      <td>1.430325e-17</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>Brain_Spinal_cord_cervical_c_1</td>\n",
       "      <td>0.241836</td>\n",
       "      <td>2.487122e+06</td>\n",
       "      <td>5.942189e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>Brain_Substantia_nigra</td>\n",
       "      <td>0.331473</td>\n",
       "      <td>2.193071e+06</td>\n",
       "      <td>2.406004e-08</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>Breast_Mammary_Tissue</td>\n",
       "      <td>0.246867</td>\n",
       "      <td>2.470620e+06</td>\n",
       "      <td>4.108888e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>Cells_EBV_transformed_lymphocytes</td>\n",
       "      <td>0.445741</td>\n",
       "      <td>1.818222e+06</td>\n",
       "      <td>1.386010e-14</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>Cells_Transformed_fibroblasts</td>\n",
       "      <td>0.272376</td>\n",
       "      <td>2.386939e+06</td>\n",
       "      <td>5.599603e-06</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>Cervix_Ectocervix</td>\n",
       "      <td>0.342773</td>\n",
       "      <td>2.156004e+06</td>\n",
       "      <td>7.367727e-09</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>Cervix_Endocervix</td>\n",
       "      <td>0.240312</td>\n",
       "      <td>2.492121e+06</td>\n",
       "      <td>6.634522e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>Colon_Sigmoid</td>\n",
       "      <td>0.113073</td>\n",
       "      <td>2.909526e+06</td>\n",
       "      <td>6.355260e-02</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>Colon_Transverse</td>\n",
       "      <td>0.286684</td>\n",
       "      <td>2.340000e+06</td>\n",
       "      <td>1.669769e-06</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>Esophagus_Gastroesophageal_Junction</td>\n",
       "      <td>0.089215</td>\n",
       "      <td>2.987791e+06</td>\n",
       "      <td>1.437249e-01</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>Esophagus_Mucosa</td>\n",
       "      <td>0.151190</td>\n",
       "      <td>2.784481e+06</td>\n",
       "      <td>1.287890e-02</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>Esophagus_Muscularis</td>\n",
       "      <td>0.145051</td>\n",
       "      <td>2.804622e+06</td>\n",
       "      <td>1.707908e-02</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>Fallopian_Tube</td>\n",
       "      <td>0.197114</td>\n",
       "      <td>2.633831e+06</td>\n",
       "      <td>1.130364e-03</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>Heart_Atrial_Appendage</td>\n",
       "      <td>0.389225</td>\n",
       "      <td>2.003620e+06</td>\n",
       "      <td>3.375173e-11</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>32</th>\n",
       "      <td>Heart_Left_Ventricle</td>\n",
       "      <td>0.408752</td>\n",
       "      <td>1.939563e+06</td>\n",
       "      <td>2.687194e-12</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>33</th>\n",
       "      <td>Kidney_Cortex</td>\n",
       "      <td>0.275241</td>\n",
       "      <td>2.377538e+06</td>\n",
       "      <td>4.418263e-06</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>34</th>\n",
       "      <td>Liver</td>\n",
       "      <td>0.332767</td>\n",
       "      <td>2.188827e+06</td>\n",
       "      <td>2.106179e-08</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>35</th>\n",
       "      <td>Lung</td>\n",
       "      <td>0.184729</td>\n",
       "      <td>2.674461e+06</td>\n",
       "      <td>2.306835e-03</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>36</th>\n",
       "      <td>MedianExp</td>\n",
       "      <td>0.774107</td>\n",
       "      <td>7.410333e+05</td>\n",
       "      <td>3.836743e-55</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>37</th>\n",
       "      <td>Minor_Salivary_Gland</td>\n",
       "      <td>0.237933</td>\n",
       "      <td>2.499927e+06</td>\n",
       "      <td>7.869225e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>38</th>\n",
       "      <td>Muscle_Skeletal</td>\n",
       "      <td>0.169126</td>\n",
       "      <td>2.725644e+06</td>\n",
       "      <td>5.332431e-03</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>39</th>\n",
       "      <td>Nerve_Tibial</td>\n",
       "      <td>0.105805</td>\n",
       "      <td>2.933367e+06</td>\n",
       "      <td>8.267741e-02</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>40</th>\n",
       "      <td>Ovary</td>\n",
       "      <td>0.234602</td>\n",
       "      <td>2.510852e+06</td>\n",
       "      <td>9.963682e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>41</th>\n",
       "      <td>Pancreas</td>\n",
       "      <td>0.364623</td>\n",
       "      <td>2.084326e+06</td>\n",
       "      <td>6.510536e-10</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>42</th>\n",
       "      <td>Pituitary</td>\n",
       "      <td>0.196577</td>\n",
       "      <td>2.635592e+06</td>\n",
       "      <td>1.166905e-03</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>43</th>\n",
       "      <td>Prostate</td>\n",
       "      <td>0.133083</td>\n",
       "      <td>2.843882e+06</td>\n",
       "      <td>2.878882e-02</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>44</th>\n",
       "      <td>Skin_Not_Sun_Exposed_Suprapubic</td>\n",
       "      <td>0.237301</td>\n",
       "      <td>2.501999e+06</td>\n",
       "      <td>8.231634e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>45</th>\n",
       "      <td>Skin_Sun_Exposed_Lower_leg</td>\n",
       "      <td>0.234349</td>\n",
       "      <td>2.511682e+06</td>\n",
       "      <td>1.014248e-04</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>46</th>\n",
       "      <td>Small_Intestine_Terminal_Ileum</td>\n",
       "      <td>0.267304</td>\n",
       "      <td>2.403575e+06</td>\n",
       "      <td>8.460813e-06</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>47</th>\n",
       "      <td>Spleen</td>\n",
       "      <td>0.261049</td>\n",
       "      <td>2.424094e+06</td>\n",
       "      <td>1.391770e-05</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>48</th>\n",
       "      <td>Stomach</td>\n",
       "      <td>0.029026</td>\n",
       "      <td>3.185237e+06</td>\n",
       "      <td>6.349086e-01</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>49</th>\n",
       "      <td>Testis</td>\n",
       "      <td>0.403773</td>\n",
       "      <td>1.955897e+06</td>\n",
       "      <td>5.204594e-12</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>50</th>\n",
       "      <td>Thyroid</td>\n",
       "      <td>0.101948</td>\n",
       "      <td>2.946020e+06</td>\n",
       "      <td>9.457166e-02</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>51</th>\n",
       "      <td>Uterus</td>\n",
       "      <td>-0.001885</td>\n",
       "      <td>3.286637e+06</td>\n",
       "      <td>9.754101e-01</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>52</th>\n",
       "      <td>Vagina</td>\n",
       "      <td>0.275902</td>\n",
       "      <td>2.375371e+06</td>\n",
       "      <td>4.181810e-06</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>53</th>\n",
       "      <td>Whole_Blood</td>\n",
       "      <td>0.475460</td>\n",
       "      <td>1.720731e+06</td>\n",
       "      <td>1.234954e-16</td>\n",
       "      <td>Spearman's rank correlation rho</td>\n",
       "      <td>two.sided</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                                   sample  ...  alternative\n",
       "0                    Adipose_Subcutaneous  ...    two.sided\n",
       "1                Adipose_Visceral_Omentum  ...    two.sided\n",
       "2                           Adrenal_Gland  ...    two.sided\n",
       "3                            Artery_Aorta  ...    two.sided\n",
       "4                         Artery_Coronary  ...    two.sided\n",
       "5                           Artery_Tibial  ...    two.sided\n",
       "6                                 Bladder  ...    two.sided\n",
       "7                          Brain_Amygdala  ...    two.sided\n",
       "8    Brain_Anterior_cingulate_cortex_BA24  ...    two.sided\n",
       "9             Brain_Caudate_basal_ganglia  ...    two.sided\n",
       "10            Brain_Cerebellar_Hemisphere  ...    two.sided\n",
       "11                       Brain_Cerebellum  ...    two.sided\n",
       "12                           Brain_Cortex  ...    two.sided\n",
       "13               Brain_Frontal_Cortex_BA9  ...    two.sided\n",
       "14                      Brain_Hippocampus  ...    two.sided\n",
       "15                     Brain_Hypothalamus  ...    two.sided\n",
       "16  Brain_Nucleus_accumbens_basal_ganglia  ...    two.sided\n",
       "17            Brain_Putamen_basal_ganglia  ...    two.sided\n",
       "18         Brain_Spinal_cord_cervical_c_1  ...    two.sided\n",
       "19                 Brain_Substantia_nigra  ...    two.sided\n",
       "20                  Breast_Mammary_Tissue  ...    two.sided\n",
       "21      Cells_EBV_transformed_lymphocytes  ...    two.sided\n",
       "22          Cells_Transformed_fibroblasts  ...    two.sided\n",
       "23                      Cervix_Ectocervix  ...    two.sided\n",
       "24                      Cervix_Endocervix  ...    two.sided\n",
       "25                          Colon_Sigmoid  ...    two.sided\n",
       "26                       Colon_Transverse  ...    two.sided\n",
       "27    Esophagus_Gastroesophageal_Junction  ...    two.sided\n",
       "28                       Esophagus_Mucosa  ...    two.sided\n",
       "29                   Esophagus_Muscularis  ...    two.sided\n",
       "30                         Fallopian_Tube  ...    two.sided\n",
       "31                 Heart_Atrial_Appendage  ...    two.sided\n",
       "32                   Heart_Left_Ventricle  ...    two.sided\n",
       "33                          Kidney_Cortex  ...    two.sided\n",
       "34                                  Liver  ...    two.sided\n",
       "35                                   Lung  ...    two.sided\n",
       "36                              MedianExp  ...    two.sided\n",
       "37                   Minor_Salivary_Gland  ...    two.sided\n",
       "38                        Muscle_Skeletal  ...    two.sided\n",
       "39                           Nerve_Tibial  ...    two.sided\n",
       "40                                  Ovary  ...    two.sided\n",
       "41                               Pancreas  ...    two.sided\n",
       "42                              Pituitary  ...    two.sided\n",
       "43                               Prostate  ...    two.sided\n",
       "44        Skin_Not_Sun_Exposed_Suprapubic  ...    two.sided\n",
       "45             Skin_Sun_Exposed_Lower_leg  ...    two.sided\n",
       "46         Small_Intestine_Terminal_Ileum  ...    two.sided\n",
       "47                                 Spleen  ...    two.sided\n",
       "48                                Stomach  ...    two.sided\n",
       "49                                 Testis  ...    two.sided\n",
       "50                                Thyroid  ...    two.sided\n",
       "51                                 Uterus  ...    two.sided\n",
       "52                                 Vagina  ...    two.sided\n",
       "53                            Whole_Blood  ...    two.sided\n",
       "\n",
       "[54 rows x 6 columns]"
      ]
     },
     "execution_count": 9,
     "metadata": {
      "tags": []
     },
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Compute prediction accuracy for each sample\n",
    "! Rscript --vanilla --slave functions/calc_performance.R \"$outloc$best_model\" &> /dev/null \n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/test_data/cor_tbl.txt: Correlation between acutual and predicted gene expression for each sample\n",
    "pd.read_csv(outloc+best_model+'/test_data/cor_tbl.txt',sep=\"\\t\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "TT73r5luO2yq"
   },
   "source": [
    "### Compute average DeepLIFT score for each regulator"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 1000
    },
    "colab_type": "code",
    "id": "oz8OzOknO2yr",
    "outputId": "326b7ba6-17f8-43e8-d897-b9321f45b9c3"
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "W0826 19:27:07.657358 140285664106368 deprecation.py:323] From /usr/local/lib/python2.7/dist-packages/shap/explainers/deep/deep_tf.py:450: where (from tensorflow.python.ops.array_ops) is deprecated and will be removed in a future version.\n",
      "Instructions for updating:\n",
      "Use tf.where in 2.0, which has the same broadcast rule as np.where\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
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     ]
    }
   ],
   "source": [
    "# Read the best model\n",
    "with open(outloc+\"/summary/best_model.txt\") as f:\n",
    "    best_model=f.readline().rstrip()\n",
    "\n",
    "# Estimate variable imporance using test samples\n",
    "model_utils.compute_DeepLIFT(outloc,\n",
    "                             best_model,\n",
    "                             X_mRNA_test,\n",
    "                             X_promoter_test,\n",
    "                             Y_test)\n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/DeepLIFT/DNA_{sample index}.txt.gz: DeepLIFT scores of promoter regulators for each sample. The sample index corresponds to the column index of gene expression data, which starts from 0. DeepLIFT scores of regulators were sparated with commas. Its order is identical to the one appeared in {outloc}/feature_norm_stats.txt   \n",
    "#.{outloc}/{best_model}/DeepLIFT/RNA_{sample index}}.txt.gz: DeepLIFT scores of RNA regulators for each sample. The sample index corresponds to the column index of gene expression data, which starts from 0. DeepLIFT scores of regulators were sparated with commas. Its order is identical to the one appeared in {outloc}/feature_norm_stats.txt "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 1000
    },
    "colab_type": "code",
    "id": "ZYKrSI4OO2yt",
    "outputId": "158a9fb2-f6c6-48bb-ceff-71784737ad42",
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
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       "\n",
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       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>sample_name</th>\n",
       "      <th>AEBP2</th>\n",
       "      <th>AHR</th>\n",
       "      <th>AHRR</th>\n",
       "      <th>APC</th>\n",
       "      <th>AR</th>\n",
       "      <th>ARID1A</th>\n",
       "      <th>ARID1B</th>\n",
       "      <th>ARID2</th>\n",
       "      <th>ARID3A</th>\n",
       "      <th>ARID4B</th>\n",
       "      <th>ARNT</th>\n",
       "      <th>ARNT2</th>\n",
       "      <th>ARNTL</th>\n",
       "      <th>ASCL1</th>\n",
       "      <th>ASCL2</th>\n",
       "      <th>ATF1</th>\n",
       "      <th>ATF2</th>\n",
       "      <th>ATF3</th>\n",
       "      <th>ATF4</th>\n",
       "      <th>ATF5</th>\n",
       "      <th>ATF6</th>\n",
       "      <th>ATF7</th>\n",
       "      <th>ATOH1</th>\n",
       "      <th>ATRX</th>\n",
       "      <th>BACH1</th>\n",
       "      <th>BACH2</th>\n",
       "      <th>BARHL1</th>\n",
       "      <th>BARX1</th>\n",
       "      <th>BARX2</th>\n",
       "      <th>BATF</th>\n",
       "      <th>BATF3</th>\n",
       "      <th>BCL11A</th>\n",
       "      <th>BCL11B</th>\n",
       "      <th>BCL3</th>\n",
       "      <th>BCL6</th>\n",
       "      <th>BHLHE40</th>\n",
       "      <th>BRD4</th>\n",
       "      <th>CDC5L</th>\n",
       "      <th>CDX2</th>\n",
       "      <th>...</th>\n",
       "      <th>ZNF623</th>\n",
       "      <th>ZNF629</th>\n",
       "      <th>ZNF639</th>\n",
       "      <th>ZNF644</th>\n",
       "      <th>ZNF652</th>\n",
       "      <th>ZNF654</th>\n",
       "      <th>ZNF664</th>\n",
       "      <th>ZNF680</th>\n",
       "      <th>ZNF687</th>\n",
       "      <th>ZNF692</th>\n",
       "      <th>ZNF7</th>\n",
       "      <th>ZNF701</th>\n",
       "      <th>ZNF711</th>\n",
       "      <th>ZNF740</th>\n",
       "      <th>ZNF75A</th>\n",
       "      <th>ZNF76</th>\n",
       "      <th>ZNF766</th>\n",
       "      <th>ZNF768</th>\n",
       "      <th>ZNF770</th>\n",
       "      <th>ZNF778</th>\n",
       "      <th>ZNF784</th>\n",
       "      <th>ZNF792</th>\n",
       "      <th>ZNF8</th>\n",
       "      <th>ZNF816</th>\n",
       "      <th>ZNF83</th>\n",
       "      <th>ZNF84</th>\n",
       "      <th>ZNF85</th>\n",
       "      <th>ZNF92</th>\n",
       "      <th>ZSCAN16</th>\n",
       "      <th>ZSCAN2</th>\n",
       "      <th>ZSCAN21</th>\n",
       "      <th>ZSCAN22</th>\n",
       "      <th>ZSCAN29</th>\n",
       "      <th>ZSCAN31</th>\n",
       "      <th>ZSCAN4</th>\n",
       "      <th>ZSCAN5A</th>\n",
       "      <th>ZSCAN5DP</th>\n",
       "      <th>ZSCAN9</th>\n",
       "      <th>ZXDB</th>\n",
       "      <th>ZXDC</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>Adipose_Subcutaneous</td>\n",
       "      <td>3.346075e-04</td>\n",
       "      <td>-0.004190</td>\n",
       "      <td>-0.001368</td>\n",
       "      <td>0.002606</td>\n",
       "      <td>-0.062573</td>\n",
       "      <td>0.000075</td>\n",
       "      <td>0.007642</td>\n",
       "      <td>-0.000335</td>\n",
       "      <td>-0.000493</td>\n",
       "      <td>-0.001375</td>\n",
       "      <td>-0.005749</td>\n",
       "      <td>-1.830860e-04</td>\n",
       "      <td>0.000345</td>\n",
       "      <td>-0.020718</td>\n",
       "      <td>-0.008279</td>\n",
       "      <td>0.004546</td>\n",
       "      <td>0.002894</td>\n",
       "      <td>-0.008350</td>\n",
       "      <td>0.000932</td>\n",
       "      <td>-0.000491</td>\n",
       "      <td>0.000658</td>\n",
       "      <td>-0.000438</td>\n",
       "      <td>0.000031</td>\n",
       "      <td>0.000096</td>\n",
       "      <td>-0.003111</td>\n",
       "      <td>0.001163</td>\n",
       "      <td>-0.000071</td>\n",
       "      <td>0.000517</td>\n",
       "      <td>0.003132</td>\n",
       "      <td>0.005774</td>\n",
       "      <td>-3.432590e-07</td>\n",
       "      <td>-0.001290</td>\n",
       "      <td>-0.004309</td>\n",
       "      <td>0.010666</td>\n",
       "      <td>-0.013139</td>\n",
       "      <td>-0.000942</td>\n",
       "      <td>-0.002903</td>\n",
       "      <td>0.000035</td>\n",
       "      <td>-0.006180</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000194</td>\n",
       "      <td>0.003130</td>\n",
       "      <td>-0.000694</td>\n",
       "      <td>0.000835</td>\n",
       "      <td>0.000603</td>\n",
       "      <td>2.442221e-04</td>\n",
       "      <td>-0.000174</td>\n",
       "      <td>0.000722</td>\n",
       "      <td>0.002802</td>\n",
       "      <td>-0.001888</td>\n",
       "      <td>-0.001804</td>\n",
       "      <td>-0.002768</td>\n",
       "      <td>0.004027</td>\n",
       "      <td>0.000770</td>\n",
       "      <td>0.001181</td>\n",
       "      <td>-0.005704</td>\n",
       "      <td>-0.000201</td>\n",
       "      <td>0.000035</td>\n",
       "      <td>-0.008549</td>\n",
       "      <td>0.005569</td>\n",
       "      <td>-0.001170</td>\n",
       "      <td>0.003127</td>\n",
       "      <td>0.000216</td>\n",
       "      <td>-0.000632</td>\n",
       "      <td>-0.000071</td>\n",
       "      <td>-0.000059</td>\n",
       "      <td>-0.001268</td>\n",
       "      <td>-0.000075</td>\n",
       "      <td>0.000177</td>\n",
       "      <td>0.000506</td>\n",
       "      <td>0.000527</td>\n",
       "      <td>0.005083</td>\n",
       "      <td>-0.002429</td>\n",
       "      <td>0.000544</td>\n",
       "      <td>0.003949</td>\n",
       "      <td>0.002405</td>\n",
       "      <td>0.001795</td>\n",
       "      <td>-0.001066</td>\n",
       "      <td>0.001416</td>\n",
       "      <td>-0.005460</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>Adipose_Visceral_Omentum</td>\n",
       "      <td>5.258322e-04</td>\n",
       "      <td>-0.005644</td>\n",
       "      <td>-0.001788</td>\n",
       "      <td>0.002077</td>\n",
       "      <td>-0.049528</td>\n",
       "      <td>0.000107</td>\n",
       "      <td>0.007555</td>\n",
       "      <td>-0.000276</td>\n",
       "      <td>-0.001579</td>\n",
       "      <td>-0.002271</td>\n",
       "      <td>-0.001860</td>\n",
       "      <td>-3.674158e-04</td>\n",
       "      <td>0.000844</td>\n",
       "      <td>-0.015808</td>\n",
       "      <td>-0.002019</td>\n",
       "      <td>0.001558</td>\n",
       "      <td>-0.001019</td>\n",
       "      <td>-0.012159</td>\n",
       "      <td>0.000908</td>\n",
       "      <td>-0.000238</td>\n",
       "      <td>0.000994</td>\n",
       "      <td>-0.000678</td>\n",
       "      <td>0.000087</td>\n",
       "      <td>-0.000832</td>\n",
       "      <td>-0.003887</td>\n",
       "      <td>0.001083</td>\n",
       "      <td>0.000188</td>\n",
       "      <td>0.001712</td>\n",
       "      <td>0.002195</td>\n",
       "      <td>0.006735</td>\n",
       "      <td>-2.544933e-04</td>\n",
       "      <td>-0.002472</td>\n",
       "      <td>-0.001576</td>\n",
       "      <td>0.005200</td>\n",
       "      <td>-0.011960</td>\n",
       "      <td>-0.000952</td>\n",
       "      <td>-0.002700</td>\n",
       "      <td>0.000052</td>\n",
       "      <td>-0.001121</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000098</td>\n",
       "      <td>0.000595</td>\n",
       "      <td>-0.002171</td>\n",
       "      <td>0.000691</td>\n",
       "      <td>0.002948</td>\n",
       "      <td>3.053344e-04</td>\n",
       "      <td>0.000147</td>\n",
       "      <td>0.000578</td>\n",
       "      <td>0.002627</td>\n",
       "      <td>-0.002198</td>\n",
       "      <td>-0.002049</td>\n",
       "      <td>-0.003501</td>\n",
       "      <td>0.003370</td>\n",
       "      <td>0.001063</td>\n",
       "      <td>0.001513</td>\n",
       "      <td>-0.004702</td>\n",
       "      <td>-0.000113</td>\n",
       "      <td>0.000230</td>\n",
       "      <td>-0.007775</td>\n",
       "      <td>0.005897</td>\n",
       "      <td>-0.001424</td>\n",
       "      <td>0.005519</td>\n",
       "      <td>0.000307</td>\n",
       "      <td>-0.000712</td>\n",
       "      <td>0.002219</td>\n",
       "      <td>-0.000285</td>\n",
       "      <td>-0.001299</td>\n",
       "      <td>-0.000061</td>\n",
       "      <td>-0.001082</td>\n",
       "      <td>0.000617</td>\n",
       "      <td>0.000572</td>\n",
       "      <td>-0.002927</td>\n",
       "      <td>-0.003070</td>\n",
       "      <td>0.000086</td>\n",
       "      <td>0.002724</td>\n",
       "      <td>0.002127</td>\n",
       "      <td>0.001135</td>\n",
       "      <td>-0.002844</td>\n",
       "      <td>0.000620</td>\n",
       "      <td>-0.004052</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>Adrenal_Gland</td>\n",
       "      <td>1.616744e-04</td>\n",
       "      <td>-0.001091</td>\n",
       "      <td>0.000101</td>\n",
       "      <td>0.000941</td>\n",
       "      <td>-0.015609</td>\n",
       "      <td>0.000336</td>\n",
       "      <td>-0.001759</td>\n",
       "      <td>0.000812</td>\n",
       "      <td>-0.000471</td>\n",
       "      <td>-0.000373</td>\n",
       "      <td>-0.000260</td>\n",
       "      <td>-2.321270e-05</td>\n",
       "      <td>0.000503</td>\n",
       "      <td>0.010186</td>\n",
       "      <td>0.003824</td>\n",
       "      <td>0.003171</td>\n",
       "      <td>-0.001237</td>\n",
       "      <td>0.002315</td>\n",
       "      <td>-0.000263</td>\n",
       "      <td>0.000619</td>\n",
       "      <td>-0.000421</td>\n",
       "      <td>-0.000630</td>\n",
       "      <td>-0.000114</td>\n",
       "      <td>-0.000363</td>\n",
       "      <td>-0.000169</td>\n",
       "      <td>0.001511</td>\n",
       "      <td>0.000112</td>\n",
       "      <td>0.000876</td>\n",
       "      <td>-0.000568</td>\n",
       "      <td>-0.000618</td>\n",
       "      <td>-3.551392e-04</td>\n",
       "      <td>0.001604</td>\n",
       "      <td>0.003532</td>\n",
       "      <td>-0.008504</td>\n",
       "      <td>0.003524</td>\n",
       "      <td>0.002026</td>\n",
       "      <td>0.000428</td>\n",
       "      <td>-0.000067</td>\n",
       "      <td>0.004585</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000255</td>\n",
       "      <td>-0.005726</td>\n",
       "      <td>0.000079</td>\n",
       "      <td>0.000374</td>\n",
       "      <td>0.002368</td>\n",
       "      <td>-1.357475e-04</td>\n",
       "      <td>0.000001</td>\n",
       "      <td>-0.000833</td>\n",
       "      <td>-0.000514</td>\n",
       "      <td>0.000258</td>\n",
       "      <td>0.000381</td>\n",
       "      <td>0.000358</td>\n",
       "      <td>-0.001470</td>\n",
       "      <td>0.000568</td>\n",
       "      <td>-0.000220</td>\n",
       "      <td>0.001746</td>\n",
       "      <td>0.000027</td>\n",
       "      <td>0.000369</td>\n",
       "      <td>-0.000815</td>\n",
       "      <td>-0.000752</td>\n",
       "      <td>0.000020</td>\n",
       "      <td>0.004251</td>\n",
       "      <td>-0.000145</td>\n",
       "      <td>-0.000030</td>\n",
       "      <td>-0.001555</td>\n",
       "      <td>-0.000008</td>\n",
       "      <td>0.000431</td>\n",
       "      <td>-0.000262</td>\n",
       "      <td>-0.000191</td>\n",
       "      <td>-0.000639</td>\n",
       "      <td>-0.000142</td>\n",
       "      <td>-0.004132</td>\n",
       "      <td>-0.000012</td>\n",
       "      <td>0.000029</td>\n",
       "      <td>-0.001197</td>\n",
       "      <td>-0.000962</td>\n",
       "      <td>-0.001244</td>\n",
       "      <td>0.004285</td>\n",
       "      <td>0.001105</td>\n",
       "      <td>0.000742</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>Artery_Aorta</td>\n",
       "      <td>3.575876e-07</td>\n",
       "      <td>-0.000303</td>\n",
       "      <td>-0.001413</td>\n",
       "      <td>0.002678</td>\n",
       "      <td>-0.020910</td>\n",
       "      <td>0.000138</td>\n",
       "      <td>0.004456</td>\n",
       "      <td>-0.000874</td>\n",
       "      <td>0.000052</td>\n",
       "      <td>-0.003106</td>\n",
       "      <td>-0.001607</td>\n",
       "      <td>8.057584e-05</td>\n",
       "      <td>0.000074</td>\n",
       "      <td>-0.006889</td>\n",
       "      <td>-0.007726</td>\n",
       "      <td>-0.000274</td>\n",
       "      <td>0.002400</td>\n",
       "      <td>0.004322</td>\n",
       "      <td>0.000792</td>\n",
       "      <td>-0.000488</td>\n",
       "      <td>0.000508</td>\n",
       "      <td>-0.000214</td>\n",
       "      <td>0.000028</td>\n",
       "      <td>-0.000123</td>\n",
       "      <td>-0.000366</td>\n",
