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kchu25 committed Aug 21, 2024
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Expand Up @@ -28,9 +28,9 @@ will give

The information content $IC(\cdot)$ (i.e. the "letter height") of the $i$-th column $c_i$ in a position weight matrix (PWM) is

$$
```math
IC(c_i) = \sum_{\alpha}\,f_{\alpha i}\,\log_2 \frac{f_{\alpha i}}{\beta_\alpha}
$$
```

where $f_{\alpha i}$ the frequency of nucleotide $\alpha\in\{A,C,G,T\}$ at the $i$-th column of a PWM. The $4$-dimensional vector $\beta$ is the assumed genomic background

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