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Update README.md #257

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Feb 20, 2024
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Update README.md #257

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7 changes: 6 additions & 1 deletion README.md
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Expand Up @@ -322,12 +322,17 @@ quite light and usually start running as soon as they are scheduled.
### 5e) Known limitations

* **Swapping if the number of queries too high.** If the number of queries is
too high, the auxiliary Python scripts start to use too much memory, which
too high (e.g., 10M Illumina reads),
the auxiliary Python scripts start to use too much memory, which
may result in swapping. Try to keep the number of queries moderate and
ideally their names short.
* **No support for ambiguous characters in queries.** As the tools used
internally by MOF-Search support only the nucleotide alphabet, all non-ACGT
characters in queries are first converted to A.
* **Too many reported hits.** When queries have too many equally good hits in
the database, even if the threshold on the maximum number of hits is chosen
low – for instance 10 – the program will take top 10 + ties, which can be a
huge number (especially for short sequences).


## 6. License
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