       "      <td>0.000372</td>\n",
       "      <td>-0.000064</td>\n",
       "      <td>-0.000042</td>\n",
       "      <td>0.002343</td>\n",
       "      <td>-0.000068</td>\n",
       "      <td>3.239651e-04</td>\n",
       "      <td>-0.005569</td>\n",
       "      <td>-0.004989</td>\n",
       "      <td>0.010829</td>\n",
       "      <td>-0.002231</td>\n",
       "      <td>0.001946</td>\n",
       "      <td>-0.001602</td>\n",
       "      <td>0.000028</td>\n",
       "      <td>0.000057</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000316</td>\n",
       "      <td>0.004338</td>\n",
       "      <td>-0.003658</td>\n",
       "      <td>0.002804</td>\n",
       "      <td>-0.001246</td>\n",
       "      <td>-1.374252e-05</td>\n",
       "      <td>-0.000493</td>\n",
       "      <td>0.001356</td>\n",
       "      <td>0.000158</td>\n",
       "      <td>-0.000518</td>\n",
       "      <td>-0.001514</td>\n",
       "      <td>-0.004576</td>\n",
       "      <td>0.004982</td>\n",
       "      <td>-0.000258</td>\n",
       "      <td>0.000939</td>\n",
       "      <td>-0.003750</td>\n",
       "      <td>-0.000151</td>\n",
       "      <td>0.000219</td>\n",
       "      <td>-0.008283</td>\n",
       "      <td>0.002297</td>\n",
       "      <td>-0.000570</td>\n",
       "      <td>0.003007</td>\n",
       "      <td>-0.000067</td>\n",
       "      <td>-0.000522</td>\n",
       "      <td>0.003586</td>\n",
       "      <td>-0.000414</td>\n",
       "      <td>-0.000347</td>\n",
       "      <td>0.000051</td>\n",
       "      <td>0.000828</td>\n",
       "      <td>0.001428</td>\n",
       "      <td>0.000329</td>\n",
       "      <td>0.000340</td>\n",
       "      <td>-0.001405</td>\n",
       "      <td>0.000834</td>\n",
       "      <td>0.001912</td>\n",
       "      <td>0.001723</td>\n",
       "      <td>-0.000524</td>\n",
       "      <td>-0.000886</td>\n",
       "      <td>0.000283</td>\n",
       "      <td>-0.002274</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>Artery_Coronary</td>\n",
       "      <td>-2.994203e-04</td>\n",
       "      <td>0.000762</td>\n",
       "      <td>-0.001242</td>\n",
       "      <td>0.002350</td>\n",
       "      <td>-0.028607</td>\n",
       "      <td>0.001075</td>\n",
       "      <td>0.004310</td>\n",
       "      <td>-0.000891</td>\n",
       "      <td>-0.000326</td>\n",
       "      <td>-0.001023</td>\n",
       "      <td>-0.003893</td>\n",
       "      <td>-9.579547e-05</td>\n",
       "      <td>0.000890</td>\n",
       "      <td>-0.010784</td>\n",
       "      <td>-0.008674</td>\n",
       "      <td>-0.001377</td>\n",
       "      <td>0.002305</td>\n",
       "      <td>-0.003959</td>\n",
       "      <td>0.000547</td>\n",
       "      <td>-0.000381</td>\n",
       "      <td>-0.000296</td>\n",
       "      <td>-0.001948</td>\n",
       "      <td>0.000184</td>\n",
       "      <td>0.000069</td>\n",
       "      <td>-0.000681</td>\n",
       "      <td>0.000796</td>\n",
       "      <td>-0.000068</td>\n",
       "      <td>0.000910</td>\n",
       "      <td>0.001072</td>\n",
       "      <td>0.001799</td>\n",
       "      <td>2.871171e-04</td>\n",
       "      <td>-0.002102</td>\n",
       "      <td>-0.002613</td>\n",
       "      <td>0.008845</td>\n",
       "      <td>-0.011279</td>\n",
       "      <td>0.001932</td>\n",
       "      <td>-0.002380</td>\n",
       "      <td>0.000035</td>\n",
       "      <td>-0.005141</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000209</td>\n",
       "      <td>0.001670</td>\n",
       "      <td>-0.001265</td>\n",
       "      <td>0.001117</td>\n",
       "      <td>-0.001741</td>\n",
       "      <td>1.547758e-04</td>\n",
       "      <td>-0.000110</td>\n",
       "      <td>0.001061</td>\n",
       "      <td>-0.000862</td>\n",
       "      <td>-0.001075</td>\n",
       "      <td>-0.001607</td>\n",
       "      <td>-0.004712</td>\n",
       "      <td>0.003626</td>\n",
       "      <td>-0.000199</td>\n",
       "      <td>0.000791</td>\n",
       "      <td>-0.002338</td>\n",
       "      <td>-0.000167</td>\n",
       "      <td>0.000403</td>\n",
       "      <td>-0.008189</td>\n",
       "      <td>0.002802</td>\n",
       "      <td>-0.000507</td>\n",
       "      <td>0.000636</td>\n",
       "      <td>-0.000165</td>\n",
       "      <td>-0.000597</td>\n",
       "      <td>-0.001440</td>\n",
       "      <td>-0.000164</td>\n",
       "      <td>-0.000546</td>\n",
       "      <td>0.000098</td>\n",
       "      <td>0.000517</td>\n",
       "      <td>0.000862</td>\n",
       "      <td>0.000276</td>\n",
       "      <td>0.001337</td>\n",
       "      <td>-0.001551</td>\n",
       "      <td>0.000510</td>\n",
       "      <td>0.002770</td>\n",
       "      <td>0.002669</td>\n",
       "      <td>-0.000046</td>\n",
       "      <td>-0.004633</td>\n",
       "      <td>0.001628</td>\n",
       "      <td>-0.006450</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>Artery_Tibial</td>\n",
       "      <td>-7.869059e-04</td>\n",
       "      <td>0.001349</td>\n",
       "      <td>-0.000852</td>\n",
       "      <td>0.003234</td>\n",
       "      <td>0.000871</td>\n",
       "      <td>0.001048</td>\n",
       "      <td>0.004975</td>\n",
       "      <td>-0.000723</td>\n",
       "      <td>-0.000770</td>\n",
       "      <td>-0.002827</td>\n",
       "      <td>-0.004729</td>\n",
       "      <td>-2.442245e-04</td>\n",
       "      <td>0.000237</td>\n",
       "      <td>-0.009641</td>\n",
       "      <td>-0.007109</td>\n",
       "      <td>-0.003596</td>\n",
       "      <td>0.002198</td>\n",
       "      <td>-0.006301</td>\n",
       "      <td>0.000037</td>\n",
       "      <td>-0.000669</td>\n",
       "      <td>-0.000364</td>\n",
       "      <td>-0.001321</td>\n",
       "      <td>0.000130</td>\n",
       "      <td>0.000017</td>\n",
       "      <td>-0.000931</td>\n",
       "      <td>0.000477</td>\n",
       "      <td>-0.000119</td>\n",
       "      <td>0.000653</td>\n",
       "      <td>0.000632</td>\n",
       "      <td>0.002616</td>\n",
       "      <td>4.313657e-04</td>\n",
       "      <td>-0.001094</td>\n",
       "      <td>-0.004006</td>\n",
       "      <td>0.008977</td>\n",
       "      <td>-0.014960</td>\n",
       "      <td>0.001796</td>\n",
       "      <td>-0.001132</td>\n",
       "      <td>-0.000042</td>\n",
       "      <td>-0.001989</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000295</td>\n",
       "      <td>-0.000350</td>\n",
       "      <td>-0.001538</td>\n",
       "      <td>0.001043</td>\n",
       "      <td>-0.000873</td>\n",
       "      <td>1.903548e-04</td>\n",
       "      <td>-0.000170</td>\n",
       "      <td>0.000770</td>\n",
       "      <td>-0.002083</td>\n",
       "      <td>-0.001430</td>\n",
       "      <td>-0.001461</td>\n",
       "      <td>-0.004150</td>\n",
       "      <td>0.003454</td>\n",
       "      <td>0.000355</td>\n",
       "      <td>0.000518</td>\n",
       "      <td>-0.001034</td>\n",
       "      <td>-0.000133</td>\n",
       "      <td>0.000256</td>\n",
       "      <td>-0.005319</td>\n",
       "      <td>0.003511</td>\n",
       "      <td>-0.000539</td>\n",
       "      <td>-0.002284</td>\n",
       "      <td>-0.000082</td>\n",
       "      <td>-0.000724</td>\n",
       "      <td>-0.001599</td>\n",
       "      <td>-0.000621</td>\n",
       "      <td>-0.000572</td>\n",
       "      <td>0.000010</td>\n",
       "      <td>0.001384</td>\n",
       "      <td>-0.000178</td>\n",
       "      <td>0.000169</td>\n",
       "      <td>0.002332</td>\n",
       "      <td>-0.001314</td>\n",
       "      <td>-0.000151</td>\n",
       "      <td>0.003059</td>\n",
       "      <td>0.002439</td>\n",
       "      <td>0.000100</td>\n",
       "      <td>-0.005217</td>\n",
       "      <td>-0.000030</td>\n",
       "      <td>-0.003652</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>Bladder</td>\n",
       "      <td>3.787277e-04</td>\n",
       "      <td>-0.005539</td>\n",
       "      <td>-0.001071</td>\n",
       "      <td>0.002355</td>\n",
       "      <td>0.041396</td>\n",
       "      <td>-0.001656</td>\n",
       "      <td>0.007459</td>\n",
       "      <td>-0.000884</td>\n",
       "      <td>-0.001419</td>\n",
       "      <td>-0.002765</td>\n",
       "      <td>0.007403</td>\n",
       "      <td>-1.467931e-04</td>\n",
       "      <td>-0.001175</td>\n",
       "      <td>-0.004640</td>\n",
       "      <td>0.007013</td>\n",
       "      <td>-0.005017</td>\n",
       "      <td>-0.005860</td>\n",
       "      <td>-0.012359</td>\n",
       "      <td>-0.000524</td>\n",
       "      <td>-0.000178</td>\n",
       "      <td>0.001147</td>\n",
       "      <td>0.001145</td>\n",
       "      <td>-0.000027</td>\n",
       "      <td>-0.001478</td>\n",
       "      <td>-0.002438</td>\n",
       "      <td>-0.002822</td>\n",
       "      <td>0.000333</td>\n",
       "      <td>0.000488</td>\n",
       "      <td>0.000966</td>\n",
       "      <td>0.002466</td>\n",
       "      <td>-4.126969e-04</td>\n",
       "      <td>-0.009040</td>\n",
       "      <td>-0.007863</td>\n",
       "      <td>0.001831</td>\n",
       "      <td>-0.006385</td>\n",
       "      <td>-0.002653</td>\n",
       "      <td>0.000478</td>\n",
       "      <td>0.000258</td>\n",
       "      <td>0.009430</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000295</td>\n",
       "      <td>0.001864</td>\n",
       "      <td>-0.004969</td>\n",
       "      <td>0.001352</td>\n",
       "      <td>0.006113</td>\n",
       "      <td>5.591933e-04</td>\n",
       "      <td>0.001163</td>\n",
       "      <td>0.000660</td>\n",
       "      <td>0.002320</td>\n",
       "      <td>-0.001735</td>\n",
       "      <td>-0.001358</td>\n",
       "      <td>0.001739</td>\n",
       "      <td>0.004531</td>\n",
       "      <td>0.001118</td>\n",
       "      <td>0.001426</td>\n",
       "      <td>-0.000463</td>\n",
       "      <td>0.000071</td>\n",
       "      <td>-0.000415</td>\n",
       "      <td>0.001414</td>\n",
       "      <td>0.003559</td>\n",
       "      <td>-0.001433</td>\n",
       "      <td>0.001672</td>\n",
       "      <td>0.000636</td>\n",
       "      <td>-0.000155</td>\n",
       "      <td>0.007956</td>\n",
       "      <td>-0.000971</td>\n",
       "      <td>-0.000907</td>\n",
       "      <td>-0.000088</td>\n",
       "      <td>-0.001110</td>\n",
       "      <td>0.000949</td>\n",
       "      <td>0.000267</td>\n",
       "      <td>0.000415</td>\n",
       "      <td>-0.001209</td>\n",
       "      <td>-0.000550</td>\n",
       "      <td>-0.000493</td>\n",
       "      <td>-0.000405</td>\n",
       "      <td>0.001111</td>\n",
       "      <td>-0.000175</td>\n",
       "      <td>-0.003288</td>\n",
       "      <td>0.008086</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>Brain_Amygdala</td>\n",
       "      <td>-2.451743e-03</td>\n",
       "      <td>0.016590</td>\n",
       "      <td>0.004662</td>\n",
       "      <td>-0.004015</td>\n",
       "      <td>0.073268</td>\n",
       "      <td>0.000729</td>\n",
       "      <td>-0.022341</td>\n",
       "      <td>0.001348</td>\n",
       "      <td>0.003361</td>\n",
       "      <td>0.010994</td>\n",
       "      <td>-0.005024</td>\n",
       "      <td>4.292027e-04</td>\n",
       "      <td>-0.000019</td>\n",
       "      <td>0.042254</td>\n",
       "      <td>-0.001966</td>\n",
       "      <td>0.000994</td>\n",
       "      <td>0.005178</td>\n",
       "      <td>0.022990</td>\n",
       "      <td>-0.002646</td>\n",
       "      <td>0.000687</td>\n",
       "      <td>-0.002542</td>\n",
       "      <td>0.000758</td>\n",
       "      <td>0.000516</td>\n",
       "      <td>0.002625</td>\n",
       "      <td>0.009303</td>\n",
       "      <td>0.001158</td>\n",
       "      <td>-0.000273</td>\n",
       "      <td>-0.002989</td>\n",
       "      <td>-0.005726</td>\n",
       "      <td>-0.010491</td>\n",
       "      <td>3.941879e-04</td>\n",
       "      <td>0.017654</td>\n",
       "      <td>0.010462</td>\n",
       "      <td>-0.017005</td>\n",
       "      <td>0.019553</td>\n",
       "      <td>0.002266</td>\n",
       "      <td>0.003916</td>\n",
       "      <td>-0.000535</td>\n",
       "      <td>-0.000947</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000266</td>\n",
       "      <td>-0.000204</td>\n",
       "      <td>0.005593</td>\n",
       "      <td>-0.000995</td>\n",
       "      <td>-0.010930</td>\n",
       "      <td>-1.258139e-03</td>\n",
       "      <td>0.000680</td>\n",
       "      <td>-0.001313</td>\n",
       "      <td>-0.007082</td>\n",
       "      <td>0.004676</td>\n",
       "      <td>0.004987</td>\n",
       "      <td>0.006785</td>\n",
       "      <td>-0.007500</td>\n",
       "      <td>-0.002656</td>\n",
       "      <td>-0.003372</td>\n",
       "      <td>0.009057</td>\n",
       "      <td>0.000278</td>\n",
       "      <td>-0.000343</td>\n",
       "      <td>0.018585</td>\n",
       "      <td>-0.011746</td>\n",
       "      <td>0.003392</td>\n",
       "      <td>-0.013181</td>\n",
       "      <td>-0.001272</td>\n",
       "      <td>0.001399</td>\n",
       "      <td>-0.007349</td>\n",
       "      <td>0.000043</td>\n",
       "      <td>0.002700</td>\n",
       "      <td>0.000181</td>\n",
       "      <td>0.002154</td>\n",
       "      <td>-0.001680</td>\n",
       "      <td>-0.001384</td>\n",
       "      <td>0.005261</td>\n",
       "      <td>0.005308</td>\n",
       "      <td>-0.000675</td>\n",
       "      <td>-0.007352</td>\n",
       "      <td>-0.002516</td>\n",
       "      <td>-0.003122</td>\n",
       "      <td>-0.000450</td>\n",
       "      <td>0.001319</td>\n",
       "      <td>0.003035</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>Brain_Anterior_cingulate_cortex_BA24</td>\n",
       "      <td>-2.210161e-03</td>\n",
       "      <td>0.015099</td>\n",
       "      <td>0.005166</td>\n",
       "      <td>-0.005686</td>\n",
       "      <td>0.088770</td>\n",
       "      <td>-0.000828</td>\n",
       "      <td>-0.022046</td>\n",
       "      <td>0.001474</td>\n",
       "      <td>0.004975</td>\n",
       "      <td>0.008627</td>\n",
       "      <td>-0.000419</td>\n",
       "      <td>5.829565e-04</td>\n",
       "      <td>-0.000216</td>\n",
       "      <td>0.046404</td>\n",
       "      <td>-0.000795</td>\n",
       "      <td>-0.002030</td>\n",
       "      <td>0.008751</td>\n",
       "      <td>0.028505</td>\n",
       "      <td>-0.001817</td>\n",
       "      <td>0.000446</td>\n",
       "      <td>-0.002553</td>\n",
       "      <td>0.002047</td>\n",
       "      <td>0.000389</td>\n",
       "      <td>0.002953</td>\n",
       "      <td>0.010573</td>\n",
       "      <td>0.001314</td>\n",
       "      <td>-0.000084</td>\n",
       "      <td>-0.004016</td>\n",
       "      <td>-0.007463</td>\n",
       "      <td>-0.010762</td>\n",
       "      <td>8.762490e-04</td>\n",
       "      <td>0.017948</td>\n",
       "      <td>0.009462</td>\n",
       "      <td>-0.011137</td>\n",
       "      <td>0.025507</td>\n",
       "      <td>0.002068</td>\n",
       "      <td>0.005472</td>\n",
       "      <td>-0.000563</td>\n",
       "      <td>0.001782</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000394</td>\n",
       "      <td>0.001668</td>\n",
       "      <td>0.005121</td>\n",
       "      <td>-0.001088</td>\n",
       "      <td>-0.014086</td>\n",
       "      <td>-1.472430e-03</td>\n",
       "      <td>-0.000009</td>\n",
       "      <td>-0.000871</td>\n",
       "      <td>-0.008956</td>\n",
       "      <td>0.004815</td>\n",
       "      <td>0.005392</td>\n",
       "      <td>0.005291</td>\n",
       "      <td>-0.006255</td>\n",
       "      <td>-0.002920</td>\n",
       "      <td>-0.004533</td>\n",
       "      <td>0.010441</td>\n",
       "      <td>0.000329</td>\n",
       "      <td>-0.000241</td>\n",
       "      <td>0.016754</td>\n",
       "      <td>-0.012766</td>\n",
       "      <td>0.003871</td>\n",
       "      <td>-0.017730</td>\n",
       "      <td>-0.000959</td>\n",
       "      <td>0.001206</td>\n",
       "      <td>-0.006341</td>\n",
       "      <td>0.000874</td>\n",
       "      <td>0.002838</td>\n",
       "      <td>0.000429</td>\n",
       "      <td>0.003143</td>\n",
       "      <td>-0.001478</td>\n",
       "      <td>-0.001575</td>\n",
       "      <td>0.009191</td>\n",
       "      <td>0.007324</td>\n",
       "      <td>0.000240</td>\n",
       "      <td>-0.007556</td>\n",
       "      <td>-0.003043</td>\n",
       "      <td>-0.003183</td>\n",
       "      <td>0.000665</td>\n",
       "      <td>0.002266</td>\n",
       "      <td>0.001264</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>Brain_Caudate_basal_ganglia</td>\n",
       "      <td>-2.278672e-03</td>\n",
       "      <td>0.012482</td>\n",
       "      <td>0.004231</td>\n",
       "      <td>-0.004744</td>\n",
       "      <td>0.091918</td>\n",
       "      <td>-0.000414</td>\n",
       "      <td>-0.021047</td>\n",
       "      <td>0.001558</td>\n",
       "      <td>0.003570</td>\n",
       "      <td>0.007244</td>\n",
       "      <td>0.002540</td>\n",
       "      <td>5.521202e-04</td>\n",
       "      <td>0.000123</td>\n",
       "      <td>0.042740</td>\n",
       "      <td>-0.000877</td>\n",
       "      <td>-0.003464</td>\n",
       "      <td>0.008042</td>\n",
       "      <td>0.028503</td>\n",
       "      <td>-0.001876</td>\n",
       "      <td>0.000648</td>\n",
       "      <td>-0.002018</td>\n",
       "      <td>0.001951</td>\n",
       "      <td>0.000368</td>\n",
       "      <td>0.002994</td>\n",
       "      <td>0.009452</td>\n",
       "      <td>0.001650</td>\n",
       "      <td>0.000065</td>\n",
       "      <td>-0.003462</td>\n",
       "      <td>-0.005972</td>\n",
       "      <td>-0.008737</td>\n",
       "      <td>7.638694e-04</td>\n",
       "      <td>0.015572</td>\n",
       "      <td>0.009133</td>\n",
       "      <td>-0.013554</td>\n",
       "      <td>0.026158</td>\n",
       "      <td>0.003082</td>\n",
       "      <td>0.005000</td>\n",
       "      <td>-0.000441</td>\n",
       "      <td>0.003486</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000377</td>\n",
       "      <td>0.000794</td>\n",
       "      <td>0.002748</td>\n",
       "      <td>0.000102</td>\n",
       "      <td>-0.013618</td>\n",
       "      <td>-1.257414e-03</td>\n",
       "      <td>0.000085</td>\n",
       "      <td>-0.000853</td>\n",
       "      <td>-0.006904</td>\n",
       "      <td>0.004858</td>\n",
       "      <td>0.004517</td>\n",
       "      <td>0.004725</td>\n",
       "      <td>-0.006579</td>\n",
       "      <td>-0.002737</td>\n",
       "      <td>-0.003811</td>\n",
       "      <td>0.009035</td>\n",
       "      <td>0.000209</td>\n",
       "      <td>-0.000226</td>\n",
       "      <td>0.015245</td>\n",
       "      <td>-0.011803</td>\n",
       "      <td>0.003666</td>\n",
       "      <td>-0.012771</td>\n",
       "      <td>-0.000909</td>\n",
       "      <td>0.001383</td>\n",
       "      <td>-0.004740</td>\n",
       "      <td>0.000253</td>\n",
       "      <td>0.002731</td>\n",
       "      <td>0.000359</td>\n",
       "      <td>0.001905</td>\n",
       "      <td>-0.001725</td>\n",
       "      <td>-0.001378</td>\n",
       "      <td>0.004972</td>\n",
       "      <td>0.005848</td>\n",
       "      <td>0.000004</td>\n",
       "      <td>-0.007609</td>\n",
       "      <td>-0.002401</td>\n",
       "      <td>-0.003597</td>\n",
       "      <td>0.001352</td>\n",
       "      <td>0.001614</td>\n",
       "      <td>0.002608</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>Brain_Cerebellar_Hemisphere</td>\n",
       "      <td>-2.634194e-03</td>\n",
       "      <td>0.014901</td>\n",
       "      <td>0.005066</td>\n",
       "      <td>-0.003218</td>\n",
       "      <td>0.070018</td>\n",
       "      <td>0.000562</td>\n",
       "      <td>-0.021708</td>\n",
       "      <td>0.001329</td>\n",
       "      <td>0.003089</td>\n",
       "      <td>0.008852</td>\n",
       "      <td>-0.006507</td>\n",
       "      <td>5.516422e-04</td>\n",
       "      <td>-0.001474</td>\n",
       "      <td>0.043316</td>\n",
       "      <td>0.002383</td>\n",
       "      <td>0.002751</td>\n",
       "      <td>0.007300</td>\n",
       "      <td>0.022225</td>\n",
       "      <td>-0.002967</td>\n",
       "      <td>0.000430</td>\n",
       "      <td>-0.002789</td>\n",
       "      <td>0.000719</td>\n",
       "      <td>0.000441</td>\n",
       "      <td>0.002531</td>\n",
       "      <td>0.009549</td>\n",
       "      <td>0.000259</td>\n",
       "      <td>-0.000378</td>\n",
       "      <td>-0.003583</td>\n",
       "      <td>-0.006737</td>\n",
       "      <td>-0.013500</td>\n",
       "      <td>6.576996e-04</td>\n",
       "      <td>0.020310</td>\n",
       "      <td>0.008047</td>\n",
       "      <td>-0.011769</td>\n",
       "      <td>0.016336</td>\n",
       "      <td>0.001464</td>\n",
       "      <td>0.004652</td>\n",
       "      <td>-0.000581</td>\n",
       "      <td>-0.000122</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000243</td>\n",
       "      <td>-0.001914</td>\n",
       "      <td>0.009875</td>\n",
       "      <td>-0.003440</td>\n",
       "      <td>-0.011964</td>\n",
       "      <td>-1.274714e-03</td>\n",
       "      <td>0.000317</td>\n",
       "      <td>-0.001258</td>\n",
       "      <td>-0.007808</td>\n",
       "      <td>0.004369</td>\n",
       "      <td>0.005876</td>\n",
       "      <td>0.005739</td>\n",
       "      <td>-0.006848</td>\n",
       "      <td>-0.002593</td>\n",
       "      <td>-0.004783</td>\n",
       "      <td>0.011739</td>\n",
       "      <td>0.000270</td>\n",
       "      <td>-0.000147</td>\n",
       "      <td>0.019509</td>\n",
       "      <td>-0.012574</td>\n",
       "      <td>0.003071</td>\n",
       "      <td>-0.018510</td>\n",
       "      <td>-0.001093</td>\n",
       "      <td>0.000874</td>\n",
       "      <td>-0.009794</td>\n",
       "      <td>0.000497</td>\n",
       "      <td>0.002644</td>\n",
       "      <td>0.000155</td>\n",
       "      <td>0.002764</td>\n",
       "      <td>-0.002796</td>\n",
       "      <td>-0.001625</td>\n",
       "      <td>0.014419</td>\n",
       "      <td>0.005865</td>\n",
       "      <td>-0.001041</td>\n",
       "      <td>-0.006557</td>\n",
       "      <td>-0.003635</td>\n",
       "      <td>-0.001913</td>\n",
       "      <td>-0.001963</td>\n",
       "      <td>0.000768</td>\n",
       "      <td>0.001971</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>Brain_Cerebellum</td>\n",
       "      <td>-2.781179e-03</td>\n",
       "      <td>0.013936</td>\n",
       "      <td>0.005983</td>\n",
       "      <td>-0.005148</td>\n",
       "      <td>0.121446</td>\n",
       "      <td>-0.000935</td>\n",
       "      <td>-0.024225</td>\n",
       "      <td>0.002102</td>\n",
       "      <td>0.002302</td>\n",
       "      <td>0.011196</td>\n",
       "      <td>-0.006772</td>\n",
       "      <td>7.716754e-04</td>\n",
       "      <td>-0.002513</td>\n",
       "      <td>0.046564</td>\n",
       "      <td>0.004411</td>\n",
       "      <td>0.002444</td>\n",
       "      <td>0.005842</td>\n",
       "      <td>0.022640</td>\n",
       "      <td>-0.003447</td>\n",
       "      <td>0.000717</td>\n",
       "      <td>-0.002166</td>\n",
       "      <td>0.002410</td>\n",
       "      <td>0.000456</td>\n",
       "      <td>0.002144</td>\n",
       "      <td>0.011549</td>\n",
       "      <td>0.000291</td>\n",
       "      <td>-0.000209</td>\n",
       "      <td>-0.004429</td>\n",
       "      <td>-0.006879</td>\n",
       "      <td>-0.012343</td>\n",
       "      <td>4.906546e-04</td>\n",
       "      <td>0.021609</td>\n",
       "      <td>0.008958</td>\n",
       "      <td>-0.012984</td>\n",
       "      <td>0.026074</td>\n",
       "      <td>-0.000273</td>\n",
       "      <td>0.005793</td>\n",
       "      <td>-0.000648</td>\n",
       "      <td>0.004798</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000085</td>\n",
       "      <td>0.000472</td>\n",
       "      <td>0.009965</td>\n",
       "      <td>-0.004283</td>\n",
       "      <td>-0.011497</td>\n",
       "      <td>-1.250526e-03</td>\n",
       "      <td>0.000968</td>\n",
       "      <td>-0.001516</td>\n",
       "      <td>-0.007704</td>\n",
       "      <td>0.005179</td>\n",
       "      <td>0.006529</td>\n",
       "      <td>0.008958</td>\n",
       "      <td>-0.008812</td>\n",
       "      <td>-0.003048</td>\n",
       "      <td>-0.004953</td>\n",
       "      <td>0.012193</td>\n",
       "      <td>0.000319</td>\n",
       "      <td>-0.000479</td>\n",
       "      <td>0.026735</td>\n",
       "      <td>-0.015023</td>\n",
       "      <td>0.003842</td>\n",
       "      <td>-0.022093</td>\n",
       "      <td>-0.001177</td>\n",
       "      <td>0.001518</td>\n",
       "      <td>-0.004431</td>\n",
       "      <td>0.000158</td>\n",
       "      <td>0.003049</td>\n",
       "      <td>0.000060</td>\n",
       "      <td>0.003065</td>\n",
       "      <td>-0.002810</td>\n",
       "      <td>-0.001626</td>\n",
       "      <td>0.018691</td>\n",
       "      <td>0.006324</td>\n",
       "      <td>-0.001267</td>\n",
       "      <td>-0.008443</td>\n",
       "      <td>-0.004444</td>\n",
       "      <td>-0.002278</td>\n",
       "      <td>0.001151</td>\n",
       "      <td>0.001430</td>\n",
       "      <td>0.008633</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>Brain_Cortex</td>\n",
       "      <td>-2.279946e-03</td>\n",
       "      <td>0.014685</td>\n",
       "      <td>0.004498</td>\n",
       "      <td>-0.004910</td>\n",
       "      <td>0.096457</td>\n",
       "      <td>-0.000763</td>\n",
       "      <td>-0.020534</td>\n",
       "      <td>0.001138</td>\n",
       "      <td>0.004050</td>\n",
       "      <td>0.008887</td>\n",
       "      <td>-0.001991</td>\n",
       "      <td>6.127223e-04</td>\n",
       "      <td>-0.001452</td>\n",
       "      <td>0.038861</td>\n",
       "      <td>0.000619</td>\n",
       "      <td>0.003712</td>\n",
       "      <td>0.004953</td>\n",
       "      <td>0.024810</td>\n",
       "      <td>-0.002419</td>\n",
       "      <td>0.000275</td>\n",
       "      <td>-0.001806</td>\n",
       "      <td>0.002602</td>\n",
       "      <td>0.000420</td>\n",
       "      <td>0.002763</td>\n",
       "      <td>0.009419</td>\n",
       "      <td>0.000315</td>\n",
       "      <td>-0.000146</td>\n",
       "      <td>-0.004006</td>\n",
       "      <td>-0.005696</td>\n",
       "      <td>-0.010218</td>\n",
       "      <td>5.971358e-04</td>\n",
