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Annotated Table 1 Example |Link to Table 1 KG  |Modeling Examples

Annotated Table 1 Example

An annotated example of Table 1 from a clinical trial "Telmisartan, ramipril, or both in patients at high risk for vascular events" [50] cited in the Cardiovascular Complications (Chapter 9) of the ADA 2018 CPG

Table 1 KG 

    Image generated using the RDF Viewer tool hosted at http://jimmccusker.github.io/rdfviewer/

    Visualizing the RDF representation for an age characteristic with the descriptive statistics for the Ramipril study arm, of the "Telmisartan, ramipril, or both in patients at high risk for vascular events" clinical trial

Knowledge graph of Table 1s for the various papers -> https://raw.githubusercontent.com/tetherless-world/study-cohort-ontology/master/KnowledgeGraph/Table1KG

Modeling Examples

    Modeling of Collections of Study Subjects

    Listing 1: Sample RDF N-Triples representation snippet of the Ramipril intervention arm

       sco-i:RamiprilArm
            a                      owl:Class, sco:InterventionArm; 
            rdfs:subClassOf        sio:StudySubject;
            sio:isParticipantIn    sco-i:TelmisartanRamiprilStudy;   
           sio:hasAttribute    
           [ a sco:PopulationSize; sio:hasValue 8576] .
      

    Listing 2: Representation of a sub-population within a study arm

      sco-i:AsianSubPopulation a owl:Class;
            rdfs:subClassOf sco-i:RamiprilArm;
            rdfs:subClassOf 
            [ 
                a owl:Restriction; 
                owl:onProperty sio:hasAttribute;
                owl:someValuesFrom chear:Asian
            ];
            sio:hasAttribute
            [ a sco:PopulationSize; sio:hasValue 1182],
            [ a sio:Percentage; sio:hasValue 13.8 ] .
        

    Modeling of Subject Characteristics

    Listing 1: Representation of a continuous characteristic on the Ramipril Study Arm

       sco-i:RamiprilArm
            a    owl:Class, sio:InterventionGroup; 
            rdfs:subClassOf        sio:StudySubject;
            sio:isParticipantIn    sco-i:TelmisartanRamiprilStudy;   
           sio:hasAttribute    
           [ a sco:PopulationSize; 
           sio:hasValue 8576],
            [ a sio:Age; sio:hasUnit sio:Year
            ] . 
      

    Listing 2: Representation of a categorical characteristic on the Ramipril Study Arm

      sco-i:PeripheralArteryDiseaseSubPopulation a owl:Class;
            rdfs:subClassOf sco-i:RamiprilArm;
            rdfs:subClassOf [ a owl:Restriction; 
            owl:onProperty sio:hasAttribute;
             owl:someValuesFrom doid:PeripheralArteryDisease];
         sio:hasAttribute 
         [ a sco:PopulationSize; sio:hasValue 1136 ], 
         [ a sio:Percentage; sio:hasValue 13.2 ] .
        

    Modeling of Aggregations on Subject Characteristics

    Listing 1: Representation of a descriptive statistics measures of mean +/- standard deviation on Age
      sco-i:RamiprilArm
            a    owl:Class, sio:InterventionGroup; 
            rdfs:subClassOf        sio:StudySubject;
            sio:isParticipantIn    sco-i:TelmisartanRamiprilStudy;   
           sio:hasAttribute    [ a sco:PopulationSize; sio:hasValue 8576],
            [ a sio:Age; sio:hasUnit sio:Year;
              sio:hasAttribute [ a sio:Mean; sio:hasValue 66.4],
               [a sio:StandardDeviation; sio:hasValue 7.2 ]  
            ] . 
       

    Listing 2: Representation of a descriptive statistics measure of median +/- interquartile range

      sco-i:XStudyArm
        a owl:Class, sio:InterventionGroup;
        rdfs:subClassOf sio:StudySubject; 
        sio:hasAttribute
            [
              a sio:Age; sio:hasUnit sio:Year;
              sio:hasAttribute [
                a sio:Median;
                sio:hasValue 56
              ], 
              [
                a obo:STATO_0000164; 
                sio:hasAttribute 
                [ a sio:MinimalValue; sio:hasValue 75],
                [ a sio:MaximalValue; sio:hasValue 45] 
              ] 
            ] .