database downloading error, Network is unreachable.

[Liao-PRIC]

Hi,

I can't download any databases using the command below:
foldseek databases ProstT5 weights tmp

#Failed to connect to foldseek.steineggerlab.workers.dev port 443: Connection timed out. Connecting to foldseek.steineggerlab.workers.dev (foldseek.steineggerlab.workers.dev)|2a03:2880:f11f:83:face:b00c:0:25de|:443... failed: Network is unreachable.
Error: Could not download https://foldseek.steineggerlab.workers.dev/prostt5-f16-safetensors.tar.gz to tmp/667848509520158939/prostt5-f16-safetensors.tar.gz

Same for the other databases. I guess it is because of the internet issue in China. So I downloaded the files using the link provided in the report, via my PC with VPN, and then manually copied the files to the tmp directory. However, when I ran the createdb command below,
createdb ./gene_catalogue.faa db --prostt5-model weights
I got this error ’Could not find ProstT5 model weights. Download with foldseek databases ProstT5 prostt5_out tmp”.
It seems that the files manually downloaded and put in the tmp directly does not work as expected.

So my questions are:

1. How can I set up the databases correctly by using the files downloaded manually, if I can't download them from the internet using the foldseek command?
2. I try to create a custom structure database by using a group of amino acid sequences as the input following the tutorial document. Will I be able to search the custom database using an amino acid sequence as the query and find hits with similar sturcutres? Could you take a look at the command below:
   foldseek createdb customdb.fa db --prostt5-model weights #it requires dowloading ProstT5 before creating custom database?
   foldseek easy-search QUERY.fasta customdb result.m8 tmp --prostt5-model weights #is it correct?

Thank you very much for helping me out.
Li

[xjhzjucas]

Hi, did you solve this problem?