       "      <td>0.014888</td>\n",
       "      <td>0.006398</td>\n",
       "      <td>-0.008375</td>\n",
       "      <td>0.021018</td>\n",
       "      <td>0.000515</td>\n",
       "      <td>0.004206</td>\n",
       "      <td>-0.000494</td>\n",
       "      <td>0.002536</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000382</td>\n",
       "      <td>0.002173</td>\n",
       "      <td>0.001698</td>\n",
       "      <td>-0.003033</td>\n",
       "      <td>-0.012350</td>\n",
       "      <td>-1.342563e-03</td>\n",
       "      <td>0.000029</td>\n",
       "      <td>-0.001146</td>\n",
       "      <td>-0.007619</td>\n",
       "      <td>0.004590</td>\n",
       "      <td>0.005225</td>\n",
       "      <td>0.005512</td>\n",
       "      <td>-0.005870</td>\n",
       "      <td>-0.002658</td>\n",
       "      <td>-0.004568</td>\n",
       "      <td>0.008923</td>\n",
       "      <td>0.000283</td>\n",
       "      <td>-0.000446</td>\n",
       "      <td>0.019533</td>\n",
       "      <td>-0.011649</td>\n",
       "      <td>0.003164</td>\n",
       "      <td>-0.018434</td>\n",
       "      <td>-0.001068</td>\n",
       "      <td>0.001203</td>\n",
       "      <td>-0.004571</td>\n",
       "      <td>0.000596</td>\n",
       "      <td>0.002556</td>\n",
       "      <td>0.000542</td>\n",
       "      <td>0.001923</td>\n",
       "      <td>-0.001484</td>\n",
       "      <td>-0.001379</td>\n",
       "      <td>0.011843</td>\n",
       "      <td>0.005280</td>\n",
       "      <td>-0.000492</td>\n",
       "      <td>-0.007001</td>\n",
       "      <td>-0.003478</td>\n",
       "      <td>-0.001965</td>\n",
       "      <td>-0.001981</td>\n",
       "      <td>0.000884</td>\n",
       "      <td>0.003710</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>Brain_Frontal_Cortex_BA9</td>\n",
       "      <td>-2.249482e-03</td>\n",
       "      <td>0.014829</td>\n",
       "      <td>0.005627</td>\n",
       "      <td>-0.006216</td>\n",
       "      <td>0.090318</td>\n",
       "      <td>-0.000294</td>\n",
       "      <td>-0.023537</td>\n",
       "      <td>0.001764</td>\n",
       "      <td>0.004281</td>\n",
       "      <td>0.012019</td>\n",
       "      <td>-0.002280</td>\n",
       "      <td>7.112943e-04</td>\n",
       "      <td>-0.000588</td>\n",
       "      <td>0.046674</td>\n",
       "      <td>0.002311</td>\n",
       "      <td>0.002526</td>\n",
       "      <td>0.005211</td>\n",
       "      <td>0.025645</td>\n",
       "      <td>-0.002075</td>\n",
       "      <td>0.000890</td>\n",
       "      <td>-0.002620</td>\n",
       "      <td>0.003012</td>\n",
       "      <td>0.000385</td>\n",
       "      <td>0.002552</td>\n",
       "      <td>0.010117</td>\n",
       "      <td>0.001456</td>\n",
       "      <td>-0.000256</td>\n",
       "      <td>-0.003470</td>\n",
       "      <td>-0.006573</td>\n",
       "      <td>-0.010488</td>\n",
       "      <td>3.692992e-04</td>\n",
       "      <td>0.018826</td>\n",
       "      <td>0.009216</td>\n",
       "      <td>-0.019609</td>\n",
       "      <td>0.027922</td>\n",
       "      <td>-0.000165</td>\n",
       "      <td>0.004760</td>\n",
       "      <td>-0.000522</td>\n",
       "      <td>0.001560</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000127</td>\n",
       "      <td>-0.000115</td>\n",
       "      <td>0.006997</td>\n",
       "      <td>-0.001656</td>\n",
       "      <td>-0.009990</td>\n",
       "      <td>-1.322547e-03</td>\n",
       "      <td>0.000408</td>\n",
       "      <td>-0.002217</td>\n",
       "      <td>-0.007632</td>\n",
       "      <td>0.004946</td>\n",
       "      <td>0.005871</td>\n",
       "      <td>0.008881</td>\n",
       "      <td>-0.009740</td>\n",
       "      <td>-0.002575</td>\n",
       "      <td>-0.004578</td>\n",
       "      <td>0.009636</td>\n",
       "      <td>0.000347</td>\n",
       "      <td>-0.000350</td>\n",
       "      <td>0.022924</td>\n",
       "      <td>-0.014376</td>\n",
       "      <td>0.003909</td>\n",
       "      <td>-0.014395</td>\n",
       "      <td>-0.000993</td>\n",
       "      <td>0.001686</td>\n",
       "      <td>-0.006995</td>\n",
       "      <td>0.000821</td>\n",
       "      <td>0.002971</td>\n",
       "      <td>0.000290</td>\n",
       "      <td>0.002977</td>\n",
       "      <td>-0.001808</td>\n",
       "      <td>-0.001486</td>\n",
       "      <td>0.009269</td>\n",
       "      <td>0.006703</td>\n",
       "      <td>-0.000431</td>\n",
       "      <td>-0.008893</td>\n",
       "      <td>-0.004230</td>\n",
       "      <td>-0.002481</td>\n",
       "      <td>0.003960</td>\n",
       "      <td>0.001562</td>\n",
       "      <td>0.003592</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>Brain_Hippocampus</td>\n",
       "      <td>-2.218950e-03</td>\n",
       "      <td>0.011680</td>\n",
       "      <td>0.003914</td>\n",
       "      <td>-0.004056</td>\n",
       "      <td>0.081130</td>\n",
       "      <td>0.000187</td>\n",
       "      <td>-0.018402</td>\n",
       "      <td>0.001520</td>\n",
       "      <td>0.003678</td>\n",
       "      <td>0.006931</td>\n",
       "      <td>-0.000820</td>\n",
       "      <td>4.777322e-04</td>\n",
       "      <td>-0.000503</td>\n",
       "      <td>0.037012</td>\n",
       "      <td>-0.001106</td>\n",
       "      <td>0.000364</td>\n",
       "      <td>0.005931</td>\n",
       "      <td>0.023483</td>\n",
       "      <td>-0.002133</td>\n",
       "      <td>0.000546</td>\n",
       "      <td>-0.001660</td>\n",
       "      <td>0.001855</td>\n",
       "      <td>0.000259</td>\n",
       "      <td>0.002273</td>\n",
       "      <td>0.007637</td>\n",
       "      <td>0.001320</td>\n",
       "      <td>-0.000137</td>\n",
       "      <td>-0.003304</td>\n",
       "      <td>-0.004645</td>\n",
       "      <td>-0.008541</td>\n",
       "      <td>2.764147e-04</td>\n",
       "      <td>0.014767</td>\n",
       "      <td>0.006093</td>\n",
       "      <td>-0.016617</td>\n",
       "      <td>0.021947</td>\n",
       "      <td>0.001680</td>\n",
       "      <td>0.003667</td>\n",
       "      <td>-0.000430</td>\n",
       "      <td>0.004460</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000148</td>\n",
       "      <td>0.000963</td>\n",
       "      <td>0.001872</td>\n",
       "      <td>0.000168</td>\n",
       "      <td>-0.009977</td>\n",
       "      <td>-1.182301e-03</td>\n",
       "      <td>0.000158</td>\n",
       "      <td>-0.001038</td>\n",
       "      <td>-0.006572</td>\n",
       "      <td>0.003730</td>\n",
       "      <td>0.004069</td>\n",
       "      <td>0.005104</td>\n",
       "      <td>-0.006088</td>\n",
       "      <td>-0.002083</td>\n",
       "      <td>-0.003295</td>\n",
       "      <td>0.007863</td>\n",
       "      <td>0.000214</td>\n",
       "      <td>-0.000190</td>\n",
       "      <td>0.015188</td>\n",
       "      <td>-0.010471</td>\n",
       "      <td>0.002823</td>\n",
       "      <td>-0.011253</td>\n",
       "      <td>-0.000705</td>\n",
       "      <td>0.001018</td>\n",
       "      <td>-0.002350</td>\n",
       "      <td>0.000251</td>\n",
       "      <td>0.002131</td>\n",
       "      <td>0.000188</td>\n",
       "      <td>0.002177</td>\n",
       "      <td>-0.001202</td>\n",
       "      <td>-0.001101</td>\n",
       "      <td>0.002360</td>\n",
       "      <td>0.004416</td>\n",
       "      <td>-0.000284</td>\n",
       "      <td>-0.006410</td>\n",
       "      <td>-0.002893</td>\n",
       "      <td>-0.002653</td>\n",
       "      <td>-0.000084</td>\n",
       "      <td>-0.001017</td>\n",
       "      <td>0.004118</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>Brain_Hypothalamus</td>\n",
       "      <td>-2.172592e-03</td>\n",
       "      <td>0.015303</td>\n",
       "      <td>0.004613</td>\n",
       "      <td>-0.004876</td>\n",
       "      <td>0.056136</td>\n",
       "      <td>0.000241</td>\n",
       "      <td>-0.021123</td>\n",
       "      <td>0.001722</td>\n",
       "      <td>0.002741</td>\n",
       "      <td>0.010365</td>\n",
       "      <td>-0.003551</td>\n",
       "      <td>4.107611e-04</td>\n",
       "      <td>0.000129</td>\n",
       "      <td>0.038295</td>\n",
       "      <td>-0.001023</td>\n",
       "      <td>-0.001489</td>\n",
       "      <td>0.006579</td>\n",
       "      <td>0.021477</td>\n",
       "      <td>-0.002153</td>\n",
       "      <td>0.000724</td>\n",
       "      <td>-0.002678</td>\n",
       "      <td>-0.000611</td>\n",
       "      <td>0.000298</td>\n",
       "      <td>0.002340</td>\n",
       "      <td>0.008472</td>\n",
       "      <td>0.001535</td>\n",
       "      <td>-0.000221</td>\n",
       "      <td>-0.003345</td>\n",
       "      <td>-0.005544</td>\n",
       "      <td>-0.008700</td>\n",
       "      <td>5.104779e-04</td>\n",
       "      <td>0.015891</td>\n",
       "      <td>0.011398</td>\n",
       "      <td>-0.013220</td>\n",
       "      <td>0.021036</td>\n",
       "      <td>0.004119</td>\n",
       "      <td>0.003802</td>\n",
       "      <td>-0.000494</td>\n",
       "      <td>-0.000848</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000366</td>\n",
       "      <td>-0.000929</td>\n",
       "      <td>0.007372</td>\n",
       "      <td>-0.001717</td>\n",
       "      <td>-0.012047</td>\n",
       "      <td>-1.121792e-03</td>\n",
       "      <td>0.000362</td>\n",
       "      <td>-0.001084</td>\n",
       "      <td>-0.007766</td>\n",
       "      <td>0.004245</td>\n",
       "      <td>0.004688</td>\n",
       "      <td>0.006540</td>\n",
       "      <td>-0.007669</td>\n",
       "      <td>-0.002516</td>\n",
       "      <td>-0.003358</td>\n",
       "      <td>0.008699</td>\n",
       "      <td>0.000245</td>\n",
       "      <td>-0.000135</td>\n",
       "      <td>0.013857</td>\n",
       "      <td>-0.011245</td>\n",
       "      <td>0.003335</td>\n",
       "      <td>-0.013155</td>\n",
       "      <td>-0.001241</td>\n",
       "      <td>0.001092</td>\n",
       "      <td>-0.007649</td>\n",
       "      <td>0.000626</td>\n",
       "      <td>0.002715</td>\n",
       "      <td>0.000217</td>\n",
       "      <td>0.003065</td>\n",
       "      <td>-0.001809</td>\n",
       "      <td>-0.001263</td>\n",
       "      <td>0.004035</td>\n",
       "      <td>0.005400</td>\n",
       "      <td>-0.000295</td>\n",
       "      <td>-0.006687</td>\n",
       "      <td>-0.001828</td>\n",
       "      <td>-0.002827</td>\n",
       "      <td>-0.000041</td>\n",
       "      <td>0.002069</td>\n",
       "      <td>0.001994</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>Brain_Nucleus_accumbens_basal_ganglia</td>\n",
       "      <td>-2.008186e-03</td>\n",
       "      <td>0.011540</td>\n",
       "      <td>0.005012</td>\n",
       "      <td>-0.006265</td>\n",
       "      <td>0.090191</td>\n",
       "      <td>-0.001100</td>\n",
       "      <td>-0.022403</td>\n",
       "      <td>0.001887</td>\n",
       "      <td>0.004187</td>\n",
       "      <td>0.011409</td>\n",
       "      <td>-0.001624</td>\n",
       "      <td>5.673332e-04</td>\n",
       "      <td>-0.000633</td>\n",
       "      <td>0.046490</td>\n",
       "      <td>0.004696</td>\n",
       "      <td>0.001037</td>\n",
       "      <td>0.002512</td>\n",
       "      <td>0.023783</td>\n",
       "      <td>-0.002204</td>\n",
       "      <td>0.000798</td>\n",
       "      <td>-0.001833</td>\n",
       "      <td>0.003557</td>\n",
       "      <td>0.000244</td>\n",
       "      <td>0.002472</td>\n",
       "      <td>0.010025</td>\n",
       "      <td>0.001231</td>\n",
       "      <td>0.000095</td>\n",
       "      <td>-0.003857</td>\n",
       "      <td>-0.006823</td>\n",
       "      <td>-0.009633</td>\n",
       "      <td>5.319663e-05</td>\n",
       "      <td>0.020000</td>\n",
       "      <td>0.007879</td>\n",
       "      <td>-0.020450</td>\n",
       "      <td>0.024999</td>\n",
       "      <td>-0.003802</td>\n",
       "      <td>0.005091</td>\n",
       "      <td>-0.000467</td>\n",
       "      <td>0.004105</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000105</td>\n",
       "      <td>0.001943</td>\n",
       "      <td>0.006114</td>\n",
       "      <td>-0.001942</td>\n",
       "      <td>-0.009985</td>\n",
       "      <td>-1.388697e-03</td>\n",
       "      <td>0.000443</td>\n",
       "      <td>-0.001835</td>\n",
       "      <td>-0.004995</td>\n",
       "      <td>0.004501</td>\n",
       "      <td>0.005500</td>\n",
       "      <td>0.006692</td>\n",
       "      <td>-0.008924</td>\n",
       "      <td>-0.002488</td>\n",
       "      <td>-0.004465</td>\n",
       "      <td>0.009647</td>\n",
       "      <td>0.000330</td>\n",
       "      <td>-0.000455</td>\n",
       "      <td>0.022452</td>\n",
       "      <td>-0.013074</td>\n",
       "      <td>0.003634</td>\n",
       "      <td>-0.014905</td>\n",
       "      <td>-0.000579</td>\n",
       "      <td>0.001637</td>\n",
       "      <td>-0.004441</td>\n",
       "      <td>0.000381</td>\n",
       "      <td>0.002614</td>\n",
       "      <td>0.000238</td>\n",
       "      <td>0.002063</td>\n",
       "      <td>-0.001540</td>\n",
       "      <td>-0.001299</td>\n",
       "      <td>0.009827</td>\n",
       "      <td>0.005903</td>\n",
       "      <td>-0.001175</td>\n",
       "      <td>-0.007884</td>\n",
       "      <td>-0.004579</td>\n",
       "      <td>-0.001566</td>\n",
       "      <td>0.001448</td>\n",
       "      <td>-0.000864</td>\n",
       "      <td>0.004215</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>Brain_Putamen_basal_ganglia</td>\n",
       "      <td>-2.152133e-03</td>\n",
       "      <td>0.012703</td>\n",
       "      <td>0.004303</td>\n",
       "      <td>-0.006011</td>\n",
       "      <td>0.084859</td>\n",
       "      <td>-0.000511</td>\n",
       "      <td>-0.020996</td>\n",
       "      <td>0.001358</td>\n",
       "      <td>0.004448</td>\n",
       "      <td>0.010314</td>\n",
       "      <td>-0.002963</td>\n",
       "      <td>5.440183e-04</td>\n",
       "      <td>0.000540</td>\n",
       "      <td>0.039933</td>\n",
       "      <td>-0.002244</td>\n",
       "      <td>0.004214</td>\n",
       "      <td>0.008294</td>\n",
       "      <td>0.025931</td>\n",
       "      <td>-0.000739</td>\n",
       "      <td>0.000393</td>\n",
       "      <td>-0.001890</td>\n",
       "      <td>0.003419</td>\n",
       "      <td>0.000178</td>\n",
       "      <td>0.002995</td>\n",
       "      <td>0.010009</td>\n",
       "      <td>0.002444</td>\n",
       "      <td>0.000091</td>\n",
       "      <td>-0.003140</td>\n",
       "      <td>-0.006874</td>\n",
       "      <td>-0.009631</td>\n",
       "      <td>6.950340e-04</td>\n",
       "      <td>0.019538</td>\n",
       "      <td>0.006945</td>\n",
       "      <td>-0.014055</td>\n",
       "      <td>0.022490</td>\n",
       "      <td>-0.000449</td>\n",
       "      <td>0.003851</td>\n",
       "      <td>-0.000484</td>\n",
       "      <td>0.001932</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000364</td>\n",
       "      <td>0.000770</td>\n",
       "      <td>0.005247</td>\n",
       "      <td>-0.000559</td>\n",
       "      <td>-0.010795</td>\n",
       "      <td>-1.272609e-03</td>\n",
       "      <td>-0.000055</td>\n",
       "      <td>-0.001413</td>\n",
       "      <td>-0.007678</td>\n",
       "      <td>0.004421</td>\n",
       "      <td>0.004870</td>\n",
       "      <td>0.003509</td>\n",
       "      <td>-0.007124</td>\n",
       "      <td>-0.002952</td>\n",
       "      <td>-0.004723</td>\n",
       "      <td>0.007522</td>\n",
       "      <td>0.000279</td>\n",
       "      <td>-0.000177</td>\n",
       "      <td>0.016669</td>\n",
       "      <td>-0.012481</td>\n",
       "      <td>0.003495</td>\n",
       "      <td>-0.011671</td>\n",
       "      <td>-0.000725</td>\n",
       "      <td>0.000966</td>\n",
       "      <td>-0.006837</td>\n",
       "      <td>0.000600</td>\n",
       "      <td>0.002675</td>\n",
       "      <td>0.000341</td>\n",
       "      <td>0.002366</td>\n",
       "      <td>-0.001295</td>\n",
       "      <td>-0.001286</td>\n",
       "      <td>0.007089</td>\n",
       "      <td>0.006103</td>\n",
       "      <td>-0.000463</td>\n",
       "      <td>-0.006734</td>\n",
       "      <td>-0.002812</td>\n",
       "      <td>-0.002574</td>\n",
       "      <td>0.000327</td>\n",
       "      <td>0.001570</td>\n",
       "      <td>-0.001038</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>Brain_Spinal_cord_cervical_c_1</td>\n",
       "      <td>-1.516657e-03</td>\n",
       "      <td>0.007838</td>\n",
       "      <td>0.003248</td>\n",
       "      <td>-0.003078</td>\n",
       "      <td>0.023425</td>\n",
       "      <td>-0.000189</td>\n",
       "      <td>-0.013780</td>\n",
       "      <td>0.001680</td>\n",
       "      <td>0.002359</td>\n",
       "      <td>0.005409</td>\n",
       "      <td>-0.006517</td>\n",
       "      <td>2.604424e-04</td>\n",
       "      <td>0.000593</td>\n",
       "      <td>0.025423</td>\n",
       "      <td>-0.004316</td>\n",
       "      <td>-0.001098</td>\n",
       "      <td>0.011409</td>\n",
       "      <td>0.019890</td>\n",
       "      <td>-0.000086</td>\n",
       "      <td>0.000380</td>\n",
       "      <td>-0.001633</td>\n",
       "      <td>-0.000398</td>\n",
       "      <td>0.000164</td>\n",
       "      <td>0.002302</td>\n",
       "      <td>0.006442</td>\n",
       "      <td>0.003080</td>\n",
       "      <td>0.000007</td>\n",
       "      <td>-0.002768</td>\n",
       "      <td>-0.003797</td>\n",
       "      <td>-0.004296</td>\n",
       "      <td>7.933349e-04</td>\n",
       "      <td>0.015097</td>\n",
       "      <td>0.008926</td>\n",
       "      <td>-0.002185</td>\n",
       "      <td>0.014738</td>\n",
       "      <td>0.003357</td>\n",
       "      <td>0.002468</td>\n",
       "      <td>-0.000501</td>\n",
       "      <td>-0.002595</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000529</td>\n",
       "      <td>0.000493</td>\n",
       "      <td>0.006956</td>\n",
       "      <td>-0.000411</td>\n",
       "      <td>-0.012484</td>\n",
       "      <td>-9.699093e-04</td>\n",
       "      <td>-0.000177</td>\n",
       "      <td>-0.000218</td>\n",
       "      <td>-0.006034</td>\n",
       "      <td>0.003207</td>\n",
       "      <td>0.002989</td>\n",
       "      <td>0.001528</td>\n",
       "      <td>-0.004403</td>\n",
       "      <td>-0.001672</td>\n",
       "      <td>-0.003128</td>\n",
       "      <td>0.005870</td>\n",
       "      <td>0.000046</td>\n",
       "      <td>0.000159</td>\n",
       "      <td>0.004637</td>\n",
       "      <td>-0.007515</td>\n",
       "      <td>0.002787</td>\n",
       "      <td>-0.010968</td>\n",
       "      <td>-0.000800</td>\n",
       "      <td>0.000534</td>\n",
       "      <td>-0.007390</td>\n",
       "      <td>0.000441</td>\n",
       "      <td>0.001889</td>\n",
       "      <td>0.000207</td>\n",
       "      <td>0.003544</td>\n",
       "      <td>-0.001147</td>\n",
       "      <td>-0.000867</td>\n",
       "      <td>0.010533</td>\n",
       "      <td>0.003543</td>\n",
       "      <td>0.000523</td>\n",
       "      <td>-0.003739</td>\n",
       "      <td>-0.000020</td>\n",
       "      <td>-0.002449</td>\n",
       "      <td>0.001178</td>\n",
       "      <td>0.004070</td>\n",
       "      <td>-0.003346</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>Brain_Substantia_nigra</td>\n",
       "      <td>-1.822131e-03</td>\n",
       "      <td>0.011603</td>\n",
       "      <td>0.004033</td>\n",
       "      <td>-0.005913</td>\n",
       "      <td>0.029767</td>\n",
       "      <td>0.000019</td>\n",
       "      <td>-0.018461</td>\n",
       "      <td>0.001257</td>\n",
       "      <td>0.003933</td>\n",
       "      <td>0.006763</td>\n",
       "      <td>-0.002765</td>\n",
       "      <td>3.686941e-04</td>\n",
       "      <td>0.000668</td>\n",
       "      <td>0.035299</td>\n",
       "      <td>-0.001641</td>\n",
       "      <td>-0.000092</td>\n",
       "      <td>0.005074</td>\n",
       "      <td>0.025692</td>\n",
       "      <td>-0.001315</td>\n",
       "      <td>0.000582</td>\n",
       "      <td>-0.001789</td>\n",
       "      <td>0.001041</td>\n",
       "      <td>0.000283</td>\n",
       "      <td>0.002401</td>\n",
       "      <td>0.007957</td>\n",
       "      <td>0.001347</td>\n",
       "      <td>-0.000112</td>\n",
       "      <td>-0.003180</td>\n",
       "      <td>-0.005449</td>\n",
       "      <td>-0.008887</td>\n",
       "      <td>4.283443e-04</td>\n",
       "      <td>0.017119</td>\n",
       "      <td>0.009837</td>\n",
       "      <td>-0.017055</td>\n",
       "      <td>0.019524</td>\n",
       "      <td>0.001517</td>\n",
       "      <td>0.004042</td>\n",
       "      <td>-0.000446</td>\n",
       "      <td>-0.000424</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000327</td>\n",
       "      <td>0.000387</td>\n",
       "      <td>0.005482</td>\n",
       "      <td>-0.000507</td>\n",
       "      <td>-0.010668</td>\n",
       "      <td>-1.214582e-03</td>\n",
       "      <td>-0.000233</td>\n",
       "      <td>-0.001152</td>\n",
       "      <td>-0.005373</td>\n",
       "      <td>0.003797</td>\n",
       "      <td>0.004318</td>\n",
       "      <td>0.003256</td>\n",
       "      <td>-0.007778</td>\n",
       "      <td>-0.002434</td>\n",
       "      <td>-0.003654</td>\n",
       "      <td>0.007283</td>\n",
       "      <td>0.000208</td>\n",
       "      <td>-0.000144</td>\n",
       "      <td>0.011918</td>\n",
       "      <td>-0.010931</td>\n",
       "      <td>0.003230</td>\n",
       "      <td>-0.011297</td>\n",
       "      <td>-0.000775</td>\n",
       "      <td>0.001225</td>\n",
       "      <td>-0.005860</td>\n",
       "      <td>0.000587</td>\n",
       "      <td>0.002112</td>\n",
       "      <td>0.000316</td>\n",
       "      <td>0.001538</td>\n",
       "      <td>-0.001263</td>\n",
       "      <td>-0.001109</td>\n",
       "      <td>0.000909</td>\n",
       "      <td>0.005043</td>\n",
       "      <td>-0.000160</td>\n",
       "      <td>-0.005687</td>\n",
       "      <td>-0.002702</td>\n",
       "      <td>-0.002718</td>\n",
       "      <td>0.000314</td>\n",
       "      <td>0.000258</td>\n",
       "      <td>-0.000789</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>Breast_Mammary_Tissue</td>\n",
       "      <td>4.687478e-04</td>\n",
       "      <td>-0.005324</td>\n",
       "      <td>-0.001723</td>\n",
       "      <td>0.001615</td>\n",
       "      <td>0.016027</td>\n",
       "      <td>-0.000932</td>\n",
       "      <td>0.007939</td>\n",
       "      <td>-0.000869</td>\n",
       "      <td>-0.001061</td>\n",
       "      <td>-0.002455</td>\n",
       "      <td>0.006092</td>\n",
       "      <td>-1.080352e-04</td>\n",
       "      <td>-0.000455</td>\n",
       "      <td>-0.010291</td>\n",
       "      <td>0.005024</td>\n",
       "      <td>-0.001661</td>\n",
       "      <td>-0.006507</td>\n",
       "      <td>-0.012066</td>\n",
       "      <td>-0.000110</td>\n",
       "      <td>-0.000285</td>\n",
       "      <td>0.001369</td>\n",
       "      <td>0.001664</td>\n",
       "      <td>-0.000045</td>\n",
       "      <td>-0.000871</td>\n",
       "      <td>-0.002389</td>\n",
       "      <td>-0.001905</td>\n",
       "      <td>0.000238</td>\n",
       "      <td>0.001012</td>\n",
       "      <td>0.000964</td>\n",
       "      <td>0.002490</td>\n",
       "      <td>-5.793836e-04</td>\n",
       "      <td>-0.009644</td>\n",
       "      <td>-0.007457</td>\n",
       "      <td>-0.000063</td>\n",
       "      <td>-0.004504</td>\n",
       "      <td>-0.003867</td>\n",
       "      <td>-0.000112</td>\n",
       "      <td>0.000322</td>\n",
       "      <td>0.006339</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000259</td>\n",
       "      <td>0.002960</td>\n",
       "      <td>-0.004010</td>\n",
       "      <td>0.001751</td>\n",
       "      <td>0.007300</td>\n",
       "      <td>5.260597e-04</td>\n",
       "      <td>0.000677</td>\n",
       "      <td>0.000452</td>\n",
       "      <td>0.004053</td>\n",
       "      <td>-0.001563</td>\n",
       "      <td>-0.001631</td>\n",
       "      <td>-0.000531</td>\n",
       "      <td>0.003398</td>\n",
       "      <td>0.000730</td>\n",
       "      <td>0.001515</td>\n",
       "      <td>-0.003035</td>\n",
       "      <td>-0.000024</td>\n",
       "      <td>-0.000258</td>\n",
       "      <td>-0.000385</td>\n",
       "      <td>0.003807</td>\n",
       "      <td>-0.000873</td>\n",
       "      <td>0.005278</td>\n",
       "      <td>0.000540</td>\n",
       "      <td>-0.000095</td>\n",
       "      <td>0.007269</td>\n",
       "      <td>-0.000672</td>\n",
       "      <td>-0.001037</td>\n",
       "      <td>-0.000067</td>\n",
       "      <td>-0.001634</td>\n",
       "      <td>0.001367</td>\n",
       "      <td>0.000614</td>\n",
       "      <td>-0.000246</td>\n",
       "      <td>-0.001568</td>\n",
       "      <td>-0.000339</td>\n",
       "      <td>0.000464</td>\n",
       "      <td>0.000185</td>\n",
       "      <td>0.001306</td>\n",
       "      <td>0.001421</td>\n",
       "      <td>-0.004103</td>\n",
       "      <td>0.004161</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>Cells_EBV_transformed_lymphocytes</td>\n",
       "      <td>2.365113e-03</td>\n",
       "      <td>-0.010862</td>\n",
       "      <td>0.001155</td>\n",
       "      <td>-0.005572</td>\n",
       "      <td>-0.113850</td>\n",
       "      <td>0.000999</td>\n",
       "      <td>-0.005497</td>\n",
       "      <td>0.004395</td>\n",
       "      <td>-0.004071</td>\n",
       "      <td>0.005161</td>\n",
       "      <td>0.001155</td>\n",
       "      <td>-7.687986e-04</td>\n",
       "      <td>0.002151</td>\n",
       "      <td>0.004570</td>\n",
       "      <td>0.016140</td>\n",
       "      <td>0.002469</td>\n",
       "      <td>-0.006752</td>\n",
       "      <td>-0.014401</td>\n",
       "      <td>-0.000915</td>\n",
       "      <td>0.002186</td>\n",
       "      <td>0.000636</td>\n",
       "      <td>-0.005352</td>\n",
       "      <td>-0.000082</td>\n",
       "      <td>-0.001248</td>\n",
       "      <td>-0.005595</td>\n",
       "      <td>0.003720</td>\n",
       "      <td>0.000215</td>\n",
       "      <td>0.002458</td>\n",
       "      <td>0.002999</td>\n",
       "      <td>0.012233</td>\n",
       "      <td>-2.111701e-03</td>\n",
       "      <td>0.007944</td>\n",
       "      <td>0.022238</td>\n",
       "      <td>-0.038313</td>\n",
       "      <td>0.006989</td>\n",
       "      <td>0.001779</td>\n",
