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Update msk_met_2021 license details #2118

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Jan 24, 2025
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Update msk_met_2021 license details #2118

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Update meta_study.txt
Rima-Waleed Jan 9, 2025
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Update meta_study.txt
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Update meta_study.txt
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Merge branch 'master' into msk_met_update
ritikakundra Jan 23, 2025
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4 changes: 2 additions & 2 deletions public/msk_met_2021/meta_study.txt
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Expand Up @@ -2,6 +2,6 @@ type_of_cancer: mixed
cancer_study_identifier: msk_met_2021
name: MSK MetTropism (MSK, Cell 2021)
short_name: Mixed (MSK, Cell 2021)
description: MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is an integrated pan-cancer cohort of tumor genomic and clinical outcome data from 25,000 patients. We analyzed this dataset to identify associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. We also identified specific somatic alterations associated with increased metastatic burden and specific routes of metastatic spread. Our data offer a unique resource for the investigation of the biologic basis for metastatic spread and highlight the crucial role of chromosomal instability in cancer progression
description: MSK-MET (Memorial Sloan Kettering - Metastatic Events and Tropisms) is a pan-cancer cohort of tumor genomic and clinical outcome data from 25,000 patients. The dataset identifies associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types; showing that chromosomal instability is strongly correlated with metastatic burden in some tumor types, like prostate and lung adenocarcinomas and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. The study also identifies somatic alterations associated with increased metastatic burden and routes of metastatic spread. Our data offers a resource for the investigation of the biologic basis for metastatic spread and highlights the role of chromosomal instability in cancer progression. This data is available under the <a href="https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en">Creative Commons BY-NC-ND 4.0 license</a>.
pmid: 35120664
citation: Nguyen et al. Cell 2022
citation: Nguyen et al. Cell 2022