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@salilab

Sali Lab

Laboratory of Andrej Sali at the University of California San Francisco

Laboratory of Andrej Sali: Integrative Structural Biology

We aim to develop and apply computational methods for integrative determination of the structures and dynamics of macromolecular assemblies, in turn informing the function and evolution of these systems as well as how to modulate them. The broad goal is to contribute to a predictive spatiotemporal model of the cell. This goal is being achieved by a formal integration of experiment, physics, and statistical inference, spanning all relevant size and time scales. Our computational methods are implemented in the open source Integrative Modeling Platform package (IMP) and the resulting models are deposited in the PDB-Dev database. This research enhances the discovery of general principles that underlie all cellular processes, which in turn also facilitates drug discovery.

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  1. imp imp Public

    The Integrative Modeling Platform

    C++ 76 30

  2. pmi pmi Public

    Python Modeling Interface

    Python 13 11

  3. rmf rmf Public

    The library to support reading and writing of RMF files.

    C++ 9

Repositories

Showing 10 of 81 repositories
  • imp_nightly_builds Public

    Infrastructure to build and test IMP on a nightly basis

    salilab/imp_nightly_builds’s past year of commit activity
    Python 0 CC-BY-SA-4.0 0 0 0 Updated Apr 20, 2025
  • pyRMSD Public Forked from victor-gil-sepulveda/pyRMSD

    pyRMSD is a small Python package that aims to offer an integrative and efficient way of performing RMSD calculations of large sets of structures. It is specially tuned to do fast collective RMSD calculations, as pairwise RMSD matrices.

    salilab/pyRMSD’s past year of commit activity
    C++ 4 14 0 0 Updated Apr 17, 2025
  • imp Public

    The Integrative Modeling Platform

    salilab/imp’s past year of commit activity
    C++ 76 GPL-3.0 30 63 1 Updated Apr 16, 2025
  • mdt Public

    Generate frequency tables used by Modeller and IMP.

    salilab/mdt’s past year of commit activity
    C 0 GPL-2.0 0 0 0 Updated Apr 5, 2025
  • homebrew-salilab Public

    🍻 Sali Lab formulae for homebrew

    salilab/homebrew-salilab’s past year of commit activity
    Ruby 1 CC-BY-SA-4.0 0 0 0 Updated Apr 5, 2025
  • threading Public

    IMP module to sample sequence threading

    salilab/threading’s past year of commit activity
    Python 1 0 0 1 Updated Mar 30, 2025
  • imp_spatiotemporal_tutorial Public

    Tutorial for computing spatiotemporal integrative models in IMP

    salilab/imp_spatiotemporal_tutorial’s past year of commit activity
    Python 0 CC-BY-SA-4.0 0 0 0 Updated Mar 27, 2025
  • pmi Public

    Python Modeling Interface

    salilab/pmi’s past year of commit activity
    Python 13 11 37 1 Updated Mar 19, 2025
  • conda-recipes Public

    Recipes for the conda package manager

    salilab/conda-recipes’s past year of commit activity
    Shell 3 CC-BY-SA-4.0 2 3 0 Updated Mar 12, 2025
  • npctransport Public

    IMP module for simulating transport through the NPC.

    salilab/npctransport’s past year of commit activity
    C++ 3 2 6 0 Updated Mar 6, 2025

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