       "      <td>-0.002776</td>\n",
       "      <td>0.000089</td>\n",
       "      <td>-0.004360</td>\n",
       "      <td>...</td>\n",
       "      <td>0.001525</td>\n",
       "      <td>-0.010033</td>\n",
       "      <td>0.008012</td>\n",
       "      <td>-0.005547</td>\n",
       "      <td>0.007040</td>\n",
       "      <td>3.861532e-04</td>\n",
       "      <td>0.001616</td>\n",
       "      <td>-0.003433</td>\n",
       "      <td>0.007190</td>\n",
       "      <td>0.000392</td>\n",
       "      <td>0.000433</td>\n",
       "      <td>0.009480</td>\n",
       "      <td>-0.014081</td>\n",
       "      <td>0.002175</td>\n",
       "      <td>0.000647</td>\n",
       "      <td>-0.001129</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>0.000165</td>\n",
       "      <td>0.004600</td>\n",
       "      <td>-0.000785</td>\n",
       "      <td>-0.000023</td>\n",
       "      <td>0.008198</td>\n",
       "      <td>0.000171</td>\n",
       "      <td>0.001747</td>\n",
       "      <td>-0.005183</td>\n",
       "      <td>0.001000</td>\n",
       "      <td>-0.000433</td>\n",
       "      <td>-0.000817</td>\n",
       "      <td>-0.004120</td>\n",
       "      <td>-0.001744</td>\n",
       "      <td>0.000349</td>\n",
       "      <td>-0.012916</td>\n",
       "      <td>-0.004341</td>\n",
       "      <td>-0.000043</td>\n",
       "      <td>-0.002730</td>\n",
       "      <td>-0.003591</td>\n",
       "      <td>0.001007</td>\n",
       "      <td>0.012432</td>\n",
       "      <td>0.003209</td>\n",
       "      <td>0.003276</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>Cells_Transformed_fibroblasts</td>\n",
       "      <td>3.247789e-04</td>\n",
       "      <td>0.001775</td>\n",
       "      <td>-0.001395</td>\n",
       "      <td>0.004214</td>\n",
       "      <td>0.034439</td>\n",
       "      <td>0.001055</td>\n",
       "      <td>0.004489</td>\n",
       "      <td>-0.001705</td>\n",
       "      <td>-0.001697</td>\n",
       "      <td>-0.002489</td>\n",
       "      <td>0.004441</td>\n",
       "      <td>-4.693929e-05</td>\n",
       "      <td>0.001076</td>\n",
       "      <td>-0.005449</td>\n",
       "      <td>-0.002498</td>\n",
       "      <td>-0.005401</td>\n",
       "      <td>-0.000436</td>\n",
       "      <td>-0.003429</td>\n",
       "      <td>0.000308</td>\n",
       "      <td>-0.000259</td>\n",
       "      <td>-0.000230</td>\n",
       "      <td>-0.004008</td>\n",
       "      <td>-0.000133</td>\n",
       "      <td>-0.001064</td>\n",
       "      <td>-0.001799</td>\n",
       "      <td>-0.001131</td>\n",
       "      <td>-0.000144</td>\n",
       "      <td>0.001720</td>\n",
       "      <td>0.000865</td>\n",
       "      <td>-0.001137</td>\n",
       "      <td>5.425394e-04</td>\n",
       "      <td>-0.010403</td>\n",
       "      <td>-0.002169</td>\n",
       "      <td>0.011425</td>\n",
       "      <td>-0.004987</td>\n",
       "      <td>0.006449</td>\n",
       "      <td>0.000162</td>\n",
       "      <td>0.000072</td>\n",
       "      <td>-0.001941</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000027</td>\n",
       "      <td>-0.001933</td>\n",
       "      <td>-0.001726</td>\n",
       "      <td>0.002872</td>\n",
       "      <td>0.001566</td>\n",
       "      <td>3.441477e-04</td>\n",
       "      <td>-0.000099</td>\n",
       "      <td>0.001287</td>\n",
       "      <td>-0.002346</td>\n",
       "      <td>-0.000711</td>\n",
       "      <td>-0.001559</td>\n",
       "      <td>-0.001914</td>\n",
       "      <td>0.003494</td>\n",
       "      <td>0.000494</td>\n",
       "      <td>0.002155</td>\n",
       "      <td>-0.001326</td>\n",
       "      <td>-0.000060</td>\n",
       "      <td>0.000206</td>\n",
       "      <td>-0.008823</td>\n",
       "      <td>0.002688</td>\n",
       "      <td>-0.001388</td>\n",
       "      <td>0.004507</td>\n",
       "      <td>-0.000263</td>\n",
       "      <td>-0.000575</td>\n",
       "      <td>-0.000631</td>\n",
       "      <td>-0.000859</td>\n",
       "      <td>-0.000178</td>\n",
       "      <td>-0.000177</td>\n",
       "      <td>0.000559</td>\n",
       "      <td>0.001134</td>\n",
       "      <td>0.000168</td>\n",
       "      <td>-0.005319</td>\n",
       "      <td>-0.000151</td>\n",
       "      <td>0.000225</td>\n",
       "      <td>0.001030</td>\n",
       "      <td>0.002126</td>\n",
       "      <td>-0.001353</td>\n",
       "      <td>-0.002143</td>\n",
       "      <td>0.001850</td>\n",
       "      <td>-0.000427</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>Cervix_Ectocervix</td>\n",
       "      <td>1.504101e-05</td>\n",
       "      <td>-0.005681</td>\n",
       "      <td>-0.001405</td>\n",
       "      <td>0.003582</td>\n",
       "      <td>-0.000179</td>\n",
       "      <td>-0.000416</td>\n",
       "      <td>0.009240</td>\n",
       "      <td>-0.000862</td>\n",
       "      <td>-0.000712</td>\n",
       "      <td>-0.003611</td>\n",
       "      <td>-0.000355</td>\n",
       "      <td>-1.097001e-04</td>\n",
       "      <td>-0.001214</td>\n",
       "      <td>-0.013328</td>\n",
       "      <td>0.001155</td>\n",
       "      <td>0.002514</td>\n",
       "      <td>-0.002085</td>\n",
       "      <td>-0.011037</td>\n",
       "      <td>0.000304</td>\n",
       "      <td>-0.000716</td>\n",
       "      <td>0.000828</td>\n",
       "      <td>0.001288</td>\n",
       "      <td>-0.000021</td>\n",
       "      <td>-0.000783</td>\n",
       "      <td>-0.002726</td>\n",
       "      <td>-0.001031</td>\n",
       "      <td>0.000139</td>\n",
       "      <td>0.000937</td>\n",
       "      <td>0.001234</td>\n",
       "      <td>0.002977</td>\n",
       "      <td>-1.074258e-04</td>\n",
       "      <td>-0.006024</td>\n",
       "      <td>-0.007350</td>\n",
       "      <td>0.013802</td>\n",
       "      <td>-0.012737</td>\n",
       "      <td>-0.004199</td>\n",
       "      <td>-0.000599</td>\n",
       "      <td>0.000090</td>\n",
       "      <td>0.003024</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000081</td>\n",
       "      <td>0.001042</td>\n",
       "      <td>-0.002687</td>\n",
       "      <td>-0.000104</td>\n",
       "      <td>0.004330</td>\n",
       "      <td>3.316701e-04</td>\n",
       "      <td>0.000239</td>\n",
       "      <td>0.000712</td>\n",
       "      <td>0.001710</td>\n",
       "      <td>-0.001988</td>\n",
       "      <td>-0.001283</td>\n",
       "      <td>-0.002331</td>\n",
       "      <td>0.005943</td>\n",
       "      <td>0.001158</td>\n",
       "      <td>0.001000</td>\n",
       "      <td>-0.001944</td>\n",
       "      <td>-0.000083</td>\n",
       "      <td>-0.000023</td>\n",
       "      <td>-0.002101</td>\n",
       "      <td>0.005471</td>\n",
       "      <td>-0.001194</td>\n",
       "      <td>0.001865</td>\n",
       "      <td>0.000254</td>\n",
       "      <td>-0.000682</td>\n",
       "      <td>0.003769</td>\n",
       "      <td>-0.000372</td>\n",
       "      <td>-0.001189</td>\n",
       "      <td>0.000079</td>\n",
       "      <td>-0.000359</td>\n",
       "      <td>0.000406</td>\n",
       "      <td>0.000393</td>\n",
       "      <td>0.008516</td>\n",
       "      <td>-0.001618</td>\n",
       "      <td>-0.000243</td>\n",
       "      <td>0.001740</td>\n",
       "      <td>0.000490</td>\n",
       "      <td>0.001648</td>\n",
       "      <td>-0.001735</td>\n",
       "      <td>-0.001209</td>\n",
       "      <td>-0.000173</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>Cervix_Endocervix</td>\n",
       "      <td>1.162671e-04</td>\n",
       "      <td>-0.004829</td>\n",
       "      <td>-0.001208</td>\n",
       "      <td>0.003347</td>\n",
       "      <td>0.036227</td>\n",
       "      <td>-0.001013</td>\n",
       "      <td>0.008153</td>\n",
       "      <td>-0.000803</td>\n",
       "      <td>-0.001730</td>\n",
       "      <td>-0.000625</td>\n",
       "      <td>-0.000793</td>\n",
       "      <td>-1.179819e-04</td>\n",
       "      <td>-0.000214</td>\n",
       "      <td>-0.015193</td>\n",
       "      <td>0.000657</td>\n",
       "      <td>0.002133</td>\n",
       "      <td>-0.001734</td>\n",
       "      <td>-0.016604</td>\n",
       "      <td>0.000302</td>\n",
       "      <td>-0.000474</td>\n",
       "      <td>0.001155</td>\n",
       "      <td>-0.000030</td>\n",
       "      <td>-0.000053</td>\n",
       "      <td>-0.000901</td>\n",
       "      <td>-0.002502</td>\n",
       "      <td>-0.000182</td>\n",
       "      <td>0.000299</td>\n",
       "      <td>0.001628</td>\n",
       "      <td>0.000680</td>\n",
       "      <td>0.005584</td>\n",
       "      <td>-2.049881e-04</td>\n",
       "      <td>-0.004161</td>\n",
       "      <td>-0.005622</td>\n",
       "      <td>0.009916</td>\n",
       "      <td>-0.014983</td>\n",
       "      <td>-0.001349</td>\n",
       "      <td>-0.001013</td>\n",
       "      <td>-0.000016</td>\n",
       "      <td>0.002559</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000015</td>\n",
       "      <td>0.000163</td>\n",
       "      <td>-0.002675</td>\n",
       "      <td>-0.000292</td>\n",
       "      <td>0.004200</td>\n",
       "      <td>3.588821e-04</td>\n",
       "      <td>0.000636</td>\n",
       "      <td>0.000428</td>\n",
       "      <td>0.000777</td>\n",
       "      <td>-0.001712</td>\n",
       "      <td>-0.001621</td>\n",
       "      <td>-0.001950</td>\n",
       "      <td>0.005346</td>\n",
       "      <td>0.001168</td>\n",
       "      <td>0.000749</td>\n",
       "      <td>-0.002377</td>\n",
       "      <td>-0.000074</td>\n",
       "      <td>0.000124</td>\n",
       "      <td>-0.001560</td>\n",
       "      <td>0.005128</td>\n",
       "      <td>-0.001284</td>\n",
       "      <td>0.000617</td>\n",
       "      <td>0.000347</td>\n",
       "      <td>-0.000811</td>\n",
       "      <td>0.001402</td>\n",
       "      <td>-0.000827</td>\n",
       "      <td>-0.001039</td>\n",
       "      <td>-0.000036</td>\n",
       "      <td>-0.000584</td>\n",
       "      <td>0.000465</td>\n",
       "      <td>0.000441</td>\n",
       "      <td>0.004386</td>\n",
       "      <td>-0.002231</td>\n",
       "      <td>-0.000314</td>\n",
       "      <td>0.001379</td>\n",
       "      <td>0.001435</td>\n",
       "      <td>0.001482</td>\n",
       "      <td>-0.003539</td>\n",
       "      <td>0.001705</td>\n",
       "      <td>-0.000206</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>Colon_Sigmoid</td>\n",
       "      <td>-4.677901e-04</td>\n",
       "      <td>0.000121</td>\n",
       "      <td>-0.000446</td>\n",
       "      <td>0.000838</td>\n",
       "      <td>0.021186</td>\n",
       "      <td>-0.000767</td>\n",
       "      <td>0.001712</td>\n",
       "      <td>-0.000367</td>\n",
       "      <td>0.000047</td>\n",
       "      <td>-0.000647</td>\n",
       "      <td>-0.000750</td>\n",
       "      <td>-1.366718e-04</td>\n",
       "      <td>-0.000159</td>\n",
       "      <td>-0.004104</td>\n",
       "      <td>-0.002224</td>\n",
       "      <td>-0.001428</td>\n",
       "      <td>0.000318</td>\n",
       "      <td>-0.004771</td>\n",
       "      <td>-0.000305</td>\n",
       "      <td>-0.000485</td>\n",
       "      <td>0.000632</td>\n",
       "      <td>0.001969</td>\n",
       "      <td>0.000168</td>\n",
       "      <td>0.000411</td>\n",
       "      <td>0.000123</td>\n",
       "      <td>0.000133</td>\n",
       "      <td>0.000086</td>\n",
       "      <td>-0.000128</td>\n",
       "      <td>0.000161</td>\n",
       "      <td>0.002658</td>\n",
       "      <td>-1.106441e-04</td>\n",
       "      <td>0.000906</td>\n",
       "      <td>-0.005403</td>\n",
       "      <td>0.002876</td>\n",
       "      <td>-0.009034</td>\n",
       "      <td>-0.002987</td>\n",
       "      <td>-0.000786</td>\n",
       "      <td>-0.000003</td>\n",
       "      <td>0.000561</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000066</td>\n",
       "      <td>0.003467</td>\n",
       "      <td>-0.003363</td>\n",
       "      <td>0.000318</td>\n",
       "      <td>-0.001524</td>\n",
       "      <td>7.831063e-07</td>\n",
       "      <td>0.000052</td>\n",
       "      <td>0.000143</td>\n",
       "      <td>0.000006</td>\n",
       "      <td>-0.001045</td>\n",
       "      <td>-0.000282</td>\n",
       "      <td>-0.002061</td>\n",
       "      <td>0.001642</td>\n",
       "      <td>-0.000102</td>\n",
       "      <td>-0.000356</td>\n",
       "      <td>-0.001574</td>\n",
       "      <td>0.000013</td>\n",
       "      <td>-0.000126</td>\n",
       "      <td>0.001732</td>\n",
       "      <td>0.001456</td>\n",
       "      <td>-0.000167</td>\n",
       "      <td>-0.004096</td>\n",
       "      <td>0.000090</td>\n",
       "      <td>-0.000276</td>\n",
       "      <td>0.000468</td>\n",
       "      <td>-0.000464</td>\n",
       "      <td>-0.000490</td>\n",
       "      <td>0.000160</td>\n",
       "      <td>0.000469</td>\n",
       "      <td>0.000001</td>\n",
       "      <td>0.000082</td>\n",
       "      <td>0.007467</td>\n",
       "      <td>-0.000601</td>\n",
       "      <td>-0.000241</td>\n",
       "      <td>0.001284</td>\n",
       "      <td>0.000624</td>\n",
       "      <td>0.001222</td>\n",
       "      <td>-0.003636</td>\n",
       "      <td>-0.000721</td>\n",
       "      <td>-0.001881</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>Colon_Transverse</td>\n",
       "      <td>7.112175e-04</td>\n",
       "      <td>-0.007063</td>\n",
       "      <td>-0.000792</td>\n",
       "      <td>-0.002899</td>\n",
       "      <td>0.021977</td>\n",
       "      <td>-0.002285</td>\n",
       "      <td>0.004390</td>\n",
       "      <td>-0.000082</td>\n",
       "      <td>-0.000027</td>\n",
       "      <td>-0.002160</td>\n",
       "      <td>0.010641</td>\n",
       "      <td>-2.297021e-04</td>\n",
       "      <td>-0.001150</td>\n",
       "      <td>0.001883</td>\n",
       "      <td>0.011773</td>\n",
       "      <td>-0.002442</td>\n",
       "      <td>-0.010278</td>\n",
       "      <td>-0.005569</td>\n",
       "      <td>-0.000786</td>\n",
       "      <td>0.000195</td>\n",
       "      <td>0.002227</td>\n",
       "      <td>0.004785</td>\n",
       "      <td>-0.000054</td>\n",
       "      <td>-0.001082</td>\n",
       "      <td>-0.001192</td>\n",
       "      <td>-0.001753</td>\n",
       "      <td>0.000691</td>\n",
       "      <td>0.000713</td>\n",
       "      <td>-0.000427</td>\n",
       "      <td>0.002753</td>\n",
       "      <td>-1.285384e-03</td>\n",
       "      <td>-0.004495</td>\n",
       "      <td>-0.005349</td>\n",
       "      <td>-0.013923</td>\n",
       "      <td>0.000810</td>\n",
       "      <td>-0.008901</td>\n",
       "      <td>0.000629</td>\n",
       "      <td>0.000385</td>\n",
       "      <td>0.014977</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000600</td>\n",
       "      <td>0.001305</td>\n",
       "      <td>-0.010556</td>\n",
       "      <td>0.000289</td>\n",
       "      <td>0.008385</td>\n",
       "      <td>3.273166e-04</td>\n",
       "      <td>0.001145</td>\n",
       "      <td>-0.000894</td>\n",
       "      <td>0.005004</td>\n",
       "      <td>-0.001136</td>\n",
       "      <td>-0.000842</td>\n",
       "      <td>0.001583</td>\n",
       "      <td>0.000632</td>\n",
       "      <td>0.000420</td>\n",
       "      <td>0.000425</td>\n",
       "      <td>-0.001025</td>\n",
       "      <td>0.000104</td>\n",
       "      <td>-0.000462</td>\n",
       "      <td>0.007431</td>\n",
       "      <td>0.001299</td>\n",
       "      <td>-0.000569</td>\n",
       "      <td>0.005274</td>\n",
       "      <td>0.000663</td>\n",
       "      <td>0.000667</td>\n",
       "      <td>0.012118</td>\n",
       "      <td>-0.000544</td>\n",
       "      <td>-0.000610</td>\n",
       "      <td>-0.000036</td>\n",
       "      <td>-0.003433</td>\n",
       "      <td>0.001017</td>\n",
       "      <td>0.000343</td>\n",
       "      <td>-0.004420</td>\n",
       "      <td>-0.001567</td>\n",
       "      <td>-0.000696</td>\n",
       "      <td>-0.001949</td>\n",
       "      <td>-0.002511</td>\n",
       "      <td>0.000330</td>\n",
       "      <td>0.004523</td>\n",
       "      <td>-0.004536</td>\n",
       "      <td>0.008752</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>Esophagus_Gastroesophageal_Junction</td>\n",
       "      <td>-4.213836e-04</td>\n",
       "      <td>0.000103</td>\n",
       "      <td>-0.000820</td>\n",
       "      <td>0.002426</td>\n",
       "      <td>0.004356</td>\n",
       "      <td>-0.001078</td>\n",
       "      <td>0.006078</td>\n",
       "      <td>-0.001023</td>\n",
       "      <td>0.000225</td>\n",
       "      <td>-0.002119</td>\n",
       "      <td>-0.003867</td>\n",
       "      <td>6.052521e-05</td>\n",
       "      <td>-0.000953</td>\n",
       "      <td>-0.012676</td>\n",
       "      <td>-0.002021</td>\n",
       "      <td>0.000690</td>\n",
       "      <td>0.001509</td>\n",
       "      <td>-0.006043</td>\n",
       "      <td>0.000523</td>\n",
       "      <td>-0.000713</td>\n",
       "      <td>0.000531</td>\n",
       "      <td>0.003468</td>\n",
       "      <td>0.000096</td>\n",
       "      <td>-0.000155</td>\n",
       "      <td>-0.000113</td>\n",
       "      <td>-0.000701</td>\n",
       "      <td>-0.000021</td>\n",
       "      <td>0.000083</td>\n",
       "      <td>0.000826</td>\n",
       "      <td>0.001142</td>\n",
       "      <td>3.210505e-04</td>\n",
       "      <td>-0.000918</td>\n",
       "      <td>-0.010530</td>\n",
       "      <td>0.012025</td>\n",
       "      <td>-0.009762</td>\n",
       "      <td>-0.006954</td>\n",
       "      <td>-0.000942</td>\n",
       "      <td>0.000114</td>\n",
       "      <td>0.002117</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000331</td>\n",
       "      <td>0.005584</td>\n",
       "      <td>-0.002333</td>\n",
       "      <td>0.000574</td>\n",
       "      <td>0.000097</td>\n",
       "      <td>1.073925e-04</td>\n",
       "      <td>-0.000120</td>\n",
       "      <td>0.000737</td>\n",
       "      <td>0.000563</td>\n",
       "      <td>-0.001513</td>\n",
       "      <td>-0.000935</td>\n",
       "      <td>-0.003787</td>\n",
       "      <td>0.005356</td>\n",
       "      <td>0.000081</td>\n",
       "      <td>0.000108</td>\n",
       "      <td>-0.001551</td>\n",
       "      <td>-0.000116</td>\n",
       "      <td>-0.000129</td>\n",
       "      <td>-0.002304</td>\n",
       "      <td>0.002476</td>\n",
       "      <td>-0.000539</td>\n",
       "      <td>-0.002357</td>\n",
       "      <td>0.000314</td>\n",
       "      <td>-0.001045</td>\n",
       "      <td>0.003489</td>\n",
       "      <td>0.000140</td>\n",
       "      <td>-0.000809</td>\n",
       "      <td>0.000192</td>\n",
       "      <td>0.001422</td>\n",
       "      <td>0.000340</td>\n",
       "      <td>0.000267</td>\n",
       "      <td>0.010927</td>\n",
       "      <td>-0.000908</td>\n",
       "      <td>-0.000022</td>\n",
       "      <td>0.003352</td>\n",
       "      <td>0.001438</td>\n",
       "      <td>0.002249</td>\n",
       "      <td>-0.003707</td>\n",
       "      <td>-0.001474</td>\n",
       "      <td>-0.002173</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>Esophagus_Mucosa</td>\n",
       "      <td>2.159301e-03</td>\n",
       "      <td>-0.012406</td>\n",
       "      <td>-0.001647</td>\n",
       "      <td>-0.003074</td>\n",
       "      <td>-0.002762</td>\n",
       "      <td>-0.002209</td>\n",
       "      <td>0.007977</td>\n",
       "      <td>0.000121</td>\n",
       "      <td>-0.003456</td>\n",
       "      <td>-0.003974</td>\n",
       "      <td>0.020866</td>\n",
       "      <td>-5.721882e-04</td>\n",
       "      <td>-0.001803</td>\n",
       "      <td>-0.001615</td>\n",
       "      <td>0.027040</td>\n",
       "      <td>-0.006710</td>\n",
       "      <td>-0.023098</td>\n",
       "      <td>-0.020222</td>\n",
       "      <td>-0.002198</td>\n",
       "      <td>0.001167</td>\n",
       "      <td>0.003081</td>\n",
       "      <td>0.003121</td>\n",
       "      <td>-0.000071</td>\n",
       "      <td>-0.003872</td>\n",
       "      <td>-0.006540</td>\n",
       "      <td>-0.005183</td>\n",
       "      <td>0.000509</td>\n",
       "      <td>0.002628</td>\n",
       "      <td>0.002307</td>\n",
       "      <td>0.005373</td>\n",
       "      <td>-2.455629e-03</td>\n",
       "      <td>-0.015873</td>\n",
       "      <td>-0.002104</td>\n",
       "      <td>-0.027827</td>\n",
       "      <td>0.006735</td>\n",
       "      <td>-0.007500</td>\n",
       "      <td>0.001675</td>\n",
       "      <td>0.000678</td>\n",
       "      <td>0.018626</td>\n",
       "      <td>...</td>\n",
       "      <td>0.001604</td>\n",
       "      <td>-0.002257</td>\n",
       "      <td>-0.012260</td>\n",
       "      <td>-0.001459</td>\n",
       "      <td>0.019331</td>\n",
       "      <td>1.102475e-03</td>\n",
       "      <td>0.002632</td>\n",
       "      <td>-0.001898</td>\n",
       "      <td>0.010239</td>\n",
       "      <td>-0.002122</td>\n",
       "      <td>-0.001582</td>\n",
       "      <td>0.010989</td>\n",
       "      <td>-0.002589</td>\n",
       "      <td>0.002392</td>\n",
       "      <td>0.003892</td>\n",
       "      <td>-0.001386</td>\n",
       "      <td>0.000330</td>\n",
       "      <td>-0.000821</td>\n",
       "      <td>0.011069</td>\n",
       "      <td>0.003677</td>\n",
       "      <td>-0.001808</td>\n",
       "      <td>0.014938</td>\n",
       "      <td>0.000879</td>\n",
       "      <td>0.001372</td>\n",
       "      <td>0.017480</td>\n",
       "      <td>-0.000674</td>\n",
       "      <td>-0.001517</td>\n",
       "      <td>-0.000557</td>\n",
       "      <td>-0.005638</td>\n",
       "      <td>0.001339</td>\n",
       "      <td>0.000934</td>\n",
       "      <td>-0.014600</td>\n",
       "      <td>-0.002617</td>\n",
       "      <td>-0.001104</td>\n",
       "      <td>-0.003793</td>\n",
       "      <td>-0.004503</td>\n",
       "      <td>0.001176</td>\n",
       "      <td>0.012925</td>\n",
       "      <td>-0.007667</td>\n",
       "      <td>0.021668</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>Esophagus_Muscularis</td>\n",
       "      <td>-1.149822e-03</td>\n",
       "      <td>0.003060</td>\n",
       "      <td>-0.000472</td>\n",
       "      <td>0.002073</td>\n",
       "      <td>-0.003436</td>\n",
       "      <td>-0.000523</td>\n",
       "      <td>0.002022</td>\n",
       "      <td>-0.000768</td>\n",
       "      <td>0.001076</td>\n",
       "      <td>0.000099</td>\n",
       "      <td>-0.003241</td>\n",
       "      <td>6.357289e-05</td>\n",
       "      <td>-0.000143</td>\n",
       "      <td>-0.002839</td>\n",
       "      <td>-0.006156</td>\n",
       "      <td>0.000891</td>\n",
       "      <td>0.000905</td>\n",
       "      <td>0.000527</td>\n",
       "      <td>-0.000292</td>\n",
       "      <td>-0.000618</td>\n",
       "      <td>0.000091</td>\n",
       "      <td>0.001776</td>\n",
       "      <td>0.000135</td>\n",
       "      <td>0.000777</td>\n",
       "      <td>0.001864</td>\n",
       "      <td>0.000422</td>\n",
       "      <td>0.000042</td>\n",
       "      <td>-0.000178</td>\n",
       "      <td>-0.000050</td>\n",
       "      <td>-0.000439</td>\n",
       "      <td>1.425713e-04</td>\n",
       "      <td>-0.000454</td>\n",
       "      <td>-0.007579</td>\n",
       "      <td>0.005570</td>\n",
       "      <td>-0.008035</td>\n",
       "      <td>-0.002065</td>\n",
       "      <td>-0.000863</td>\n",
       "      <td>-0.000013</td>\n",
       "      <td>0.003108</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000570</td>\n",
       "      <td>0.004798</td>\n",
       "      <td>-0.004850</td>\n",
       "      <td>0.001130</td>\n",
       "      <td>-0.002050</td>\n",
       "      <td>-1.498157e-04</td>\n",
       "      <td>0.000026</td>\n",
       "      <td>0.000744</td>\n",
       "      <td>-0.000823</td>\n",
       "      <td>-0.000476</td>\n",
       "      <td>-0.000588</td>\n",
       "      <td>-0.004151</td>\n",
       "      <td>0.004955</td>\n",
       "      <td>-0.000896</td>\n",
       "      <td>-0.000409</td>\n",
       "      <td>-0.000882</td>\n",
       "      <td>-0.000090</td>\n",
       "      <td>0.000034</td>\n",
       "      <td>-0.002497</td>\n",
       "      <td>0.000750</td>\n",
       "      <td>0.000036</td>\n",
       "      <td>-0.002624</td>\n",
       "      <td>-0.000044</td>\n",
       "      <td>-0.000652</td>\n",
       "      <td>0.002226</td>\n",
       "      <td>-0.000146</td>\n",
       "      <td>-0.000321</td>\n",
       "      <td>0.000218</td>\n",
       "      <td>0.000741</td>\n",
       "      <td>0.000699</td>\n",
       "      <td>0.000186</td>\n",
       "      <td>0.005077</td>\n",
       "      <td>-0.000952</td>\n",
       "      <td>0.000081</td>\n",
       "      <td>0.002215</td>\n",
       "      <td>0.001423</td>\n",
       "      <td>0.000388</td>\n",
       "      <td>-0.003392</td>\n",
       "      <td>-0.001377</td>\n",
       "      <td>-0.002081</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>Fallopian_Tube</td>\n",
       "      <td>-3.916526e-05</td>\n",
       "      <td>-0.006011</td>\n",
       "      <td>-0.001469</td>\n",
       "      <td>0.001983</td>\n",
       "      <td>0.029846</td>\n",
       "      <td>-0.000217</td>\n",
       "      <td>0.007764</td>\n",
       "      <td>-0.000554</td>\n",
       "      <td>-0.002052</td>\n",
       "      <td>-0.002905</td>\n",
       "      <td>0.003662</td>\n",
       "      <td>-2.171636e-04</td>\n",
       "      <td>-0.000963</td>\n",
       "      <td>-0.008566</td>\n",
       "      <td>0.004882</td>\n",
       "      <td>-0.000646</td>\n",
       "      <td>-0.004542</td>\n",
       "      <td>-0.014020</td>\n",
       "      <td>-0.000303</td>\n",
       "      <td>-0.000232</td>\n",
       "      <td>0.001483</td>\n",
       "      <td>0.001123</td>\n",
       "      <td>-0.000078</td>\n",
       "      <td>-0.001097</td>\n",
       "      <td>-0.002705</td>\n",
       "      <td>-0.001064</td>\n",
       "      <td>0.000247</td>\n",
       "      <td>0.001355</td>\n",
       "      <td>0.000374</td>\n",
       "      <td>0.004453</td>\n",
       "      <td>-7.850422e-04</td>\n",
       "      <td>-0.004805</td>\n",
       "      <td>-0.007713</td>\n",
       "      <td>-0.001804</td>\n",
       "      <td>-0.012455</td>\n",
       "      <td>-0.002633</td>\n",
       "      <td>-0.000784</td>\n",
       "      <td>0.000195</td>\n",
       "      <td>0.008362</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000525</td>\n",
