add modules + subworkflow for protein activity

[juanesarango]

Tools for computational inference of protein activity network and its interactions, useful for precision medicine to understand how drugs are involved in protein pathways.

Tools like VIPER and ARACne from the Califano Lab are useful in understanding the protein-activity interactions, on an individual sample basis, from gene expression profile data:

"Under the premise that cellular phenotypes not only result from alterations in the genomic code but also depend on the influences of multiscale networks of molecular interactions that regulate gene expression, protein abundance, epigenetic state, and signaling activity. Therefore, understanding how the code embedded in the genome eventually generates cellular phenotypes requires the development of methods for integrating data describing these various levels of activity." Source

Goal

Create modules and a subworkflow for the computational inference of protein activity network and its interactions, useful for precision medicine to understand how drugs are involved in protein pathways.

Depends on issues:

• new module: protein-activity/viper #7990
• new module: protein-activity/aracne #7991