       "      <td>-0.001161</td>\n",
       "      <td>-0.004483</td>\n",
       "      <td>0.001385</td>\n",
       "      <td>0.006133</td>\n",
       "      <td>5.639457e-04</td>\n",
       "      <td>0.000871</td>\n",
       "      <td>-0.000164</td>\n",
       "      <td>0.002031</td>\n",
       "      <td>-0.002179</td>\n",
       "      <td>-0.001790</td>\n",
       "      <td>-0.001130</td>\n",
       "      <td>0.002929</td>\n",
       "      <td>0.000967</td>\n",
       "      <td>0.000725</td>\n",
       "      <td>-0.001754</td>\n",
       "      <td>0.000010</td>\n",
       "      <td>0.000123</td>\n",
       "      <td>0.003095</td>\n",
       "      <td>0.003903</td>\n",
       "      <td>-0.001245</td>\n",
       "      <td>0.002981</td>\n",
       "      <td>0.000460</td>\n",
       "      <td>-0.000437</td>\n",
       "      <td>0.005233</td>\n",
       "      <td>-0.000850</td>\n",
       "      <td>-0.000931</td>\n",
       "      <td>-0.000153</td>\n",
       "      <td>-0.001046</td>\n",
       "      <td>0.000387</td>\n",
       "      <td>0.000353</td>\n",
       "      <td>0.001260</td>\n",
       "      <td>-0.002223</td>\n",
       "      <td>-0.000603</td>\n",
       "      <td>0.000641</td>\n",
       "      <td>0.000150</td>\n",
       "      <td>0.000987</td>\n",
       "      <td>-0.000418</td>\n",
       "      <td>-0.003064</td>\n",
       "      <td>0.002734</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>Heart_Atrial_Appendage</td>\n",
       "      <td>-3.049119e-04</td>\n",
       "      <td>0.003422</td>\n",
       "      <td>-0.000106</td>\n",
       "      <td>0.000981</td>\n",
       "      <td>-0.012010</td>\n",
       "      <td>-0.000508</td>\n",
       "      <td>-0.000607</td>\n",
       "      <td>-0.000359</td>\n",
       "      <td>0.001367</td>\n",
       "      <td>-0.000879</td>\n",
       "      <td>-0.000112</td>\n",
       "      <td>3.178129e-07</td>\n",
       "      <td>0.000136</td>\n",
       "      <td>0.005346</td>\n",
       "      <td>-0.002406</td>\n",
       "      <td>-0.004573</td>\n",
       "      <td>-0.000129</td>\n",
       "      <td>0.004394</td>\n",
       "      <td>-0.000342</td>\n",
       "      <td>-0.000264</td>\n",
       "      <td>-0.000273</td>\n",
       "      <td>0.000231</td>\n",
       "      <td>0.000069</td>\n",
       "      <td>0.000276</td>\n",
       "      <td>0.000694</td>\n",
       "      <td>0.000270</td>\n",
       "      <td>-0.000040</td>\n",
       "      <td>-0.000305</td>\n",
       "      <td>0.000618</td>\n",
       "      <td>0.000020</td>\n",
       "      <td>3.837496e-04</td>\n",
       "      <td>-0.000910</td>\n",
       "      <td>-0.003267</td>\n",
       "      <td>0.003115</td>\n",
       "      <td>0.000643</td>\n",
       "      <td>-0.000366</td>\n",
       "      <td>-0.000081</td>\n",
       "      <td>-0.000037</td>\n",
       "      <td>0.001293</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000252</td>\n",
       "      <td>0.003924</td>\n",
       "      <td>-0.003629</td>\n",
       "      <td>0.001033</td>\n",
       "      <td>-0.003581</td>\n",
       "      <td>-2.300594e-04</td>\n",
       "      <td>-0.000076</td>\n",
       "      <td>0.000616</td>\n",
       "      <td>-0.000221</td>\n",
       "      <td>-0.000106</td>\n",
       "      <td>-0.000171</td>\n",
       "      <td>-0.002168</td>\n",
       "      <td>0.002449</td>\n",
       "      <td>0.000056</td>\n",
       "      <td>0.000053</td>\n",
       "      <td>-0.000980</td>\n",
       "      <td>-0.000059</td>\n",
       "      <td>-0.000100</td>\n",
       "      <td>-0.003814</td>\n",
       "      <td>0.000357</td>\n",
       "      <td>-0.000405</td>\n",
       "      <td>-0.003301</td>\n",
       "      <td>0.000018</td>\n",
       "      <td>-0.000140</td>\n",
       "      <td>0.002935</td>\n",
       "      <td>0.000133</td>\n",
       "      <td>-0.000110</td>\n",
       "      <td>0.000238</td>\n",
       "      <td>0.000744</td>\n",
       "      <td>0.000146</td>\n",
       "      <td>0.000020</td>\n",
       "      <td>0.001005</td>\n",
       "      <td>0.000006</td>\n",
       "      <td>0.000392</td>\n",
       "      <td>0.001078</td>\n",
       "      <td>0.000801</td>\n",
       "      <td>0.000747</td>\n",
       "      <td>-0.001094</td>\n",
       "      <td>-0.001703</td>\n",
       "      <td>-0.001386</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>32</th>\n",
       "      <td>Heart_Left_Ventricle</td>\n",
       "      <td>-2.449080e-04</td>\n",
       "      <td>0.004179</td>\n",
       "      <td>0.000980</td>\n",
       "      <td>-0.000111</td>\n",
       "      <td>0.009336</td>\n",
       "      <td>-0.000207</td>\n",
       "      <td>-0.006901</td>\n",
       "      <td>0.000496</td>\n",
       "      <td>0.001430</td>\n",
       "      <td>-0.000122</td>\n",
       "      <td>0.003545</td>\n",
       "      <td>1.155678e-04</td>\n",
       "      <td>0.000537</td>\n",
       "      <td>0.017310</td>\n",
       "      <td>-0.001194</td>\n",
       "      <td>-0.005227</td>\n",
       "      <td>0.004684</td>\n",
       "      <td>0.013546</td>\n",
       "      <td>0.000198</td>\n",
       "      <td>0.000105</td>\n",
       "      <td>-0.000852</td>\n",
       "      <td>-0.001357</td>\n",
       "      <td>-0.000235</td>\n",
       "      <td>0.000763</td>\n",
       "      <td>0.001954</td>\n",
       "      <td>0.000951</td>\n",
       "      <td>-0.000075</td>\n",
       "      <td>-0.000903</td>\n",
       "      <td>-0.001609</td>\n",
       "      <td>-0.002950</td>\n",
       "      <td>7.344740e-04</td>\n",
       "      <td>0.002293</td>\n",
       "      <td>0.004867</td>\n",
       "      <td>-0.000047</td>\n",
       "      <td>0.007884</td>\n",
       "      <td>0.004530</td>\n",
       "      <td>0.001977</td>\n",
       "      <td>-0.000200</td>\n",
       "      <td>0.000385</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000389</td>\n",
       "      <td>-0.001384</td>\n",
       "      <td>-0.001615</td>\n",
       "      <td>-0.000402</td>\n",
       "      <td>-0.007677</td>\n",
       "      <td>-4.347043e-04</td>\n",
       "      <td>-0.000628</td>\n",
       "      <td>0.000156</td>\n",
       "      <td>-0.003365</td>\n",
       "      <td>0.001450</td>\n",
       "      <td>0.001315</td>\n",
       "      <td>-0.000385</td>\n",
       "      <td>-0.000889</td>\n",
       "      <td>-0.000608</td>\n",
       "      <td>-0.000980</td>\n",
       "      <td>0.003330</td>\n",
       "      <td>-0.000024</td>\n",
       "      <td>0.000117</td>\n",
       "      <td>-0.003091</td>\n",
       "      <td>-0.002267</td>\n",
       "      <td>0.000749</td>\n",
       "      <td>-0.004095</td>\n",
       "      <td>-0.000304</td>\n",
       "      <td>0.000161</td>\n",
       "      <td>-0.003332</td>\n",
       "      <td>0.000316</td>\n",
       "      <td>0.001017</td>\n",
       "      <td>0.000125</td>\n",
       "      <td>0.001116</td>\n",
       "      <td>-0.000726</td>\n",
       "      <td>-0.000525</td>\n",
       "      <td>-0.004179</td>\n",
       "      <td>0.002263</td>\n",
       "      <td>0.000660</td>\n",
       "      <td>-0.001829</td>\n",
       "      <td>-0.000366</td>\n",
       "      <td>-0.001690</td>\n",
       "      <td>0.000327</td>\n",
       "      <td>0.002189</td>\n",
       "      <td>-0.001493</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>33</th>\n",
       "      <td>Kidney_Cortex</td>\n",
       "      <td>1.459853e-03</td>\n",
       "      <td>-0.007294</td>\n",
       "      <td>-0.000252</td>\n",
       "      <td>-0.005575</td>\n",
       "      <td>0.009776</td>\n",
       "      <td>-0.002408</td>\n",
       "      <td>0.001636</td>\n",
       "      <td>-0.000239</td>\n",
       "      <td>0.001314</td>\n",
       "      <td>-0.000040</td>\n",
       "      <td>0.011473</td>\n",
       "      <td>7.540270e-05</td>\n",
       "      <td>-0.000586</td>\n",
       "      <td>0.003833</td>\n",
       "      <td>0.011318</td>\n",
       "      <td>0.006224</td>\n",
       "      <td>-0.007275</td>\n",
       "      <td>0.003137</td>\n",
       "      <td>0.000723</td>\n",
       "      <td>0.000461</td>\n",
       "      <td>0.001806</td>\n",
       "      <td>0.005830</td>\n",
       "      <td>-0.000353</td>\n",
       "      <td>-0.000956</td>\n",
       "      <td>-0.000945</td>\n",
       "      <td>-0.001190</td>\n",
       "      <td>0.000541</td>\n",
       "      <td>0.000851</td>\n",
       "      <td>-0.001779</td>\n",
       "      <td>-0.000019</td>\n",
       "      <td>-1.078965e-03</td>\n",
       "      <td>-0.001827</td>\n",
       "      <td>-0.003105</td>\n",
       "      <td>-0.014403</td>\n",
       "      <td>0.010448</td>\n",
       "      <td>-0.008865</td>\n",
       "      <td>0.001105</td>\n",
       "      <td>0.000365</td>\n",
       "      <td>0.010917</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000672</td>\n",
       "      <td>-0.000566</td>\n",
       "      <td>-0.007193</td>\n",
       "      <td>-0.000563</td>\n",
       "      <td>0.008489</td>\n",
       "      <td>1.923545e-04</td>\n",
       "      <td>0.000642</td>\n",
       "      <td>-0.001463</td>\n",
       "      <td>0.004351</td>\n",
       "      <td>-0.000125</td>\n",
       "      <td>-0.000072</td>\n",
       "      <td>0.001800</td>\n",
       "      <td>-0.001440</td>\n",
       "      <td>-0.000057</td>\n",
       "      <td>-0.000213</td>\n",
       "      <td>-0.001401</td>\n",
       "      <td>0.000153</td>\n",
       "      <td>-0.000094</td>\n",
       "      <td>0.008785</td>\n",
       "      <td>-0.001555</td>\n",
       "      <td>-0.000416</td>\n",
       "      <td>0.009789</td>\n",
       "      <td>0.001008</td>\n",
       "      <td>0.000546</td>\n",
       "      <td>0.008159</td>\n",
       "      <td>0.000783</td>\n",
       "      <td>-0.000236</td>\n",
       "      <td>-0.000119</td>\n",
       "      <td>-0.003909</td>\n",
       "      <td>0.001228</td>\n",
       "      <td>0.000200</td>\n",
       "      <td>-0.009170</td>\n",
       "      <td>0.000755</td>\n",
       "      <td>-0.000029</td>\n",
       "      <td>-0.002880</td>\n",
       "      <td>-0.004476</td>\n",
       "      <td>0.000244</td>\n",
       "      <td>0.008083</td>\n",
       "      <td>-0.002152</td>\n",
       "      <td>0.004546</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>34</th>\n",
       "      <td>Liver</td>\n",
       "      <td>1.088776e-03</td>\n",
       "      <td>-0.000632</td>\n",
       "      <td>-0.000518</td>\n",
       "      <td>-0.004816</td>\n",
       "      <td>-0.049006</td>\n",
       "      <td>0.000047</td>\n",
       "      <td>-0.004163</td>\n",
       "      <td>-0.000281</td>\n",
       "      <td>0.003395</td>\n",
       "      <td>0.000830</td>\n",
       "      <td>0.012355</td>\n",
       "      <td>-7.901670e-05</td>\n",
       "      <td>0.001725</td>\n",
       "      <td>0.017785</td>\n",
       "      <td>0.006039</td>\n",
       "      <td>0.006134</td>\n",
       "      <td>-0.010959</td>\n",
       "      <td>0.016911</td>\n",
       "      <td>0.000582</td>\n",
       "      <td>0.000520</td>\n",
       "      <td>0.000713</td>\n",
       "      <td>0.003056</td>\n",
       "      <td>-0.000657</td>\n",
       "      <td>-0.000293</td>\n",
       "      <td>0.001057</td>\n",
       "      <td>-0.000480</td>\n",
       "      <td>0.000310</td>\n",
       "      <td>0.000928</td>\n",
       "      <td>-0.003502</td>\n",
       "      <td>-0.005715</td>\n",
       "      <td>-7.594709e-04</td>\n",
       "      <td>-0.000712</td>\n",
       "      <td>-0.000244</td>\n",
       "      <td>-0.026699</td>\n",
       "      <td>0.012708</td>\n",
       "      <td>-0.003440</td>\n",
       "      <td>0.001073</td>\n",
       "      <td>0.000196</td>\n",
       "      <td>0.010161</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000460</td>\n",
       "      <td>-0.006494</td>\n",
       "      <td>-0.007061</td>\n",
       "      <td>0.001864</td>\n",
       "      <td>0.006055</td>\n",
       "      <td>-3.862262e-04</td>\n",
       "      <td>-0.000982</td>\n",
       "      <td>-0.001971</td>\n",
       "      <td>0.003159</td>\n",
       "      <td>0.000262</td>\n",
       "      <td>0.000835</td>\n",
       "      <td>-0.003579</td>\n",
       "      <td>-0.004839</td>\n",
       "      <td>-0.000810</td>\n",
       "      <td>-0.000622</td>\n",
       "      <td>-0.001191</td>\n",
       "      <td>0.000149</td>\n",
       "      <td>0.000516</td>\n",
       "      <td>0.001529</td>\n",
       "      <td>-0.002396</td>\n",
       "      <td>-0.000240</td>\n",
       "      <td>0.015942</td>\n",
       "      <td>0.000926</td>\n",
       "      <td>0.000695</td>\n",
       "      <td>0.002966</td>\n",
       "      <td>0.000761</td>\n",
       "      <td>0.000622</td>\n",
       "      <td>-0.000104</td>\n",
       "      <td>-0.004472</td>\n",
       "      <td>0.000766</td>\n",
       "      <td>-0.000053</td>\n",
       "      <td>-0.030213</td>\n",
       "      <td>0.002081</td>\n",
       "      <td>-0.000634</td>\n",
       "      <td>-0.001076</td>\n",
       "      <td>-0.005587</td>\n",
       "      <td>-0.001268</td>\n",
       "      <td>0.005769</td>\n",
       "      <td>-0.005945</td>\n",
       "      <td>-0.003680</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>35</th>\n",
       "      <td>Lung</td>\n",
       "      <td>6.469219e-04</td>\n",
       "      <td>-0.004095</td>\n",
       "      <td>-0.000570</td>\n",
       "      <td>-0.001369</td>\n",
       "      <td>-0.045876</td>\n",
       "      <td>0.000371</td>\n",
       "      <td>0.003434</td>\n",
       "      <td>0.000601</td>\n",
       "      <td>-0.000595</td>\n",
       "      <td>0.001892</td>\n",
       "      <td>0.001448</td>\n",
       "      <td>-4.258249e-04</td>\n",
       "      <td>0.000440</td>\n",
       "      <td>-0.010352</td>\n",
       "      <td>0.003492</td>\n",
       "      <td>0.002659</td>\n",
       "      <td>-0.007270</td>\n",
       "      <td>-0.013930</td>\n",
       "      <td>-0.000939</td>\n",
       "      <td>0.000004</td>\n",
       "      <td>0.000847</td>\n",
       "      <td>-0.001720</td>\n",
       "      <td>0.000047</td>\n",
       "      <td>-0.000052</td>\n",
       "      <td>-0.003058</td>\n",
       "      <td>0.000057</td>\n",
       "      <td>0.000176</td>\n",
       "      <td>0.000957</td>\n",
       "      <td>0.000139</td>\n",
       "      <td>0.007447</td>\n",
       "      <td>-1.180762e-03</td>\n",
       "      <td>-0.001671</td>\n",
       "      <td>0.001279</td>\n",
       "      <td>-0.012764</td>\n",
       "      <td>-0.008687</td>\n",
       "      <td>-0.001769</td>\n",
       "      <td>-0.001350</td>\n",
       "      <td>0.000163</td>\n",
       "      <td>0.000286</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000310</td>\n",
       "      <td>-0.002808</td>\n",
       "      <td>-0.003337</td>\n",
       "      <td>-0.000946</td>\n",
       "      <td>0.004564</td>\n",
       "      <td>2.647999e-04</td>\n",
       "      <td>0.000705</td>\n",
       "      <td>-0.000431</td>\n",
       "      <td>0.004529</td>\n",
       "      <td>-0.001168</td>\n",
       "      <td>-0.001141</td>\n",
       "      <td>0.000741</td>\n",
       "      <td>-0.000840</td>\n",
       "      <td>0.000551</td>\n",
       "      <td>0.000468</td>\n",
       "      <td>-0.002369</td>\n",
       "      <td>0.000005</td>\n",
       "      <td>0.000106</td>\n",
       "      <td>-0.000334</td>\n",
       "      <td>0.003731</td>\n",
       "      <td>-0.000653</td>\n",
       "      <td>0.003995</td>\n",
       "      <td>0.000472</td>\n",
       "      <td>0.000506</td>\n",
       "      <td>0.002290</td>\n",
       "      <td>-0.000148</td>\n",
       "      <td>-0.000932</td>\n",
       "      <td>-0.000072</td>\n",
       "      <td>-0.004118</td>\n",
       "      <td>0.000133</td>\n",
       "      <td>0.000347</td>\n",
       "      <td>-0.011006</td>\n",
       "      <td>-0.003295</td>\n",
       "      <td>-0.000759</td>\n",
       "      <td>0.001378</td>\n",
       "      <td>-0.000501</td>\n",
       "      <td>0.001225</td>\n",
       "      <td>-0.000639</td>\n",
       "      <td>-0.003093</td>\n",
       "      <td>0.000124</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>36</th>\n",
       "      <td>MedianExp</td>\n",
       "      <td>-1.322297e-04</td>\n",
       "      <td>0.002228</td>\n",
       "      <td>-0.001600</td>\n",
       "      <td>0.004303</td>\n",
       "      <td>-0.020435</td>\n",
       "      <td>0.001195</td>\n",
       "      <td>0.006969</td>\n",
       "      <td>-0.000846</td>\n",
       "      <td>-0.002404</td>\n",
       "      <td>-0.003089</td>\n",
       "      <td>-0.007922</td>\n",
       "      <td>-1.856729e-04</td>\n",
       "      <td>0.000111</td>\n",
       "      <td>-0.018708</td>\n",
       "      <td>-0.006935</td>\n",
       "      <td>-0.001947</td>\n",
       "      <td>0.001439</td>\n",
       "      <td>-0.006769</td>\n",
       "      <td>-0.000389</td>\n",
       "      <td>-0.000486</td>\n",
       "      <td>0.000177</td>\n",
       "      <td>-0.000933</td>\n",
       "      <td>0.000161</td>\n",
       "      <td>-0.000429</td>\n",
       "      <td>-0.002162</td>\n",
       "      <td>0.000322</td>\n",
       "      <td>-0.000360</td>\n",
       "      <td>0.001282</td>\n",
       "      <td>0.003402</td>\n",
       "      <td>0.001774</td>\n",
       "      <td>8.102108e-05</td>\n",
       "      <td>-0.004291</td>\n",
       "      <td>-0.002503</td>\n",
       "      <td>0.012837</td>\n",
       "      <td>-0.010272</td>\n",
       "      <td>0.001294</td>\n",
       "      <td>-0.002714</td>\n",
       "      <td>-0.000005</td>\n",
       "      <td>-0.003719</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000377</td>\n",
       "      <td>0.001538</td>\n",
       "      <td>-0.001536</td>\n",
       "      <td>0.001546</td>\n",
       "      <td>0.000766</td>\n",
       "      <td>3.879094e-04</td>\n",
       "      <td>0.000124</td>\n",
       "      <td>0.001400</td>\n",
       "      <td>0.000006</td>\n",
       "      <td>-0.001019</td>\n",
       "      <td>-0.002322</td>\n",
       "      <td>-0.003376</td>\n",
       "      <td>0.005801</td>\n",
       "      <td>0.000557</td>\n",
       "      <td>0.002052</td>\n",
       "      <td>-0.003613</td>\n",
       "      <td>-0.000166</td>\n",
       "      <td>0.000292</td>\n",
       "      <td>-0.007198</td>\n",
       "      <td>0.004114</td>\n",
       "      <td>-0.001356</td>\n",
       "      <td>0.002149</td>\n",
       "      <td>-0.000477</td>\n",
       "      <td>-0.001100</td>\n",
       "      <td>0.000765</td>\n",
       "      <td>-0.000580</td>\n",
       "      <td>-0.000656</td>\n",
       "      <td>-0.000069</td>\n",
       "      <td>0.001703</td>\n",
       "      <td>0.000470</td>\n",
       "      <td>0.000412</td>\n",
       "      <td>0.002983</td>\n",
       "      <td>-0.002636</td>\n",
       "      <td>0.000498</td>\n",
       "      <td>0.003345</td>\n",
       "      <td>0.003830</td>\n",
       "      <td>-0.000091</td>\n",
       "      <td>-0.003170</td>\n",
       "      <td>0.000765</td>\n",
       "      <td>-0.001933</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>37</th>\n",
       "      <td>Minor_Salivary_Gland</td>\n",
       "      <td>1.520276e-03</td>\n",
       "      <td>-0.008705</td>\n",
       "      <td>-0.000576</td>\n",
       "      <td>-0.003702</td>\n",
       "      <td>0.009357</td>\n",
       "      <td>-0.002143</td>\n",
       "      <td>0.003824</td>\n",
       "      <td>0.000530</td>\n",
       "      <td>-0.001740</td>\n",
       "      <td>0.000499</td>\n",
       "      <td>0.014951</td>\n",
       "      <td>-4.166779e-04</td>\n",
       "      <td>-0.001494</td>\n",
       "      <td>-0.005042</td>\n",
       "      <td>0.020727</td>\n",
       "      <td>-0.001622</td>\n",
       "      <td>-0.017009</td>\n",
       "      <td>-0.018237</td>\n",
       "      <td>-0.001646</td>\n",
       "      <td>0.000877</td>\n",
       "      <td>0.002100</td>\n",
       "      <td>0.002293</td>\n",
       "      <td>-0.000177</td>\n",
       "      <td>-0.002375</td>\n",
       "      <td>-0.004910</td>\n",
       "      <td>-0.003321</td>\n",
       "      <td>0.000476</td>\n",
       "      <td>0.001577</td>\n",
       "      <td>0.000106</td>\n",
       "      <td>0.006673</td>\n",
       "      <td>-1.808642e-03</td>\n",
       "      <td>-0.009225</td>\n",
       "      <td>-0.000590</td>\n",
       "      <td>-0.022776</td>\n",
       "      <td>0.002026</td>\n",
       "      <td>-0.006291</td>\n",
       "      <td>0.001061</td>\n",
       "      <td>0.000438</td>\n",
       "      <td>0.013120</td>\n",
       "      <td>...</td>\n",
       "      <td>0.001201</td>\n",
       "      <td>-0.003031</td>\n",
       "      <td>-0.008940</td>\n",
       "      <td>-0.002834</td>\n",
       "      <td>0.012737</td>\n",
       "      <td>8.034387e-04</td>\n",
       "      <td>0.001606</td>\n",
       "      <td>-0.001893</td>\n",
       "      <td>0.007862</td>\n",
       "      <td>-0.001478</td>\n",
       "      <td>-0.000688</td>\n",
       "      <td>0.008030</td>\n",
       "      <td>-0.003288</td>\n",
       "      <td>0.001681</td>\n",
       "      <td>0.001816</td>\n",
       "      <td>-0.001361</td>\n",
       "      <td>0.000238</td>\n",
       "      <td>-0.000566</td>\n",
       "      <td>0.010370</td>\n",
       "      <td>0.002464</td>\n",
       "      <td>-0.001517</td>\n",
       "      <td>0.008644</td>\n",
       "      <td>0.000819</td>\n",
       "      <td>0.001173</td>\n",
       "      <td>0.011714</td>\n",
       "      <td>-0.000213</td>\n",
       "      <td>-0.001218</td>\n",
       "      <td>-0.000338</td>\n",
       "      <td>-0.004538</td>\n",
       "      <td>0.000298</td>\n",
       "      <td>0.000564</td>\n",
       "      <td>-0.010672</td>\n",
       "      <td>-0.002205</td>\n",
       "      <td>-0.001369</td>\n",
       "      <td>-0.002035</td>\n",
       "      <td>-0.004310</td>\n",
       "      <td>0.001810</td>\n",
       "      <td>0.008816</td>\n",
       "      <td>-0.005588</td>\n",
       "      <td>0.013110</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>38</th>\n",
       "      <td>Muscle_Skeletal</td>\n",
       "      <td>-1.604136e-04</td>\n",
       "      <td>0.000322</td>\n",
       "      <td>-0.000239</td>\n",
       "      <td>0.001450</td>\n",
       "      <td>-0.042889</td>\n",
       "      <td>0.000544</td>\n",
       "      <td>-0.001971</td>\n",
       "      <td>0.000189</td>\n",
       "      <td>0.001800</td>\n",
       "      <td>-0.002305</td>\n",
       "      <td>-0.000288</td>\n",
       "      <td>6.577701e-05</td>\n",
       "      <td>0.000622</td>\n",
       "      <td>0.009638</td>\n",
       "      <td>-0.006532</td>\n",
       "      <td>0.000114</td>\n",
       "      <td>0.005806</td>\n",
       "      <td>0.012068</td>\n",
       "      <td>0.001176</td>\n",
       "      <td>-0.000241</td>\n",
       "      <td>-0.001072</td>\n",
       "      <td>-0.000889</td>\n",
       "      <td>-0.000134</td>\n",
       "      <td>0.000757</td>\n",
       "      <td>0.001430</td>\n",
       "      <td>0.001428</td>\n",
       "      <td>-0.000014</td>\n",
       "      <td>-0.000564</td>\n",
       "      <td>-0.000019</td>\n",
       "      <td>-0.003980</td>\n",
       "      <td>9.848071e-04</td>\n",
       "      <td>0.003354</td>\n",
       "      <td>0.001462</td>\n",
       "      <td>0.008193</td>\n",
       "      <td>0.004735</td>\n",
       "      <td>0.001454</td>\n",
       "      <td>-0.000415</td>\n",
       "      <td>-0.000116</td>\n",
       "      <td>-0.003358</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000494</td>\n",
       "      <td>-0.001099</td>\n",
       "      <td>0.000185</td>\n",
       "      <td>0.000079</td>\n",
       "      <td>-0.006039</td>\n",
       "      <td>-4.027754e-04</td>\n",
       "      <td>-0.001229</td>\n",
       "      <td>0.000509</td>\n",
       "      <td>-0.001185</td>\n",
       "      <td>0.000703</td>\n",
       "      <td>0.000305</td>\n",
       "      <td>-0.004263</td>\n",
       "      <td>0.001475</td>\n",
       "      <td>-0.000421</td>\n",
       "      <td>-0.000764</td>\n",
       "      <td>0.000972</td>\n",
       "      <td>-0.000144</td>\n",
       "      <td>0.000276</td>\n",
       "      <td>-0.007751</td>\n",
       "      <td>0.000082</td>\n",
       "      <td>-0.000009</td>\n",
       "      <td>-0.000243</td>\n",
       "      <td>0.000077</td>\n",
       "      <td>-0.000222</td>\n",
       "      <td>-0.002893</td>\n",
       "      <td>0.000588</td>\n",
       "      <td>0.000441</td>\n",
       "      <td>0.000118</td>\n",
       "      <td>0.000910</td>\n",
       "      <td>-0.000475</td>\n",
       "      <td>-0.000292</td>\n",
       "      <td>-0.001301</td>\n",
       "      <td>0.000936</td>\n",
       "      <td>0.000595</td>\n",
       "      <td>0.001002</td>\n",
       "      <td>0.000231</td>\n",
       "      <td>-0.000722</td>\n",
       "      <td>-0.000169</td>\n",
       "      <td>0.001375</td>\n",
       "      <td>-0.006562</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>39</th>\n",
       "      <td>Nerve_Tibial</td>\n",
       "      <td>8.790419e-05</td>\n",
       "      <td>-0.001068</td>\n",
       "      <td>-0.001371</td>\n",
       "      <td>0.003913</td>\n",
       "      <td>0.017449</td>\n",
       "      <td>0.000130</td>\n",
       "      <td>0.007428</td>\n",
       "      <td>-0.001510</td>\n",
       "      <td>-0.001080</td>\n",
       "      <td>-0.004488</td>\n",
       "      <td>-0.000239</td>\n",
       "      <td>-2.955989e-05</td>\n",
       "      <td>-0.000201</td>\n",
       "      <td>-0.017994</td>\n",
       "      <td>-0.004263</td>\n",
       "      <td>-0.000747</td>\n",
       "      <td>-0.000531</td>\n",
       "      <td>-0.007819</td>\n",
       "      <td>0.000319</td>\n",
       "      <td>-0.000675</td>\n",
       "      <td>0.000478</td>\n",
       "      <td>-0.000237</td>\n",
       "      <td>-0.000027</td>\n",
       "      <td>-0.000775</td>\n",
       "      <td>-0.002330</td>\n",
       "      <td>-0.001333</td>\n",
       "      <td>-0.000183</td>\n",
       "      <td>0.001337</td>\n",
       "      <td>0.001319</td>\n",
       "      <td>0.001750</td>\n",
       "      <td>3.737665e-04</td>\n",
       "      <td>-0.009809</td>\n",
       "      <td>-0.007180</td>\n",
       "      <td>0.012438</td>\n",
       "      <td>-0.011937</td>\n",
       "      <td>0.001724</td>\n",
       "      <td>-0.001373</td>\n",
       "      <td>0.000001</td>\n",
       "      <td>-0.001903</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000142</td>\n",
       "      <td>0.002708</td>\n",
       "      <td>-0.003810</td>\n",
       "      <td>0.000435</td>\n",
       "      <td>0.001920</td>\n",
       "      <td>2.281238e-04</td>\n",
       "      <td>-0.000086</td>\n",
       "      <td>0.000993</td>\n",
       "      <td>-0.000223</td>\n",
       "      <td>-0.001450</td>\n",
       "      <td>-0.001574</td>\n",
       "      <td>-0.003223</td>\n",
       "      <td>0.004452</td>\n",
       "      <td>0.000427</td>\n",
       "      <td>0.001486</td>\n",
       "      <td>-0.003042</td>\n",
       "      <td>-0.000065</td>\n",
       "      <td>0.000079</td>\n",
       "      <td>-0.003455</td>\n",
       "      <td>0.003927</td>\n",
       "      <td>-0.001099</td>\n",
       "      <td>0.001470</td>\n",
       "      <td>0.000133</td>\n",
       "      <td>-0.000953</td>\n",
       "      <td>0.001199</td>\n",
       "      <td>-0.000092</td>\n",
       "      <td>-0.001231</td>\n",
       "      <td>0.000033</td>\n",
       "      <td>0.000763</td>\n",
       "      <td>0.000913</td>\n",
       "      <td>0.000370</td>\n",
       "      <td>0.001712</td>\n",
       "      <td>-0.001043</td>\n",
       "      <td>0.000322</td>\n",
       "      <td>0.002801</td>\n",
       "      <td>0.002074</td>\n",
       "      <td>0.000966</td>\n",
       "      <td>-0.005319</td>\n",
       "      <td>-0.001137</td>\n",
       "      <td>-0.001889</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>40</th>\n",
       "      <td>Ovary</td>\n",
       "      <td>-4.582781e-05</td>\n",
       "      <td>-0.003656</td>\n",
       "      <td>-0.000845</td>\n",
       "      <td>0.002795</td>\n",
       "      <td>0.033703</td>\n",
       "      <td>0.000361</td>\n",
       "      <td>0.005261</td>\n",
       "      <td>-0.000780</td>\n",
       "      <td>-0.000737</td>\n",
       "      <td>-0.002620</td>\n",
       "      <td>-0.001223</td>\n",
       "      <td>3.446333e-05</td>\n",
       "      <td>-0.000062</td>\n",
       "      <td>-0.008020</td>\n",
       "      <td>-0.005231</td>\n",
       "      <td>0.000931</td>\n",
       "      <td>0.005028</td>\n",
       "      <td>-0.003814</td>\n",
       "      <td>0.001431</td>\n",
       "      <td>-0.000409</td>\n",
       "      <td>-0.000255</td>\n",
       "      <td>-0.000800</td>\n",
       "      <td>-0.000182</td>\n",
       "      <td>-0.000364</td>\n",
       "      <td>-0.000896</td>\n",
       "      <td>0.000466</td>\n",
       "      <td>0.000070</td>\n",
       "      <td>0.000663</td>\n",
       "      <td>0.000047</td>\n",
       "      <td>0.000992</td>\n",
       "      <td>5.514952e-04</td>\n",
       "      <td>-0.004687</td>\n",
       "      <td>-0.004803</td>\n",
       "      <td>0.013546</td>\n",
       "      <td>-0.006114</td>\n",
       "      <td>0.003595</td>\n",
       "      <td>-0.000147</td>\n",
       "      <td>-0.000124</td>\n",
       "      <td>-0.000714</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000137</td>\n",
       "      <td>-0.000936</td>\n",
       "      <td>0.004388</td>\n",
       "      <td>0.001863</td>\n",
       "      <td>0.001257</td>\n",
       "      <td>2.002856e-04</td>\n",
       "      <td>-0.000399</td>\n",
       "      <td>0.000808</td>\n",
       "      <td>-0.001662</td>\n",
       "      <td>-0.000815</td>\n",
       "      <td>-0.001480</td>\n",
       "      <td>-0.003731</td>\n",
       "      <td>0.003018</td>\n",
       "      <td>0.000551</td>\n",
       "      <td>0.000246</td>\n",
       "      <td>-0.000849</td>\n",
       "      <td>-0.000098</td>\n",
       "      <td>0.000368</td>\n",
       "      <td>-0.004308</td>\n",
       "      <td>0.002163</td>\n",
       "      <td>-0.000441</td>\n",
       "      <td>0.002154</td>\n",
       "      <td>0.000412</td>\n",
       "      <td>-0.000806</td>\n",
       "      <td>-0.002015</td>\n",
       "      <td>-0.000281</td>\n",
       "      <td>-0.000362</td>\n",
       "      <td>-0.000043</td>\n",
       "      <td>0.001631</td>\n",
       "      <td>0.000508</td>\n",
       "      <td>0.000117</td>\n",
       "      <td>0.001959</td>\n",
       "      <td>0.000249</td>\n",
       "      <td>0.000141</td>\n",
       "      <td>0.001513</td>\n",
       "      <td>0.001324</td>\n",
       "      <td>-0.000173</td>\n",
       "      <td>-0.001968</td>\n",
       "      <td>0.001753</td>\n",
       "      <td>-0.003594</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>41</th>\n",
       "      <td>Pancreas</td>\n",
       "      <td>8.820569e-04</td>\n",
       "      <td>-0.005041</td>\n",
       "      <td>0.000442</td>\n",
       "      <td>-0.004396</td>\n",
       "      <td>0.044712</td>\n",
       "      <td>-0.002726</td>\n",
       "      <td>-0.000836</td>\n",
       "      <td>0.000107</td>\n",
       "      <td>0.001168</td>\n",
       "      <td>0.002442</td>\n",
       "      <td>0.011638</td>\n",
       "      <td>3.433442e-04</td>\n",
       "      <td>-0.001645</td>\n",
       "      <td>0.011706</td>\n",
       "      <td>0.013000</td>\n",
       "      <td>0.004602</td>\n",
       "      <td>-0.007991</td>\n",
       "      <td>0.005569</td>\n",
       "      <td>0.000030</td>\n",
       "      <td>0.000458</td>\n",
       "      <td>0.001910</td>\n",
       "      <td>0.005589</td>\n",
       "      <td>-0.000411</td>\n",
       "      <td>-0.001300</td>\n",
       "      <td>0.000794</td>\n",
       "      <td>-0.002254</td>\n",
       "      <td>0.000528</td>\n",
       "      <td>-0.000288</td>\n",
       "      <td>-0.001456</td>\n",
       "      <td>-0.002107</td>\n",
       "      <td>-7.091684e-04</td>\n",
       "      <td>-0.000795</td>\n",
       "      <td>-0.004392</td>\n",
       "      <td>-0.016184</td>\n",
       "      <td>0.014858</td>\n",
       "      <td>-0.004197</td>\n",
       "      <td>0.002286</td>\n",
       "      <td>0.000205</td>\n",
       "      <td>0.015430</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000475</td>\n",
       "      <td>-0.000649</td>\n",
       "      <td>-0.007759</td>\n",
       "      <td>0.000239</td>\n",
       "      <td>0.006663</td>\n",
       "      <td>-6.781537e-05</td>\n",
       "      <td>0.000461</td>\n",
       "      <td>-0.001546</td>\n",
       "      <td>0.002259</td>\n",
       "      <td>0.000404</td>\n",
       "      <td>0.000682</td>\n",
       "      <td>0.003962</td>\n",
       "      <td>-0.001810</td>\n",
       "      <td>0.000041</td>\n",
       "      <td>-0.000368</td>\n",
       "      <td>0.001044</td>\n",
       "      <td>0.000158</td>\n",
       "      <td>-0.000207</td>\n",
       "      <td>0.010839</td>\n",
       "      <td>-0.003059</td>\n",
       "      <td>-0.000010</td>\n",
       "      <td>0.004661</td>\n",
       "      <td>0.000820</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>0.009108</td>\n",
       "      <td>-0.000153</td>\n",
       "      <td>0.000213</td>\n",
       "      <td>-0.000006</td>\n",
       "      <td>-0.002748</td>\n",
       "      <td>0.001088</td>\n",
       "      <td>0.000019</td>\n",
       "      <td>-0.008014</td>\n",
       "      <td>0.001442</td>\n",
       "      <td>-0.000476</td>\n",
       "      <td>-0.003425</td>\n",
       "      <td>-0.004972</td>\n",
       "      <td>0.000194</td>\n",
       "      <td>0.008437</td>\n",
       "      <td>-0.003543</td>\n",
       "      <td>0.009771</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>42</th>\n",
       "      <td>Pituitary</td>\n",
       "      <td>-6.130586e-04</td>\n",
       "      <td>0.000960</td>\n",
       "      <td>0.002617</td>\n",
       "      <td>-0.005066</td>\n",
       "      <td>0.100253</td>\n",
       "      <td>-0.002221</td>\n",
       "      <td>-0.008877</td>\n",
       "      <td>0.000565</td>\n",
       "      <td>0.001325</td>\n",
       "      <td>0.007652</td>\n",
       "      <td>0.001256</td>\n",
       "      <td>5.212118e-04</td>\n",
       "      <td>-0.002279</td>\n",
       "      <td>0.019830</td>\n",
       "      <td>0.010504</td>\n",
       "      <td>0.009207</td>\n",
       "      <td>-0.003510</td>\n",
       "      <td>0.006387</td>\n",
       "      <td>-0.000738</td>\n",
       "      <td>0.000694</td>\n",
       "      <td>0.000495</td>\n",
       "      <td>0.006174</td>\n",
       "      <td>-0.000028</td>\n",
       "      <td>0.000236</td>\n",
       "      <td>0.005619</td>\n",
       "      <td>-0.001252</td>\n",
       "      <td>0.000238</td>\n",
       "      <td>-0.001755</td>\n",
       "      <td>-0.004398</td>\n",
       "      <td>-0.007268</td>\n",
       "      <td>-6.038473e-04</td>\n",
       "      <td>0.007230</td>\n",
       "      <td>-0.001394</td>\n",
       "      <td>-0.016077</td>\n",
       "      <td>0.016888</td>\n",
       "      <td>-0.006637</td>\n",
       "      <td>0.003677</td>\n",
       "      <td>-0.000086</td>\n",
       "      <td>0.010714</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000309</td>\n",
       "      <td>0.001260</td>\n",
       "      <td>0.002297</td>\n",
       "      <td>-0.001753</td>\n",
       "      <td>0.003772</td>\n",
       "      <td>-3.411047e-04</td>\n",
       "      <td>0.001189</td>\n",
       "      <td>-0.002023</td>\n",
       "      <td>-0.000096</td>\n",
       "      <td>0.002171</td>\n",
       "      <td>0.003358</td>\n",
       "      <td>0.007030</td>\n",
       "      <td>-0.005460</td>\n",
       "      <td>-0.001232</td>\n",
       "      <td>-0.002560</td>\n",
       "      <td>0.004625</td>\n",
       "      <td>0.000305</td>\n",
       "      <td>-0.000603</td>\n",
       "      <td>0.021830</td>\n",
       "      <td>-0.008890</td>\n",
       "      <td>0.001507</td>\n",
       "      <td>-0.003748</td>\n",
       "      <td>0.000191</td>\n",
       "      <td>0.000949</td>\n",
       "      <td>0.003532</td>\n",
       "      <td>0.000128</td>\n",
       "      <td>0.001350</td>\n",
       "      <td>-0.000039</td>\n",
       "      <td>0.000245</td>\n",
       "      <td>-0.000114</td>\n",
       "      <td>-0.000516</td>\n",
       "      <td>0.009562</td>\n",
       "      <td>0.003947</td>\n",
       "      <td>-0.001474</td>\n",
       "      <td>-0.006091</td>\n",
       "      <td>-0.005372</td>\n",
       "      <td>-0.000026</td>\n",
       "      <td>0.006610</td>\n",
       "      <td>-0.001902</td>\n",
       "      <td>0.009997</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>43</th>\n",
       "      <td>Prostate</td>\n",
       "      <td>6.404887e-04</td>\n",
       "      <td>-0.006386</td>\n",
       "      <td>-0.000085</td>\n",
       "      <td>-0.001281</td>\n",
       "      <td>0.070466</td>\n",
       "      <td>-0.001310</td>\n",
       "      <td>0.003098</td>\n",
       "      <td>-0.000261</td>\n",
       "      <td>-0.001015</td>\n",
       "      <td>0.000857</td>\n",
       "      <td>0.010253</td>\n",
       "      <td>3.869199e-05</td>\n",
       "      <td>-0.001552</td>\n",
       "      <td>-0.001757</td>\n",
       "      <td>0.011967</td>\n",
       "      <td>0.002325</td>\n",
       "      <td>-0.009832</td>\n",
       "      <td>-0.012525</td>\n",
       "      <td>-0.000785</td>\n",
       "      <td>0.000283</td>\n",
       "      <td>0.001469</td>\n",
       "      <td>0.002429</td>\n",
       "      <td>-0.000146</td>\n",
       "      <td>-0.001681</td>\n",
       "      <td>-0.002067</td>\n",
       "      <td>-0.002072</td>\n",
       "      <td>0.000285</td>\n",
       "      <td>0.001172</td>\n",
       "      <td>-0.001334</td>\n",
       "      <td>0.002490</td>\n",
       "      <td>-1.052240e-03</td>\n",
       "      <td>-0.007898</td>\n",
       "      <td>-0.003318</td>\n",
       "      <td>-0.011615</td>\n",
       "      <td>0.001403</td>\n",
       "      <td>-0.002034</td>\n",
       "      <td>0.002061</td>\n",
       "      <td>0.000226</td>\n",
       "      <td>0.011207</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000736</td>\n",
       "      <td>-0.002016</td>\n",
       "      <td>-0.005775</td>\n",
       "      <td>-0.000554</td>\n",
       "      <td>0.009909</td>\n",
       "      <td>4.110930e-04</td>\n",
       "      <td>0.001351</td>\n",
       "      <td>-0.001165</td>\n",
       "      <td>0.002253</td>\n",
       "      <td>-0.000866</td>\n",
       "      <td>-0.000120</td>\n",
       "      <td>0.005773</td>\n",
       "      <td>-0.001486</td>\n",
       "      <td>0.000980</td>\n",
       "      <td>0.000764</td>\n",
       "      <td>0.000263</td>\n",
       "      <td>0.000187</td>\n",
       "      <td>-0.000244</td>\n",
       "      <td>0.010779</td>\n",
       "      <td>0.000398</td>\n",
       "      <td>-0.000405</td>\n",
       "      <td>0.004324</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>0.000407</td>\n",
       "      <td>0.007016</td>\n",
       "      <td>-0.000452</td>\n",
       "      <td>-0.000533</td>\n",
       "      <td>-0.000218</td>\n",
       "      <td>-0.002175</td>\n",
       "      <td>0.000696</td>\n",
       "      <td>0.000201</td>\n",
       "      <td>-0.003546</td>\n",
       "      <td>0.000163</td>\n",
       "      <td>-0.001038</td>\n",
       "      <td>-0.002982</td>\n",
       "      <td>-0.002957</td>\n",
       "      <td>0.000541</td>\n",
       "      <td>0.004249</td>\n",
       "      <td>-0.002886</td>\n",
       "      <td>0.010183</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>44</th>\n",
       "      <td>Skin_Not_Sun_Exposed_Suprapubic</td>\n",
       "      <td>2.009114e-03</td>\n",
       "      <td>-0.011661</td>\n",
       "      <td>-0.001222</td>\n",
       "      <td>-0.002364</td>\n",
       "      <td>0.045817</td>\n",
       "      <td>-0.003381</td>\n",
       "      <td>0.007867</td>\n",
       "      <td>-0.000582</td>\n",
       "      <td>-0.001169</td>\n",
       "      <td>-0.004487</td>\n",
       "      <td>0.023782</td>\n",
       "      <td>-3.253580e-04</td>\n",
       "      <td>-0.001800</td>\n",
       "      <td>-0.001210</td>\n",
       "      <td>0.027878</td>\n",
       "      <td>-0.005785</td>\n",
       "      <td>-0.019826</td>\n",
       "      <td>-0.023024</td>\n",
       "      <td>-0.001019</td>\n",
       "      <td>0.000852</td>\n",
       "      <td>0.002681</td>\n",
       "      <td>0.004881</td>\n",
       "      <td>-0.000140</td>\n",
       "      <td>-0.002964</td>\n",
       "      <td>-0.005013</td>\n",
       "      <td>-0.006133</td>\n",
       "      <td>0.000580</td>\n",
       "      <td>0.002005</td>\n",
       "      <td>-0.000207</td>\n",
       "      <td>0.003748</td>\n",
       "      <td>-1.826121e-03</td>\n",
       "      <td>-0.014786</td>\n",
       "      <td>-0.006650</td>\n",
       "      <td>-0.022058</td>\n",
       "      <td>-0.000011</td>\n",
       "      <td>-0.011007</td>\n",
       "      <td>0.002637</td>\n",
       "      <td>0.000733</td>\n",
       "      <td>0.017661</td>\n",
       "      <td>...</td>\n",
       "      <td>0.001361</td>\n",
       "      <td>-0.000903</td>\n",
       "      <td>-0.008861</td>\n",
       "      <td>-0.001613</td>\n",
       "      <td>0.017097</td>\n",
       "      <td>1.009967e-03</td>\n",
       "      <td>0.002020</td>\n",
       "      <td>-0.001916</td>\n",
       "      <td>0.008904</td>\n",
       "      <td>-0.002174</td>\n",
       "      <td>-0.000452</td>\n",
       "      <td>0.008763</td>\n",
       "      <td>-0.001734</td>\n",
       "      <td>0.001993</td>\n",
       "      <td>0.001636</td>\n",
       "      <td>0.000083</td>\n",
       "      <td>0.000349</td>\n",
       "      <td>-0.001060</td>\n",
       "      <td>0.013163</td>\n",
       "      <td>0.002921</td>\n",
       "      <td>-0.001315</td>\n",
       "      <td>0.008871</td>\n",
       "      <td>0.001275</td>\n",
       "      <td>0.001201</td>\n",
       "      <td>0.013284</td>\n",
       "      <td>-0.000128</td>\n",
       "      <td>-0.001137</td>\n",
       "      <td>-0.000174</td>\n",
       "      <td>-0.005688</td>\n",
       "      <td>0.000824</td>\n",
       "      <td>0.000562</td>\n",
       "      <td>-0.005860</td>\n",
       "      <td>-0.000397</td>\n",
       "      <td>-0.001306</td>\n",
       "      <td>-0.003340</td>\n",
       "      <td>-0.005395</td>\n",
       "      <td>0.002683</td>\n",
       "      <td>0.009037</td>\n",
       "      <td>-0.007391</td>\n",
       "      <td>0.017251</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>45</th>\n",
       "      <td>Skin_Sun_Exposed_Lower_leg</td>\n",
       "      <td>1.481231e-03</td>\n",
       "      <td>-0.011555</td>\n",
       "      <td>-0.001136</td>\n",
       "      <td>-0.002059</td>\n",
       "      <td>0.038965</td>\n",
       "      <td>-0.002317</td>\n",
       "      <td>0.007212</td>\n",
       "      <td>-0.000315</td>\n",
       "      <td>-0.002267</td>\n",
       "      <td>-0.002235</td>\n",
       "      <td>0.020556</td>\n",
       "      <td>-3.925078e-04</td>\n",
       "      <td>-0.001437</td>\n",
       "      <td>-0.002345</td>\n",
       "      <td>0.023654</td>\n",
       "      <td>-0.005865</td>\n",
       "      <td>-0.018426</td>\n",
       "      <td>-0.022793</td>\n",
       "      <td>-0.001384</td>\n",
       "      <td>0.000939</td>\n",
       "      <td>0.002456</td>\n",
       "      <td>0.003315</td>\n",
       "      <td>-0.000067</td>\n",
       "      <td>-0.002974</td>\n",
       "      <td>-0.004789</td>\n",
       "      <td>-0.004531</td>\n",
       "      <td>0.000465</td>\n",
       "      <td>0.001806</td>\n",
       "      <td>0.000103</td>\n",
       "      <td>0.005122</td>\n",
       "      <td>-1.982961e-03</td>\n",
       "      <td>-0.012662</td>\n",
       "      <td>-0.004537</td>\n",
       "      <td>-0.025302</td>\n",
       "      <td>0.001918</td>\n",
       "      <td>-0.007492</td>\n",
       "      <td>0.002083</td>\n",
       "      <td>0.000661</td>\n",
       "      <td>0.016627</td>\n",
       "      <td>...</td>\n",
       "      <td>0.001467</td>\n",
       "      <td>-0.001266</td>\n",
       "      <td>-0.009739</td>\n",
       "      <td>0.000111</td>\n",
       "      <td>0.016065</td>\n",
       "      <td>1.075328e-03</td>\n",
       "      <td>0.002377</td>\n",
       "      <td>-0.001650</td>\n",
       "      <td>0.008112</td>\n",
       "      <td>-0.002151</td>\n",
       "      <td>-0.001144</td>\n",
       "      <td>0.008644</td>\n",
       "      <td>-0.002142</td>\n",
       "      <td>0.001798</td>\n",
       "      <td>0.002281</td>\n",
       "      <td>-0.000613</td>\n",
       "      <td>0.000283</td>\n",
       "      <td>-0.000714</td>\n",
       "      <td>0.011001</td>\n",
       "      <td>0.002534</td>\n",
       "      <td>-0.001268</td>\n",
       "      <td>0.009756</td>\n",
       "      <td>0.001118</td>\n",
       "      <td>0.001234</td>\n",
       "      <td>0.014189</td>\n",
       "      <td>-0.000691</td>\n",
       "      <td>-0.001052</td>\n",
       "      <td>-0.000447</td>\n",
       "      <td>-0.004913</td>\n",
       "      <td>0.001173</td>\n",
       "      <td>0.000606</td>\n",
       "      <td>-0.008995</td>\n",
       "      <td>-0.001710</td>\n",
       "      <td>-0.001277</td>\n",
       "      <td>-0.003528</td>\n",
       "      <td>-0.004664</td>\n",
       "      <td>0.001499</td>\n",
       "      <td>0.009440</td>\n",
       "      <td>-0.007053</td>\n",
       "      <td>0.016949</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>46</th>\n",
       "      <td>Small_Intestine_Terminal_Ileum</td>\n",
       "      <td>1.779614e-03</td>\n",
       "      <td>-0.010180</td>\n",
       "      <td>-0.001557</td>\n",
       "      <td>-0.003771</td>\n",
       "      <td>-0.028507</td>\n",
       "      <td>-0.001565</td>\n",
       "      <td>0.005569</td>\n",
       "      <td>0.000377</td>\n",
       "      <td>-0.000211</td>\n",
       "      <td>-0.000805</td>\n",
       "      <td>0.009700</td>\n",
       "      <td>-2.788474e-04</td>\n",
       "      <td>-0.000063</td>\n",
       "      <td>-0.004542</td>\n",
       "      <td>0.010790</td>\n",
       "      <td>0.004383</td>\n",
       "      <td>-0.011690</td>\n",
       "      <td>-0.001988</td>\n",
       "      <td>0.000213</td>\n",
       "      <td>0.000614</td>\n",
       "      <td>0.002158</td>\n",
       "      <td>0.003697</td>\n",
       "      <td>-0.000207</td>\n",
       "      <td>-0.001020</td>\n",
       "      <td>-0.002695</td>\n",
       "      <td>-0.000842</td>\n",
       "      <td>0.000722</td>\n",
       "      <td>0.001223</td>\n",
       "      <td>0.000506</td>\n",
       "      <td>0.003326</td>\n",
       "      <td>-1.660619e-03</td>\n",
       "      <td>-0.005833</td>\n",
       "      <td>-0.002381</td>\n",
       "      <td>-0.019231</td>\n",
       "      <td>0.005733</td>\n",
       "      <td>-0.008748</td>\n",
       "      <td>-0.001306</td>\n",
       "      <td>0.000418</td>\n",
       "      <td>0.011464</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000668</td>\n",
       "      <td>0.000004</td>\n",
       "      <td>-0.005995</td>\n",
       "      <td>0.000327</td>\n",
       "      <td>0.010879</td>\n",
       "      <td>2.866393e-04</td>\n",
       "      <td>0.000472</td>\n",
       "      <td>-0.001234</td>\n",
       "      <td>0.008591</td>\n",
       "      <td>-0.000966</td>\n",
       "      <td>-0.001207</td>\n",
       "      <td>-0.000222</td>\n",
       "      <td>-0.001408</td>\n",
       "      <td>0.000766</td>\n",
       "      <td>0.000918</td>\n",
       "      <td>-0.004091</td>\n",
       "      <td>0.000053</td>\n",
       "      <td>-0.000071</td>\n",
       "      <td>0.003689</td>\n",
       "      <td>0.001948</td>\n",
       "      <td>-0.001213</td>\n",
       "      <td>0.013590</td>\n",
       "      <td>0.001199</td>\n",
       "      <td>0.000594</td>\n",
       "      <td>0.010364</td>\n",
       "      <td>0.000321</td>\n",
       "      <td>-0.000851</td>\n",
       "      <td>-0.000185</td>\n",
       "      <td>-0.004119</td>\n",
       "      <td>0.001626</td>\n",
       "      <td>0.000699</td>\n",
       "      <td>-0.012546</td>\n",
       "      <td>-0.001874</td>\n",
       "      <td>-0.000492</td>\n",
       "      <td>-0.000584</td>\n",
       "      <td>-0.003245</td>\n",
       "      <td>0.000996</td>\n",
       "      <td>0.006505</td>\n",
       "      <td>-0.005312</td>\n",
       "      <td>0.004214</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>47</th>\n",
       "      <td>Spleen</td>\n",
       "      <td>1.036728e-03</td>\n",
       "      <td>-0.007322</td>\n",
       "      <td>-0.000584</td>\n",
       "      <td>-0.000490</td>\n",
       "      <td>-0.091440</td>\n",
       "      <td>0.001687</td>\n",
       "      <td>0.001607</td>\n",
       "      <td>0.002109</td>\n",
       "      <td>-0.002908</td>\n",
       "      <td>0.001594</td>\n",
       "      <td>-0.001062</td>\n",
       "      <td>-6.504044e-04</td>\n",
       "      <td>0.001851</td>\n",
       "      <td>-0.010556</td>\n",
       "      <td>0.003683</td>\n",
       "      <td>0.001526</td>\n",
       "      <td>-0.006808</td>\n",
       "      <td>-0.018372</td>\n",
       "      <td>-0.000496</td>\n",
       "      <td>0.000844</td>\n",
       "      <td>0.000516</td>\n",
       "      <td>-0.007000</td>\n",
       "      <td>0.000126</td>\n",
       "      <td>-0.001043</td>\n",
       "      <td>-0.005264</td>\n",
       "      <td>0.002412</td>\n",
       "      <td>0.000135</td>\n",
       "      <td>0.003055</td>\n",
       "      <td>0.002238</td>\n",
       "      <td>0.011102</td>\n",
       "      <td>-1.350164e-03</td>\n",
       "      <td>0.000590</td>\n",
       "      <td>0.012285</td>\n",
       "      <td>-0.018796</td>\n",
       "      <td>-0.010218</td>\n",
       "      <td>0.005606</td>\n",
       "      <td>-0.003379</td>\n",
       "      <td>0.000051</td>\n",
       "      <td>-0.005120</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000645</td>\n",
       "      <td>-0.007932</td>\n",
       "      <td>0.000294</td>\n",
       "      <td>-0.003847</td>\n",
       "      <td>0.004127</td>\n",
       "      <td>3.362713e-04</td>\n",
       "      <td>0.000737</td>\n",
       "      <td>-0.001136</td>\n",
       "      <td>0.004091</td>\n",
       "      <td>-0.000970</td>\n",
       "      <td>-0.001410</td>\n",
       "      <td>0.001282</td>\n",
       "      <td>-0.005495</td>\n",
       "      <td>0.001654</td>\n",
       "      <td>0.001085</td>\n",
       "      <td>-0.002266</td>\n",
       "      <td>-0.000004</td>\n",
       "      <td>0.000633</td>\n",
       "      <td>-0.003933</td>\n",
       "      <td>0.004110</td>\n",
       "      <td>-0.000696</td>\n",
       "      <td>0.004922</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>0.000324</td>\n",
       "      <td>-0.003900</td>\n",
       "      <td>0.000327</td>\n",
       "      <td>-0.001198</td>\n",
       "      <td>-0.000385</td>\n",
       "      <td>-0.003641</td>\n",
       "      <td>-0.000828</td>\n",
       "      <td>0.000514</td>\n",
       "      <td>-0.015307</td>\n",
       "      <td>-0.005070</td>\n",
       "      <td>0.000016</td>\n",
       "      <td>0.000978</td>\n",
       "      <td>0.000208</td>\n",
       "      <td>0.000690</td>\n",
       "      <td>0.000208</td>\n",
       "      <td>0.001730</td>\n",
       "      <td>-0.003553</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>48</th>\n",
       "      <td>Stomach</td>\n",
       "      <td>6.766976e-04</td>\n",
       "      <td>-0.007108</td>\n",
       "      <td>-0.000137</td>\n",
       "      <td>-0.002653</td>\n",
       "      <td>0.004023</td>\n",
       "      <td>-0.002036</td>\n",
       "      <td>0.001064</td>\n",
       "      <td>0.000477</td>\n",
       "      <td>-0.000771</td>\n",
       "      <td>-0.001251</td>\n",
       "      <td>0.009535</td>\n",
       "      <td>-1.748260e-04</td>\n",
       "      <td>-0.000707</td>\n",
       "      <td>0.003550</td>\n",
       "      <td>0.010853</td>\n",
       "      <td>0.000702</td>\n",
       "      <td>-0.007385</td>\n",
       "      <td>-0.003424</td>\n",
       "      <td>-0.000442</td>\n",
       "      <td>0.000634</td>\n",
       "      <td>0.001521</td>\n",
       "      <td>0.002544</td>\n",
       "      <td>-0.000052</td>\n",
       "      <td>-0.001335</td>\n",
       "      <td>-0.001427</td>\n",
       "      <td>-0.001245</td>\n",
       "      <td>0.000581</td>\n",
       "      <td>0.000846</td>\n",
       "      <td>-0.000075</td>\n",
       "      <td>0.001991</td>\n",
       "      <td>-9.549572e-04</td>\n",
       "      <td>-0.003395</td>\n",
       "      <td>0.000122</td>\n",
       "      <td>-0.014771</td>\n",
       "      <td>0.007367</td>\n",
       "      <td>-0.002773</td>\n",
       "      <td>0.000759</td>\n",
       "      <td>0.000280</td>\n",
       "      <td>0.012120</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000610</td>\n",
       "      <td>-0.000699</td>\n",
       "      <td>-0.007192</td>\n",
       "      <td>-0.000892</td>\n",
       "      <td>0.006917</td>\n",
       "      <td>2.622801e-04</td>\n",
       "      <td>0.001342</td>\n",
       "      <td>-0.001147</td>\n",
       "      <td>0.003434</td>\n",
       "      <td>-0.000241</td>\n",
       "      <td>-0.000314</td>\n",
       "      <td>0.004708</td>\n",
       "      <td>-0.002112</td>\n",
       "      <td>0.000513</td>\n",
       "      <td>0.000722</td>\n",
       "      <td>0.000272</td>\n",
       "      <td>0.000116</td>\n",
       "      <td>-0.000386</td>\n",
       "      <td>0.007223</td>\n",
       "      <td>-0.000714</td>\n",
       "      <td>-0.000549</td>\n",
       "      <td>0.006516</td>\n",
       "      <td>0.000551</td>\n",
       "      <td>0.000769</td>\n",
       "      <td>0.008573</td>\n",
       "      <td>0.000029</td>\n",
       "      <td>-0.000226</td>\n",
       "      <td>-0.000165</td>\n",
       "      <td>-0.002623</td>\n",
       "      <td>0.000748</td>\n",
       "      <td>0.000268</td>\n",
       "      <td>-0.007163</td>\n",
       "      <td>-0.000884</td>\n",
       "      <td>-0.000542</td>\n",
       "      <td>-0.002822</td>\n",
       "      <td>-0.002913</td>\n",
       "      <td>-0.000336</td>\n",
       "      <td>0.005887</td>\n",
       "      <td>-0.002679</td>\n",
       "      <td>0.010624</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>49</th>\n",
       "      <td>Testis</td>\n",
       "      <td>5.087845e-04</td>\n",
       "      <td>-0.000432</td>\n",
       "      <td>0.002794</td>\n",
       "      <td>-0.009168</td>\n",
       "      <td>0.052696</td>\n",
       "      <td>-0.002435</td>\n",
       "      <td>-0.012104</td>\n",
       "      <td>0.001051</td>\n",
       "      <td>0.004798</td>\n",
       "      <td>0.002575</td>\n",
       "      <td>0.014065</td>\n",
       "      <td>4.490330e-04</td>\n",
       "      <td>-0.000152</td>\n",
       "      <td>0.023471</td>\n",
       "      <td>0.006519</td>\n",
       "      <td>0.001357</td>\n",
       "      <td>0.002160</td>\n",
       "      <td>0.018344</td>\n",
       "      <td>0.001274</td>\n",
       "      <td>0.000287</td>\n",
       "      <td>-0.000064</td>\n",
       "      <td>0.002708</td>\n",
       "      <td>-0.000389</td>\n",
       "      <td>0.001325</td>\n",
       "      <td>0.004868</td>\n",
       "      <td>-0.001336</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>-0.003044</td>\n",
       "      <td>-0.005272</td>\n",
       "      <td>-0.006969</td>\n",
       "      <td>7.640357e-04</td>\n",
       "      <td>0.003251</td>\n",
       "      <td>0.005971</td>\n",
       "      <td>-0.010148</td>\n",
       "      <td>0.027989</td>\n",
       "      <td>0.001409</td>\n",
       "      <td>0.005583</td>\n",
       "      <td>0.000155</td>\n",
       "      <td>0.002760</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000131</td>\n",
       "      <td>0.001480</td>\n",
       "      <td>0.005866</td>\n",
       "      <td>0.000821</td>\n",
       "      <td>-0.002750</td>\n",
       "      <td>-5.006073e-04</td>\n",
       "      <td>-0.001199</td>\n",
       "      <td>-0.000577</td>\n",
       "      <td>-0.000924</td>\n",
       "      <td>0.002937</td>\n",
       "      <td>0.002887</td>\n",
       "      <td>0.005969</td>\n",
       "      <td>-0.008281</td>\n",
       "      <td>-0.000879</td>\n",
       "      <td>-0.002564</td>\n",
       "      <td>0.004739</td>\n",
       "      <td>0.000151</td>\n",
       "      <td>-0.000797</td>\n",
       "      <td>0.007825</td>\n",
       "      <td>-0.009154</td>\n",
       "      <td>0.002143</td>\n",
       "      <td>-0.000851</td>\n",
       "      <td>0.000808</td>\n",
       "      <td>0.001900</td>\n",
       "      <td>-0.001154</td>\n",
       "      <td>0.001067</td>\n",
       "      <td>0.002134</td>\n",
       "      <td>0.000462</td>\n",
       "      <td>-0.000714</td>\n",
       "      <td>0.000238</td>\n",
       "      <td>-0.000877</td>\n",
       "      <td>-0.008915</td>\n",
       "      <td>0.006795</td>\n",
       "      <td>-0.000450</td>\n",
       "      <td>-0.006091</td>\n",
       "      <td>-0.004333</td>\n",
       "      <td>-0.001854</td>\n",
       "      <td>0.004869</td>\n",
       "      <td>-0.001288</td>\n",
       "      <td>0.003122</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>50</th>\n",
       "      <td>Thyroid</td>\n",
       "      <td>7.620525e-04</td>\n",
       "      <td>-0.006713</td>\n",
       "      <td>-0.001611</td>\n",
       "      <td>-0.000677</td>\n",
       "      <td>-0.007884</td>\n",
       "      <td>-0.001144</td>\n",
       "      <td>0.007836</td>\n",
       "      <td>-0.000492</td>\n",
       "      <td>-0.001094</td>\n",
       "      <td>-0.003348</td>\n",
       "      <td>0.004282</td>\n",
       "      <td>-3.514626e-04</td>\n",
       "      <td>-0.000425</td>\n",
       "      <td>-0.010478</td>\n",
       "      <td>0.005157</td>\n",
       "      <td>0.000078</td>\n",
       "      <td>-0.006669</td>\n",
       "      <td>-0.011464</td>\n",
       "      <td>0.000164</td>\n",
       "      <td>-0.000172</td>\n",
       "      <td>0.001675</td>\n",
       "      <td>0.002054</td>\n",
       "      <td>0.000029</td>\n",
       "      <td>-0.000826</td>\n",
       "      <td>-0.002247</td>\n",
       "      <td>-0.001339</td>\n",
       "      <td>0.000407</td>\n",
       "      <td>0.000888</td>\n",
       "      <td>0.001086</td>\n",
       "      <td>0.002868</td>\n",
       "      <td>-7.290150e-04</td>\n",
       "      <td>-0.007547</td>\n",
       "      <td>-0.004939</td>\n",
       "      <td>0.000053</td>\n",
       "      <td>-0.003184</td>\n",
       "      <td>-0.004760</td>\n",
       "      <td>-0.000186</td>\n",
       "      <td>0.000250</td>\n",
       "      <td>0.006016</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000340</td>\n",
       "      <td>0.001835</td>\n",
       "      <td>-0.003180</td>\n",
       "      <td>0.001078</td>\n",
       "      <td>0.008483</td>\n",
       "      <td>4.909468e-04</td>\n",
       "      <td>0.000627</td>\n",
       "      <td>-0.000044</td>\n",
       "      <td>0.004769</td>\n",
       "      <td>-0.001705</td>\n",
       "      <td>-0.001578</td>\n",
       "      <td>0.000240</td>\n",
       "      <td>0.002151</td>\n",
       "      <td>0.000898</td>\n",
       "      <td>0.001351</td>\n",
       "      <td>-0.002282</td>\n",
       "      <td>0.000070</td>\n",
       "      <td>-0.000238</td>\n",
       "      <td>-0.000702</td>\n",
       "      <td>0.003995</td>\n",
       "      <td>-0.000724</td>\n",
       "      <td>0.006545</td>\n",
       "      <td>0.000530</td>\n",
       "      <td>0.000019</td>\n",
       "      <td>0.007335</td>\n",
       "      <td>-0.000400</td>\n",
       "      <td>-0.001037</td>\n",
       "      <td>-0.000091</td>\n",
       "      <td>-0.001668</td>\n",
       "      <td>0.001174</td>\n",
       "      <td>0.000581</td>\n",
       "      <td>0.000507</td>\n",
       "      <td>-0.001762</td>\n",
       "      <td>-0.000427</td>\n",
       "      <td>0.000401</td>\n",
       "      <td>-0.000002</td>\n",
       "      <td>0.001062</td>\n",
       "      <td>0.002103</td>\n",
       "      <td>-0.003110</td>\n",
       "      <td>0.004066</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>51</th>\n",
       "      <td>Uterus</td>\n",
       "      <td>-3.315096e-04</td>\n",
       "      <td>-0.000500</td>\n",
       "      <td>-0.000222</td>\n",
       "      <td>0.001088</td>\n",
       "      <td>0.060255</td>\n",
       "      <td>0.000153</td>\n",
       "      <td>0.002618</td>\n",
       "      <td>-0.000491</td>\n",
       "      <td>-0.001066</td>\n",
       "      <td>0.000684</td>\n",
       "      <td>-0.003590</td>\n",
       "      <td>1.261430e-04</td>\n",
       "      <td>-0.000597</td>\n",
       "      <td>-0.008325</td>\n",
       "      <td>-0.002015</td>\n",
       "      <td>0.001535</td>\n",
       "      <td>0.002597</td>\n",
       "      <td>-0.007894</td>\n",
       "      <td>0.000452</td>\n",
       "      <td>-0.000410</td>\n",
       "      <td>0.000148</td>\n",
       "      <td>0.000311</td>\n",
       "      <td>-0.000027</td>\n",
       "      <td>-0.000291</td>\n",
       "      <td>-0.000058</td>\n",
       "      <td>-0.000238</td>\n",
       "      <td>-0.000007</td>\n",
       "      <td>0.000119</td>\n",
       "      <td>-0.001053</td>\n",
       "      <td>0.002027</td>\n",
       "      <td>2.145799e-04</td>\n",
       "      <td>-0.000527</td>\n",
       "      <td>-0.003521</td>\n",
       "      <td>0.007944</td>\n",
       "      <td>-0.007746</td>\n",
       "      <td>0.001219</td>\n",
       "      <td>0.000092</td>\n",
       "      <td>-0.000031</td>\n",
       "      <td>-0.000064</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.000022</td>\n",
       "      <td>-0.001622</td>\n",
       "      <td>0.002245</td>\n",
       "      <td>0.000435</td>\n",
       "      <td>0.000964</td>\n",
       "      <td>3.913476e-04</td>\n",
       "      <td>0.000164</td>\n",
       "      <td>0.000286</td>\n",
       "      <td>-0.002859</td>\n",
       "      <td>-0.000541</td>\n",
       "      <td>-0.000735</td>\n",
       "      <td>-0.000887</td>\n",
       "      <td>0.001173</td>\n",
       "      <td>-0.000021</td>\n",
       "      <td>-0.000386</td>\n",
       "      <td>0.000473</td>\n",
       "      <td>0.000014</td>\n",
       "      <td>0.000232</td>\n",
       "      <td>0.001252</td>\n",
       "      <td>-0.000032</td>\n",
       "      <td>0.000198</td>\n",
       "      <td>-0.002415</td>\n",
       "      <td>-0.000037</td>\n",
       "      <td>-0.000471</td>\n",
       "      <td>-0.002025</td>\n",
       "      <td>-0.000581</td>\n",
       "      <td>0.000089</td>\n",
       "      <td>0.000033</td>\n",
       "      <td>0.000637</td>\n",
       "      <td>-0.000032</td>\n",
       "      <td>-0.000086</td>\n",
       "      <td>0.004020</td>\n",
       "      <td>-0.000013</td>\n",
       "      <td>-0.000333</td>\n",
       "      <td>0.000190</td>\n",
       "      <td>0.001333</td>\n",
       "      <td>-0.000291</td>\n",
       "      <td>-0.003102</td>\n",
       "      <td>0.001497</td>\n",
       "      <td>-0.000751</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>52</th>\n",
       "      <td>Vagina</td>\n",
       "      <td>1.179596e-03</td>\n",
       "      <td>-0.011231</td>\n",
       "      <td>-0.001884</td>\n",
       "      <td>0.001258</td>\n",
       "      <td>0.058689</td>\n",
       "      <td>-0.002026</td>\n",
       "      <td>0.011549</td>\n",
       "      <td>-0.000588</td>\n",
       "      <td>-0.003017</td>\n",
       "      <td>-0.003870</td>\n",
       "      <td>0.011650</td>\n",
       "      <td>-1.039324e-04</td>\n",
       "      <td>-0.002577</td>\n",
       "      <td>-0.013583</td>\n",
       "      <td>0.016754</td>\n",
       "      <td>-0.000605</td>\n",
       "      <td>-0.014325</td>\n",
       "      <td>-0.023778</td>\n",
       "      <td>-0.001112</td>\n",
       "      <td>0.000165</td>\n",
       "      <td>0.002582</td>\n",
       "      <td>0.003343</td>\n",
       "      <td>-0.000004</td>\n",
       "      <td>-0.002740</td>\n",
       "      <td>-0.004760</td>\n",
       "      <td>-0.003940</td>\n",
       "      <td>0.000393</td>\n",
       "      <td>0.001902</td>\n",
       "      <td>0.002102</td>\n",
       "      <td>0.005383</td>\n",
       "      <td>-1.422610e-03</td>\n",
       "      <td>-0.012921</td>\n",
       "      <td>-0.008978</td>\n",
       "      <td>-0.007182</td>\n",
       "      <td>-0.006855</td>\n",
       "      <td>-0.007339</td>\n",
       "      <td>-0.000039</td>\n",
       "      <td>0.000457</td>\n",
       "      <td>0.014096</td>\n",
       "      <td>...</td>\n",
       "      <td>0.000973</td>\n",
       "      <td>0.000398</td>\n",
       "      <td>-0.009381</td>\n",
       "      <td>-0.000888</td>\n",
       "      <td>0.014262</td>\n",
       "      <td>8.641858e-04</td>\n",
       "      <td>0.001756</td>\n",
       "      <td>-0.000637</td>\n",
       "      <td>0.006681</td>\n",
       "      <td>-0.002306</td>\n",
       "      <td>-0.001693</td>\n",
       "      <td>0.003975</td>\n",
       "      <td>0.002405</td>\n",
       "      <td>0.001802</td>\n",
       "      <td>0.002036</td>\n",
       "      <td>-0.001971</td>\n",
       "      <td>0.000150</td>\n",
       "      <td>-0.000555</td>\n",
       "      <td>0.008484</td>\n",
       "      <td>0.004614</td>\n",
       "      <td>-0.001638</td>\n",
       "      <td>0.004659</td>\n",
       "      <td>0.000822</td>\n",
       "      <td>0.000269</td>\n",
       "      <td>0.013356</td>\n",
       "      <td>-0.000855</td>\n",
       "      <td>-0.001751</td>\n",
       "      <td>-0.000250</td>\n",
       "      <td>-0.003743</td>\n",
       "      <td>0.001029</td>\n",
       "      <td>0.000702</td>\n",
       "      <td>0.000509</td>\n",
       "      <td>-0.003177</td>\n",
       "      <td>-0.000972</td>\n",
       "      <td>-0.001346</td>\n",
       "      <td>-0.002495</td>\n",
       "      <td>0.002509</td>\n",
       "      <td>0.003490</td>\n",
       "      <td>-0.004979</td>\n",
       "      <td>0.013948</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>53</th>\n",
       "      <td>Whole_Blood</td>\n",
       "      <td>2.435642e-03</td>\n",
       "      <td>-0.009391</td>\n",
       "      <td>0.000035</td>\n",
       "      <td>-0.004766</td>\n",
       "      <td>-0.131825</td>\n",
       "      <td>0.001525</td>\n",
       "      <td>-0.001870</td>\n",
       "      <td>0.002693</td>\n",
       "      <td>-0.000918</td>\n",
       "      <td>0.001038</td>\n",
       "      <td>0.003992</td>\n",
       "      <td>-9.429999e-04</td>\n",
       "      <td>0.003633</td>\n",
       "      <td>-0.001352</td>\n",
       "      <td>0.010203</td>\n",
       "      <td>0.004819</td>\n",
       "      <td>-0.009171</td>\n",
       "      <td>-0.012620</td>\n",
       "      <td>0.000669</td>\n",
       "      <td>0.001506</td>\n",
       "      <td>0.000823</td>\n",
       "      <td>-0.005160</td>\n",
       "      <td>-0.000071</td>\n",
       "      <td>-0.000433</td>\n",
       "      <td>-0.006079</td>\n",
       "      <td>0.003668</td>\n",
       "      <td>0.000543</td>\n",
       "      <td>0.003907</td>\n",
       "      <td>0.001008</td>\n",
       "      <td>0.012455</td>\n",
       "      <td>-1.657452e-03</td>\n",
       "      <td>0.005504</td>\n",
       "      <td>0.016947</td>\n",
       "      <td>-0.031746</td>\n",
       "      <td>-0.003962</td>\n",
       "      <td>0.000226</td>\n",
       "      <td>-0.003965</td>\n",
       "      <td>0.000117</td>\n",
       "      <td>-0.006036</td>\n",
       "      <td>...</td>\n",
       "      <td>0.001201</td>\n",
       "      <td>-0.011613</td>\n",
       "      <td>0.002339</td>\n",
       "      <td>-0.005547</td>\n",
       "      <td>0.005292</td>\n",
       "      <td>1.060509e-05</td>\n",
       "      <td>0.000434</td>\n",
       "      <td>-0.003219</td>\n",
       "      <td>0.006662</td>\n",
       "      <td>-0.000375</td>\n",
       "      <td>-0.000008</td>\n",
       "      <td>0.001443</td>\n",
       "      <td>-0.011763</td>\n",
       "      <td>0.002194</td>\n",
       "      <td>-0.000357</td>\n",
       "      <td>-0.003371</td>\n",
       "      <td>0.000067</td>\n",
       "      <td>0.000702</td>\n",
       "      <td>0.000136</td>\n",
       "      <td>0.003370</td>\n",
       "      <td>-0.000915</td>\n",
       "      <td>0.009122</td>\n",
       "      <td>0.000660</td>\n",
       "      <td>0.001063</td>\n",
       "      <td>-0.008365</td>\n",
       "      <td>0.001768</td>\n",
       "      <td>-0.000933</td>\n",
       "      <td>-0.000342</td>\n",
       "      <td>-0.005848</td>\n",
       "      <td>-0.001305</td>\n",
       "      <td>0.000477</td>\n",
       "      <td>-0.019155</td>\n",
       "      <td>-0.003660</td>\n",
       "      <td>-0.000253</td>\n",
       "      <td>-0.000146</td>\n",
       "      <td>-0.002828</td>\n",
       "      <td>0.002185</td>\n",
       "      <td>0.004560</td>\n",
       "      <td>0.001536</td>\n",
       "      <td>-0.007673</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>54 rows × 602 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                              sample_name         AEBP2  ...      ZXDB      ZXDC\n",
       "0                    Adipose_Subcutaneous  3.346075e-04  ...  0.001416 -0.005460\n",
       "1                Adipose_Visceral_Omentum  5.258322e-04  ...  0.000620 -0.004052\n",
       "2                           Adrenal_Gland  1.616744e-04  ...  0.001105  0.000742\n",
       "3                            Artery_Aorta  3.575876e-07  ...  0.000283 -0.002274\n",
       "4                         Artery_Coronary -2.994203e-04  ...  0.001628 -0.006450\n",
       "5                           Artery_Tibial -7.869059e-04  ... -0.000030 -0.003652\n",
       "6                                 Bladder  3.787277e-04  ... -0.003288  0.008086\n",
       "7                          Brain_Amygdala -2.451743e-03  ...  0.001319  0.003035\n",
       "8    Brain_Anterior_cingulate_cortex_BA24 -2.210161e-03  ...  0.002266  0.001264\n",
       "9             Brain_Caudate_basal_ganglia -2.278672e-03  ...  0.001614  0.002608\n",
       "10            Brain_Cerebellar_Hemisphere -2.634194e-03  ...  0.000768  0.001971\n",
       "11                       Brain_Cerebellum -2.781179e-03  ...  0.001430  0.008633\n",
       "12                           Brain_Cortex -2.279946e-03  ...  0.000884  0.003710\n",
       "13               Brain_Frontal_Cortex_BA9 -2.249482e-03  ...  0.001562  0.003592\n",
       "14                      Brain_Hippocampus -2.218950e-03  ... -0.001017  0.004118\n",
       "15                     Brain_Hypothalamus -2.172592e-03  ...  0.002069  0.001994\n",
       "16  Brain_Nucleus_accumbens_basal_ganglia -2.008186e-03  ... -0.000864  0.004215\n",
       "17            Brain_Putamen_basal_ganglia -2.152133e-03  ...  0.001570 -0.001038\n",
       "18         Brain_Spinal_cord_cervical_c_1 -1.516657e-03  ...  0.004070 -0.003346\n",
       "19                 Brain_Substantia_nigra -1.822131e-03  ...  0.000258 -0.000789\n",
       "20                  Breast_Mammary_Tissue  4.687478e-04  ... -0.004103  0.004161\n",
       "21      Cells_EBV_transformed_lymphocytes  2.365113e-03  ...  0.003209  0.003276\n",
       "22          Cells_Transformed_fibroblasts  3.247789e-04  ...  0.001850 -0.000427\n",
       "23                      Cervix_Ectocervix  1.504101e-05  ... -0.001209 -0.000173\n",
       "24                      Cervix_Endocervix  1.162671e-04  ...  0.001705 -0.000206\n",
       "25                          Colon_Sigmoid -4.677901e-04  ... -0.000721 -0.001881\n",
       "26                       Colon_Transverse  7.112175e-04  ... -0.004536  0.008752\n",
       "27    Esophagus_Gastroesophageal_Junction -4.213836e-04  ... -0.001474 -0.002173\n",
       "28                       Esophagus_Mucosa  2.159301e-03  ... -0.007667  0.021668\n",
       "29                   Esophagus_Muscularis -1.149822e-03  ... -0.001377 -0.002081\n",
       "30                         Fallopian_Tube -3.916526e-05  ... -0.003064  0.002734\n",
       "31                 Heart_Atrial_Appendage -3.049119e-04  ... -0.001703 -0.001386\n",
       "32                   Heart_Left_Ventricle -2.449080e-04  ...  0.002189 -0.001493\n",
       "33                          Kidney_Cortex  1.459853e-03  ... -0.002152  0.004546\n",
       "34                                  Liver  1.088776e-03  ... -0.005945 -0.003680\n",
       "35                                   Lung  6.469219e-04  ... -0.003093  0.000124\n",
       "36                              MedianExp -1.322297e-04  ...  0.000765 -0.001933\n",
       "37                   Minor_Salivary_Gland  1.520276e-03  ... -0.005588  0.013110\n",
       "38                        Muscle_Skeletal -1.604136e-04  ...  0.001375 -0.006562\n",
       "39                           Nerve_Tibial  8.790419e-05  ... -0.001137 -0.001889\n",
       "40                                  Ovary -4.582781e-05  ...  0.001753 -0.003594\n",
       "41                               Pancreas  8.820569e-04  ... -0.003543  0.009771\n",
       "42                              Pituitary -6.130586e-04  ... -0.001902  0.009997\n",
       "43                               Prostate  6.404887e-04  ... -0.002886  0.010183\n",
       "44        Skin_Not_Sun_Exposed_Suprapubic  2.009114e-03  ... -0.007391  0.017251\n",
       "45             Skin_Sun_Exposed_Lower_leg  1.481231e-03  ... -0.007053  0.016949\n",
       "46         Small_Intestine_Terminal_Ileum  1.779614e-03  ... -0.005312  0.004214\n",
       "47                                 Spleen  1.036728e-03  ...  0.001730 -0.003553\n",
       "48                                Stomach  6.766976e-04  ... -0.002679  0.010624\n",
       "49                                 Testis  5.087845e-04  ... -0.001288  0.003122\n",
       "50                                Thyroid  7.620525e-04  ... -0.003110  0.004066\n",
       "51                                 Uterus -3.315096e-04  ...  0.001497 -0.000751\n",
       "52                                 Vagina  1.179596e-03  ... -0.004979  0.013948\n",
       "53                            Whole_Blood  2.435642e-03  ...  0.001536 -0.007673\n",
       "\n",
       "[54 rows x 602 columns]"
      ]
     },
     "execution_count": 11,
     "metadata": {
      "tags": []
     },
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Concatenate and summarize DeepLIFT scores \n",
    "! Rscript --vanilla --slave functions/summarize_DeepLIFT.R \"$outloc$best_model\" &> /dev/null \n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/DeepLIFT/RNA_importance_mean.txt: Average DeepLIFT score for each RNA regulator in each tissue.\n",
    "#.{outloc}/{best_model}/DeepLIFT/promoter_importance_mean.txt: Average DeepLIFT score for each promoter regulator in each tissue.\n",
    "pd.read_csv(outloc+best_model+'/DeepLIFT/RNA_importance_mean.txt',sep=\"\\t\")\n",
    "pd.read_csv(outloc+best_model+'/DeepLIFT/promoter_importance_mean.txt',sep=\"\\t\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "AC8f7GvQO2yv"
   },
   "source": [
    "### Simulate the concequence of regulator knockout"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 0,
   "metadata": {
    "colab": {},
    "colab_type": "code",
    "id": "NTRY0TDkO2yv"
   },
   "outputs": [],
   "source": [
    "# Simulate the concequence of regulator knockout\n",
    "genes=[\"ENSG00000268903\",\"ENSG00000239906\"]\n",
    "model_utils.coexpression_with_KO(genes,\n",
    "                                 outloc,\n",
    "                                 best_model,\n",
    "                                 X_mRNA_test,\n",
    "                                 X_promoter_test,\n",
    "                                 Y_test)  \n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/regulator_KO/coexpression.txt.gz: The 1st column and the 2nd column indicates Spearman's correlation between genes and corresoponding p-value, respectively. The 3rd column indicates indexes of RNA regulators knockouted, separated by commas. The 4th column indicates indexes of DNA regulators knockouted, separated by commas. Regulator index corresponds to one in {outloc}/feature_norm_stats.txt.           "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 762
    },
    "colab_type": "code",
    "id": "fSvbJi49O2yx",
    "outputId": "380e84b7-791b-4082-aa7f-ee22920818df",
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
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       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>term</th>\n",
       "      <th>estimate</th>\n",
       "      <th>std.error</th>\n",
       "      <th>statistic</th>\n",
       "      <th>p.value</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>EGR1</td>\n",
       "      <td>0.019071</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>34.754318</td>\n",
       "      <td>6.349288e-250</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>ESR1</td>\n",
       "      <td>0.013733</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>25.042667</td>\n",
       "      <td>2.778717e-134</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>WT1</td>\n",
       "      <td>-0.010967</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>-20.001986</td>\n",
       "      <td>2.684291e-87</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>CEBPA</td>\n",
       "      <td>-0.010542</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>-19.219337</td>\n",
       "      <td>7.304835e-81</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>ZNF18</td>\n",
       "      <td>-0.010246</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>-18.683391</td>\n",
       "      <td>1.358906e-76</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>ZBTB33</td>\n",
       "      <td>0.007998</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>14.573703</td>\n",
       "      <td>1.271898e-47</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>MYCN</td>\n",
       "      <td>0.007575</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>13.816717</td>\n",
       "      <td>5.026077e-43</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>ESRRA</td>\n",
       "      <td>0.006425</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>11.715854</td>\n",
       "      <td>1.699357e-31</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>SP1</td>\n",
       "      <td>0.006124</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>11.168537</td>\n",
       "      <td>8.610233e-29</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>ZNF592</td>\n",
       "      <td>0.006016</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>10.959262</td>\n",
       "      <td>8.637257e-28</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>NR2F1</td>\n",
       "      <td>-0.005765</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>-10.508947</td>\n",
       "      <td>1.069970e-25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>CEBPG</td>\n",
       "      <td>0.005200</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>9.481714</td>\n",
       "      <td>3.072929e-21</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>RARA</td>\n",
       "      <td>0.004996</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>9.104690</td>\n",
       "      <td>1.030954e-19</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>SP5</td>\n",
       "      <td>-0.003823</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>-6.969737</td>\n",
       "      <td>3.376234e-12</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>ZBTB7A</td>\n",
       "      <td>-0.003350</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>-6.106875</td>\n",
       "      <td>1.053893e-09</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>NR2F6</td>\n",
       "      <td>-0.003329</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>-6.069577</td>\n",
       "      <td>1.329147e-09</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>NR2C2</td>\n",
       "      <td>-0.002899</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>-5.287327</td>\n",
       "      <td>1.267415e-07</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>NR2C1</td>\n",
       "      <td>0.002705</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>4.932488</td>\n",
       "      <td>8.249865e-07</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>VEZF1</td>\n",
       "      <td>0.002518</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>4.590295</td>\n",
       "      <td>4.480296e-06</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>ZNF639</td>\n",
       "      <td>-0.001717</td>\n",
       "      <td>0.000549</td>\n",
       "      <td>-3.129276</td>\n",
       "      <td>1.757426e-03</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>GRHL3</td>\n",
       "      <td>0.001635</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>2.981290</td>\n",
       "      <td>2.877298e-03</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>RUNX1</td>\n",
       "      <td>0.001582</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>2.884609</td>\n",
       "      <td>3.927390e-03</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>CEBPB</td>\n",
       "      <td>-0.000787</td>\n",
       "      <td>0.000548</td>\n",
       "      <td>-1.434446</td>\n",
       "      <td>1.514764e-01</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "      term  estimate  std.error  statistic        p.value\n",
       "0     EGR1  0.019071   0.000549  34.754318  6.349288e-250\n",
       "1     ESR1  0.013733   0.000548  25.042667  2.778717e-134\n",
       "2      WT1 -0.010967   0.000548 -20.001986   2.684291e-87\n",
       "3    CEBPA -0.010542   0.000549 -19.219337   7.304835e-81\n",
       "4    ZNF18 -0.010246   0.000548 -18.683391   1.358906e-76\n",
       "5   ZBTB33  0.007998   0.000549  14.573703   1.271898e-47\n",
       "6     MYCN  0.007575   0.000548  13.816717   5.026077e-43\n",
       "7    ESRRA  0.006425   0.000548  11.715854   1.699357e-31\n",
       "8      SP1  0.006124   0.000548  11.168537   8.610233e-29\n",
       "9   ZNF592  0.006016   0.000549  10.959262   8.637257e-28\n",
       "10   NR2F1 -0.005765   0.000549 -10.508947   1.069970e-25\n",
       "11   CEBPG  0.005200   0.000548   9.481714   3.072929e-21\n",
       "12    RARA  0.004996   0.000549   9.104690   1.030954e-19\n",
       "13     SP5 -0.003823   0.000549  -6.969737   3.376234e-12\n",
       "14  ZBTB7A -0.003350   0.000549  -6.106875   1.053893e-09\n",
       "15   NR2F6 -0.003329   0.000549  -6.069577   1.329147e-09\n",
       "16   NR2C2 -0.002899   0.000548  -5.287327   1.267415e-07\n",
       "17   NR2C1  0.002705   0.000548   4.932488   8.249865e-07\n",
       "18   VEZF1  0.002518   0.000548   4.590295   4.480296e-06\n",
       "19  ZNF639 -0.001717   0.000549  -3.129276   1.757426e-03\n",
       "20   GRHL3  0.001635   0.000548   2.981290   2.877298e-03\n",
       "21   RUNX1  0.001582   0.000548   2.884609   3.927390e-03\n",
       "22   CEBPB -0.000787   0.000548  -1.434446   1.514764e-01"
      ]
     },
     "execution_count": 13,
     "metadata": {
      "tags": []
     },
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Identification of key regulators of coexpression via multiple linear regression.\n",
    "! Rscript --vanilla --slave functions/test_KO.R \"$outloc$best_model\" &> /dev/null \n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/regulator_KO/regression_res.txt: Result of regression test.\n",
    "pd.read_csv(outloc+best_model+'/regulator_KO/regression_res.txt',sep=\"\\t\")\n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "colab_type": "text",
    "id": "5TnegIbXO2yz"
   },
   "source": [
    "### Simulate the concequence of binding site removals"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 0,
   "metadata": {
    "colab": {},
    "colab_type": "code",
    "id": "70iO5EzsO2yz"
   },
   "outputs": [],
   "source": [
    "# Simulate the concequence of binding site removals\n",
    "genes=[\"ENSG00000268903\",\"ENSG00000239906\"]\n",
    "model_utils.coexpression_with_binding_site_removal(genes,\n",
    "                                                   outloc,\n",
    "                                                   best_model,\n",
    "                                                   X_mRNA_test,\n",
    "                                                   X_promoter_test,\n",
    "                                                   Y_test)\n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/binding_site_removal/coexpression.txt.gz: The 1st column indicates gene whose biniding sites were removed. The 2nd and the 3rd column indicates Spearman's correlation between genes and corresoponding p-value, respectively. The 4th column indicates indexes of RNA interval where biding sites were removed, separated by commas. The 5th column indicates indexes of promoter interval where biding sites were removed, separated by commas."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {
    "colab": {
     "base_uri": "https://localhost:8080/",
     "height": 1000
    },
    "colab_type": "code",
    "id": "oUar33B1O2y1",
    "outputId": "2a0c0d05-4de0-453c-b779-118ff74718f4",
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
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       "    .dataframe thead th {\n",
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       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>term</th>\n",
       "      <th>estimate</th>\n",
       "      <th>std.error</th>\n",
       "      <th>statistic</th>\n",
       "      <th>p.value</th>\n",
       "      <th>Gene</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>promoter_interval_27</td>\n",
       "      <td>1.404362e-02</td>\n",
       "      <td>2.082604e-04</td>\n",
       "      <td>6.743297e+01</td>\n",
       "      <td>0.000000e+00</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>promoter_interval_28</td>\n",
       "      <td>1.434568e-02</td>\n",
       "      <td>2.083366e-04</td>\n",
       "      <td>6.885817e+01</td>\n",
       "      <td>0.000000e+00</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>promoter_interval_30</td>\n",
       "      <td>6.450572e-04</td>\n",
       "      <td>6.514633e-18</td>\n",
       "      <td>9.901667e+13</td>\n",
       "      <td>0.000000e+00</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>promoter_interval_14</td>\n",
       "      <td>7.401378e-03</td>\n",
       "      <td>2.083081e-04</td>\n",
       "      <td>3.553093e+01</td>\n",
       "      <td>1.834235e-260</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>promoter_interval_11</td>\n",
       "      <td>5.935169e-03</td>\n",
       "      <td>2.082483e-04</td>\n",
       "      <td>2.850044e+01</td>\n",
       "      <td>7.945986e-172</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>promoter_interval_10</td>\n",
       "      <td>-5.225048e-03</td>\n",
       "      <td>2.084236e-04</td>\n",
       "      <td>-2.506937e+01</td>\n",
       "      <td>1.494389e-134</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>promoter_interval_13</td>\n",
       "      <td>4.137921e-03</td>\n",
       "      <td>2.083907e-04</td>\n",
       "      <td>1.985656e+01</td>\n",
       "      <td>4.407078e-86</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>promoter_interval_12</td>\n",
       "      <td>-3.136259e-03</td>\n",
       "      <td>2.082211e-04</td>\n",
       "      <td>-1.506216e+01</td>\n",
       "      <td>1.036337e-50</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>promoter_interval_16</td>\n",
       "      <td>2.590693e-03</td>\n",
       "      <td>2.082527e-04</td>\n",
       "      <td>1.244014e+01</td>\n",
       "      <td>2.889767e-35</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>promoter_interval_15</td>\n",
       "      <td>-2.217819e-03</td>\n",
       "      <td>2.083146e-04</td>\n",
       "      <td>-1.064649e+01</td>\n",
       "      <td>2.507232e-26</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>promoter_interval_29</td>\n",
       "      <td>2.018174e-03</td>\n",
       "      <td>2.082784e-04</td>\n",
       "      <td>9.689788e+00</td>\n",
       "      <td>4.170606e-22</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>promoter_interval_26</td>\n",
       "      <td>4.602962e-04</td>\n",
       "      <td>2.083079e-04</td>\n",
       "      <td>2.209691e+00</td>\n",
       "      <td>2.714926e-02</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>promoter_interval_2</td>\n",
       "      <td>-4.414119e-04</td>\n",
       "      <td>2.083163e-04</td>\n",
       "      <td>-2.118950e+00</td>\n",
       "      <td>3.411938e-02</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>promoter_interval_6</td>\n",
       "      <td>3.639901e-04</td>\n",
       "      <td>2.083177e-04</td>\n",
       "      <td>1.747284e+00</td>\n",
       "      <td>8.061893e-02</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>promoter_interval_8</td>\n",
       "      <td>2.998532e-04</td>\n",
       "      <td>2.083565e-04</td>\n",
       "      <td>1.439135e+00</td>\n",
       "      <td>1.501436e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>promoter_interval_19</td>\n",
       "      <td>2.935165e-04</td>\n",
       "      <td>2.082525e-04</td>\n",
       "      <td>1.409426e+00</td>\n",
       "      <td>1.587405e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>promoter_interval_4</td>\n",
       "      <td>-2.895187e-04</td>\n",
       "      <td>2.083148e-04</td>\n",
       "      <td>-1.389813e+00</td>\n",
       "      <td>1.646167e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>promoter_interval_17</td>\n",
       "      <td>-2.854850e-04</td>\n",
       "      <td>2.082155e-04</td>\n",
       "      <td>-1.371103e+00</td>\n",
       "      <td>1.703736e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>promoter_interval_9</td>\n",
       "      <td>-2.722893e-04</td>\n",
       "      <td>2.083700e-04</td>\n",
       "      <td>-1.306759e+00</td>\n",
       "      <td>1.913247e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>RNA_interval_4</td>\n",
       "      <td>-2.656886e-04</td>\n",
       "      <td>2.084212e-04</td>\n",
       "      <td>-1.274768e+00</td>\n",
       "      <td>2.024212e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>RNA_interval_2</td>\n",
       "      <td>2.629946e-04</td>\n",
       "      <td>2.085904e-04</td>\n",
       "      <td>1.260818e+00</td>\n",
       "      <td>2.074038e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>promoter_interval_21</td>\n",
       "      <td>2.384083e-04</td>\n",
       "      <td>2.083867e-04</td>\n",
       "      <td>1.144067e+00</td>\n",
       "      <td>2.526235e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>promoter_interval_25</td>\n",
       "      <td>-2.351393e-04</td>\n",
       "      <td>2.083981e-04</td>\n",
       "      <td>-1.128318e+00</td>\n",
       "      <td>2.592130e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>promoter_interval_18</td>\n",
       "      <td>-2.341228e-04</td>\n",
       "      <td>2.083751e-04</td>\n",
       "      <td>-1.123564e+00</td>\n",
       "      <td>2.612249e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>promoter_interval_3</td>\n",
       "      <td>-2.332801e-04</td>\n",
       "      <td>2.082310e-04</td>\n",
       "      <td>-1.120295e+00</td>\n",
       "      <td>2.626152e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>promoter_interval_7</td>\n",
       "      <td>2.313951e-04</td>\n",
       "      <td>2.083475e-04</td>\n",
       "      <td>1.110621e+00</td>\n",
       "      <td>2.667583e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>RNA_interval_2</td>\n",
       "      <td>7.189265e-18</td>\n",
       "      <td>6.517884e-18</td>\n",
       "      <td>1.103006e+00</td>\n",
       "      <td>2.700512e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>RNA_interval_3</td>\n",
       "      <td>7.173850e-18</td>\n",
       "      <td>6.515152e-18</td>\n",
       "      <td>1.101102e+00</td>\n",
       "      <td>2.708787e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>promoter_interval_12</td>\n",
       "      <td>7.119031e-18</td>\n",
       "      <td>6.519230e-18</td>\n",
       "      <td>1.092005e+00</td>\n",
       "      <td>2.748573e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>promoter_interval_10</td>\n",
       "      <td>7.057541e-18</td>\n",
       "      <td>6.516699e-18</td>\n",
       "      <td>1.082993e+00</td>\n",
       "      <td>2.788376e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>38</th>\n",
       "      <td>promoter_interval_19</td>\n",
       "      <td>6.655176e-18</td>\n",
       "      <td>6.519335e-18</td>\n",
       "      <td>1.020837e+00</td>\n",
       "      <td>3.073567e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>39</th>\n",
       "      <td>promoter_interval_23</td>\n",
       "      <td>6.636696e-18</td>\n",
       "      <td>6.512713e-18</td>\n",
       "      <td>1.019037e+00</td>\n",
       "      <td>3.082101e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>40</th>\n",
       "      <td>promoter_interval_9</td>\n",
       "      <td>6.604662e-18</td>\n",
       "      <td>6.514126e-18</td>\n",
       "      <td>1.013898e+00</td>\n",
       "      <td>3.106558e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>41</th>\n",
       "      <td>promoter_interval_14</td>\n",
       "      <td>6.605981e-18</td>\n",
       "      <td>6.518042e-18</td>\n",
       "      <td>1.013492e+00</td>\n",
       "      <td>3.108500e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>42</th>\n",
       "      <td>promoter_interval_26</td>\n",
       "      <td>6.553259e-18</td>\n",
       "      <td>6.520925e-18</td>\n",
       "      <td>1.004958e+00</td>\n",
       "      <td>3.149413e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>43</th>\n",
       "      <td>promoter_interval_5</td>\n",
       "      <td>6.488284e-18</td>\n",
       "      <td>6.517497e-18</td>\n",
       "      <td>9.955178e-01</td>\n",
       "      <td>3.195087e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>44</th>\n",
       "      <td>promoter_interval_2</td>\n",
       "      <td>6.411584e-18</td>\n",
       "      <td>6.519090e-18</td>\n",
       "      <td>9.835091e-01</td>\n",
       "      <td>3.253808e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>45</th>\n",
       "      <td>promoter_interval_28</td>\n",
       "      <td>6.375772e-18</td>\n",
       "      <td>6.517487e-18</td>\n",
       "      <td>9.782563e-01</td>\n",
       "      <td>3.279713e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>46</th>\n",
       "      <td>promoter_interval_25</td>\n",
       "      <td>6.360781e-18</td>\n",
       "      <td>6.515324e-18</td>\n",
       "      <td>9.762802e-01</td>\n",
       "      <td>3.289493e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>47</th>\n",
       "      <td>promoter_interval_7</td>\n",
       "      <td>6.358017e-18</td>\n",
       "      <td>6.517175e-18</td>\n",
       "      <td>9.755786e-01</td>\n",
       "      <td>3.292970e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>48</th>\n",
       "      <td>RNA_interval_1</td>\n",
       "      <td>6.353941e-18</td>\n",
       "      <td>6.515164e-18</td>\n",
       "      <td>9.752542e-01</td>\n",
       "      <td>3.294578e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>49</th>\n",
       "      <td>promoter_interval_1</td>\n",
       "      <td>-2.032341e-04</td>\n",
       "      <td>2.084043e-04</td>\n",
       "      <td>-9.751915e-01</td>\n",
       "      <td>3.294889e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>50</th>\n",
       "      <td>promoter_interval_22</td>\n",
       "      <td>6.339769e-18</td>\n",
       "      <td>6.515765e-18</td>\n",
       "      <td>9.729892e-01</td>\n",
       "      <td>3.305823e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>51</th>\n",
       "      <td>promoter_interval_8</td>\n",
       "      <td>6.306255e-18</td>\n",
       "      <td>6.517015e-18</td>\n",
       "      <td>9.676601e-01</td>\n",
       "      <td>3.332376e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>52</th>\n",
       "      <td>promoter_interval_16</td>\n",
       "      <td>6.292300e-18</td>\n",
       "      <td>6.516710e-18</td>\n",
       "      <td>9.655639e-01</td>\n",
       "      <td>3.342859e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>53</th>\n",
       "      <td>promoter_interval_4</td>\n",
       "      <td>6.244234e-18</td>\n",
       "      <td>6.518950e-18</td>\n",
       "      <td>9.578588e-01</td>\n",
       "      <td>3.381572e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>54</th>\n",
       "      <td>promoter_interval_20</td>\n",
       "      <td>6.215755e-18</td>\n",
       "      <td>6.514914e-18</td>\n",
       "      <td>9.540809e-01</td>\n",
       "      <td>3.400658e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>55</th>\n",
       "      <td>promoter_interval_27</td>\n",
       "      <td>6.157438e-18</td>\n",
       "      <td>6.523485e-18</td>\n",
       "      <td>9.438878e-01</td>\n",
       "      <td>3.452498e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>56</th>\n",
       "      <td>promoter_interval_18</td>\n",
       "      <td>6.132255e-18</td>\n",
       "      <td>6.514078e-18</td>\n",
       "      <td>9.413849e-01</td>\n",
       "      <td>3.465305e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>57</th>\n",
       "      <td>promoter_interval_1</td>\n",
       "      <td>6.046775e-18</td>\n",
       "      <td>6.516830e-18</td>\n",
       "      <td>9.278706e-01</td>\n",
       "      <td>3.534971e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>58</th>\n",
       "      <td>promoter_interval_3</td>\n",
       "      <td>6.041331e-18</td>\n",
       "      <td>6.516423e-18</td>\n",
       "      <td>9.270932e-01</td>\n",
       "      <td>3.539006e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>59</th>\n",
       "      <td>promoter_interval_11</td>\n",
       "      <td>6.005614e-18</td>\n",
       "      <td>6.520314e-18</td>\n",
       "      <td>9.210621e-01</td>\n",
       "      <td>3.570403e-01</td>\n",
       "      <td>ENSG00000239906</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>60</th>\n",
       "      <td>promoter_interval_30</td>\n",
       "      <td>1.557867e-04</td>\n",
       "      <td>2.082315e-04</td>\n",
       "      <td>7.481419e-01</td>\n",
       "      <td>4.543922e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>61</th>\n",
       "      <td>RNA_interval_3</td>\n",
       "      <td>1.386885e-04</td>\n",
       "      <td>2.082786e-04</td>\n",
       "      <td>6.658800e-01</td>\n",
       "      <td>5.055032e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>62</th>\n",
       "      <td>promoter_interval_20</td>\n",
       "      <td>1.208213e-04</td>\n",
       "      <td>2.082986e-04</td>\n",
       "      <td>5.800390e-01</td>\n",
       "      <td>5.619014e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>63</th>\n",
       "      <td>promoter_interval_23</td>\n",
       "      <td>-9.140562e-05</td>\n",
       "      <td>2.082648e-04</td>\n",
       "      <td>-4.388914e-01</td>\n",
       "      <td>6.607498e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>64</th>\n",
       "      <td>promoter_interval_22</td>\n",
       "      <td>5.841694e-05</td>\n",
       "      <td>2.084496e-04</td>\n",
       "      <td>2.802449e-01</td>\n",
       "      <td>7.792954e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>65</th>\n",
       "      <td>promoter_interval_5</td>\n",
       "      <td>4.157665e-05</td>\n",
       "      <td>2.085881e-04</td>\n",
       "      <td>1.993242e-01</td>\n",
       "      <td>8.420132e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>66</th>\n",
       "      <td>RNA_interval_1</td>\n",
       "      <td>-2.650963e-05</td>\n",
       "      <td>2.083905e-04</td>\n",
       "      <td>-1.272113e-01</td>\n",
       "      <td>8.987757e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>67</th>\n",
       "      <td>promoter_interval_24</td>\n",
       "      <td>-1.474109e-05</td>\n",
       "      <td>2.084097e-04</td>\n",
       "      <td>-7.073131e-02</td>\n",
       "      <td>9.436130e-01</td>\n",
       "      <td>ENSG00000268903</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>68 rows × 6 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                    term      estimate  ...        p.value             Gene\n",
       "0   promoter_interval_27  1.404362e-02  ...   0.000000e+00  ENSG00000268903\n",
       "1   promoter_interval_28  1.434568e-02  ...   0.000000e+00  ENSG00000268903\n",
       "2   promoter_interval_30  6.450572e-04  ...   0.000000e+00  ENSG00000239906\n",
       "3   promoter_interval_14  7.401378e-03  ...  1.834235e-260  ENSG00000268903\n",
       "4   promoter_interval_11  5.935169e-03  ...  7.945986e-172  ENSG00000268903\n",
       "5   promoter_interval_10 -5.225048e-03  ...  1.494389e-134  ENSG00000268903\n",
       "6   promoter_interval_13  4.137921e-03  ...   4.407078e-86  ENSG00000268903\n",
       "7   promoter_interval_12 -3.136259e-03  ...   1.036337e-50  ENSG00000268903\n",
       "8   promoter_interval_16  2.590693e-03  ...   2.889767e-35  ENSG00000268903\n",
       "9   promoter_interval_15 -2.217819e-03  ...   2.507232e-26  ENSG00000268903\n",
       "10  promoter_interval_29  2.018174e-03  ...   4.170606e-22  ENSG00000268903\n",
       "11  promoter_interval_26  4.602962e-04  ...   2.714926e-02  ENSG00000268903\n",
       "12   promoter_interval_2 -4.414119e-04  ...   3.411938e-02  ENSG00000268903\n",
       "13   promoter_interval_6  3.639901e-04  ...   8.061893e-02  ENSG00000268903\n",
       "14   promoter_interval_8  2.998532e-04  ...   1.501436e-01  ENSG00000268903\n",
       "15  promoter_interval_19  2.935165e-04  ...   1.587405e-01  ENSG00000268903\n",
       "16   promoter_interval_4 -2.895187e-04  ...   1.646167e-01  ENSG00000268903\n",
       "17  promoter_interval_17 -2.854850e-04  ...   1.703736e-01  ENSG00000268903\n",
       "18   promoter_interval_9 -2.722893e-04  ...   1.913247e-01  ENSG00000268903\n",
       "19        RNA_interval_4 -2.656886e-04  ...   2.024212e-01  ENSG00000268903\n",
       "20        RNA_interval_2  2.629946e-04  ...   2.074038e-01  ENSG00000268903\n",
       "21  promoter_interval_21  2.384083e-04  ...   2.526235e-01  ENSG00000268903\n",
       "22  promoter_interval_25 -2.351393e-04  ...   2.592130e-01  ENSG00000268903\n",
       "23  promoter_interval_18 -2.341228e-04  ...   2.612249e-01  ENSG00000268903\n",
       "24   promoter_interval_3 -2.332801e-04  ...   2.626152e-01  ENSG00000268903\n",
       "25   promoter_interval_7  2.313951e-04  ...   2.667583e-01  ENSG00000268903\n",
       "26        RNA_interval_2  7.189265e-18  ...   2.700512e-01  ENSG00000239906\n",
       "27        RNA_interval_3  7.173850e-18  ...   2.708787e-01  ENSG00000239906\n",
       "28  promoter_interval_12  7.119031e-18  ...   2.748573e-01  ENSG00000239906\n",
       "29  promoter_interval_10  7.057541e-18  ...   2.788376e-01  ENSG00000239906\n",
       "..                   ...           ...  ...            ...              ...\n",
       "38  promoter_interval_19  6.655176e-18  ...   3.073567e-01  ENSG00000239906\n",
       "39  promoter_interval_23  6.636696e-18  ...   3.082101e-01  ENSG00000239906\n",
       "40   promoter_interval_9  6.604662e-18  ...   3.106558e-01  ENSG00000239906\n",
       "41  promoter_interval_14  6.605981e-18  ...   3.108500e-01  ENSG00000239906\n",
       "42  promoter_interval_26  6.553259e-18  ...   3.149413e-01  ENSG00000239906\n",
       "43   promoter_interval_5  6.488284e-18  ...   3.195087e-01  ENSG00000239906\n",
       "44   promoter_interval_2  6.411584e-18  ...   3.253808e-01  ENSG00000239906\n",
       "45  promoter_interval_28  6.375772e-18  ...   3.279713e-01  ENSG00000239906\n",
       "46  promoter_interval_25  6.360781e-18  ...   3.289493e-01  ENSG00000239906\n",
       "47   promoter_interval_7  6.358017e-18  ...   3.292970e-01  ENSG00000239906\n",
       "48        RNA_interval_1  6.353941e-18  ...   3.294578e-01  ENSG00000239906\n",
       "49   promoter_interval_1 -2.032341e-04  ...   3.294889e-01  ENSG00000268903\n",
       "50  promoter_interval_22  6.339769e-18  ...   3.305823e-01  ENSG00000239906\n",
       "51   promoter_interval_8  6.306255e-18  ...   3.332376e-01  ENSG00000239906\n",
       "52  promoter_interval_16  6.292300e-18  ...   3.342859e-01  ENSG00000239906\n",
       "53   promoter_interval_4  6.244234e-18  ...   3.381572e-01  ENSG00000239906\n",
       "54  promoter_interval_20  6.215755e-18  ...   3.400658e-01  ENSG00000239906\n",
       "55  promoter_interval_27  6.157438e-18  ...   3.452498e-01  ENSG00000239906\n",
       "56  promoter_interval_18  6.132255e-18  ...   3.465305e-01  ENSG00000239906\n",
       "57   promoter_interval_1  6.046775e-18  ...   3.534971e-01  ENSG00000239906\n",
       "58   promoter_interval_3  6.041331e-18  ...   3.539006e-01  ENSG00000239906\n",
       "59  promoter_interval_11  6.005614e-18  ...   3.570403e-01  ENSG00000239906\n",
       "60  promoter_interval_30  1.557867e-04  ...   4.543922e-01  ENSG00000268903\n",
       "61        RNA_interval_3  1.386885e-04  ...   5.055032e-01  ENSG00000268903\n",
       "62  promoter_interval_20  1.208213e-04  ...   5.619014e-01  ENSG00000268903\n",
       "63  promoter_interval_23 -9.140562e-05  ...   6.607498e-01  ENSG00000268903\n",
       "64  promoter_interval_22  5.841694e-05  ...   7.792954e-01  ENSG00000268903\n",
       "65   promoter_interval_5  4.157665e-05  ...   8.420132e-01  ENSG00000268903\n",
       "66        RNA_interval_1 -2.650963e-05  ...   8.987757e-01  ENSG00000268903\n",
       "67  promoter_interval_24 -1.474109e-05  ...   9.436130e-01  ENSG00000268903\n",
       "\n",
       "[68 rows x 6 columns]"
      ]
     },
     "execution_count": 15,
     "metadata": {
      "tags": []
     },
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Identification of key genomic intervals for the coexpression via multiple linear regression.\n",
    "! Rscript --vanilla --slave functions/test_interval.R \"$outloc$best_model\" &> /dev/null \n",
    "# Descriptions of outputs\n",
    "#.{outloc}/{best_model}/binding_site_removal/regression_res.txt: Result of regression test.\n",
    "pd.read_csv(outloc+best_model+'/binding_site_removal/regression_res.txt',sep=\"\\t\")"
   ]
  }
 ],
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